Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Blood

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2006-01-0017PMID 16527889
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms

  2005cited by this paper
• Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells

  2005cited by this paper
• Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings.

  2005cited by this paper
• The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance

  2005cited by this paper
• Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion1

  2005cited by this paper
• Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo1

  2004cited by this paper
• Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

  2004cited by this paper
• The molecular program induced in T cells undergoing homeostatic proliferation.

  2004cited by this paper
• Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire.

  2004cited by this paper
• On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells

  2003cited by this paper
• Neonates support lymphopenia-induced proliferation.

  2003cited by this paper
• Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

  2003cited by this paper
• Self-recognition and the regulation of CD4+ T cell survival.

  2002cited by this paper
• TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells1

  2002cited by this paper
• Maintaining the norm: T-cell homeostasis

  2002cited by this paper
• MHC-dependent survival of naïve T cells? A complicated answer to a simple question.

  2002cited by this paper
• HIV and autoimmunity.

  2002cited by this paper
• Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes

  2002cited by this paper
• TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells1

  2002cited by this paper
• T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo.

  2001cited by this paper
• How alpha beta T cells deal with induced TCR alpha ablation.

  2001cited by this paper
• Class II essential for CD4 survival

  2001cited by this paper
• IL-7 is critical for homeostatic proliferation and survival of naïve T cells

  2001cited by this paper
• How much TCR does a T cell need?

  2001cited by this paper
• γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

  2000cited by this paper
• The organization of mature T-cell pools.

  2000cited by this paper
• Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.

  2000cited by this paper
• CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

  2000cited by this paper
• Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

  2000cited by this paper
• Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes1

  2000cited by this paper
• Mice lacking all conventional MHC class II genes.

  1999cited by this paper
• The organization of mature T-cell pools.

  1998cited by this paper
• Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

  1997cited by this paper
• Peripheral Selection of  T Cell Repertoires: The Role of Continuous Thymus Output

  1997cited by this paper
• Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses.

  1997cited by this paper
• Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

  1997influential reference
• Organ‐specific Autoimmunity Induced by Lymphopenia

  1996cited by this paper
• MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span.

  1996cited by this paper
• Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

  1996cited by this paper
• Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor

  1995cited by this paper
• Organ‐specific autoimmunity induced by adult thymectomy and cyclophosphamide‐induced lymphopenia

  1995cited by this paper
• Selective events in T cell development.

  1994cited by this paper
• Another view of the selective model of thymocyte selection.

  1993cited by this paper
• Mice lacking MHC class II molecules.

  1991cited by this paper
• The thymus selects the useful, neglects the useless and destroys the harmful.

  1989cited by this paper

• Sustained immune youth risks autoimmune disease in the aging host

  2025cites this paper
• Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy.

  2024cites this paper
• Towards a unified model of naive T cell dynamics across the lifespan

  2022cites this paper
• Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity

  2021cites this paper
• The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis

  2021cites this paper
• Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling

  2021cites this paper
• IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

  2020cites this paper
• [Endosomal signaling by the TCR ζ chain is required for T lymphocyte survival in secondary lymphoid organs].

  2020cites this paper
• Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells

  2020cites this paper
• Fate Mapping Quantifies the Dynamics of B Cell Development and Activation throughout Life

  2019cites this paper
• Getting in and Staying Alive: Role for Coronin 1 in the Survival of Pathogenic Mycobacteria and Naïve T Cells

  2018cites this paper
• The natural history of naive T cells from birth to maturity

  2018cites this paper
• Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis

  2018cites this paper
• Two Strikes and You’re Out? The Pathogenic Interplay of Coinhibitor Deficiency and Lymphopenia-Induced Proliferation

  2017cites this paper
• Predicting CD4 T‐Cell Reconstitution Following Pediatric Hematopoietic Stem Cell Transplantation

  2017cites this paper
• Calcium-mediated shaping of naive CD4 T-cell phenotype and function

  2017cites this paper
• Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells

  2017cites this paper
• Characterisation of CD3-enhanced gene-modified CD4+ T cells for cancer immunotherapy

  2017cites this paper
• Predicting CD 4 T-cell reconstitution following pediatric haematopoietic stem cell transplantation

  2017cites this paper
• Modelling immune reconstitution following paediatric haematopoietic stem cell transplantation and in HIV-infected children

  2016cites this paper
• Rôles de deux corécepteurs impliqués dans le maintien des cellules T mémoires CD8+ et la maturation des cellules dendritiques

  2016cites this paper
• Adaptive Immune-like γ/δ T Lymphocytes Share Many Common Features with Their α/β T Cell Counterparts

  2015cites this paper
• The immune system as a self-centered network of lymphocytes.

  2015cites this paper
• Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism

  2015cites this paper
• Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2.

  2015cites this paper
• T Cell Counterparts β / α Share Many Common Features with Their T Lymphocytes δ / γ Adaptive Immune-like

  2015cites this paper
• TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery

  2014cites this paper
• The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

  2014cites this paper
• Betrixaban (PRT054021): pharmacology, dose selection and clinical studies.

  2014cites this paper
• and Suppressive Capacities in the PeripheryNumbers Maintaining CD4 Regulatory T Cell TCR-Signaling Events Are Required for

  2014cites this paper
• Premature CD4+ T Cell Aging and Its Contribution to Lymphopenia-Induced Proliferation of Memory Cells in Autoimmune-Prone Non-Obese Diabetic Mice

  2014cites this paper
• Modeling the T cell immune response: a fascinating challenge

  2014cites this paper
• Function of the immunoregulatory CD4-CD8- T cells in the context of autoimmune diabetes

  2013cites this paper
• Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells

  2013cites this paper
• Rôle de l’autoréactivité sur les capacités suppressives des lymphocytes T régulateurs CD4+ Foxp3+

  2013cites this paper
• Functional analysis of T cells lacking germline-encoded complementarity-determining regions

  2013cites this paper
• The role of Zap70 in naïve T cell homeostasis

  2013cites this paper
• AutoimmunityCD8+ T Cell-Mediated Regulatory CD4+ T Cells Are Crucial for

  2013cites this paper
• Limited-stage mantle cell lymphoma: not so different from advanced-stage

  2013cites this paper
• Mathematical Modeling of Oncogenesis Control in Mature T-Cell Populations

  2013cites this paper
• Self-recognition of structurally identical, rod-shaped macroions with different central metal atoms during their assembly process.

  2013cites this paper
• Mathematical Model of Naive T Cell Division and Survival IL-7 Thresholds

  2013cites this paper
• Experimental models to investigate the function of dendritic cell subsets: challenges and implications

  2013cites this paper
• This information is current as Nonobese Diabetic Mice Initial Effector T Cell Activation Timing in Lymphopenia: Role of Thymus Ablation and Autoimmunity during Thymectomy-Induced

  2013cites this paper
• Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells

  2012cites this paper
• Conventional CD 4 Balance between the Regulatory and IL-2 and IL-7 Determine the Homeostatic

  2012cites this paper
• Persistence Memory T Cell + Antigen-Specific CD 4 Homeostatic Division Is Not Necessary for Staub and

  2012cites this paper
• Homeostatic Division Is Not Necessary for Antigen-Specific CD4+ Memory T Cell Persistence

  2012cites this paper
• Seminars in Immunology

  2012cites this paper
• Homeostatic maintenance of T cells and natural killer cells

  2012cites this paper
• Quanti fi cation of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD 4 + and CD 8 + T cells

  2012cites this paper
• The race for the prize: T-cell trafficking strategies for optimal surveillance.

  2012cites this paper
• CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1‐inducing role of mesenteric lymph node macrophages during colitis

  2012cites this paper
• Foxp3‐independent loss of regulatory CD4+ T‐cell suppressive capacities induced by self‐deprivation

  2012cites this paper
• IL-2 and IL-7 Determine the Homeostatic Balance between the Regulatory and Conventional CD4+ T Cell Compartments during Peripheral T Cell Reconstitution

  2012cites this paper
• The role of SLP-76 in the homeostasis of CD4+ T cells

  2012cites this paper
• Characterization Of The Mamu-A*01-Restricted Cd8-Positive T Lymphocyte Immunodominance Hierarchy In Simian Immunodeficiency Virus-Infected Rhesus Monkeys

  2012influential citation
• Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects.

  2012cites this paper
• Coronin 1-Mediated Naive T Cell Survival Is Essential for the Development of Autoimmune Encephalomyelitis

  2011cites this paper
• This information is current as Autoimmune Encephalomyelitis Essential for the Development of Coronin 1-Mediated Naive T Cell Survival Is Rolink

  2011cites this paper
• Novel findings on the impact of HIV infection: Interplay between T cell development and peripheral T cell homeostasis

  2011cites this paper
• Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs

  2010cites this paper
• On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands.

  2010cites this paper
• Temporal Differences in the Dependency on Phosphoinositide-Dependent Kinase 1 Distinguish the Development of Invariant Vα14 NKT Cells and Conventional T Cells

  2010cites this paper
• Peripheral Interactions with APCs Conversion of Human T Cells Depend on Homeostatic Expansion and Phenotypic

  2010cites this paper
• Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

  2009cites this paper
• Age-associated increase in lifespan of naïve CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

  2009cites this paper
• Differential lymphopenia‐induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury

  2009cites this paper
• Self–class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

  2009influential citation
• MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival1

  2009cites this paper
• Naive T cell homeostasis: from awareness of space to a sense of place

  2009cites this paper
• Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice1

  2009cites this paper
• Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking

  2009cites this paper
• Modelling naive T‐cell homeostasis: consequences of heritable cellular lifespan during ageing

  2009cites this paper
• Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development.

  2009cites this paper
• The zinc finger transcription factor Early Growth Response 2 (Egr-2) is an intrinsic regulator of T cell tolerance and homeostasis

  2009cites this paper
• The Role of Thymic Stromal Lymphopoietin in CD8+ T Cell Homeostasis1

  2008cites this paper
• Regulatory T Cells + to the Action of Foxp 3 of TCR-MHC Engagement and Is Insensitive Mutant Mice Unfolds Independently Y 136 F Lat Th 2 Lymphoproliferative Disorder of

  2008cites this paper
• T cell homeostasis

  2008cites this paper
• This information is current as Autoimmunity T Cell-Mediated + Preventing CD 8 T Cells Are Crucial for + Regulatory CD 4 Campion

  2008cites this paper
• The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

  2008cites this paper
• Regulatory CD4+ T Cells Are Crucial for Preventing CD8+ T Cell-Mediated Autoimmunity1

  2008cites this paper
• Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells1

  2008cites this paper
• The HMG‐CoA inhibitor, simvastatin, triggers in vitro anti‐tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia

  2008cites this paper
• Quantitative analysis of T cell homeostatic proliferation.

  2007cites this paper
• Memory CD4 T Cell Function Cell Metabolism to Establish Optimal Molecules Is Essential for Maintenance of T Noncognate Interaction with MHC Class II

  2007cites this paper
• Noncognate Interaction with MHC Class II Molecules Is Essential for Maintenance of T Cell Metabolism to Establish Optimal Memory CD4 T Cell Function1

  2007cites this paper
• Homeostatic Expansion Permits T Cells to Re‐Enter the Thymus and Deliver Antigen in a Tolerogenic Fashion

  2007cites this paper