A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  American Journal of Pathology

• Publication date

  2003-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)63507-9PMID 14507657PMCID PMC1868297
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Introduction: functional polarity of motile neutrophils.

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