Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular and Cellular Biology

• Publication date

  1992-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.12.1.207-219.1992PMID 1729599PMCID PMC364085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of Protein Synthesis in Virus-Infected Animal Cells

  2008cited by this paper
• Human Retroviruses and AIDS. A compilation and analysis of nucleic acid and amino acid sequences: I--II; III--V

  1993cited by this paper
• Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein

  1992cited by this paper
• Expression of human immunodeficiency virus type 1 vif and vpr mRNAs is Rev-dependent and regulated by splicing.

  1991cited by this paper
• Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs

  1990cited by this paper
• A tripartite HIV‐1 tat‐env‐rev fusion protein.

  1990cited by this paper
• Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein

  1990cited by this paper
• Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA

  1990cited by this paper
• Conservative Mutations in the Putative Metal-Binding Region of Human Immunodeficiency Virus Tat Disrupt Virus Replication

  1990cited by this paper
• Identification of a cis-acting element in human immunodeficiency virus type 2 (HIV-2) that is responsive to the HIV-1 rev and human T-cell leukemia virus types I and II rex proteins

  1990cited by this paper
• Tat and Rev: positive regulators of HIV gene expression.

  1990cited by this paper
• Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1

  1990cited by this paper
• Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

  1990cited by this paper
• A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins

  1990cited by this paper
• Simian immunodeficiency virus displays complex patterns of RNA splicing

  1990cited by this paper
• Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

  1990cited by this paper
• Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1

  1990cited by this paper
• Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism.

  1990cited by this paper
• Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells.

  1990cited by this paper
• Functional analysis of the internal translation initiation site of foot-and-mouth disease virus

  1990cited by this paper
• Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells

  1990cited by this paper
• Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.

  1989cited by this paper
• Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein

  1989cited by this paper
• Rev-induced modulation of Nef protein underlies temporal regulation of human immunodeficiency virus replication.

  1989cited by this paper
• Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting

  1989cited by this paper
• Structure of simian immunodeficiency virus regulatory genes.

  1989cited by this paper
• rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

  1989cited by this paper
• How ‘hidden’ reading frames are expressed

  1989influential reference
• The scanning model for translation: an update

  1989influential reference
• The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

  1989cited by this paper
• Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

  1989cited by this paper
• Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control.

  1989cited by this paper
• Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts

  1989cited by this paper
• Functional role of human immunodeficiency virus type 1 vpu.

  1989cited by this paper
• Scanning independent ribosomal initiation of the Sendai virus Y proteins in vitro and in vivo.

  1989cited by this paper
• Alternatives for the initiation of translation.

  1989cited by this paper
• Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core-polymerase fusion proteins.

  1989cited by this paper
• Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region.

  1988cited by this paper
• An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis

  1988cited by this paper
• Picornaviruses break the rules

  1988cited by this paper
• Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

  1988cited by this paper
• Identification of a protein encoded by the vpu gene of HIV-1

  1988cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• The leading sequence of caulimovirus large RNA can be folded into a large stem-loop structure.

  1988cited by this paper
• RNA translation. Picornaviruses break the rules.

  1988cited by this paper
• Scanning independent ribosomal initiation of the Sendai virus X protein.

  1988cited by this paper
• A novel gene of HIV-1, vpu, and its 16-kilodalton product.

  1988cited by this paper
• Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1.

  1988cited by this paper
• Evidence that the GCN2 protein kinase regulates reinitiation by yeast ribosomes.

  1988cited by this paper
• Functional comparison of transactivation by simian immunodeficiency virus from rhesus macaques and human immunodeficiency virus type 1

  1988cited by this paper
• Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.

  1988cited by this paper
• Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region

  1988cited by this paper
• Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells.

  1988cited by this paper
• A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript.

  1987cited by this paper
• Selective translation initiation on bicistronic simian virus 40 late mRNA

  1987cited by this paper
• Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.

  1987cited by this paper
• An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

  1987cited by this paper
• Genome organization and transactivation of the human immunodeficiency virus type 2

  1987cited by this paper
• Complete Nucleotide Sequences of Functional Clones of the AIDS Virus

  1987cited by this paper
• Effects of cDNA hybridization on translation of encephalomyocarditis virus RNA

  1987cited by this paper
• Complete nucleotide sequences of functional clones of the virus associated with the acquired immunodeficiency syndrome, HTLV-III/LAV.

  1987cited by this paper
• Translational regulation of SV40 early mRNA defines a new viral protein.

  1987cited by this paper
• Isolation of RNA for dot hybridization by heparin-DNase I treatment of whole cell lysate.

  1987cited by this paper
• The specificity of the human immunodeficiency virus type 2 transactivator is different from that of human immunodeficiency virus type 1.

  1987cited by this paper
• New human and simian HIV-related retroviruses possess functional transactivator (tat) gene

  1987cited by this paper
• Three novel genes of human T-lymphotropic virus type III: immune reactivity of their products with sera from acquired immune deficiency syndrome patients.

  1986cited by this paper
• HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.

  1986cited by this paper
• Bifunctional messenger RNAs in eukaryotes.

  1986influential reference
• A second post-transcriptional trans-activator gene required for HTLV-III replication

  1986cited by this paper
• Termination-reinitiation occurs in the translation of mammalian cell mRNAs

  1986cited by this paper
• Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

  1986influential reference
• Multiple cis-acting elements modulate the translational efficiency of GCN4 mRNA in yeast.

  1986cited by this paper
• Internal initiation of translation on the vesicular stomatitis virus phosphoprotein mRNA yields a second protein

  1986cited by this paper
• Multiple upstream AUG codons mediate translational control of GCN4.

  1986cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986cited by this paper
• The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.

  1985cited by this paper
• Complete nucleotide sequence of the AIDS virus, HTLV-III

  1985cited by this paper
• mRNA cap binding proteins: essential factors for initiating translation.

  1985cited by this paper
• Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus

  1985cited by this paper
• Enzymatic amplification of ?-globin genomic sequences and restriction site analysis for diagnosis of

  1985cited by this paper
• Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

  1985cited by this paper
• Mutation of a termination codon affects src initiation

  1984cited by this paper
• Initiation of translation of the cauliflower mosaic virus genome from a polycistronic mRNA: evidence from deletion mutagenesis

  1984cited by this paper
• Initiation of translation at internal AUG codons in mammalian cells

  1984cited by this paper
• Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

  1982cited by this paper
• Capping of eucaryotic mRNAs.

  1976cited by this paper
• A new technique for the assay of infectivity of human adenovirus 5 DNA.

  1973cited by this paper

• Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation

  2022cites this paper
• Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new 1 tool to study their functional interplay within a single infected CD 4 + T cell 2 3

  2021cites this paper
• Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis

  2021cites this paper
• Evaluation of HIV-1 Latency Reversal and Antibody-Dependent Viral Clearance by Quantification of Singly Spliced HIV-1 vpu/env mRNA

  2021cites this paper
• Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4+ T Cell

  2021cites this paper
• Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain

  2019cites this paper
• HIV-1 virus cycle replication: a review of RNA polymerase II transcription, alternative splicing and protein synthesis.

  2019cites this paper
• Cell type specific profiling of alternative translation identifies novel protein isoforms in the mouse brain

  2018cites this paper
• Third-generation Sequencing Reveals Extensive Polycistronism and Transcriptional Overlapping in a Baculovirus

  2018cites this paper
• Focus on Translation Initiation of the HIV-1 mRNAs

  2018cites this paper
• Regulation of human immunodeficiency virus type 1 (HIV-1) mRNA translation.

  2017cites this paper
• Experiment design for early molecular events in HIV infection

  2017cites this paper
• Cellular microRNAs in HIV replication and latency

  2017influential citation
• A researcher’s guide to the galaxy of IRESs

  2016cites this paper
• Efavirenz versus Nevirapina : comparação da efectividade e do perfil de segurança, a longo prazo, no tratamento da infecção por vírus da imunodeficiência humana tipo 1

  2016cites this paper
• Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1)

  2016cites this paper
• When biologist meets chemist: a search for HIV-1 inhibitors

  2015cites this paper
• A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1

  2015cites this paper
• HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus

  2015influential citation
• Computational Analysis and Mapping of Novel Open Reading Frames in Influenza A Viruses

  2014cites this paper
• In vitro and in vivo testing of conditionally replicating SIV and HIV-1 strains to study viral gene expression

  2013cites this paper
• A Variant Macaque-Tropic Human Immunodeficiency Virus Type 1 Is Resistant to Alpha Interferon-Induced Restriction in Pig-Tailed Macaque CD4+ T Cells

  2013cites this paper
• Evidence that Vpu Modulates HIV-1 Gag-Envelope Interaction towards Envelope Incorporation and Infectivity in a Cell Type Dependent Manner

  2013cites this paper
• Advances in HIV-1 Assembly and Release

  2013cites this paper
• Posttranscriptional regulation of retroviral gene expression: primary RNA transcripts play three roles as pre‐mRNA, mRNA, and genomic RNA

  2013cites this paper
• An AUG codon upstream of rev and env open reading frames ensures optimal translation of the simian immunodeficiency virus Env protein.

  2013cites this paper
• UvA-DARE ( Digital Academic Repository ) In vitro and in vivo testing of conditionally replicating SIV and HIV-1 strains to study viral gene expression

  2013cites this paper
• Synthesis of Functional and Variable HIV-1 Envelope Glycoproteins

  2013cites this paper
• Dual Mechanisms of Translation Initiation of the Full-Length HIV-1 mRNA Contribute to Gag Synthesis

  2013cites this paper
• HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

  2013cites this paper
• Specific VpU codon changes were significantly associated with gp120 V3 tropic signatures in HIV-1 B-subtype

  2012cites this paper
• Functional control of HIV-1 post-transcriptional gene expression by host cell factors

  2012cites this paper
• TranslationRegulate Rev and Env Protein Immunodeficiency Virus SIVmac239 Upstream AUG Codons in the Simian

  2012cites this paper
• Upstream AUG Codons in the Simian Immunodeficiency Virus SIVmac239 Genome Regulate Rev and Env Protein Translation

  2012cites this paper
• HIV-1 NEF: THERAPEUTIC STRATEGIES AND VIROLOGICAL SYNAPSE-MEDIATED INFECTION

  2011cites this paper
• Ribosomal scanning on the 5′-untranslated region of the human immunodeficiency virus RNA genome

  2011cites this paper
• Rôle de la lysyl-ARNt synthétase mitochondriale humaine dans la réplication du VIH-1

  2011cites this paper
• Characterization of 5 UTR splicing and the CGI in HIV-2 RNA

  2011influential citation
• Papel da carga viral celular na imunodeficiência HIV/SIDA : contributo do estudo da infecção pelo HIV-2

  2011cites this paper
• Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.

  2011cites this paper
• Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation

  2011cites this paper
• Viral SELEX reveals individual and cooperative roles of the C-box and G-box in HIV-2 replication.

  2011cites this paper
• Strategies to quantify unspliced and multiply spliced mRNA expression in HIV-2 infection.

  2011cites this paper
• Inhibition of splicing by serine-arginine rich protein 55 (SRp55) causes the appearance of partially spliced HIV-1 mRNAs in the cytoplasm.

  2011cites this paper
• Identification of cellular proteins interacting with equine infectious anemia virus S2 protein.

  2010cites this paper
• HIV-1 NEF: THERAPEUTIC STRATEGIES AND VIROLOGICAL

  2010cites this paper
• Refined methods for propagating vesicular stomatitis virus vectors that are defective for G protein expression.

  2010cites this paper
• Serine- and Arginine-rich Proteins 55 and 75 (SRp55 and SRp75) Induce Production of HIV-1 vpr mRNA by Inhibiting the 5′-Splice Site of Exon 3

  2010cites this paper
• Die Bedeutung intragenischer CpG Dinukleotide für die in vitro Expression von Immunmodulatoren

  2009cites this paper
• Use of HIV as a gene transfer vector.

  2009cites this paper
• Optimal Translation Initiation Enables Vif-Deficient Human Immunodeficiency Virus Type 1 To Escape Restriction by APOBEC3G

  2009cites this paper
• Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens

  2009cites this paper
• The effect of alpha-HGA on HIV-1 replication

  2009cites this paper
• Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome

  2009cites this paper
• Translational control of eukaryotic gene expression

  2009cites this paper
• Study of translation control by a RNA helicase A-responsive post-transcriptional control element in Retroviridae.

  2008cites this paper
• Human Immunodeficiency Virus Type 1-Associated Cd4 Downmodulation

  2008cites this paper
• Optimierung und Charakterisierung des lentiviralen Gentransfers in humanen mesenchymalen Stammzellen

  2008cites this paper
• Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation

  2008cites this paper
• The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA

  2008cites this paper
• Etude sur le complexe TAR/Tat/cycline T1 Et Etude des régulations de l'épissage de l'ARN pré-messager du virus HIV-1 : effet global des protéines virales et analyse fine du rôle des protéines SR ASF/SF2 et 9G8 au site accepteur A3

  2008cites this paper
• Modulating HIV-1 RNA processing and utilization.

  2008cites this paper
• Selective Pressure Against AUG Triplets in the 5´ Untranslated Region of Human Immunodeficiency Virus Type 1 Supports Cap-Dependent Translation Initiation Mechanism

  2008cites this paper
• Both Linear and Discontinuous Ribosome Scanning Are Used for Translation Initiation from Bicistronic Human Immunodeficiency Virus Type 1 env mRNAs

  2007cites this paper
• A minimal uORF within the HIV-1 vpu leader allows efficient translation initiation at the downstream env AUG.

  2007cites this paper
• Étude mécanistique et fonctionnelle de l'acquisition des molécules HLA-DR et CD40L par le virus de l'immunodéficience humaine de type 1

  2007cites this paper
• Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages.

  2007cites this paper
• Translational control of mRNAs transcribed from HIV-1 provirus and HIV-1 based lentiviral vectors

  2007cites this paper
• Posttranscriptional control of HIV-1 and other retroviruses and its practical applications.

  2007cites this paper
• Incorporation of chimeric HIV-SIV-Env and modified HIV-Env proteins into HIV pseudovirions.

  2007cites this paper
• Translation initiation in human immunodeficiency virus type 1 (HIV-1)

  2007influential citation
• Efficient Systemic Expression of Bioactive IL-15 in Mice upon Delivery of Optimized DNA Expression Plasmids

  2007influential citation
• Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1.

  2006cites this paper
• Protein synthesis in eukaryotes: the growing biological relevance of cap-independent translation initiation.

  2005cites this paper
• Identification of a novel splice acceptor in the HIV-1 genome: independent expression of the cytoplasmic tail of the envelope protein

  2005cites this paper
• Robust growth of human immunodeficiency virus type 1 (HIV-1).

  2005cites this paper
• Towards the Development of Synergistic Inhibitors that Exploit the Replication Strategy of HIV-1

  2005cites this paper
• In silico mutagenesis of RNA splicing in HIV-1.

  2005cites this paper
• Viral strategies of translation initiation: Ribosomal shunt and reinitiation

  2004cites this paper
• Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression.

  2004cites this paper
• Higher order structure of the HIV-1 leader RNA: a case for RNA switches that regulate virus replication

  2003cites this paper
• Determinants of translational fidelity and efficiency in vertebrate mRNAs

  2003cites this paper
• Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals: application to HIV-1 INS.

  2003cites this paper
• Pushing the limits of the scanning mechanism for initiation of translation

  2002cites this paper
• Emerging links between initiation of translation and human diseases

  2002cites this paper
• Overview of the HIV‐1 Lentiviral Vector System

  2002cites this paper
• Influence of the small leader exons 2 and 3 on human immunodeficiency virus type 1 gene expression.

  2001cites this paper
• Numerical modelling of the perturbation of HIV-1 during combination anti-retroviral therapy

  2001cites this paper
• Expression of human BRE in multiple isoforms.

  2001cites this paper
• The Human Immunodeficiency Virus Type 1gag Gene Encodes an Internal Ribosome Entry Site

  2001cites this paper
• Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing.

  2000cites this paper
• Translational Control of Viral Gene Expression in Eukaryotes

  2000cites this paper
• Human tumor antigens for cancer vaccine development

  1999cites this paper
• Activation of a Cryptic Splice Donor in Human Immunodeficiency Virus Type-1

  1999cites this paper
• Facile characterization of translation initiation via nonsense codon suppression.

  1999cites this paper
• Human tumor antigens: implications for cancer vaccine development

  1999cites this paper
• Activation of a cryptic splice donor in human immunodeficiency virus type-1.

  1999cites this paper
• Multiply spliced env and nef transcripts of simian immunodeficiency virus from West African green monkey (SIVagm-sab).

  1998cites this paper
• Retroviral Vector-Mediated Expression in Primary Human T Cells of an Endoplasmic Reticulum-Retained CD4 Chimera Inhibits Human Immunodeficiency Virus Type-1 Replication

  1998cites this paper
• An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus.

  1998cites this paper