The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan

No abstract is available for this paper.

• Publication year

  2017

• Venue

  mAbs

• Publication date

  2017-01-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/19420862.2016.1255390PMID 27834568PMCID PMC5240645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies

  2016cited by this paper
• Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease.

  2016cited by this paper
• Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin*

  2016cited by this paper
• Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia.

  2016cited by this paper
• Bispecific antibodies.

  2015cited by this paper
• TriFabs—Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery

  2015cited by this paper
• Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

  2015cited by this paper
• Alternative molecular formats and therapeutic applications for bispecific antibodies.

  2015cited by this paper
• Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins.

  2015cited by this paper
• A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+ tumor cells

  2015cited by this paper
• A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells

  2014cited by this paper
• Design and characterization of structured protein linkers with differing flexibilities

  2014cited by this paper
• Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

  2014cited by this paper
• A high‐yielding CHO transient system: Coexpression of genes encoding EBNA‐1 and GS enhances transient protein expression

  2014cited by this paper
• Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

  2014influential reference
• Tumor-antigen-binding bispecific antibodies for cancer treatment.

  2014cited by this paper
• Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

  2014cited by this paper
• O-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins

  2014cited by this paper
• Integrin-mediated regulation of TGFβ in fibrosis.

  2013cited by this paper
• Linkers in the structural biology of protein–protein interactions

  2013cited by this paper
• Unambiguous Phosphosite Localization using Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)

  2013cited by this paper
• O-xylosylation in a recombinant protein is directed at a common motif on glycine-serine linkers.

  2013cited by this paper
• Quantification of Competing H3PO4 Versus HPO3 + H2O Neutral Losses from Regioselective 18O-Labeled Phosphopeptides

  2013cited by this paper
• Discovery and investigation of O-xylosylation in engineered proteins containing a (GGGGS)n linker.

  2013cited by this paper
• Fusion protein linkers: property, design and functionality.

  2013cited by this paper
• A mammalian expression system for high throughput antibody screening.

  2013cited by this paper
• Recombinant human lecithin‐cholesterol acyltransferase Fc fusion: Analysis of N‐ and O‐linked glycans and identification and elimination of a xylose‐based O‐linked tetrasaccharide core in the linker region

  2013cited by this paper
• Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

  2012cited by this paper
• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.

  2012cited by this paper
• Targeting the TGFβ signalling pathway in disease

  2012cited by this paper
• Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties

  2012cited by this paper
• Targeting the TGFβ signalling pathway in disease

  2012cited by this paper
• Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.

  2011cited by this paper
• Transforming growth factor-beta: recent advances on its role in immune tolerance.

  2011cited by this paper
• Latent TGF-β structure and activation

  2011cited by this paper
• Regulation of integrin affinity on cell surfaces

  2011cited by this paper
• Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing

  2010cited by this paper
• Separation of 2-aminobenzamide labeled glycans using hydrophilic interaction chromatography columns packed with 1.7 microm sorbent.

  2010cited by this paper
• Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

  2010cited by this paper
• Biopharmaceutical drug targeting to the brain

  2010cited by this paper
• A modular IgG-scFv bispecific antibody topology.

  2010cited by this paper
• Insertion of the Designed Helical Linker Led to Increased Expression of Tf-Based Fusion Proteins

  2009cited by this paper
• Single-chain antibodies as diagnostic tools and therapeutic agents

  2009cited by this paper
• Engineering and characterization of a bispecific HER2 × EGFR‐binding affibody molecule

  2009cited by this paper
• Integrins

  2009cited by this paper
• Transforming growth factor-beta in systemic sclerosis (scleroderma).

  2009cited by this paper
• Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

  2009cited by this paper
• Comprehensive Comparison of Collision Induced Dissociation and Electron Transfer Dissociation

  2008cited by this paper
• GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy *S

  2008cited by this paper
• Increasing the homogeneity, stability and activity of human serum albumin and interferon-alpha2b fusion protein by linker engineering.

  2008cited by this paper
• Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

  2008cited by this paper
• Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

  2008cited by this paper
• Prolonged in-vivo half-life of factor VIIa by fusion to albumin

  2008cited by this paper
• Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship.

  2008cited by this paper
• Performance Characteristics of Electron Transfer Dissociation Mass Spectrometry*S

  2007cited by this paper
• Mechanisms of specificity in protein phosphorylation

  2007cited by this paper
• Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

  2007cited by this paper
• Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody

  2006cited by this paper
• Improving the Oral Efficacy of Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Protein by Spacer Optimization

  2006cited by this paper
• Phosphorylation Analysis by Mass Spectrometry

  2006cited by this paper
• Transforming growth factor-beta: recent advances on its role in immune tolerance.

  2006cited by this paper
• Transforming growth factor-β: Recent advances on its role in immune tolerance

  2006cited by this paper
• A Dimeric Angiogenin Immunofusion Protein Mediates Selective Toxicity Toward CD22+ Tumor Cells

  2005cited by this paper
• Inactivation of the Mgat1 Gene in Oocytes Impairs Oogenesis, but Embryos Lacking Complex and Hybrid N-Glycans Develop and Implant

  2004cited by this paper
• Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence

  2004cited by this paper
• Assembly of Cell Regulatory Systems Through Protein Interaction Domains

  2003cited by this paper
• Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase*

  2003cited by this paper
• The Protein Kinase Complement of the Human Genome

  2002cited by this paper
• Fragmentation of phosphopeptides by atmospheric pressure MALDI and ESI/ion trap mass spectrometry

  2002cited by this paper
• Evolution of protein kinase signaling from yeast to man.

  2002cited by this paper
• Inactivation of the Integrin [36 Subunit Gene Reveals a Role of Epithelial Integrins in Regulating Inflammation in the Lungs and Skin

  2002cited by this paper
• Analysis of phosphorylated proteins and peptides by mass spectrometry.

  2001cited by this paper
• Assessment of Actual Significance Levels for Covariate Effects in NONMEM

  2001cited by this paper
• Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51

  2000cited by this paper
• Sequence and structure-based prediction of eukaryotic protein phosphorylation sites.

  1999cited by this paper
• The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

  1999cited by this paper
• Fragmentation of phosphopeptides in an ion trap mass spectrometer

  1998cited by this paper
• Redox-mediated activation of latent transforming growth factor-beta 1.

  1996cited by this paper
• A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

  1995cited by this paper
• An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.

  1994cited by this paper
• Multimerization behaviour of single chain Fv variants for the tumour-binding antibody B72.3.

  1994cited by this paper
• An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

  1994cited by this paper
• Oligosaccharide valency and conformation in determining binding to the asialoglycoprotein receptor of rat hepatocytes.

  1993cited by this paper
• Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

  1993cited by this paper
• Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

  1992cited by this paper
• Sequences of proteins of immunological interest

  1991cited by this paper
• An investigation of oligopeptides linking domains in protein tertiary structures and possible candidates for general gene fusion.

  1990cited by this paper
• Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium

  1988cited by this paper
• Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

  1988cited by this paper
• The action of purified alkaline phosphatases on di- and tri- phosphopyridine nucleotides.

  1955cited by this paper
• The substrate specificity and inhibition of alkaline phosphatases of cow's milk and calf intestinal mucosa.

  1955cited by this paper

• Targeting TGF-beta activation in cutaneous T-cell lymphomas.

  2024cites this paper