Induction of platelet‐derived growth factor A and B chains and over‐expression of their receptors in human pancreatic cancer

No abstract is available for this paper.

• Publication year

  1995

• Venue

  International Journal of Cancer

• Publication date

  1995-09-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.2910620507PMID 7665222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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