Coronavirus reverse genetic systems: Infectious clones and replicons

Highlights • The four different reverse genetic systems developed for CoVs are reviewed and discussed.• These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector.• CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis.• These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.

• Publication year

  2014

• Venue

  Virus Research

• Publication date

  2014-06-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virusres.2014.05.026PMID 24930446PMCID 4727449
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Middle East respiratory syndrome coronavirus☆

  2015cited by this paper
• Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

  2013cited by this paper
• Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

  2013influential reference
• Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1

  2013cited by this paper
• Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

  2013influential reference
• Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

  2013cited by this paper
• Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.

  2012cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

  2012cited by this paper
• A Reverse Genetics Approach To Study Feline Infectious Peritonitis

  2012cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

  2012cited by this paper
• Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination

  2012cited by this paper
• Molecular Characterization of Feline Infectious Peritonitis Virus Strain DF-2 and Studies of the Role of ORF3abc in Viral Cell Tropism

  2012cited by this paper
• Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex

  2011influential reference
• Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

  2011influential reference
• Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy.

  2011influential reference
• Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

  2010cited by this paper
• A New Cistron in the Murine Hepatitis Virus Replicase Gene

  2010cited by this paper
• Quantitative Proteomics Analysis Reveals BAG3 as a Potential Target To Suppress Severe Acute Respiratory Syndrome Coronavirus Replication

  2010cited by this paper
• RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis

  2010cited by this paper
• Coronaviridae

  2010cited by this paper
• Establishment of the eukaryotic cell lines for inducible control of SARS-CoV nucleocapsid gene expression

  2010cited by this paper
• Host cell proteins interacting with the 3′ end of TGEV coronavirus genome influence virus replication

  2009cited by this paper
• Coronavirus Nucleocapsid Protein Facilitates Template Switching and Is Required for Efficient Transcription

  2009cited by this paper
• Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

  2009influential reference
• The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication.

  2009cited by this paper
• Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2

  2009cited by this paper
• Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

  2009cited by this paper
• Identification of a Coronavirus Transcription Enhancer

  2008cited by this paper
• Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63

  2008cited by this paper
• Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication

  2008influential reference
• A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters

  2008cited by this paper
• Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

  2008cited by this paper
• High-throughput assay using a GFP-expressing replicon for SARS-CoV drug discovery

  2008cited by this paper
• Reverse Genetics of The Largest RNA Viruses

  2008cited by this paper
• Advances in genomic research on hepatitis C virus with a useful tool, replicon system.

  2008cited by this paper
• The Molecular Biology of Coronaviruses

  2008cited by this paper
• Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein function

  2008cited by this paper
• Generation of Recombinant Coronaviruses Using Vaccinia Virus as the Cloning Vector and Stable Cell Lines Containing Coronaviral Replicon RNAs

  2007cited by this paper
• Analysis of Murine Hepatitis Virus Strain A59 Temperature-Sensitive Mutant TS-LA6 Suggests that nsp10 Plays a Critical Role in Polyprotein Processing

  2007cited by this paper
• Hepatitis C virus infection: in vivo and in vitro models

  2007cited by this paper
• Genome Organization and Reverse Genetic Analysis of a Type I Feline Coronavirus

  2007cited by this paper
• Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease

  2007cited by this paper
• Transient Dominant Selection for the Modification and Generation of Recombinant Infectious Bronchitis Coronaviruses

  2007cited by this paper
• Using RNAi to knockdown gene function

  2006cited by this paper
• Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells

  2006cited by this paper
• Construction of a Severe Acute Respiratory Syndrome Coronavirus Infectious cDNA Clone and a Replicon To Study Coronavirus RNA Synthesis

  2006influential reference
• Biochemical aspects of coronavirus replication and virus-host interaction.

  2006cited by this paper
• Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

  2006cited by this paper
• Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: Engineering a recombination-resistant genome

  2006cited by this paper
• An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells

  2006influential reference
• Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli.

  2006cited by this paper
• The Molecular Biology of Coronaviruses

  2006cited by this paper
• A Severe Acute Respiratory Syndrome Coronavirus That Lacks the E Gene Is Attenuated In Vitro and In Vivo

  2006cited by this paper
• Recovery of a Neurovirulent Human Coronavirus OC43 from an Infectious cDNA Clone

  2006cited by this paper
• Derivation of a novel SARS–coronavirus replicon cell line and its application for anti-SARS drug screening

  2006influential reference
• The Coronavirus Replicase

  2005cited by this paper
• Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia

  2005cited by this paper
• Gene 5 of the Avian Coronavirus Infectious Bronchitis Virus Is Not Essential for Replication

  2005cited by this paper
• Recombinant Mouse Hepatitis Virus Strain A59 from Cloned, Full-Length cDNA Replicates to High Titers In Vitro and Is Fully Pathogenic In Vivo

  2005influential reference
• Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro

  2005cited by this paper
• Coronavirus Replication and Reverse Genetics

  2005cited by this paper
• Reverse Genetics of Coronaviruses Using Vaccinia Virus Vectors

  2005cited by this paper
• Selective Replication of Coronavirus Genomes That Express Nucleocapsid Protein

  2005cited by this paper
• Coronavirus Reverse Genetics by Targeted RNA Recombination

  2005cited by this paper
• Development of Mouse Hepatitis Virus and SARS-CoV Infectious cDNA Constructs

  2005cited by this paper
• The Nucleoprotein Is Required for Efficient Coronavirus Genome Replication

  2004influential reference
• Generation of a recombinant avian coronavirus infectious bronchitis virus using transient dominant selection

  2004influential reference
• In vitro assembled, recombinant infectious bronchitis viruses demonstrate that the 5a open reading frame is not essential for replication

  2004influential reference
• Identification of a new human coronavirus

  2004cited by this paper
• Rapid identification of coronavirus replicase inhibitors using a selectable replicon RNA.

  2004cited by this paper
• SARS — beginning to understand a new virus

  2003cited by this paper
• Targeted modification of a human beta-globin locus BAC clone using GET Recombination and an I-Scei counterselection cassette.

  2003influential reference
• Cloning of herpesviral genomes as bacterial artificial chromosomes

  2003cited by this paper
• Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

  2003cited by this paper
• Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59

  2002influential reference
• Generation of a Replication-Competent, Propagation-Deficient Virus Vector Based on the Transmissible Gastroenteritis Coronavirus Genome

  2002cited by this paper
• Stabilization of a Full-Length Infectious cDNA Clone of Transmissible Gastroenteritis Coronavirus by Insertion of an Intron

  2002cited by this paper
• Hepatitis C virus replicons: potential role for drug development

  2002cited by this paper
• Heterologous Gene Expression from Transmissible Gastroenteritis Virus Replicon Particles

  2002influential reference
• A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA.

  2001influential reference
• Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus

  2001influential reference
• Viral Replicase Gene Products Suffice for Coronavirus Discontinuous Transcription

  2001influential reference
• Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus.

  2001influential reference
• Cooperation of an RNA Packaging Signal and a Viral Envelope Protein in Coronavirus RNA Packaging

  2001cited by this paper
• Replicon-based vectors of positive strand RNA viruses.

  2000cited by this paper
• Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome.

  2000influential reference
• Strategy for Systematic Assembly of Large RNA and DNA Genomes: Transmissible Gastroenteritis Virus Model

  2000influential reference
• A Phylogenetically Conserved Hairpin-Type 3′ Untranslated Region Pseudoknot Functions in Coronavirus RNA Replication

  1999cited by this paper
• Replication and Packaging of Transmissible Gastroenteritis Coronavirus-Derived Synthetic Minigenomes

  1999cited by this paper
• Genetic complementation among three panels of mouse hepatitis virus gene 1 mutants.

  1998cited by this paper
• Importance of the Positive-Strand RNA Secondary Structure of a Murine Coronavirus Defective Interfering RNA Internal Replication Signal in Positive-Strand RNA Synthesis

  1998cited by this paper
• A new logic for DNA engineering using recombination in Escherichia coli

  1998influential reference
• Complete nucleotide sequence of two generations of a bacterial artificial chromosome cloning vector.

  1997cited by this paper
• Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus.

  1996cited by this paper
• Alphavirus-based expression vectors: strategies and applications.

  1996cited by this paper
• Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer

  1996cited by this paper
• Map locations of mouse hepatitis virus temperature-sensitive mutants: confirmation of variable rates of recombination

  1994cited by this paper
• Genetics of mouse hepatitis virus transcription: evidence that subgenomic negative strands are functional templates

  1994cited by this paper
• Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

  1992influential reference
• Evidence for variable rates of recombination in the MHV genome

  1992cited by this paper

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