Regulation of ASK1 signaling by scaffold and adaptor proteins.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Advances in Biological Regulation

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jbior.2017.10.003PMID 29102394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

  2018cited by this paper
• Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1

  2018cited by this paper
• Overview of Arrestin Mediated Signaling with Receptors and Non-receptor Binding Partners

  2017cited by this paper
• Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1

  2017cited by this paper
• Scaffolding c-Jun N-Terminal Kinase Cascades: Mechanistic Insights from the Reconstituted Arrestin-JNK Cascades

  2017cited by this paper
• ASK1: a new therapeutic target for kidney disease.

  2016cited by this paper
• Peptide mini-scaffold facilitates JNK3 activation in cells

  2016cited by this paper
• Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway

  2016cited by this paper
• Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)*

  2016cited by this paper
• Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

  2015cited by this paper
• ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

  2015cited by this paper
• The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

  2015cited by this paper
• Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.

  2014cited by this paper
• A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

  2014cited by this paper
• Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

  2014cited by this paper
• Arrestin-dependent activation of JNK family kinases.

  2014cited by this paper
• Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade

  2013cited by this paper
• Dual-specificity MAP kinase phosphatases (MKPs)

  2013cited by this paper
• Arrestin-3 Binds c-Jun N-terminal Kinase 1 (JNK1) and JNK2 and Facilitates the Activation of These Ubiquitous JNK Isoforms in Cells via Scaffolding*

  2013cited by this paper
• JNK3 Enzyme Binding to Arrestin-3 Differentially Affects the Recruitment of Upstream Mitogen-activated Protein (MAP) Kinase Kinases*

  2013cited by this paper
• Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.

  2013cited by this paper
• How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches

  2012cited by this paper
• Apoptosis signal‐regulating kinase‐1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer

  2012cited by this paper
• The Neuroprotective Effect of Losartan through Inhibiting AT1/ASK1/MKK4/JNK3 Pathway Following Cerebral I/R in Rat Hippocampal CA1 Region

  2012cited by this paper
• Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

  2012cited by this paper
• Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling.

  2012cited by this paper
• Therapeutic targets in the ASK1-dependent stress signaling pathways

  2012cited by this paper
• Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

  2012cited by this paper
• Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

  2011cited by this paper
• Identification of Arrestin-3-specific Residues Necessary for JNK3 Kinase Activation*

  2011cited by this paper
• ASK1 and Its Role in Neurodegenerative Diseases

  2011cited by this paper
• Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region.

  2011cited by this paper
• The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions.

  2010cited by this paper
• Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

  2010cited by this paper
• Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.

  2010cited by this paper
• Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

  2010cited by this paper
• Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

  2010cited by this paper
• Mutant p53 disrupts the stress MAPK activation circuit induced by ASK1-dependent stabilization of Daxx.

  2009cited by this paper
• Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation.

  2009cited by this paper
• The roles of ASK family proteins in stress responses and diseases

  2009cited by this paper
• beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis.

  2009cited by this paper
• How Does Arrestin Assemble MAPKs into a Signaling Complex?*

  2009cited by this paper
• Scaffold proteins and immune-cell signalling

  2009cited by this paper
• Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation*

  2009cited by this paper
• Scaffolds: interaction platforms for cellular signalling circuits.

  2009cited by this paper
• ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

  2009cited by this paper
• Dual-specificity phosphatases: critical regulators with diverse cellular targets.

  2009cited by this paper
• Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

  2008cited by this paper
• Diversity of WD-repeat proteins.

  2008cited by this paper
• AIP1 Recruits Phosphatase PP2A to ASK1 in Tumor Necrosis Factor–Induced ASK1-JNK Activation

  2008cited by this paper
• The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells.

  2008cited by this paper
• Positive regulation of ASK1-mediated c-Jun NH2-terminal kinase signaling pathway by the WD-repeat protein Gemin5

  2007cited by this paper
• Structural and Functional Characterization of the Human Protein Kinase ASK1

  2007cited by this paper
• Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation.

  2007cited by this paper
• The MEK/ERK cascade: from signaling specificity to diverse functions.

  2007cited by this paper
• Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death‐associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by α‐lipoic acid

  2007cited by this paper
• Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells.

  2007cited by this paper
• Dynamic control of signaling by modular adaptor proteins.

  2007cited by this paper
• Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress*

  2007cited by this paper
• Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1

  2007cited by this paper
• Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance.

  2007cited by this paper
• Regulation of MAP kinases by MAP kinase phosphatases.

  2007cited by this paper
• Role of mitogen-activated protein kinase kinase kinases in signal integration

  2007cited by this paper
• Subcellular localization of Daxx determines its opposing functions in ischemic cell death

  2007cited by this paper
• Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid.

  2007cited by this paper
• New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.

  2006cited by this paper
• Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

  2006cited by this paper
• The JIP family of MAPK scaffold proteins.

  2006cited by this paper
• The SMN complex: an assembly machine for RNPs.

  2006cited by this paper
• The Gemin5 protein of the SMN complex identifies snRNAs.

  2006cited by this paper
• Dual role for TGF-beta1 in apoptosis.

  2005cited by this paper
• Dynamic Interaction between the Dual Specificity Phosphatase MKP7 and the JNK3 Scaffold Protein β-Arrestin 2*

  2005cited by this paper
• Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death*

  2005cited by this paper
• Role of the JIP4 Scaffold Protein in the Regulation of Mitogen-Activated Protein Kinase Signaling Pathways

  2005cited by this paper
• Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

  2005cited by this paper
• Daxx is required for stress-induced cell death and JNK activation

  2005cited by this paper
• Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.

  2005cited by this paper
• MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression.

  2005cited by this paper
• The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity

  2005cited by this paper
• Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.

  2005cited by this paper
• Dual role for TGF-β1 in apoptosis

  2005cited by this paper
• Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

  2004cited by this paper
• beta-arrestins: traffic cops of cell signaling.

  2004cited by this paper
• Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

  2004cited by this paper
• Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

  2004cited by this paper
• Activation of Apoptosis Signal-regulating Kinase 1 by Reactive Oxygen Species through Dephosphorylation at Serine 967 and 14-3-3 Dissociation*

  2004cited by this paper
• AKT2 Inhibition of Cisplatin-induced JNK/p38 and Bax Activation by Phosphorylation of ASK1

  2003cited by this paper
• The CD95(APO-1/Fas) DISC and beyond

  2003cited by this paper
• Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms

  2003cited by this paper
• Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

  2003cited by this paper
• AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1. IMPLICATION OF AKT2 IN CHEMORESISTANCE.

  2003cited by this paper
• ASK1 regulates influenza virus infection-induced apoptotic cell death.

  2003cited by this paper
• A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway

  2003cited by this paper
• Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization*

  2003cited by this paper
• Catalase, but not MnSOD, inhibits glucose deprivation‐activated ASK1‐MEK‐MAPK signal transduction pathway and prevents relocalization of Daxx: Hydrogen peroxide as a major second messenger of metabolic oxidative stress

  2003cited by this paper
• ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.

  2002cited by this paper
• Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway*

  2002cited by this paper
• Gemin5, a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm Proteins*

  2002cited by this paper
• Activation and autophosphorylation of apoptosis signal-regulating kinase 1 (ASK1) following cerebral ischemia in rat hippocampus.

  2002cited by this paper
• All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.

  2002cited by this paper

• Structural basis for MEKK2 dimerization and substrate recognition

  2025cites this paper
• Updated insights on ASK1 signaling: mechanisms, regulation, and therapeutic potential in diseases

  2025cites this paper
• Flavonoids in Brain Ischemia-Reperfusion and their Effect on Kinases as Signaling Pathway Activity.

  2025cites this paper
• Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway

  2024cites this paper
• Charting protein dephosphorylation triggered by Toll-like receptor (TLR) signaling in macrophages and its role in health and disease.

  2021cites this paper
• Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

  2021cites this paper
• Discovery and development of ASK1 inhibitors.

  2020cites this paper
• Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

  2020cites this paper
• Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals.

  2018cites this paper
• Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

  2018cites this paper
• Metformin influences drug sensitivity in pancreatic cancer cells.

  2018cites this paper