Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Arthritis & Rheumatism

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/art.27382PMID 20213804PMCID PMC3866029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functions and mechanisms of action of CCN matricellular proteins.

  2009cited by this paper
• Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

  2008cited by this paper
• Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.

  2008cited by this paper
• Transforming growth factor-β and fibrosis

  2007cited by this paper
• Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.

  2007cited by this paper
• Transforming growth factor-beta and fibrosis.

  2007cited by this paper
• All in the CCN family: essential matricellular signaling modulators emerge from the bunker

  2006cited by this paper
• Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis.

  2006cited by this paper
• Betaglycan induces TGF-beta signaling in a ligand-independent manner, through activation of the p38 pathway.

  2006cited by this paper
• Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-β2 in fibroblasts. Vol. 278 (2003) 13008–13015

  2005cited by this paper
• Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK

  2005cited by this paper
• Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.

  2005cited by this paper
• Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.

  2004cited by this paper
• CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.

  2004cited by this paper
• CTGF expression during mouse embryonic development

  2003cited by this paper
• Connective Tissue Growth Factor Gene Regulation

  2003cited by this paper
• Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice*

  2003cited by this paper
• Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.

  2003cited by this paper
• Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

  2003cited by this paper
• Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165*

  2002cited by this paper
• NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues

  2001cited by this paper
• The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

  2001cited by this paper
• Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis

  2001cited by this paper
• Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.

  2000cited by this paper
• Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.

  2000cited by this paper
• Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin αvβ3, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo

  1999cited by this paper
• Role and interaction of connective tissue growth factor with transforming growth factor‐β in persistent fibrosis: A mouse fibrosis model

  1999cited by this paper
• Expression of connective tissue growth factor in human renal fibrosis.

  1998cited by this paper
• A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice

  1996cited by this paper
• Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

  1993cited by this paper
• The modular architecture of a new family of growth regulators related to connective tissue growth factor

  1993cited by this paper

• Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis

  2025cites this paper
• Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics

  2025cites this paper
• Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment

  2025cites this paper
• Lung Function Changes and Connective Tissue Growth Factor Expression in Idiopathic Pulmonary Fibrosis, Other Progressive Fibrosing Interstitial Lung Diseases, and Post-COVID Fibrosis

  2025cites this paper
• CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts

  2025cites this paper
• CuO/Cu2O Coatings via Plasma Electrolytic Oxidation on Ti–4.5Cu Alloy: A Synergistic Approach to Antibacterial Properties and Cytocompatibility

  2025cites this paper
• Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives

  2025cites this paper
• Инновационный подход к вопросам лечения заднего блефарита, осложненного болезнью сухого глаза испарительного генеза

  2025cites this paper
• PSIG-GAN: a polarization structure information guided generative adversarial network for stain transformation

  2024cites this paper
• Transcriptomics of tissue exosomes to investigate miR-195-5p’s amelioration of endometrial fibrosis via the YAP-Smad7 pathway: an animal study

  2024cites this paper
• A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

  2024cites this paper
• Drugs targeting CTGF in the treatment of pulmonary fibrosis

  2024cites this paper
• Pathogenesis of interstitial lung disease in systemic sclerosis

  2024cites this paper
• Regenerative Engineering of a Limb: From Amputation to Regeneration

  2023cites this paper
• Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.

  2023cites this paper
• Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases.

  2023cites this paper
• Human Skin Aging and the Anti-Aging Properties of Retinol

  2023cites this paper
• SPARC Is Highly Expressed in Young Skin and Promotes Extracellular Matrix Integrity in Fibroblasts via the TGF-β Signaling Pathway

  2023cites this paper
• Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

  2023cites this paper
• Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Disease

  2022cites this paper
• The pathophysiology and treatment of musculoskeletal fibrosis

  2022cites this paper
• Pathophysiology of systemic sclerosis (scleroderma)

  2022cites this paper
• Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

  2022cites this paper
• Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density

  2022cites this paper
• Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges

  2022cites this paper
• Insights Into the Preclinical Models of SSc

  2021cites this paper
• Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension

  2021cites this paper
• M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways

  2021cites this paper
• Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation

  2021cites this paper
• Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery

  2020cites this paper
• TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways

  2020cites this paper
• Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis

  2020cites this paper
• Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging.

  2020cites this paper
• A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

  2020cites this paper
• Butyrate alleviates diabetic kidney disease by mediating the miR‐7a‐5p/P311/TGF‐β1 pathway

  2020cites this paper
• Si substituted hydroxyapatite nanorods on Ti for percutaneous implants

  2020cites this paper
• Immunoglobulin light chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease.

  2020cites this paper
• Effect of connective tissue growth factor gene editing using adeno-associated virus–mediated CRISPR–Cas9 on rabbit glaucoma filtering surgery outcomes

  2020cites this paper
• A Modified Beagle Model of Inducible Atrial Fibrillation Using a Right Atrium Pacemaker

  2020cites this paper
• Soluble CCN2/connective tissue growth factor levels in Egyptian systemic sclerosis patients: Possible association with cutaneous and pulmonary fibrosis

  2020cites this paper
• A bifunctional hydrogel incorporated with CuS@MoS2 microspheres for disinfection and improved wound healing

  2020cites this paper
• Cardiac Fibroblast Activation during Myocardial Infarction Wound Healing: Fibroblast polarization after MI.

  2020cites this paper
• JNK Signaling as a Key Modulator of Soft Connective Tissue Physiology, Pathology, and Healing

  2020cites this paper
• Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research

  2019cites this paper
• Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans

  2019cites this paper
• Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

  2019cites this paper
• Le rôle de la sphingosine-1-phosphate et impact des analogues de la sphingosine dans le remodelage pulmonaire

  2019influential citation
• Mechanisms of Fibrosis

  2019cites this paper
• In vitro evidence supporting applications of platelet derivatives in regenerative medicine.

  2019cites this paper
• MicroRNA‐1254 contributes to the controlling of pro‐fibrogenic environment in LX‐2 cells by modulating SMAD3 and wound repair: new insights in hepatic fibrosis

  2019influential citation
• Exosomal MALAT1 Derived from Hepatic Cells is Involved in The Activation of Hepatic Stellate Cells via miRNA-26b in Fibrosis Induced by Arsenite.

  2019cites this paper
• Renal Inflammation and Fibrosis: A Double-edged Sword

  2019cites this paper
• TGFβ1 Single Nucleotide Polymorphism C-509T Alters Mucosal Cell Function in Pediatric Eosinophilic Esophagitis

  2019cites this paper
• Notch Signaling Activity Determines Uptake and Biological Effect of Imatinib in Systemic Sclerosis Dermal Fibroblasts.

  2019cites this paper
• Fibroblast responses and antibacterial activity of Cu and Zn co-doped TiO 2 for percutaneous implants

  2018cites this paper
• In Vitro Identification of New Transcriptomic and miRNomic Profiles Associated with Pulmonary Fibrosis Induced by High Doses Everolimus: Looking for New Pathogenetic Markers and Therapeutic Targets

  2018cites this paper
• Silencing CTGF/CCN2 inactivates the MAPK signaling pathway to alleviate myocardial fibrosis and left ventricular hypertrophy in rats with dilated cardiomyopathy

  2018cites this paper
• CTGF in kidney fibrosis and glomerulonephritis

  2018cites this paper
• Local Silencing of Connective Tissue Growth Factor by siRNA/Peptide Improves Dermal Collagen Arrangements

  2018cites this paper
• Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling

  2018cites this paper
• Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis

  2018cites this paper
• CCN proteins as potential actionable targets in scleroderma

  2018cites this paper
• Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1P2) Attenuates Bleomycin-Induced Pulmonary Fibrosis

  2018cites this paper
• Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway

  2018cites this paper
• IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators

  2018cites this paper
• Fibrogenic and angiogenic commitments of human induced pluripotent stem cells derived mesenchymal stem cells in connective tissue growth factor-delivering scaffold in an immune-deficient mice model.

  2018cites this paper
• The effects of interleukin‐33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma

  2018cites this paper
• Investigating the role of CCN2 in a bleomycin model of Idiopathic Pulmonary Fibrosis

  2018cites this paper
• Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

  2018cites this paper
• The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan

  2017cites this paper
• Cutaneous Fibrosis and Normal Wound Healing

  2017cites this paper
• FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury.

  2017cites this paper
• Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants

  2017cites this paper
• Novel approaches to identify biomechanisms in systemic sclerosis

  2017cites this paper
• Pathogenesis of systemic sclerosis—current concept and emerging treatments

  2017cites this paper
• Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities

  2017cites this paper
• Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans

  2017cites this paper
• Therapeutic pro-fibrogenic signaling pathways in fibroblasts.

  2017cites this paper
• Chapter 83 – Etiology and Pathogenesis of Scleroderma

  2017cites this paper
• Pathophysiology of Fibrosis in Systemic Sclerosis

  2017cites this paper
• Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

  2017cites this paper
• Regulatory role of miR-18a to CCN2 by TGF-β1 signaling pathway in pulmonary injury induced by nano-SiO2

  2017cites this paper
• Hypoxia‐induced ADAM 17 expression is mediated by RSK1‐dependent C/EBP&bgr; activation in human lung fibroblasts

  2017cites this paper
• Molecular mechanisms involved in podocyte EMT and concomitant diabetic kidney diseases: an update

  2017cites this paper
• Microvesicle-mediated delivery of miR-1343: impact on markers of fibrosis

  2017cites this paper
• Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6.

  2017cites this paper
• Idiopathic Pulmonary Fibrosis: Molecular Endotypes of Fibrosis Stratifying Existing and Emerging Therapies

  2017cites this paper
• Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

  2017cites this paper
• Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.

  2017cites this paper
• Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression

  2017cites this paper
• Is personalised medicine the key to heterogeneity in idiopathic pulmonary fibrosis?

  2017cites this paper
• The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis

  2017influential citation
• Overview of Animal Models

  2017cites this paper
• Pathogenesis of systemic sclerosis—current concept and emerging treatments

  2017cites this paper
• Recent advances in animal models of systemic sclerosis

  2016cites this paper
• Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells

  2016cites this paper
• Transcriptome of Cultured Lung Fibroblasts in Idiopathic Pulmonary Fibrosis: Meta-Analysis of Publically Available Microarray Datasets Reveals Repression of Inflammation and Immunity Pathways

  2016cites this paper
• The dual function of Cu-doped TiO2 coatings on titanium for application in percutaneous implants.

  2016cites this paper
• Roles of ERK1/2 signaling in LMNA-cardiomyopathy

  2016cites this paper
• Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis

  2016cites this paper