Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Blood

• Publication date

  2008-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood-2007-09-111567PMID 18326817PMCID PMC2384142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.

  2007cited by this paper
• The distal location of the iron responsive region of the hepcidin promoter.

  2007cited by this paper
• Neogenin-RGMa Signaling at the Growth Cone Is Bone Morphogenetic Protein-independent and Involves RhoA, ROCK, and PKC*

  2007cited by this paper
• Different regulatory elements are required for response of hepcidin to interleukin‐6 and bone morphogenetic proteins 4 and 9

  2007cited by this paper
• Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

  2007cited by this paper
• Evidence That Inhibition of Hemojuvelin Shedding in Response to Iron Is Mediated through Neogenin*

  2007cited by this paper
• Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.

  2007cited by this paper
• Repulsive Guidance Molecule RGMa Alters Utilization of Bone Morphogenetic Protein (BMP) Type II Receptors by BMP2 and BMP4*

  2007cited by this paper
• Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells

  2006cited by this paper
• Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

  2006cited by this paper
• Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins.

  2006cited by this paper
• Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

  2006cited by this paper
• Mutual Regulation of Follicle-Stimulating Hormone Signaling and Bone Morphogenetic Protein System in Human Granulosa Cells1

  2006cited by this paper
• Interaction of Hemojuvelin with Neogenin Results in Iron Accumulation in Human Embryonic Kidney 293 Cells*

  2005cited by this paper
• DRAGON, a Bone Morphogenetic Protein Co-receptor*

  2005cited by this paper
• Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses*

  2005cited by this paper
• Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor*

  2005cited by this paper
• Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.

  2005cited by this paper
• A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

  2005cited by this paper
• Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells*

  2005cited by this paper
• The bone morphogenetic protein system in mammalian reproduction.

  2004cited by this paper
• Reconstitution and Analysis of Soluble Inhibin and Activin Receptor Complexes in a Cell-free System*

  2004cited by this paper
• DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties

  2004cited by this paper
• RGM and its receptor neogenin regulate neuronal survival

  2004cited by this paper
• Neogenin mediates the action of repulsive guidance molecule

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Isolation and expression pattern of three mouse homologues of chick Rgm.

  2004cited by this paper
• Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin.

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Balancing acts: molecular control of mammalian iron metabolism.

  2004cited by this paper
• Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

  2003cited by this paper
• Inhibin Is an Antagonist of Bone Morphogenetic Protein Signaling*

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-β family signalling

  2003cited by this paper
• Bone morphogenetic proteins BMP‐6 and BMP‐7 have differential effects on survival and neurite outgrowth of cerebellar granule cell neurons

  2002cited by this paper
• Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter*

  2002cited by this paper
• A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*

  2001cited by this paper
• Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver*

  2001cited by this paper
• Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

  2000cited by this paper
• Controlling TGF-beta signaling.

  2000cited by this paper
• Controlling TGF-β signaling

  2000cited by this paper
• LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity

  2000cited by this paper
• Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.

  1999cited by this paper
• Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.

  1999cited by this paper
• Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

  1998cited by this paper
• Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

  1990cited by this paper
• Review Balancing Acts: Molecular Control of Mammalian Iron Metabolism

  year unknowncited by this paper

• Matriptase-2-mediated suppression of hepatic hepcidin expression in mice requires hepatocyte neogenin

  2026cites this paper
• Current Research Progress of Iron Deficiency in Heart Failure

  2025cites this paper
• Iron, the Essential Micronutrient: A Comprehensive Review of Regulatory Pathways of Iron Metabolism

  2025cites this paper
• Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis

  2025cites this paper
• Extreme physical inactivity alters iron metabolism: mechanisms and health issues for astronauts and bedridden patients

  2025cites this paper
• Sevuparin strongly reduces hepcidin expression in cells, mice, and healthy human volunteers

  2024cites this paper
• Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury

  2024influential citation
• Investigational drugs in early phase trials for myelofibrosis

  2024cites this paper
• Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential

  2024cites this paper
• RGM Family Involved in the Regulation of Hepcidin Expression in Anemia of Chronic Disease

  2024cites this paper
• Hemojuvelin-mediated hepcidin induction requires both bone morphogenetic protein type I receptors ALK2 and ALK3

  2024cites this paper
• Pharmacophore-based computational study on inhibitor of TMPRSS6 as hepcidin modulator in an iron overload of beta-thalassaemia

  2024cites this paper
• Hepcidin expression is associated with increased γ-secretase–mediated cleavage of neogenin in the liver

  2024cites this paper
• Interferon-induced polarization of M1 macrophages mediates antiviral activity against the hepatitis B virus via the hepcidin-ferroportin axis.

  2024cites this paper
• Interplay between gut microbiota and the master iron regulator, hepcidin, in the pathogenesis of liver fibrosis

  2024cites this paper
• Hepcidin Is a Valuable Therapeutic Target for Colorectal Cancer

  2024cites this paper
• FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes

  2023influential citation
• TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

  2023cites this paper
• Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis

  2023cites this paper
• Iron Status in Adolescents with Eating Disorder: A Systematic Review

  2023cites this paper
• Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension.

  2022cites this paper
• Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis

  2022cites this paper
• Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress

  2022cites this paper
• Immunoregulatory effects of RGMb in gut inflammation

  2022cites this paper
• Hepatocyte neogenin, another key actor in iron homeostasis.

  2021cites this paper
• Bone morphogenetic protein 6–mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro

  2021influential citation
• Runx3 regulates iron metabolism via modulation of BMP signalling

  2021cites this paper
• Hemochromatosis

  2021cites this paper
• Hepatocyte Neogenin Is Required for Hemojuvelin-Mediated Hepcidin Expression and Iron Homeostasis in Mice.

  2021cites this paper
• TGF‐β superfamily co‐receptors in cancer

  2021cites this paper
• Hepcidin Downregulation Correlates With Disease Aggressiveness And Immune Infiltration in Liver Cancers

  2021cites this paper
• Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration

  2021cites this paper
• 20 years of Hepcidin: How far we have come.

  2021cites this paper
• Epigallocatechin-3-Gallate Suppresses BMP-6-Mediated SMAD1/5/8 Transactivation of Hepcidin Gene by Inducing SMILE in Hepatocytes

  2021cites this paper
• The Role of Iron in Benign and Malignant Hematopoiesis

  2020cites this paper
• Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2.

  2020cites this paper
• Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2.

  2020influential citation
• I biomarcatori di carenza marziale: nuove acquisizioni fisiopatologiche e necessità interpretative

  2020cites this paper
• Regulatory expression of bone morphogenetic protein 6 by 2,2'-dipyridyl.

  2020cites this paper
• Bone morphogenic proteins in iron homeostasis.

  2020cites this paper
• Function of BMP4 in the Formation of Vasculogenic Mimicry in Hepatocellular Carcinoma

  2020cites this paper
• Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age‐related muscle wasting

  2019cites this paper
• Hepcidin and the BMP-SMAD pathway: An unexpected liaison.

  2019cites this paper
• Variation in the repulsive guidance molecule family in human populations

  2019cites this paper
• Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications

  2019cites this paper
• Sustained plasma hepcidin suppression and iron elevation by Anticalin‐derived hepcidin antagonist in cynomolgus monkey

  2018cites this paper
• TGF-&bgr; family co-receptor function and signaling

  2018cites this paper
• Haemochromatosis

  2018cites this paper
• 4 – Disorders of Iron Overload

  2018cites this paper
• Oxidative damage and iron dyshomeostasis in thalassemic patients

  2018cites this paper
• Multiple Modes of Hepcidin Regulation in Breast Cancer

  2017cites this paper
• The liver in regulation of iron homeostasis.

  2017cites this paper
• The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.

  2017cites this paper
• Non-Anticoagulant Heparins Are Hepcidin Antagonists for the Treatment of Anemia

  2017cites this paper
• The liver in regulation of iron homeostasis 1

  2017cites this paper
• Regulation of the Iron Homeostatic Hormone Hepcidin.

  2017cites this paper
• Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

  2017cites this paper
• The Central Role of BMP Signaling in Regulating Iron Homeostasis

  2017cites this paper
• Soluble hemojuvelin in transfused and untransfused thalassaemic subjects

  2017cites this paper
• The TGF-β Family in Caenorhabditis elegans.

  2017cites this paper
• Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression

  2017cites this paper
• Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice1

  2016cites this paper
• Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver

  2016cites this paper
• Structural Proteins of HCV and Biological Functions

  2016cites this paper
• Running title: RGMb is not required for normal gonadal function

  2016cites this paper
• Iron metabolism and laboratory testing for iron status

  2016cites this paper
• Molecular pathogenesis of hereditary hemochromatosis.

  2016cites this paper
• Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

  2016cites this paper
• Hepcidin Regulation by Bone Morphogenetic Protein Signaling and IronHomeostasis

  2016cites this paper
• Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes.

  2016cites this paper
• Cellular and Systemic Iron Homeostasis

  2016cites this paper
• Modulation of hepcidin to treat iron deregulation: potential clinical applications

  2016cites this paper
• Functional characterization of iron transporters Nramp 1 and Nramp 2 from Dictyostelium discoideum : a model of cellular iron homeostasis

  2016cites this paper
• Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

  2016cites this paper
• New strategies to target iron metabolism for the treatment of beta thalassemia

  2016cites this paper
• Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes*

  2016cites this paper
• Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver*

  2016cites this paper
• Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases.

  2016cites this paper
• The Regulation of Iron Absorption and Homeostasis.

  2016cites this paper
• Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?

  2015cites this paper
• Effects of developmental iron deficiency and post-weaning iron repletion on the levels of iron transporter proteins in rats

  2015cites this paper
• The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension

  2015cites this paper
• Hepcidin and iron

  2015cites this paper
• Low Serum Hepcidin in Patients with Autoimmune Liver Diseases

  2015cites this paper
• Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis.

  2015cites this paper
• Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth

  2015cites this paper
• The Regulation and Expression of Hepcidin in Carcinogenesis as a Result of Iron Overload Disorders: An Extended Literature Review

  2015cites this paper
• Rôle des récepteurs Toll-like et de la protéine adaptatrice MyD88 dans la régulation de l’hepcidine et le développement des hyposidérémies associées à l’inflammation

  2015influential citation
• Enhanced expression of BMP 6 inhibits hepatic fi brosis in non-alcoholic fatty liver disease

  2015cites this paper
• Repulsive Guidance Molecule is a structural bridge between Neogenin and Bone Morphogenetic Protein

  2015cites this paper
• An overview of molecular basis of iron metabolism regulation and the associated pathologies.

  2015cites this paper
• Caracterização in situ dos orientadores de axônio por repulsão (RGMs) na musculatura esquelética, e caracterização funcional do membro A (RGMa) durante a miogênese em camundongos

  2015cites this paper
• Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice

  2015cites this paper
• Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation*

  2015cites this paper
• Identification of TMPRSS6 cleavage sites of hemojuvelin

  2015cites this paper
• BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.

  2014cites this paper
• Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

  2014cites this paper
• The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.

  2014cites this paper
• MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription*

  2014cites this paper
• The Imperative Balance of Agonist and Antagonist for BMP Signalling Driven Adult Tissue Homeostasis

  2014cites this paper