Molecular and Cellular Mechanism of Endothelin Regulation: Implications for Vascular Function

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Circulation

• Publication date

  1991-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.CIR.84.4.1457PMID 1655302
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of cerebral microvessel endothelium in regulation of cerebral blood flow through production of endothelin-1.

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• Prevention of cerebral vasospasm by actinomycin D.

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• Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

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• Hypertension associated with endothelin-secreting malignant hemangioendothelioma.

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• Mechanisms of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and Wistar-Kyoto rats.

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• L-NG-monomethyl arginine inhibits the vasodilating effects of low dose of endothelin-3 on rat mesenteric arteries.

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• Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin

  1990cited by this paper
• Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.

  1990cited by this paper
• Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats.

  1990cited by this paper
• Role of endothelin in mechanisms of local blood pressure control.

  1990cited by this paper
• Role of Endothelium in the Response to Endothelin in Hypertension

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  1990cited by this paper
• Pituitary site of action of endothelin: selective inhibition of prolactin release in vitro.

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  1990cited by this paper
• Mechanisms of endothelin-induced augmentation of the electrical and mechanical activity in rat portal vein

  1990cited by this paper
• Nickel inhibits endothelin-induced contractions of vascular smooth muscle.

  1990cited by this paper
• Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit.

  1990cited by this paper
• Mass Analysis of 1,2‐Diacylglycerol in Cultured Rabbit Vascular Smooth Muscle Cells: Comparison of Stimulation by Angiotensin II and Endothelin

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• Increased plasma endothelin level in patients with essential hypertension.

  1990cited by this paper
• Identification and characterization of endothelin converting activity in cultured bovine endothelial cells.

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• Comparison of the Effect of Endothelin on Microvessels and Macrovessels in Goldblatt II and Deoxycorticosterone Acetate‐Salt Hypertensive Rats

  1990cited by this paper
• Conversion of big endothelin-1 by membrane-bound metalloendopeptidase in cultured bovine endothelial cells.

  1990cited by this paper
• Analysis of big endothelin-1 digestion by cathepsin D.

  1990cited by this paper
• Raised plasma endothelin-I concentration following cold pressor test.

  1990cited by this paper
• Vasodilator effects of sarafotoxins and endothelin-1 in spontaneously hypertensive rats and rat isolated perfused mesentery.

  1990cited by this paper
• Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

  1990cited by this paper
• Role of thromboxane A2/prostaglandin H2 receptor in the vasoconstrictor response of rat aorta to endothelin.

  1990cited by this paper
• Endothelin release is inhibited by coculture of endothelial cells with cells of vascular media.

  1990cited by this paper
• Effects of endothelin on coronary flow, mechanical performance, oxygen uptake, and formation of purines and on outflow of prostacyclin in the isolated rabbit heart.

  1990cited by this paper
• Heterogeneity of cell surface endothelin receptors.

  1990influential reference
• Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

  1990cited by this paper
• Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

  1990cited by this paper
• Vasodilator effects of sarafotoxins and endothelin-1 in spontaneously hypertensive rats and rat isolated perfused mesentery

  1990cited by this paper
• Ischemia and reperfusion increase 125I-labeled endothelin-1 binding in rat cardiac membranes.

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  1990cited by this paper
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  1990cited by this paper
• Hemodynamic and pharmacological evaluation of the vasodilator and vasoconstrictor effects of endothelin-1 in rats.

  1990cited by this paper
• Cloning and expression of a cDNA encoding an endothelin receptor

  1990cited by this paper
• Differences in regional vascular sensitivity to endothelin‐1 between spontaneously hypertensive and normotensive Wistar‐Kyoto rats

  1990cited by this paper
• Distribution and molecular form of immunoreactive big endothelin-1 in porcine tissue.

  1990cited by this paper
• Evidence for increased myofilament Ca2+ sensitivity in norepinephrine-activated vascular smooth muscle.

  1990cited by this paper
• Contractile activity of three endothelins (ET‐1, ET‐2 and ET‐3) on the human isolated bronchus

  1990cited by this paper
• Reactivity and sensitivity of mesenteric vascular beds and aortic rings of spontaneously hypertensive rats to endothelin: effects of calcium entry blockers

  1990cited by this paper
• Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme.

  1990cited by this paper
• Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells.

  1990cited by this paper
• Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage.

  1990cited by this paper
• Plasma endothelin levels in hypertension and chronic renal failure.

  1990cited by this paper
• The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

  1990cited by this paper
• Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.

  1990cited by this paper
• Endothelin 1 causes pulmonary vasodilation in rats.

  1990cited by this paper
• A sensitive sandwich-enzyme immunoassay for human endothelin.

  1989cited by this paper
• The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

  1989cited by this paper
• Endothelin acts in feline and canine cerebral arteries from the adventitial side.

  1989cited by this paper
• Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells.

  1989cited by this paper
• Endothelin-induced Ca-independent contraction of the porcine coronary artery.

  1989cited by this paper
• Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

  1989cited by this paper
• Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?

  1989cited by this paper
• Ionic requirements of the endothelin response in aorta and portal vein.

  1989cited by this paper
• Mechanism of contraction to endothelin in isolated porcine coronary artery.

  1989cited by this paper
• The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.

  1989cited by this paper
• Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells.

  1989cited by this paper
• Cellular mechanisms of endothelin in rabbit aorta.

  1989cited by this paper
• Endothelin induces two types of contractions of rat uterus: phasic contractions by way of voltage-dependent calcium channels and developing contractions through a second type of calcium channels.

  1989cited by this paper
• Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination.

  1989cited by this paper
• Elimination of Intravenously Injected Endothelin‐1 from the Circulation of the Rat

  1989cited by this paper
• Solubilization and identification of human placental endothelin receptor.

  1989cited by this paper
• Two different forms of endothelin receptors in rat lung

  1989cited by this paper
• Receptor binding activity and cytosolic free calcium response by synthetic endothelin analogs in cultured rat vascular smooth muscle cells.

  1989cited by this paper
• Structure-activity relationship of endothelin: importance of charged groups.

  1989cited by this paper
• Endothelin-sensitive intracellular Ca2+ store overlaps with caffeine-sensitive one in rat aortic smooth muscle cells in primary cultures.

  1989cited by this paper
• Identification of two types of specific endothelin receptors in rat mesangial cell.

  1989cited by this paper
• A proposed structural model of endothelin.

  1989cited by this paper
• Conversion of Big Endothelin‐1 to 21‐Residue Endothelin‐1 Is Essential for Expression of Full Vasoconstrictor Activity: Structure‐Activity Relationships of Big Endothelin‐1

  1989cited by this paper
• Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: contribution of phosphoinositide turnover.

  1989cited by this paper
• Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction.

  1989cited by this paper
• Endothelin stimulates the release of prostacyclin from rat mesenteric arteries.

  1989cited by this paper
• Angiotensin II and phorbol-esters potently down-regulate endothelin (ET-1) binding sites in vascular smooth muscle cells.

  1989cited by this paper
• Stimulation of the Na+, K+ Pump and the (Na+, K+, Cl-) Cotransport System by Endothelin‐1 in Cultured Vascular Smooth Muscle Cells: Involvement of Cyclo‐Oxygenase Products

  1989cited by this paper
• Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.

  1989cited by this paper
• Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols.

  1989cited by this paper
• Two distinct types of endothelin receptors are present on chick cardiac membranes.

  1989cited by this paper
• Structural organization and chromosomal assignment of the gene encoding endothelin.

  1989cited by this paper
• The pharmacological properties of the peptide, endothelin

  1989cited by this paper
• Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.

  1989cited by this paper
• The C-terminal hexapeptide, endothelin-(16-21), discriminates between different endothelin receptors.

  1989cited by this paper
• The Human Preproendothelin‐1 Gene: Possible Regulation by Endothelial Phosphoinositide Turnover Signaling

  1989cited by this paper
• Endothelin‐1 and Endothelin‐3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit

  1989cited by this paper
• Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells.

  1988cited by this paper
• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper
• Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

  1988cited by this paper
• Does endothelin mobilize calcium from intracellular store sites in rat aortic vascular smooth muscle cells in primary culture?

  1988cited by this paper
• Direct G protein gating of ion channels.

  1988cited by this paper
• Molecular mechanism of action of the vasoconstrictor peptide endothelin.

  1988cited by this paper
• Binding and receptor down‐regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

  1988cited by this paper
• Structure-activity relationships of endothelin: importance of the C-terminal moiety.

  1988cited by this paper
• Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

  1988cited by this paper
• Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats.

  1988cited by this paper
• Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart.

  1988cited by this paper
• Arachidonic acid metabolism.

  1987cited by this paper

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• Sparsentan: Sparsentan- A novel, non- immunosuppressive, dual action angiotensin II and endothelin A receptor antagonist -A new hope for glomerular disease

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• Significant elevation of aqueous endothelin-1 in central retinal vein occlusion

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• Endothelin Signaling in Bone.

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• Endothelin receptor mediated Ca2+ signaling in coronary arteries after experimentally induced ischemia/reperfusion injury in rat.

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