Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Controlled Release

• Publication date

  2014-09-10

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1016/j.jconrel.2014.06.031PMID 24979210PMCID PMC4125545
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
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  2003cited by this paper
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