Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1995-03-28

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.92.7.2682PMID 7708705PMCID PMC42282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B).

  1994cited by this paper
• Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra.

  1993cited by this paper
• Protein phosphorylation and dephosphorylation in mammalian central nervous system.

  1993cited by this paper
• Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine

  1992cited by this paper
• Protein phosphatases: recent progress.

  1991cited by this paper
• Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes.

  1991cited by this paper
• Neurotransmitters and neuromodulators in the basal ganglia.

  1990cited by this paper
• Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

  1990cited by this paper
• Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.

  1989cited by this paper
• Calcineurin.

  1988cited by this paper
• Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

  1988cited by this paper
• Protein phosphatase-2C from rabbit skeletal muscle and liver: an Mg2+-dependent enzyme.

  1988cited by this paper
• DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution

  1986cited by this paper
• DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1.

  1984cited by this paper
• DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

  1984cited by this paper
• Activation of calcineurin by limited proteolysis.

  1983cited by this paper
• Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture.

  1980cited by this paper

• Bmal1 Modulates Striatal cAMP Signaling and Motor Learning

  2025cites this paper
• Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

  2025cites this paper
• Phosphodiesterase-4 Inhibition in Parkinson’s Disease: Molecular Insights and Therapeutic Potential

  2023cites this paper
• PLPP/CIN inhibits dopamine D1 receptor-mediated seizure activity via DARPP-32 serine 97 dephosphorylation in the mouse hippocampus.

  2023cites this paper
• DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum

  2023cites this paper
• Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch

  2022cites this paper
• The Signaling and Pharmacology of the Dopamine D1 Receptor

  2022cites this paper
• Exploring the Role of DARPP-32 in Addiction: A Review of the Current Limitations of Addiction Treatment Pathways and the Role of DARPP-32 to Improve Them

  2022cites this paper
• DARPP-32 40 years later.

  2021cites this paper
• Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction.

  2021cites this paper
• Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks.

  2019cites this paper
• Dopamine: Functions, Signaling, and Association with Neurological Diseases

  2018cites this paper
• CK1δ over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes

  2018cites this paper
• Regulation of Striatal Signaling by Protein Phosphatases

  2017cites this paper
• Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders

  2017cites this paper
• Cocaine and Posttranslational Modifications of Neuronal Proteins

  2017cites this paper
• Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons

  2016cites this paper
• Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution*

  2016cites this paper
• Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders

  2016influential citation
• The Role of the Dopamine D1-D2 Receptor Heteromer in Brain Reward Function: Relevance to Drug Addiction and Depression

  2015influential citation
• The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

  2014cites this paper
• Integrating neurotransmission in striatal medium spiny neurons.

  2012cites this paper
• Identification et caractérisation des inhibiteurs de type 2 et 3 de la phosphatase de type 1 chez Plasmodium falciparum

  2012cites this paper
• An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.

  2012cites this paper
• Histone post-translational modifications in the nuclei of striatal D1 and D2 neurons : development of a novel method of study and effects of cocaine

  2012cites this paper
• Rôle de la protéine phosphatase 1 dans les mécanismes d’action de la cocaïne et implication des modifications épigénétiques dans sa régulation

  2012cites this paper
• Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia.

  2012cites this paper
• Calcineurin inhibitors: status quo and perspectives

  2011cites this paper
• Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation

  2011cites this paper
• Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons

  2011cites this paper
• Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases

  2011cites this paper
• DARPP-32, Jack of All Trades… Master of Which?

  2011cites this paper
• Genetic influences on the human mesolimbic dopamine reward system

  2011cites this paper
• The Physiology, Signaling, and Pharmacology of Dopamine Receptors

  2011influential citation
• Casein kinase 1 (Csnk1) is a serine/threonine protein kinase that phosphorylates a wide array of substrates, is involved in the regulation of diverse cellular processes, and is richly expressed in multiple tissues including brain (Knippschild

  2011cites this paper
• Forebrain overexpression of CK1δ leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD

  2010cites this paper
• Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmitters.

  2010cites this paper
• Isoform specific phosphorylation of p53 by protein kinase CK1

  2010cites this paper
• A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity

  2010influential citation
• Mechanisms of Locomotor Sensitization to Drugs of Abuse in a Two-Injection Protocol

  2010cites this paper
• Biochemical Networks in Psychiatric Disease

  2010cites this paper
• Steroid Hormone Action in the Brain: Cross‐Talk Between Signalling Pathways

  2009cites this paper
• A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine

  2009cites this paper
• DARPP-32: molecular integration of phosphorylation potential

  2008cites this paper
• Modelling of DARPP-32 Regulation to Understand Intracellular Signaling in Psychiatric Disease

  2008cites this paper
• Molecular mechanisms underlying the actions of psychoactive drugs in the basal ganglia : Focus on cannabinoids and morphine

  2008cites this paper
• Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling.

  2007cites this paper
• Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

  2007cites this paper
• Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.

  2007cites this paper
• The Effects of Nicotine on the Regulation of Neuronal 7 Nicotinic Acetylcholine Receptors and Intracellular Signalling Pathways

  2007cites this paper
• The Effects of Nicotine on the Regulation of Neuronal Alpha7 Nicotinic Acetylcholine Receptors and Intracellular Signalling Pathways

  2007cites this paper
• Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons.

  2007cites this paper
• Regulation of Alzheimer's disease amyloid-β formation by casein kinase I

  2007cites this paper
• DARPP-32 Involvement in the Photic Pathway of the Circadian System

  2006cites this paper
• The first armadillo repeat is involved in the recognition and regulation of β-catenin phosphorylation by protein kinase CK1

  2006cites this paper
• Association between the Casein Kinase 1 Epsilon Gene Region and Subjective Response to D-Amphetamine

  2006cites this paper
• Transient Calcium and Dopamine Increase PKA Activity and DARPP-32 Phosphorylation

  2006cites this paper
• Cocaine Self-Administration in Mice Is Inversely Related to Phosphorylation at Thr34 (Protein Kinase A Site) and Ser130 (Kinase CK1 Site) of DARPP-32

  2006cites this paper
• DARPP-32InvolvementinthePhoticPathwayofthe CircadianSystem

  2006cites this paper
• The casein kinase 1 family: participation in multiple cellular processes in eukaryotes.

  2005cites this paper
• Molecular mechanisms regulating exocytosis : Studies of insulin secretion and neurotransmitter release

  2005cites this paper
• Chapter II Signal transduction of dopamine receptors

  2005cites this paper
• DARPP-32 mediates the actions of multiple drugs of abuse

  2005cites this paper
• Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain.

  2005cites this paper
• Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons

  2005influential citation
• Augmented Constitutive CREB Expression in the Nucleus accumbens and Striatum May Contribute to the Altered Behavioral Response to Cocaine of Adult Mice Exposed to Cocaine in utero

  2005cites this paper
• Diverse psychotomimetics act through a common signaling pathway.

  2004cites this paper
• Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation.

  2004cites this paper
• Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex

  2004cites this paper
• The role of DARPP-32 in the actions of drugs of abuse.

  2004cites this paper
• Diverse Psychotomimetics Act Through a Common Signaling Pathway

  2003cites this paper
• Mechanism of Regulation of Casein Kinase I Activity by Group I Metabotropic Glutamate Receptors*

  2002cites this paper
• CREB and Elk-1 phosphorylation by metabotropic glutamate receptors in striatal neurons (review).

  2002cites this paper
• Structural features underlying the multisite phosphorylation of the A domain of the NF-AT4 transcription factor by protein kinase CK1.

  2002cites this paper
• Signal Transduction by Dopamine D1 Receptors

  2002cites this paper
• Dopamine in the CNS I

  2002cites this paper
• DARPP-32 mediates serotonergic neurotransmission in the forebrain

  2002cites this paper
• Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

  2002cites this paper
• Are we β-ARKing up the wrong tree? Casein kinase 1α provides an additional pathway for GPCR phosphorylation

  2002cites this paper
• Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum.

  2002cites this paper
• The neurobiology of slow synaptic transmission.

  2001cites this paper
• Phosphorylation of Protein Phosphatase Inhibitor-1 by Cdk5*

  2001cites this paper
• Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors

  2001cites this paper
• Casein kinase 2 as a potentially important enzyme in the nervous system.

  2000cites this paper
• Regulation of protein phosphatase-1.

  2000influential citation
• Effects of serine/threonine protein phosphatases on ion channels in excitable membranes.

  2000cites this paper
• Quantitative Immunogold Localization of Protein Phosphatase 2B (Calcineurin) in Paramecium Cells

  2000cites this paper
• Role of Calcineurin and Protein Phosphatase‐2A in the Regulation of DARPP‐32 Dephosphorylation in Neostriatal Neurons

  1999cites this paper
• Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.

  1999cites this paper
• Regulation of voltage-sensitive sodium and calcium channels by phosphorylation.

  1999cites this paper
• Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.

  1999cites this paper
• Potential role of calcineurin for brain ischemia and traumatic injury.

  1999cites this paper
• Purification and Characterization of a Novel Physiological Substrate for Calcineurin in Mammalian Cells*

  1998cites this paper
• Molecular Components of Striatal Plasticity: The Various Routes of Cyclic AMP Pathways

  1998cites this paper
• Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family.

  1998cites this paper
• Physiologic importance of protein phosphatase inhibitors.

  1998cites this paper
• Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons.

  1998cites this paper
• The MAP kinase cascade is activated prior to the induction of gliosis in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of dopaminergic neurotoxicity.

  1998cites this paper
• The MAP Kinase Cascade Is Activated prior to the Induction of Gliosis in the 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) Model of Dopaminergic Neurotoxicity

  1998cites this paper
• The DARPP-32/protein phosphatase-1 cascade: a model for signal integration.

  1998cites this paper