MMP12, lung function, and COPD in high-risk populations.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  New England Journal of Medicine

• Publication date

  2009-12-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.1056/NEJMoa0904006PMID 20018959PMCID PMC2904064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1995cited by this paper
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  1981cited by this paper
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  1977cited by this paper
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  1974cited by this paper
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  1972cited by this paper
• [Chronic nonspecific respiratory diseases].

  1961cited by this paper
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  1961cited by this paper

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