Hippo signaling interactions with Wnt/&bgr;-catenin and Notch signaling repress liver tumorigenesis

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Clinical Investigation

• Publication date

  2017-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI88486PMID 27869648PMCID PMC5199712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

  2016cited by this paper
• β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

  2015cited by this paper
• Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

  2015cited by this paper
• Emerging roles of Notch signaling in liver disease

  2015cited by this paper
• Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer.

  2015cited by this paper
• YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

  2015cited by this paper
• Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma

  2015cited by this paper
• Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

  2015cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Alternative Wnt Signaling Activates YAP/TAZ.

  2015cited by this paper
• Revisiting STAT3 signalling in cancer: new and unexpected biological functions

  2014cited by this paper
• Therapeutic modulation of Notch signalling — are we there yet?

  2014cited by this paper
• Hippo pathway activity influences liver cell fate.

  2014cited by this paper
• Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

  2014cited by this paper
• Notch signaling and new therapeutic options in liver disease.

  2014cited by this paper
• Re-evaluation of liver stem/progenitor cells

  2014cited by this paper
• A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

  2013cited by this paper
• γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown.

  2013cited by this paper
• Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

  2013cited by this paper
• The Hippo pathway and human cancer

  2013cited by this paper
• Tissue-resident macrophages

  2013cited by this paper
• Conditional disruption of Axin1 leads to development of liver tumors in mice.

  2012cited by this paper
• Hepatocellular carcinoma

  2012cited by this paper
• Role of TAZ as mediator of Wnt signaling.

  2012cited by this paper
• Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox.

  2012cited by this paper
• Dual functions of DP1 promote biphasic Wnt‐on and Wnt‐off states during anteroposterior neural patterning

  2012cited by this paper
• Wnt/β-catenin signaling and disease.

  2012cited by this paper
• b-Catenin-Driven Cancers Require a YAP 1 Transcriptional Complex for Survival and Tumorigenesis

  2012cited by this paper
• Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

  2012cited by this paper
• Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

  2012cited by this paper
• Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.

  2012cited by this paper
• Transduction of mechanical and cytoskeletal cues by YAP and TAZ

  2012cited by this paper
• Role of YAP/TAZ in mechanotransduction

  2011cited by this paper
• Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

  2011cited by this paper
• Mst 1 and Mst 2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap 1 Oncogene

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Hepatocellular carcinoma.

  2011cited by this paper
• Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions.

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells.

  2011cited by this paper
• The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

  2011cited by this paper
• Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

  2011cited by this paper
• NF-κB and STAT3 – key players in liver inflammation and cancer

  2011influential reference
• Feature Article: From the Cover: An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

  2011cited by this paper
• Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

  2010cited by this paper
• A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

  2010cited by this paper
• Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine‐45 mutant β‐catenin

  2010cited by this paper
• Molecular determinants of liver zonation.

  2010cited by this paper
• Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

  2010cited by this paper
• Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.

  2010cited by this paper
• Organogenesis and development of the liver.

  2010cited by this paper
• Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

  2010influential reference
• The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*

  2010cited by this paper
• The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

  2010cited by this paper
• The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

  2010cited by this paper
• STATs in cancer inflammation and immunity: a leading role for STAT3

  2009cited by this paper
• Notch signaling: the core pathway and its posttranslational regulation.

  2009cited by this paper
• The canonical Notch signaling pathway: unfolding the activation mechanism.

  2009cited by this paper
• Notch signaling controls liver development by regulating biliary differentiation

  2009cited by this paper
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

  2009cited by this paper
• Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

  2009cited by this paper
• TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

  2008cited by this paper
• Conserved functions of the pRB and E2F families

  2008cited by this paper
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

  2007cited by this paper
• Elucidation of a universal size-control mechanism in Drosophila and mammals.

  2007cited by this paper
• Hepatocellular carcinoma pathogenesis: from genes to environment

  2006cited by this paper
• Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

  2006cited by this paper
• Histological assessment of non‐alcoholic fatty liver disease

  2006cited by this paper
• The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

  2005cited by this paper
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

  2005cited by this paper
• Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver.

  2005cited by this paper
• Hepatocarcinogenesis in Mice with β-Catenin and Ha-Ras Gene Mutations

  2004cited by this paper
• Liver regeneration: from myth to mechanism

  2004cited by this paper
• Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.

  2004cited by this paper
• Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation.

  2004cited by this paper
• Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation

  2004cited by this paper
• hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

  2003cited by this paper
• Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

  2001cited by this paper
• Hepatomegaly in Transgenic Mice Expressing an Oncogenic Form of β-Catenin

  2001cited by this paper
• Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

  2000cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas.

  1998cited by this paper
• A new component of the transcription factor DRTF1/E2F

  1993cited by this paper
• A new component of the transcription factor DRTF1/E2F

  1993cited by this paper
• Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.

  1993cited by this paper
• TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.

  1990cited by this paper
• Hepatocellular carcinoma.

  1986cited by this paper
• Liver Carcinogenesis by Diethylnitrosamine in the Rat

  1966cited by this paper

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• YAP/TAZ: An Epitome of Tumorigenesis.

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• Signalling pathways in hepatocellular carcinoma (HCC) metastasis and invasion: Molecular mechanisms and therapeutic implications

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• Notch signaling in cancer: metabolic reprogramming and therapeutic implications

  2025cites this paper
• Exosomes from liver progenitor cells carrying JAG1 activate notch signaling to promote liver regeneration in PVL rats

  2025cites this paper
• Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development

  2025cites this paper
• Spatial gene regulatory networks driving cell state transitions during human liver disease

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  2023cites this paper
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  2023cites this paper
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