Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  1993-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0165-6147(93)90048-OPMID 8249148
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

  1993cited by this paper
• Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

  1993cited by this paper
• Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

  1992cited by this paper
• Constitutively active mutants of rhodopsin.

  1992cited by this paper
• Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

  1992cited by this paper
• Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.

  1992cited by this paper
• Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation.

  1991cited by this paper
• Truncation of the extended carboxyl-terminal domain increases the expression and regulatory activity of the avian beta-adrenergic receptor.

  1991cited by this paper
• G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

  1991cited by this paper
• Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

  1991cited by this paper
• G-protein-coupled receptor kinases.

  1991cited by this paper
• Model systems for the study of seven-transmembrane-segment receptors.

  1991cited by this paper
• Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the β‐adrenergic receptor

  1991cited by this paper
• Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

  1990cited by this paper
• Signal sorting and amplification through G protein-coupled receptors.

  1989cited by this paper
• Signal sorting and amplification through G protein-coupled receptors

  1989cited by this paper
• Structural basis of β‐adrenergic receptor function

  1989cited by this paper
• Beta-adrenergic receptor kinase: primary structure delineates a multigene family.

  1989cited by this paper
• Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation.

  1989cited by this paper
• A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

  1980cited by this paper
• Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor

  1979cited by this paper
• Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors.

  1978cited by this paper
• Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors.

  1978cited by this paper
• Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

  1974cited by this paper

• Investigating the electrostatics underlying activation of the β2 adrenergic receptor.

  2026cites this paper
• Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment

  2025cites this paper
• An Improved Cysteine-Based Labeling Strategy for GPCR Structural Dynamics Studies.

  2025cites this paper
• International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors

  2024cites this paper
• Are Melanocortin Receptors Present in Extant Protochordates?

  2024cites this paper
• Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity

  2024cites this paper
• Get Ready to Sharpen Your Tools: A Short Guide to Heterotrimeric G Protein Activity Biosensors

  2024cites this paper
• Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges

  2024cites this paper
• Novel Nucleotides Polymorphism in CXTCR2 Gene Associated with Mastitis In River Buffalo, Egyptian Breed

  2024cites this paper
• Competition between induced fit- and conformational selection binding: how different flux-based approaches help clarifying their interplay

  2023cites this paper
• Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling

  2023cites this paper
• Model of ligand-triggered information transmission in G-protein coupled receptor complexes

  2023cites this paper
• Mutations in melanocortin-4 receptor: From fish to men.

  2022cites this paper
• Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

  2022cites this paper
• Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

  2022cites this paper
• Structural Insights Accelerate the Discovery of Opioid Alternatives.

  2021cites this paper
• The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling

  2021cites this paper
• Structural aspects of rod opsin and their implication in genetic diseases

  2021cites this paper
• Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

  2021cites this paper
• Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

  2021cites this paper
• Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [177Lu]Lu-OPS201 Compared to the Agonist [177Lu]Lu-DOTA-TATE

  2021cites this paper
• Pharmacological Receptor Theory

  2021cites this paper
• 100 years of modelling ligand–receptor binding and response: A focus on GPCRs

  2020cites this paper
• Viewing rare conformations of the β2 adrenergic receptor with pressure-resolved DEER spectroscopy

  2020cites this paper
• Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling

  2020cites this paper
• Aging-related modifications to G protein-coupled receptor signaling diversity.

  2020cites this paper
• Pharmacological characterization of three chicken melanocortin-3 receptor mutants.

  2020cites this paper
• Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation.

  2020cites this paper
• Constitutive activity of a G protein‐coupled receptor, DRD1, contributes to human cerebral organoid formation

  2020cites this paper
• G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

  2019cites this paper
• Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release.

  2019cites this paper
• The coupling of the M2 muscarinic receptor to its G protein is voltage dependent

  2019cites this paper
• Basal Histamine H4 Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif

  2019cites this paper
• Regulation of melanocortin-1 receptor pharmacology by melanocortin receptor accessory protein 2 in orange-spotted grouper (Epinephelus coioides).

  2019cites this paper
• Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells

  2019cites this paper
• The N54-αs Mutant Has Decreased Affinity for βγ and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation

  2018cites this paper
• UDC 616-006.04 GPR161 RECEPTOR AS A NOVEL TARGET FOR ANTIBODY-BASED IMMUNOTHERAPY OF TRIPLE-NEGATIVE BREAST CANCER

  2018cites this paper
• Functional coupling between adenosine A1 receptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding or [35S]GTPγS/immunoprecipitation assay

  2018cites this paper
• Chemokine signalling in malignant cell migration

  2018cites this paper
• - 1-Single-molecule observation of the ligand-induced population shift of rhodopsin , a G-protein coupled receptor

  2018cites this paper
• Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.

  2018cites this paper
• Factors influencing the specificity and bias of CB1 cannabinoid receptor signalling

  2018cites this paper
• Shift in Conformational Equilibrium Induces Constitutive Activity of G-Protein-Coupled Receptor, Rhodopsin.

  2018cites this paper
• Trace amine-associated receptor 1 is involved in various aspects of endocrine regulation

  2017cites this paper
• Dual expression of constitutively active Gαs-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment.

  2017cites this paper
• The DRY motif and the four corners of the cubic ternary complex model.

  2017cites this paper
• Theoretical Aspects of GPCR-Ligand Complex Pharmacology.

  2017cites this paper
• THROMBOXANE PROSTANOID RECEPTOR: FUNCTION, ACTIVATION AND POSSIBLE TARGET FOR CARDIOVASCULAR PROTECTION

  2017influential citation
• The role of GPR56 and collagen III in islet functions

  2017cites this paper
• Corriden, Ross and Kilpatrick, Laura E. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor

  2017cites this paper
• Comparison of the Human A2A Adenosine Receptor Recognition by Adenosine and Inosine: New Insight from Supervised Molecular Dynamics Simulations

  2017cites this paper
• Chapter 16 a-TSH RECEPTOR MUTATIONS AND DISEASES

  2017cites this paper
• Properties of GABAergic inhibition of the medial prefrontal cortex

  2016cites this paper
• Application of Differential Hydrogen Exchange Mass Spectrometry in Small Molecule Drug Discovery

  2016cites this paper
• Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer.

  2016cites this paper
• Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors

  2016cites this paper
• receptors and unmasks constitutive receptor signaling Chlorpropamide upregulates antidiuretic hormone

  2016cites this paper
• Fatores de Plasmodium falciparum envolvidos na fosforilação de eIF2α em resposta a melatonina.

  2016cites this paper
• Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms.

  2016cites this paper
• Thyroid-Stimulating Hormone Receptor Mutations∗∗Chapter titles shaded in green indicate chapters dedicated predominantly to pediatric endocrinology content.

  2016cites this paper
• The Histamine H3 Receptor: Structure, Pharmacology, and Function

  2016cites this paper
• The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons

  2016cites this paper
• Defining an olfactory receptor function in airway smooth muscle cells

  2016cites this paper
• fluid shear stress in neutrophils G protein-coupled receptors serve as mechanosensors for

  2016cites this paper
• Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12.

  2016cites this paper
• Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation

  2016cites this paper
• Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2.

  2015cites this paper
• Protein structure elucidation by combining computational and experimental methods

  2015cites this paper
• Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation

  2015cites this paper
• Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

  2015cites this paper
• G protein-coupled receptors: an overview of signaling mechanisms and screening assays.

  2015cites this paper
• PHARMREV009647 338..367

  2015cites this paper
• International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

  2015cites this paper
• Structural and functional analysis of WNT receptors : with emphasis on FZD6

  2015cites this paper
• The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

  2015cites this paper
• The hCG/LH hormone receptor

  2015cites this paper
• Modulation of GPCRs by monovalent cations and anions

  2014cites this paper
• Histamine receptors and antihistamines: from discovery to clinical applications.

  2014cites this paper
• Sodium binding to hH3R and hH4R — a molecular modeling study

  2014cites this paper
• Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

  2014cites this paper
• Constitutive Activity of the Ghrelin Receptor

  2014cites this paper
• Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: a stepwise binding mechanism.

  2014cites this paper
• Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor

  2014cites this paper
• Ligand-directed trafficking of receptor stimulus

  2014cites this paper
• Threonine 680 Phosphorylation of FLJ00018/PLEKHG2, a Rho Family-specific Guanine Nucleotide Exchange Factor, by Epidermal Growth Factor Receptor Signaling Regulates Cell Morphology of Neuro-2a Cells*

  2014cites this paper
• Single-molecule observation of the ligand-induced population shift of rhodopsin, a G-protein-coupled receptor.

  2014cites this paper
• Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists.

  2014cites this paper
• Constitutive activities and inverse agonism in dopamine receptors.

  2014cites this paper
• Controversial Constitutive TSHR Activity: Patients, Physiology, and In Vitro Characterization

  2014cites this paper
• Ligand bias prevents class equality among beta-blockers.

  2014cites this paper
• Nouveaux mécanismes d'action du récepteur mGlu7a dans le thalamus : de la synapse au comportement

  2014cites this paper
• TSH Receptor Mutations and Diseases

  2014cites this paper
• Full and Partial Agonists of Thromboxane Prostanoid Receptor Unveil Fine Tuning of Receptor Superactive Conformation and G Protein Activation

  2013influential citation
• Current Cannabinoid Receptor Nomenclature and Pharmacological Principles

  2013cites this paper
• Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology

  2013cites this paper
• Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs

  2013cites this paper
• Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition

  2013cites this paper
• Functional Autoradiography as a Pharmacological Approach for Studying G Protein-Coupled Lipid Receptor Signalling

  2013cites this paper
• Serotonin2C ligands exhibiting full negative and positive intrinsic activity elicit purposeless oral movements in rats: distinct effects of agonists and inverse agonists in a rat model of Parkinson's disease.

  2013cites this paper
• Melatonin mediated transcriptional mechanisms in the ovine pars tuberalis

  2013cites this paper