Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Human Cell

• Publication date

  2018-03-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13577-017-0192-8PMID 29549584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence.

  2017cited by this paper
• Role of endothelial‐to‐mesenchymal transition induced by TGF‐β1 in transplant kidney interstitial fibrosis

  2017cited by this paper
• Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice

  2016influential reference
• Renoprotective effect of berberine via regulating the PGE 2‐EP1‐Gαq‐Ca2+ signalling pathway in glomerular mesangial cells of diabetic rats

  2016cited by this paper
• Impaired Mechanics of Left Ventriculo-Atrial Coupling in Patients With Diabetic Nephropathy.

  2016cited by this paper
• Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis.

  2016cited by this paper
• Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1

  2016cited by this paper
• Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH.

  2016cited by this paper
• Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis

  2016cited by this paper
• Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities

  2015cited by this paper
• Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

  2015cited by this paper
• Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities

  2015cited by this paper
• Arnebin-1 promotes the angiogenesis of human umbilical vein endothelial cells and accelerates the wound healing process in diabetic rats.

  2014cited by this paper
• Which indexes are the most important risk factor for cardiorenal events in type 2 diabetic patients?

  2013cited by this paper
• Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy

  2013cited by this paper
• Pharmacological Properties of Shikonin – A Review of Literature since 2002

  2013cited by this paper
• Beneficial effect of myricetin on renal functions in streptozotocin-induced diabetes

  2012cited by this paper
• Transforming growth factor‐β/Smad signalling in diabetic nephropathy

  2012cited by this paper
• Renoprotective effects of (+)-catechin in streptozotocin-induced diabetic rat model.

  2012cited by this paper
• Risk for ESRD in type 1 diabetes remains high despite renoprotection.

  2011cited by this paper
• Activation of Peroxisome Proliferator–Activated Receptor δ Inhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice

  2011cited by this paper
• The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential

  2011cited by this paper
• Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes.

  2011cited by this paper
• The Protective Role of Smad 7 in Diabetic Kidney Disease : Mechanism and Therapeutic Potential

  2011cited by this paper
• NF-kappaB in renal inflammation.

  2010cited by this paper
• Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

  2010cited by this paper
• New insights into epithelial-mesenchymal transition in kidney fibrosis.

  2010cited by this paper
• TGF-beta and fibrosis in different organs - molecular pathway imprints.

  2009influential reference
• The role of inflammatory cytokines in diabetic nephropathy.

  2008cited by this paper
• Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling.

  2008cited by this paper
• Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

  2004cited by this paper
• CTGF Mediates TGF-– Induced Fibronectin Matrix Deposition by Upregulating Active 5 1 Integrin in Human Mesangial Cells

  2003cited by this paper
• CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells.

  2003cited by this paper
• Growth factors and the development of diabetic nephropathy

  2003cited by this paper
• Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse.

  2001cited by this paper
• Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse

  2001cited by this paper
• Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

  2000cited by this paper
• End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions.

  1999cited by this paper
• Prognosis of diabetics with diabetes onset before the age of thirty-one. I. Survival, causes of death, and complications.

  1978cited by this paper

• Potential pathways for natural active ingredients to intervene in diabetic kidney disease: targeting macrophage infiltration

  2025cites this paper
• Acetylshikonin alleviates pulmonary fibrosis through inhibition of the STAT3 signaling pathway.

  2025cites this paper
• Ethnopharmacology, Geographic Distribution, Major Chemical Constituents, and Pharmacological Effects of the Traditional Chinese Medicinal Herb Arnebia euchroma

  2025cites this paper
• Traditional Chinese Medicine targeting the TGF-β/Smad signaling pathway as a potential therapeutic strategy for renal fibrosis

  2025cites this paper
• Shen-Qi-Yan-Shen Formula attenuates diabetic renal lipid deposition by down-regulating proteoglycan expression

  2025cites this paper
• The regulatory effect and mechanism of traditional Chinese medicine on the renal inflammatory signal transduction pathways in diabetic kidney disease: A review

  2024cites this paper
• RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind Tumorigenesis

  2023cites this paper
• Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/β-catenin pathway.

  2023cites this paper
• Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy

  2023cites this paper
• Mechanisms of Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment

  2022cites this paper
• Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation

  2022cites this paper
• Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

  2022cites this paper
• Shikonin as a WT1 Inhibitor Promotes Promyeloid Leukemia Cell Differentiation

  2022cites this paper
• A Cyclopentanone Compound Attenuates the Over-Accumulation of Extracellular Matrix and Fibrosis in Diabetic Nephropathy via Downregulating the TGF-β/p38MAPK Axis

  2022cites this paper
• Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways

  2021cites this paper
• ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation

  2021influential citation
• Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review

  2020cites this paper
• A novel silkworm pupae carboxymethyl chitosan inhibits mouse L929 fibroblast proliferation

  2020cites this paper
• Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia.

  2019cites this paper
• Roscovitine attenuates renal interstitial fibrosis in diabetic mice through the TGF-β1/p38 MAPK pathway.

  2019cites this paper
• The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease

  2019cites this paper
• Effects of Acetylshikonin on the Infection and Replication of Coxsackievirus A16 in Vitro and in Vivo.

  2019cites this paper
• ClC-5 alleviates renal fibrosis in unilateral ureteral obstruction mice

  2019cites this paper