Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Oncogene

• Publication date

  2006-09-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1209871PMID 16998503
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of Brcal is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

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• Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland

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• Purification and unique properties of mammary epithelial stem cells

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• Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma

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• A role for Brca1 in chromosome end maintenance.

  2006cited by this paper
• BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

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• Paradoxical roles of the immune system during cancer development

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• ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

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• Fibroblasts in cancer

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• Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3

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• Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling

  2006cited by this paper
• Generation of a functional mammary gland from a single stem cell

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• BRCA1 participates in DNA decatenation

  2005cited by this paper
• Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

  2005cited by this paper
• Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1.

  2005cited by this paper
• Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers

  2005cited by this paper
• Is BRCA1/BRCA2‐related breast carcinogenesis estrogen dependent?

  2005cited by this paper
• A new alternative splice variant of BRCA1 containing an additional in-frame exon.

  2005cited by this paper
• Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer

  2005cited by this paper
• CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

  2005cited by this paper
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

  2005cited by this paper
• Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

  2005cited by this paper
• BRCA1 Regulates Gene Expression for Orderly Mitotic Progression

  2005cited by this paper
• Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.

  2005cited by this paper
• Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

  2005cited by this paper
• Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers.

  2004cited by this paper
• Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2

  2004cited by this paper
• A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint.

  2004influential reference
• A delayed chemically induced tumorigenesis in Brca2 mutant mice

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• Focused Review Series : BRCA 1 at 10 Years Since Discovery

  2004cited by this paper
• BRCA1 and BRCA2: 1994 and beyond

  2004cited by this paper
• Genetic Interactions between Brca1 and Gadd45a in Centrosome Duplication, Genetic Stability, and Neural Tube Closure*

  2004influential reference
• Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53+/− Mutant Mice

  2004cited by this paper
• Collaboration of Brca1 and Chk2 in tumorigenesis.

  2004cited by this paper
• BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

  2004cited by this paper
• Identification of BRCA1-IRIS, a BRCA1 locus product

  2004cited by this paper
• Emerging functions of BRCA2 in DNA recombination.

  2004cited by this paper
• Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

  2004cited by this paper
• Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues

  2003cited by this paper
• Repeated observation of breast tumor subtypes in independent gene expression data sets

  2003cited by this paper
• Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.

  2003cited by this paper
• Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.

  2003cited by this paper
• Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice

  2003cited by this paper
• Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides.

  2003cited by this paper
• BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription

  2003cited by this paper
• Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model.

  2003cited by this paper
• Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

  2003cited by this paper
• Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

  2002influential reference
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• BRCA1 supports XIST RNA concentration on the inactive X chromosome.

  2002cited by this paper
• Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

  2002cited by this paper
• The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.

  2002cited by this paper
• The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

  2002cited by this paper
• Review Cancer Susceptibility and the Functions of BRCA1 and BRCA2

  2002cited by this paper
• Conditional mouse models of sporadic cancer

  2002cited by this paper
• Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

  2001cited by this paper
• A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

  2001cited by this paper
• Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

  2001influential reference
• Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

  2001cited by this paper
• Tumorigenesis in mice carrying a truncating Brca1 mutation.

  2001influential reference
• Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

  2001influential reference
• Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

  2001cited by this paper
• BRCA2 is required for homology-directed repair of chromosomal breaks.

  2001cited by this paper
• Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

  2001influential reference
• Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

  2001cited by this paper
• Expression of Brca1 and splice variant Brca1Δ11 RNA levels in mouse mammary gland during normal development and tumorigenesis

  2000cited by this paper
• Brca1 required for T cell lineage development but not TCR loci rearrangement

  2000influential reference
• Brca2‐Null Embryonic Survival is Prolonged on the BALB/c Genetic Background

  2000cited by this paper
• Clinico-pathological characteristics of BRCA1- and BRCA2-related breast cancer.

  2000cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice

  1999cited by this paper
• BRCA1 inhibition of estrogen receptor signaling in transfected cells.

  1999cited by this paper
• Brca1 controls homology-directed DNA repair.

  1999cited by this paper
• Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

  1999influential reference
• Genomic instability in Gadd45a-deficient mice

  1999cited by this paper
• Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers.

  1999cited by this paper
• Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

  1999cited by this paper
• Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

  1999cited by this paper
• Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

  1999cited by this paper
• Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

  1999cited by this paper
• Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.

  1999influential reference
• Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

  1999cited by this paper
• Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice

  1998cited by this paper
• Involvement of Brca2 in DNA repair.

  1998cited by this paper
• A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

  1998cited by this paper
• Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence.

  1998cited by this paper
• Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

  1998cited by this paper
• Efficient BLG-Cre Mediated Gene Deletion in the Mammary Gland

  1998cited by this paper
• Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families

  1997cited by this paper
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  1997cited by this paper
• Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

  1997influential reference
• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• p53 mutations in BRCA1-associated familial breast cancer.

  1997cited by this paper
• Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52.

  1997cited by this paper
• Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

  1997influential reference
• Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b.

  1997cited by this paper
• Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

  1997cited by this paper
• Cre-mediated gene deletion in the mammary gland.

  1997cited by this paper
• Localization of BRCA1 and a splice variant identifies the nuclear localization signal

  1997cited by this paper

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• Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis

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• Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats

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• Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility

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• Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis

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• Cells-of-Origin of Breast Cancer and Intertumoral Heterogeneity.

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• Rat Models of Breast Cancer.

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• BRCA1 influences whole-body metabolism in humanized mice.

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• RAD51-mediated homologous recombination is a pro-tumour driver pathway

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• DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition.

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• Spontaneous and Radiation-induced Mammary and Thyroid Tumorigenesis in LEW and (SD×COP)F1 Brca1L63X/+ Rats

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• The Evolution of Mouse Models of Cancer: Past, Present, and Future.

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• Nontraditional models as research tools: the road not taken.

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• Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns.

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• The emergence of Fanconi anaemia type S: a phenotypic spectrum of biallelic BRCA1 mutations

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• A chromosome-assigned Mongolian gerbil genome with sequenced centromeres provides evidence of a new chromosome

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• FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks

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• BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile‐induced mesothelioma via ferroptosis resistance

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• Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

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