Prolongation of organ allograft survival by syngeneic lymphoid cells.

The role of suppressor cells was tested in vivo by passive transfer of lymphoid cells from enhanced rats bearing well functioning cardiac allografts into unmodified syngeneic animals receiving test heart grafts 1 day later. LEW rats were enhanced with 107 BN splenocytes and 1 ml LEW anti-BN antiserum 11 and 10 days, respectively, before receiving a (LEW × BN) F1 heart graft. All such grafts function over 25 days; one-third indefinitely. Grafts in unmodified hosts survive 7 ± 0.3 days. Thymocytes (108) harvested from enhanced recipients 6 days after grafting and transferred to unmodified LEW animals prolonged test graft survival to MST of 17 ± 3 days (p < 0.001). Splenocytes (nylon wool-adherent and nonadherent fractions) from such animals prolonged test graft survival to 12 ± 4 and 14 ± 4 days, respectively. Transfer of thymocytes from immunologically virgin LEW rats or LEW rats bearing acutely rejecting (LEW × BN) F1 grafts did not prolong test graft survival. Specificity was assessed by transferring cells from enhanced LEW recipients of (LEW × BN) F1 heart grafts into LEW recipients of WF grafts. WF graft survival was not prolonged. Since increased graft survival in unmodified hosts is a stringent requirement for the effect of suppressor cells in vivo, we conclude that such cells participate in the maintenance of immunologic enhancement.

• Publication year

  1978

• Venue

  Journal of Immunology

• Publication date

  1978-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4049/jimmunol.121.4.1480PMID 359709
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• These in vivo transfer results support the conclusion that suppressor cells participate in the maintenance of immunologic enhancement.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• Transfer of cells from enhanced recipients of LEW × BN F1 heart grafts into LEW recipients of WF grafts did not prolong WF graft survival, indicating antigen specificity.

  Confidence 0.97

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• Thymocytes from immunologically virgin LEW rats or from rats bearing acutely rejecting LEW × BN F1 grafts did not prolong test graft survival.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• Splenocyte fractions from enhanced recipients also prolonged test graft survival, with nylon wool-adherent cells extending survival to 12 ± 4 days and nonadherent cells to 14 ± 4 days.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• Thymocytes harvested from enhanced recipients 6 days after grafting prolonged survival of test heart grafts in unmodified LEW hosts to a median survival time of 17 ± 3 days.

  Confidence 0.99

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

• heart allografts

  graft, transplant

  Transplanted hearts used as the graft model for measuring survival after cell transfer.

  Aliases: cardiac allografts, heart grafts

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• immunologic enhancement

  immunologic state, transplant phenomenon

  A graft-tolerance state in which donor-specific pre-treatment is associated with prolonged heart allograft survival.

  Aliases: enhancement

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• lew × bn f1 heart grafts

  graft, transplant

  Heart grafts from LEW × BN F1 donors used to induce and test the enhancement setting.

  Aliases: (LEW × BN) F1 heart grafts

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• splenocytes

  cell type, lymphoid cells

  Spleen-derived lymphoid cells separated into adherent and nonadherent fractions for transfer experiments.

  Aliases: spleen cells

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• suppressor cells

  cell type, immune cell

  Lymphoid cells inferred to inhibit rejection responses in the passive-transfer experiments.

  Aliases: suppressor cell

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• syngeneic lymphoid cells

  cell type, transferred cells

  Lymphoid cells transferred between genetically identical LEW rats in the passive-transfer assays.

  Aliases: syngeneic cells

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• thymocytes

  cell type, lymphoid cells

  Thymus-derived lymphoid cells isolated from recipient rats for passive transfer.

  Aliases: thymic cells

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• wf grafts

  graft, transplant

  Heart grafts from WF donors used to assess whether the transferred cells acted in an antigen-specific manner.

  Aliases: WF heart grafts

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

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