[18F]FLT-PET in oncology: current status and opportunities

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Journal of Nuclear Medicine and Molecular Imaging

• Publication date

  2004-11-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00259-004-1687-6PMID 15565331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is 18F-3'-fluoro-3'-deoxy-L-thymidine useful for the staging and restaging of non-small cell lung cancer?

  2004cited by this paper
• Detection and Grading of Soft Tissue Sarcomas of the Extremities with 18F-3′-Fluoro-3′-Deoxy-l-Thymidine

  2004cited by this paper
• Selectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model.

  2004cited by this paper
• PET with [18F]fluorothymidine for imaging of primary breast cancer: a pilot study

  2004cited by this paper
• 18F-FLT PET for visualization of laryngeal cancer: comparison with 18F-FDG PET.

  2004cited by this paper
• Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation.

  2004influential reference
• 18 F-FLT PET for Visualization of Laryngeal Cancer : Comparison with 18 F-FDG PET

  2004cited by this paper
• Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.

  2003cited by this paper
• 3'-18F-fluoro-3'-deoxy-L-thymidine: a new tracer for staging metastatic melanoma?

  2003cited by this paper
• In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography

  2003cited by this paper
• 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.

  2003cited by this paper
• Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma.

  2003cited by this paper
• PET Imaging with 18 F-FLT and Thymidine Analogs: Promise and Pitfalls

  2003cited by this paper
• The role of FDG-PET scan in staging patients with nonsmall cell carcinoma.

  2003cited by this paper
• PET scan imaging in oncology.

  2003cited by this paper
• Identification of DNA and amino acid metabolism in human gliomas by PET

  2003cited by this paper
• Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU.

  2003cited by this paper
• High radiochemical yield synthesis of 3'-deoxy-3'-[18F]fluorothymidine using (5'-O-dimethoxytrityl-2'-deoxy-3'-O-nosyl-beta-D-threo pentofuranosyl)thymine and its 3-N-BOC-protected analogue as a labeling precursor.

  2003cited by this paper
• 3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease.

  2003cited by this paper
• [18F]FLT PET for diagnosis and staging of thoracic tumours

  2003cited by this paper
• PET imaging with 18F-FLT and thymidine analogs: promise and pitfalls.

  2003cited by this paper
• Potential impact of [18F]3'-deoxy-3'-fluorothymidine versus [18F]fluoro-2-deoxy-d-glucose in positron emission tomography for colorectal cancer

  2003cited by this paper
• Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients.

  2003cited by this paper
• Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG.

  2003cited by this paper
• Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) in pancreatic cancer cell lines

  2002cited by this paper
• In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors.

  2002cited by this paper
• New diagnostic techniques in staging in the surgical treatment of cutaneous malignant melanoma.

  2002cited by this paper
• Correlation between MIB‐1 and other proliferation markers

  2002cited by this paper
• FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence.

  2002cited by this paper
• Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.

  2002cited by this paper
• 3-deoxy-3-[(18)F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules.

  2002cited by this paper
• Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs

  2002cited by this paper
• Early changes in [18F]FLT uptake after chemotherapy: an experimental study

  2002cited by this paper
• Investigations into the regioselective deuteriation of enolates derived from silyl enol ethers and enolacetates

  2001cited by this paper
• Sentinel lymph node biopsy as an indicator for axillary dissection in early breast cancer.

  2001cited by this paper
• An improved synthesis of 3′-DEOXY-3′-[18F]fluorothymidine ([18F]FLT) and the fate of the precursor, 2, 3′-anhydro-5′-O-(4, 4′-dimethoxytrityl)-thymidine

  2001cited by this paper
• Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis.

  2001influential reference
• Radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo.

  2000cited by this paper
• A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer.

  2000cited by this paper
• Simplified Labeling Approach for Synthesizing 3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT)

  2000cited by this paper
• The Ki‐67 protein: From the known and the unknown

  2000cited by this paper
• Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging.

  1999cited by this paper
• Evaluation of serum CA27.29, CA15-3 and CEA in patients with breast cancer.

  1999cited by this paper
• 2-[C-11]thymidine imaging of malignant brain tumors.

  1999cited by this paper
• Primary Staging and Follow-Up of High Risk Melanoma Patients with Whole-Body 18 F-Fluorodeoxyglucose Positron Emission Tomography Results of a Prospective Study of 100 Patients

  1999cited by this paper
• Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.

  1998cited by this paper
• Effectiveness of positron emission tomography for the detection of melanoma metastases.

  1998cited by this paper
• Prospective evaluation of 2-[18F]-2-deoxy-D-glucose positron emission tomography in staging of regional lymph nodes in patients with cutaneous malignant melanoma.

  1998cited by this paper
• Imaging proliferation in vivo with [F-18]FLT and positron emission tomography

  1998influential reference
• In vitro and animal validation of bromine-76-bromodeoxyuridine as a proliferation marker.

  1998cited by this paper
• Primary staging and follow‐up of high risk melanoma patients with whole‐body 18F‐fluorodeoxyglucose positron emission tomography

  1998cited by this paper
• Sentinel lymphadenectomy in breast cancer.

  1997cited by this paper
• [Diagnosis and staging of thoracic tumors].

  1997cited by this paper
• FDG-PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma.

  1996cited by this paper
• In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck.

  1995cited by this paper
• Human thymidine kinase 1. Regulation in normal and malignant cells.

  1995cited by this paper
• Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET.

  1995cited by this paper
• Enhanced expression of thymidine kinase in human cells following ionizing radiation.

  1994cited by this paper
• FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor models.

  1994cited by this paper
• Purine and pyrimidine metabolism in human gliomas: relation to chromosomal aberrations.

  1994cited by this paper
• Brain tumor imaging with PET and 2-[carbon-11]thymidine.

  1994cited by this paper
• Relationship between plasma concentrations of 3'-deoxy-3'-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials.

  1994cited by this paper
• In vitro assessment of 2-fluoro-2-deoxy-D-glucose, L-methionine and thymidine as agents to monitor the early response of a human adenocarcinoma cell line to radiotherapy.

  1993cited by this paper
• Proliferation in non‐hodgkin's lymphomas as determined by immunohistochemical double staining for Ki‐67

  1992cited by this paper
• Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

  1992cited by this paper
• Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis

  1991cited by this paper
• Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides.

  1991cited by this paper
• Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs.

  1991cited by this paper
• Enhanced In Vitro Inhibition of HIV-1 Replication by 3′-Fluoro-3′-deoxythymidine Compared to Several Other Nucleoside Analogs

  1988cited by this paper
• Flow cytometric analysis by bromodeoxyuridine/DNA assay of cell cycle perturbation of methotrexate-treated mouse L1210 leukemia cells.

  1988cited by this paper
• Structural modifications at the 2'- and 3'-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter.

  1984cited by this paper
• Thymidine concentrations in serum and urine of different animal species and man.

  1977cited by this paper

• Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

  2025cites this paper
• 18F-FLT PET, a Noninvasive Pharmacodynamic Biomarker of Tumor Cell Proliferation, Detected Differential Response to Various Cyclin-Dependent Kinase (CDK) Inhibitors

  2025cites this paper
• A Review on the Positron Emission Tomography Radiotracers

  2025cites this paper
• Impact of liver diseases and pharmacological interactions on the transportome involved in hepatic drug disposition.

  2024cites this paper
• Exploration of Imaging Biomarkers for Metabolically-Targeted Osteosarcoma Therapy in a Murine Xenograft Model

  2023cites this paper
• Metabolic Imaging as a Tool to Characterize Chemoresistance and Guide Therapy in Triple-Negative Breast Cancer (TNBC).

  2023cites this paper
• "Primer shot" fractionation with an early treatment break is theoretically superior to consecutive weekday fractionation schemes for early-stage non-small cell lung cancer.

  2023cites this paper
• Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities

  2023cites this paper
• Recent advances in photochemistry for positron emission tomography imaging

  2023cites this paper
• Other Novel PET Radiotracers for Breast Cancer.

  2023cites this paper
• PET tracers in glioblastoma: Toward neurotheranostics as an individualized medicine approach

  2023cites this paper
• Positron Emission Tomography (PET)/Computed Tomography (CT) Imaging in Radiation Therapy Treatment Planning: A Review of PET Imaging Tracers and Methods to Incorporate PET/CT

  2023cites this paper
• Radiopharmaceuticals for Oncology, Nonspecific to Glucose (PET and SPECT)

  2023cites this paper
• Radiopharmaceuticals for Non-Glucose-Specific Oncology (PET and SPECT) (A Review)

  2023cites this paper
• Hematopoiesis in the spleen after engraftment in unrelated cord blood transplantation evaluated by 18F-FLT PET imaging

  2023cites this paper
• Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

  2022cites this paper
• Radionuclide Imaging of Cytotoxic Immune Cell Responses to Anti-Cancer Immunotherapy

  2022cites this paper
• Predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT.

  2022cites this paper
• Comparison of 18F-fluorothymidine Positron Emission Tomography/Computed Tomography and 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Breast Cancer

  2022influential citation
• 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor

  2022cites this paper
• Glucose–Thymidine Ratio as a Metabolism Index Using 18F-FDG and 18F-FLT PET Uptake as a Potential Imaging Biomarker for Evaluating Immune Checkpoint Inhibitor Therapy

  2022cites this paper
• Potential novel imaging targets of inflammation in cardiac sarcoidosis

  2021cites this paper
• Recent Advances in Photo-mediated-Radiofluorination.

  2021cites this paper
• Clinical efficacy of Sep-Pak® assisted one pot automated synthesis of pharmaceutical grade [18F]FLT using 5′-O-(benzoyl)-2,3′-anhydrothymidine precursor

  2021cites this paper
• Carbon-11: Radiochemistry and Target-Based PET Molecular Imaging Applications in Oncology, Cardiology, and Neurology.

  2021cites this paper
• Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for quantification of human cardiomyocyte division

  2021cites this paper
• Therapeutic Response Assessment of High-Grade Gliomas During Early-Phase Drug Development in the Era of Molecular and Immunotherapies.

  2021cites this paper
• Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas

  2021cites this paper
• Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT

  2021cites this paper
• Utilization of Antibody Allows Rapid Clearance of Nanoparticle Probes from Blood without the Need of Probe Modifications

  2021cites this paper
• Differences between [18F]FLT and [18F]FDG Uptake in PET/CT Imaging in CC Depend on Vaginal Bacteriology

  2021cites this paper
• Prospective comparison of early interim 18F-FDG-PET with 18F-FLT-PET for predicting treatment response and survival in metastatic breast cancer

  2021cites this paper
• F-18 FDG PET/CT and F-18 FLT PET/CT as predictors of outcome in patients with multiple myeloma. A pilot study.

  2021cites this paper
• Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors

  2021cites this paper
• A phase I trial of sorafenib with whole brain radiotherapy (WBRT) in breast cancer patients with brain metastases and a correlative study of FLT-PET brain imaging

  2021cites this paper
• Radiopharmaceutical Sciences

  2020cites this paper
• Non-FDG PET/CT.

  2020cites this paper
• Molecular Imaging in Oncology

  2020influential citation
• 18F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer.

  2020cites this paper
• Approaches to PET Imaging of Glioblastoma

  2020cites this paper
• Nuclear medicine and molecular imaging advances in the 21st century.

  2020cites this paper
• Why Great Mitotic Inhibitors Make Poor Cancer Drugs.

  2020cites this paper
• Radiomics Analysis for Clinical Decision Support in Nuclear Medicine.

  2019cites this paper
• Metabolism of Stem and Progenitor Cells: Proper Methods to Answer Specific Questions

  2019cites this paper
• Comparing radioactive tracers 18F-FDG and 18F-FLT in the staging of diffuse large B-cell lymphoma by PET/CT examination: A single-center prospective study.

  2019cites this paper
• Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy

  2019cites this paper
• Efficacy of 4′-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study

  2019cites this paper
• Imaging of T-cells and their responses during anti-cancer immunotherapy

  2019cites this paper
• Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia

  2019cites this paper
• Non-invasive Early Response Monitoring of Nanoparticle-assisted Photothermal Cancer Therapy Using 18F-FDG, 18F-FLT, and 18F-FET PET/CT Imaging

  2018cites this paper
• New Radiation Dosimetry Estimates for [18F]FLT based on Voxelized Phantoms

  2018cites this paper
• How Long of a Dynamic 3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) PET Acquisition Is Needed for Robust Kinetic Analysis in Breast Cancer?

  2018cites this paper
• Molecular Contrast Agents

  2018cites this paper
• Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes

  2018cites this paper
• Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry

  2018cites this paper
• [18F]FDG and [18F]FLT PET for the evaluation of response to neo-adjuvant chemotherapy in a model of triple negative breast cancer

  2018cites this paper
• 18F-labelling innovations and their potential for clinical application

  2018cites this paper
• 3 FDG-PET in Large Vessel Vasculitis

  2017cites this paper
• Description and Practical Application of the Physiologic Distribution of 3’-Deoxy-3’-[18F]Fluorothymidine in Companion Animals

  2017influential citation
• Application of molecular imaging to address current clinical challenges in breast cancer

  2017influential citation
• FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study

  2017influential citation
• PET in Benign Bone Marrow Disorders.

  2017cites this paper
• Novel Positron-Emitting Radiopharmaceuticals

  2017cites this paper
• Delivering FLT to the Central Nervous System by Means of a Promising Targeting System: Synthesis, [11C]Radiosynthesis, and in Vivo Evaluation.

  2017cites this paper
• Preclinical Applications of 3'-Deoxy-3'-[18F]Fluorothymidine in Oncology - A Systematic Review

  2017cites this paper
• Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment.

  2017cites this paper
• Use of molecular maging markers of glycolysis , hypoxia and proliferation ( 18 F-FDG , 64 Cu-ATSM and 18 F-FLT ) in a dog with fibrosarcoma

  2017cites this paper
• Comparison between Two Ethanolic Solutions for 3’-Deoxy-3’-[ 18 F]Fluorothymidine Elution

  2017cites this paper
• Monitoring Tumor Response after Liposomal Doxorubicin in Combination with Liposomal Vinorelbine Treatment Using 3′-Deoxy-3′-[18F]Fluorothymidine PET

  2017cites this paper
• Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter study

  2017cites this paper
• Baseline and longitudinal variability of normal tissue uptake values of [18F]-fluorothymidine-PET images.

  2017cites this paper
• Physiologic and Molecular Basis of PET in Cancer Imaging

  2017cites this paper
• A pilot study of the diagnostic and prognostic values of FLT-PET/CT for pancreatic cancer: comparison with FDG-PET/CT

  2017cites this paper
• Imaging Anti-Proliferative Compounds With Flt-Pet

  2016cites this paper
• 18F-FLT PET imaging of cellular proliferation in pancreatic cancer.

  2016cites this paper
• FLT PET/CT-Guided Biopsy in the Evaluation of Cancer

  2016cites this paper
• Automated and efficient radiosynthesis of [(18)F]FLT using a low amount of precursor.

  2016cites this paper
• Nanomaterials for Diagnostic Imaging of the Brain

  2016cites this paper
• Emerging Radiopharmaceuticals in Clinical Oncology

  2016cites this paper
• Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation–maximization reconstruction

  2016cites this paper
• 18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats.

  2016cites this paper
• Potential of 3’-fluoro-3’ deoxythymidine as a cellular proliferation marker in PET oncology examination

  2016influential citation
• Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

  2016cites this paper
• Influence of volumetric 4′-[methyl-11C]-thiothymidine PET/CT parameters for prediction of the clinical outcome of head and neck cancer patients

  2016cites this paper
• Fluorine-18-Labeled Thymidine Positron Emission Tomography (FLT-PET) as an Index of Cell Proliferation after Pharmacological Ascorbate-Based Therapy

  2016cites this paper
• Single-Cell Characterization of 18F-FLT Uptake with Radioluminescence Microscopy

  2016cites this paper
• PET Metabolic Biomarkers for Cancer

  2016cites this paper
• FLT-PET/CT diagnosis of primary and metastatic nodal lesions of gastric cancer: comparison with FDG-PET/CT

  2016cites this paper
• Imaging radiation response in tumor and normal tissue.

  2015cites this paper
• Ex-vivo biodistribution and micro-PET/CT imaging of 18F-FDG, 18F-FLT, 18F-FMISO, and 18F-AlF-NOTA-PRGD2 in a prostate tumor-bearing nude mouse model

  2015cites this paper
• Efficient radiosynthesis of 3’-deoxy-3’-[ 18 F]fluorothymidine using electrowetting-on-dielectric digital microfluidic chip

  2015cites this paper
• Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3′-Deoxy-3′-[18F]-fluorothymidine PET

  2015cites this paper
• Review Article Monitoring of anti-cancer treatment with 18 F-FDG and 18 F-FLT PET: a comprehensive review of pre-clinical studies

  2015cites this paper
• Monitoring of anti-cancer treatment with (18)F-FDG and (18)F-FLT PET: a comprehensive review of pre-clinical studies.

  2015cites this paper
• Organomediated Enantioselective (18)F Fluorination for PET Applications.

  2015cites this paper
• Basis of Radiopharmaceutical Localization

  2015cites this paper
• Bioresponsive probes for molecular imaging: concepts and in vivo applications.

  2015cites this paper
• 18F-FLT PET/CT as an imaging tool for early prediction of pathological response in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy: a pilot study

  2015cites this paper
• Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

  2015cites this paper
• Tumor growth prediction with reaction-diffusion and hyperelastic biomechanical model by physiological data fusion

  2015cites this paper