Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.26.4.1288-1296.2006PMID 16449642PMCID PMC1367206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• hDOT1L links histone methylation to leukemogenesis.

  2005cited by this paper
• Altered epigenetic signals in human disease

  2004cited by this paper
• The indexing potential of histone lysine methylation.

  2004cited by this paper
• Disruption of differentiation in human cancer: AML shows the way

  2003cited by this paper
• Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

  2003cited by this paper
• Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.

  2003cited by this paper
• Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.

  2003influential reference
• Histone lysine methylation: a signature for chromatin function.

  2003cited by this paper
• Histone methylation in transcriptional control.

  2002cited by this paper
• Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

  2002cited by this paper
• The tripartite motif family identifies cell compartments

  2001cited by this paper
• Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

  2001cited by this paper
• Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

  2001cited by this paper
• Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

  2001cited by this paper
• Transcriptional regulation in acute promyelocytic leukemia

  2001cited by this paper
• Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

  2000cited by this paper
• Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

  2000cited by this paper
• Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression

  2000cited by this paper
• Regulation of chromatin structure by site-specific histone H3 methyltransferases

  2000cited by this paper
• Constitutive degradation of PML/RARα through the proteasome pathway mediates retinoic acid resistance

  1999cited by this paper
• Constitutive degradation of PML/RARalpha through the proteasome pathway mediates retinoic acid resistance.

  1999cited by this paper
• High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.

  1998cited by this paper
• The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

  1998cited by this paper
• Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

  1998cited by this paper
• Analysis of chromatin structure by in vivo formaldehyde cross-linking.

  1997cited by this paper
• Oncogenic transcription factors in the human acute leukemias.

  1997cited by this paper
• Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

  1996cited by this paper
• The transcriptional control of hematopoiesis.

  1996cited by this paper
• Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.

  1996cited by this paper
• The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.

  1993cited by this paper
• The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

  1993cited by this paper

• miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia

  2023cites this paper
• Scholarship@Western Scholarship@Western

  2022cites this paper
• In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation

  2022cites this paper
• H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

  2022cites this paper
• Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke

  2021influential citation
• PML/RARα Fusion Gene and Response to Retinoic Acid and Arsenic Trioxide Treatment

  2021cites this paper
• A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity

  2021cites this paper
• Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

  2021cites this paper
• Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid

  2020cites this paper
• SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90

  2020cites this paper
• PML nuclear bodies and chromatin dynamics: catch me if you can!

  2020cites this paper
• SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia

  2020cites this paper
• Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond.

  2020cites this paper
• Vitamin A,retinoic acid and retinoid pharmacology,From front move center

  2019cites this paper
• VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW

  2019cites this paper
• Genetic and Epigenetic Profiling in Personalized Medicine: Advances in Treatment of Acute Myeloid Leukemia

  2019cites this paper
• PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts.

  2019cites this paper
• ALL-TRANS RETINOIC ACID AND ARSENIC TRIOXIDE INDUCE LASTING DIFFERENTIATION AND DEMETHYLATION OF TARGET GENES IN ACUTE PROMYELOCYTIC LEUKEMIA

  2019cites this paper
• Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics.

  2019cites this paper
• Vitamin A and its Derivatives- Retinoic Acid and Retinoid Pharmacology

  2019cites this paper
• Advances in precision epigenetic treatment for acute promyelocytic leukemia.

  2019influential citation
• Dissecting the role of PML-II in gene transcription and in IFN alpha-mediated apoptosis

  2018cites this paper
• Redistribution of cell cycle by arsenic trioxide is associated with demethylation and expression changes of cell cycle related genes in acute promyelocytic leukemia cell line (NB4)

  2018cites this paper
• Investigating the role of human cytomegalovirus protein LUNA in regulating viral gene expression during latency

  2018cites this paper
• Pathogenetic implication of fusion genes in acute promyelocytic leukemia and their diagnostic utility

  2018cites this paper
• TREATMENT OF PATIENTS WITH ADVANCED CANCER FOLLOWING CHEMOTHERAPY AND TRADITIONAL MEDICINE - LONG TERM FOLLOW UP OF 75 CASES

  2018cites this paper
• Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

  2018cites this paper
• Long Term Follow up of Patients with Advanced Cancers after Chemotherapy and Traditional Medicine (82 Cases)

  2018cites this paper
• Targeting oncogenic receptor : From molecular physiology to currently the standard of target therapy

  2017cites this paper
• Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation.

  2017cites this paper
• The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies.

  2017cites this paper
• The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

  2017cites this paper
• The Molecular Basis of Arsenic Trioxide Treatment for Acute Promyelocytic Leukemia (APL)

  2017cites this paper
• Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene

  2016cites this paper
• Silencing of Human Cytomegalovirus Gene Expression Mediated by Components of PML Nuclear Bodies

  2016cites this paper
• Downregulating oncogenic receptor: From bench to clinic

  2016cites this paper
• PHA-Induced Peripheral Blood Cytogenetics and Molecular Analysis: a Valid Diagnostic and Follow-up Modality for Acute Promyelocytic Leukemia Patients Treated with ATRA and/or Arsenic Tri-oxide.

  2016cites this paper
• Molecular Profiling of Gynaecologic Malignancies: A Review

  2016cites this paper
• Chaetocin inhibits RANKL-induced osteoclast differentiation through reduction of Blimp1 in Raw264.7 cells.

  2015cites this paper
• Epigenetic programming contributes to development of drug resistance in hematological malignancies.

  2015cites this paper
• Gene expression and epigenetic profiles of mammary gland tissue: insight into the differential predisposition of four rat strains to mammary gland cancer.

  2015cites this paper
• Epigenetic inhibitors.

  2015cites this paper
• The function, regulation and therapeutic implications of the tumor suppressor protein, PML

  2015cites this paper
• Epigenetics in acute promyelocytic leukaemia pathogenesis and treatment response: A TRAnsition to targeted therapies

  2014cites this paper
• Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation

  2014cites this paper
• overexpression in acute promyelocytic leukemia Loss of imprinting at the 14 q 32 domain is associated with microRNA

  2014cites this paper
• Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.

  2014cites this paper
• Acute promyelocytic leukemia.

  2014cites this paper
• Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia.

  2014cites this paper
• Understanding the molecular pathogenesis of acute promyelocytic leukemia.

  2014cites this paper
• The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence

  2014cites this paper
• Efficacy and resistance of molecularly targeted therapy for myeloid malignancies Mechanisms of action and resistance to all-trans retinoic acid ( ATRA ) and arsenic trioxide ( As 2 O 3 ) in acute promyelocytic leukemia

  2013cites this paper
• Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.

  2013cites this paper
• Genes Reprogramming During ATRA-induced Differentiation of Acute Promyelocytic Leukemia Cells

  2013cites this paper
• Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression

  2013cites this paper
• Disclosing the crosstalk among DNA methylation, transcription factors, and histone marks in human pluripotent cells through discovery of DNA methylation motifs

  2013cites this paper
• discovery of DNA methylation motifs factors , and histone marks in human pluripotent cells through Disclosing the crosstalk among DNA methylation , transcription Material

  2013cites this paper
• Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia

  2013cites this paper
• Inactivate the two-faced HDAC-brake: Cell cycle regulation and tumor suppression by histone deacetylases HDAC1 and HDAC2

  2013cites this paper
• Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1

  2012cites this paper
• Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance.

  2012cites this paper
• Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3

  2012cites this paper
• Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia.

  2012cites this paper
• Myxoid Liposarcoma-Associated EWSR1-DDIT3 Selectively Represses Osteoblastic and Chondrocytic Transcription in Multipotent Mesenchymal Cells

  2012cites this paper
• Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response.

  2012cites this paper
• Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs

  2012cites this paper
• Differentiation Therapy of Acute Myeloid Leukemia

  2011cites this paper
• [Histone methyltransferases: a new class of therapeutic targets in cancer treatment?].

  2011cites this paper
• Histone méthyltransférases : Une nouvelle classe de cibles thérapeutiques dans le traitement du cancer ?

  2011cites this paper
• Intrinsic cellular defense mechanisms targeting human cytomegalovirus.

  2011cites this paper
• The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha

  2011cites this paper
• Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

  2011influential citation
• Acute Promyelocytic Leukemia: A Model Disease for Targeted Cancer Therapy

  2011influential citation
• How to control an infectious bead string: nucleosome‐based regulation and targeting of herpesvirus chromatin

  2011cites this paper
• Key roles of histone methyltransferase and demethylase in leukemogenesis

  2011cites this paper
• RFX 1 regulates CD 70 and CD 11 a expression in lupus T cells by recruiting the histone methyltransferase SUV 39 H 1

  2011cites this paper
• Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.

  2010cites this paper
• Histone deacetylases and epigenetic therapies of hematological malignancies.

  2010cites this paper
• Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

  2010influential citation
• Epigenetic opportunities and challenges in cancer.

  2010cites this paper
• Cancer Epigenetics

  2010cites this paper
• RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1

  2010cites this paper
• Acute promyelocytic leukemia: a paradigm for differentiation therapy.

  2010cites this paper
• PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

  2010cites this paper
• Epigenetic regulation of pro-apoptotic genes in Drosophila

  2010cites this paper
• Dietary Manipulation of Histone Structure and Function

  2010cites this paper
• Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.

  2010cites this paper
• Bifunctional role of the zinc finger domains of the methyl-DNA-binding protein Kaiso

  2010cites this paper
• Epigenetic therapies in haematological malignancies: searching for true targets.

  2009cites this paper
• Nutrients, Histone Modifications, And Chromatin Remodeling In Chronic Inflammation

  2009cites this paper
• ASXL1 Represses Retinoic Acid Receptor-mediated Transcription through Associating with HP1 and LSD1*

  2009cites this paper
• Differentiation therapy of leukemia: 3 decades of development.

  2009cites this paper
• Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies

  2009cites this paper
• Regulation of promyelocytic leukemia protein expression

  2008cites this paper
• Advances in the treatment of acute myeloid leukemia: From chromosomal aberrations to biologically targeted therapy

  2008cites this paper
• Targeting the Epigenome with Dietary Agents

  2008cites this paper
• Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.

  2008cites this paper
• New insights into the role of the subnuclear structure ND10 for viral infection.

  2008cites this paper
• Epigenomic repression by APL oncoprotein

  2008cites this paper
• Retinoic acid receptors, hematopoiesis and leukemogenesis

  2008cites this paper