Cell cycle regulation by the NEK family of protein kinases

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.111195PMID 23132929PMCID PMC3500863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.

  2012cited by this paper
• Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition.

  2012cited by this paper
• Nek1 and TAZ interact to maintain normal levels of polycystin 2.

  2011cited by this paper
• Irreversible Nek2 kinase inhibitors with cellular activity.

  2011cited by this paper
• Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.

  2011cited by this paper
• Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

  2011cited by this paper
• Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

  2011cited by this paper
• The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

  2011cited by this paper
• The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

  2011cited by this paper
• Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint

  2011influential reference
• Nek9, Nek6, Nek7 and the separation of centrosomes

  2011cited by this paper
• Centrosomes and cilia in human disease.

  2011cited by this paper
• Mitosis is not a key target of microtubule agents in patient tumors

  2011cited by this paper
• Nek family of kinases in cell cycle, checkpoint control and cancer

  2011cited by this paper
• Nek9 is a Plk1‐activated kinase that controls early centrosome separation through Nek6/7 and Eg5

  2011influential reference
• An Undecided Coiled Coil

  2011cited by this paper
• NEK1 mutations cause short-rib polydactyly syndrome type majewski.

  2011cited by this paper
• NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells

  2011cited by this paper
• Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target

  2010cited by this paper
• Nek6 overexpression antagonizes p53-induced senescence in human cancer cells

  2010cited by this paper
• Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin

  2010cited by this paper
• Live Cell Imaging

  2010cited by this paper
• New look inside the spindle: microtubule-dependent microtubule generation within the spindle.

  2010cited by this paper
• Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.

  2010cited by this paper
• Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells*

  2010cited by this paper
• Nek10 Mediates G2/M Cell Cycle Arrest and MEK Autoactivation in Response to UV Irradiation

  2010influential reference
• Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

  2010cited by this paper
• Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

  2010cited by this paper
• Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

  2010cited by this paper
• Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization†

  2010cited by this paper
• The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

  2009influential reference
• Nek2 as a novel molecular target for the treatment of breast carcinoma

  2009cited by this paper
• An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

  2009cited by this paper
• Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

  2009cited by this paper
• NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

  2009influential reference
• The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons

  2009cited by this paper
• Control of daughter centriole formation by the pericentriolar material

  2008cited by this paper
• The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

  2008cited by this paper
• NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.

  2008cited by this paper
• The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability

  2008influential reference
• beta-Catenin is a Nek2 substrate involved in centrosome separation.

  2008cited by this paper
• Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.

  2008cited by this paper
• Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

  2008cited by this paper
• Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

  2008cited by this paper
• Never-in-mitosis related Kinase 1 functions in DNA damage response and checkpoint control

  2008cited by this paper
• Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase*

  2007cited by this paper
• Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.

  2007cited by this paper
• Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion

  2007cited by this paper
• Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization

  2007cited by this paper
• Structure and Regulation of the Human Nek2 Centrosomal Kinase*

  2007cited by this paper
• HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

  2007cited by this paper
• Phylogenetic Analysis of the Neks Reveals Early Diversification of Ciliary-Cell Cycle Kinases

  2007cited by this paper
• Mitotic regulation by NIMA-related kinases

  2007influential reference
• Targeted anti-mitotic therapies: can we improve on tubulin agents?

  2007cited by this paper
• NEK7 is a centrosomal kinase critical for microtubule nucleation.

  2007influential reference
• Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells

  2007cited by this paper
• Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

  2006influential reference
• Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression

  2006cited by this paper
• Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms.

  2006influential reference
• Rootletin forms centriole-associated filaments and functions in centrosome cohesion

  2005cited by this paper
• The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

  2005cited by this paper
• A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas

  2005influential reference
• Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells.

  2005cited by this paper
• Caught Nek-ing: cilia and centrioles

  2005influential reference
• Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.

  2005cited by this paper
• Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

  2005cited by this paper
• The Centrosomal Kinase Nek2 Displays Elevated Levels of Protein Expression in Human Breast Cancer

  2004cited by this paper
• NEK2A Interacts with MAD1 and Possibly Functions as a Novel Integrator of the Spindle Checkpoint Signaling*

  2004cited by this paper
• Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure.

  2004cited by this paper
• Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity.

  2004cited by this paper
• Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2

  2004cited by this paper
• Microtubules as a target for anticancer drugs

  2004cited by this paper
• NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response

  2004cited by this paper
• The Centrosomal Kinase Nek 2 Displays Elevated Levels of Protein Expression in Human Breast Cancer

  2004cited by this paper
• Nucleolar Nek11 Is a Novel Target of Nek2A in G1/S-arrested Cells*

  2004cited by this paper
• Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.

  2003cited by this paper
• Never say never. The NIMA-related protein kinases in mitotic control.

  2003cited by this paper
• Proteomic characterization of the human centrosome by protein correlation profiling

  2003cited by this paper
• A Mitotic Cascade of NIMA Family Kinases Nercc1/Nek9 ACTIVATES THE Nek6 AND Nek7 KINASES*

  2003influential reference
• A Mitotic Cascade of NIMA Family Kinases

  2003cited by this paper
• Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes.

  2003cited by this paper
• Schizosaccharomyces pombe NIMA‐related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB

  2002cited by this paper
• Molecular Basis for the Substrate Specificity of NIMA-related Kinase-6 (NEK6)

  2002cited by this paper
• Nek11, a New Member of the NIMA Family of Kinases, Involved in DNA Replication and Genotoxic Stress Responses*

  2002cited by this paper
• The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation.

  2002cited by this paper
• The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity

  2002cited by this paper
• A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish

  2002cited by this paper
• Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2*

  2002cited by this paper
• Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.

  2002influential reference
• APC/C‐mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A‐type D‐box

  2001cited by this paper
• NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.

  2000cited by this paper
• Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans.

  2000cited by this paper
• Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.

  2000cited by this paper
• Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease.

  1999cited by this paper
• Activity of the Human Centrosomal Kinase, Nek2, Depends on an Unusual Leucine Zipper Dimerization Motif*

  1999cited by this paper
• A NIMA homologue promotes chromatin condensation in fission yeast.

  1998cited by this paper
• A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators

  1998cited by this paper
• C-Nap 1 , a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle – regulated Protein Kinase Nek 2

  1998cited by this paper
• C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2

  1998cited by this paper
• A Role for NIMA in the Nuclear Localization of Cyclin B in Aspergillus nidulans

  1998cited by this paper

• PCID2 is essential for spermatogonial differentiation by regulating alternative splicing

  2026cites this paper
• Orchestrating Microtubules: A Review of Kinase–Dependent Regulatory Mechanisms

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• Longitudinal analysis of retinal cell state transitions in RB1-deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma

  2026influential citation
• Mutational insights and in silico characterization of NEK family kinases in OSCC patients from the Pakistani population.

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• Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis.

  2026cites this paper
• The Crohn's disease-related RNF123 prevents NLRP3 inflammasome assembly by catalyzing unanchored K63-linked ubiquitination on NEK7.

  2026cites this paper
• Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer

  2026cites this paper
• Multi-omics profiling of sodium-overload (NECSO) programs identifies NEK8 as a central driver of colorectal cancer progression through single-cell and spatial transcriptomics.

  2026cites this paper
• Involvement of a NIMA-related kinase in cell division of the liverwort Marchantia polymorpha

  2025cites this paper
• Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes

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• Differential Gene Expression Across Species Following Spinal Cord Injury: A Systematic Review and Meta-Analysis

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• NEK7 accelerates NLRP3 inflammasome activation

  2025cites this paper
• NEK Family Kinases: Structure, Function, and Role in Disease

  2025influential citation
• METTL1-mediated m7G modification of NEK1 mRNA promotes the proliferation of oral squamous cell carcinoma.

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• Identification of NEK6 as a potential biomarker for prognosis in glioma and its functional implications

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• NEK7 is an essential regulator in NLRP3 inflammasome assembly of common carp (Cyprinus carpio L.).

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• Chemoproteomic Profiling of PKA Substrates with Kinase-catalyzed Crosslinking and Immunoprecipitation (K-CLIP)

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• Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors

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• NIMA-related kinase 2: A master regulator of mitotic fidelity and chromosomal instability in cancer: From mechanisms to therapeutic targeting.

  2025cites this paper
• Transcriptional modulation in Mediterranean Mussel Mytilus galloprovincialis following exposure to four pharmaceuticals widely distributed in coastal areas.

  2025cites this paper
• NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines

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• A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis

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• NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3

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• NEK kinases in cell cycle regulation, DNA damage response, and cancer progression.

  2025cites this paper
• A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis

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• Kinesin-2 autoinhibition requires elbow phosphorylation

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• Orexin A alleviates chronic cerebral hypoperfusion-induced neuroinflammation and cognitive dysfunction by inhibiting the NEK7/NLRP3 pathway.

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• Nek family members regulate Rad54 during homologous recombination in developing mice

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• Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle

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• NEK9-mediated Wnt signalling repressor TLE3 rewires Docetaxel resistance in cancer cells by inducing pyroptosis

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• Overexpression of the NEK8 kinase inhibits homologous recombination.

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• Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics.

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