Protein Kinase PKN 1 Represses Wnt / β-Catenin Signaling in Human Melanoma Cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

  2013cited by this paper
• WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

  2012cited by this paper
• A Seven-Marker Signature and Clinical Outcome in Malignant Melanoma: A Large-Scale Tissue-Microarray Study with Two Independent Patient Cohorts

  2012cited by this paper
• The BioGRID interaction database: 2013 update

  2012cited by this paper
• Wnt/β-catenin signaling and disease.

  2012cited by this paper
• b-Catenin-Driven Cancers Require a YAP 1 Transcriptional Complex for Survival and Tumorigenesis

  2012cited by this paper
• Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

  2012cited by this paper
• Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation

  2012cited by this paper
• LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/β-Catenin Signaling

  2012cited by this paper
• Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

  2012cited by this paper
• Triple SILAC to Determine Stimulus Specific Interactions in the Wnt Pathway

  2011cited by this paper
• Inhibition of GSK3 by Wnt signalling – two contrasting models

  2011cited by this paper
• β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.

  2011cited by this paper
• Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.

  2010cited by this paper
• The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

  2010cited by this paper
• Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.

  2010cited by this paper
• Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

  2010cited by this paper
• Proximal events in Wnt signal transduction

  2009cited by this paper
• Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

  2009cited by this paper
• A Coated Vesicle-associated Kinase of 104 kDa (CVAK104) Induces Lysosomal Degradation of Frizzled 5 (Fzd5)*

  2009cited by this paper
• Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

  2009cited by this paper
• Melanoma prognostic model using tissue microarrays and genetic algorithms.

  2009cited by this paper
• Bruton’s Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling

  2009cited by this paper
• A Wnt survival guide: from flies to human disease.

  2009cited by this paper
• Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport

  2008cited by this paper
• LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin

  2008cited by this paper
• New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening

  2008cited by this paper
• Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

  2008cited by this paper
• Wilms tumor suppressor WTX negatively regulates WNT/β-catenin signaling

  2008cited by this paper
• The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry

  2008influential reference
• DNA microarray analyses of melanoma gene expression: a decade in the mines.

  2007cited by this paper
• Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.

  2007cited by this paper
• Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

  2007cited by this paper
• The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

  2006cited by this paper
• Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.

  2006cited by this paper
• The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity*

  2006cited by this paper
• β-Catenin destruction complex: insights and questions from a structural perspective

  2006influential reference
• Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma

  2005cited by this paper
• Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

  2005cited by this paper
• A uniform proteomics MS/MS analysis platform utilizing open XML file formats

  2005cited by this paper
• Human protein reference database—2006 update

  2005cited by this paper
• A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor

  2003cited by this paper
• Hyperosmotic-induced Protein Kinase N 1 Activation in a Vesicular Compartment Is Dependent upon Rac1 and 3-Phosphoinositide-dependent Kinase 1*

  2003cited by this paper
• Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

  2003cited by this paper
• The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC.

  2003cited by this paper
• Cytoscape: a software environment for integrated models of biomolecular interaction networks.

  2003cited by this paper
• Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics*

  2002cited by this paper
• Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry

  2001cited by this paper
• Loss of β‐catenin expression associated with disease progression in malignant melanoma

  2001cited by this paper
• Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway

  2001cited by this paper
• MEK Kinase 2 Binds and Activates Protein Kinase C-related Kinase 2

  2000cited by this paper
• Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling*

  2000cited by this paper
• Mechanism of Phosphorylation of Protein Kinase B/Akt by a Constitutively Active 3-Phosphoinositide-dependent Protein Kinase-1*

  2000cited by this paper
• Inhibition of Akt and Its Anti-apoptotic Activities by Tumor Necrosis Factor-induced Protein Kinase C-related Kinase 2 (PRK2) Cleavage*

  2000cited by this paper
• PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

  1999cited by this paper
• Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.

  1999cited by this paper
• The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis.

  1999cited by this paper
• Control of neural crest cell fate by the Wnt signalling pathway

  1998cited by this paper
• PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB*

  1998cited by this paper
• Redistribution and Stabilization of Cell Surface Glutamate Receptors during Synapse Formation

  1997cited by this paper
• Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database.

  1995cited by this paper

• Wnt3a signaling with serum supply induces replication stress in cultured cells

  2023cites this paper
• Clonality and Evolutionary History of Rhabdomyosarcoma

  2015cites this paper
• Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis.

  2014cites this paper