New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Science Signaling

• Publication date

  2008-11-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/scisignal.2000037PMID 19001663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of Association of Common AGGF1 Variants with Susceptibility for Klippel‐Trenaunay Syndrome Using the Structure Association Program

  2008cited by this paper
• A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

  2008cited by this paper
• Protein-protein interaction networks and biology—what's the connection?

  2008cited by this paper
• The art and design of genetic screens: RNA interference

  2008cited by this paper
• Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit

  2007cited by this paper
• Chromatin remodeling: insights and intrigue from single-molecule studies

  2007cited by this paper
• Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

  2007cited by this paper
• Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

  2007cited by this paper
• Colorectal cancer and genetic alterations in the Wnt pathway

  2006cited by this paper
• Minimizing the risk of reporting false positives in large-scale RNAi screens

  2006cited by this paper
• Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis

  2006cited by this paper
• STRING 7—recent developments in the integration and prediction of protein interactions

  2006influential reference
• The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

  2006cited by this paper
• Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP 53 Disruptions ‡

  2006cited by this paper
• Distinct Wnt signaling pathways have opposing roles in appendage regeneration

  2006cited by this paper
• Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.

  2006cited by this paper
• Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions

  2006cited by this paper
• Wnt signaling in the intestinal epithelium: from endoderm to cancer.

  2005cited by this paper
• Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway

  2005cited by this paper
• Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis.

  2004cited by this paper
• Medicine: Genetic spotlight on a blood defect

  2004cited by this paper
• Identification of an angiogenic factor that when mutated causes susceptibility to Klippel–Trenaunay syndrome

  2004influential reference
• Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• The SWI/SNF complex — chromatin and cancer

  2004cited by this paper
• WNT and β-catenin signalling: diseases and therapies

  2004cited by this paper
• WNT and beta-catenin signalling: diseases and therapies.

  2004cited by this paper
• Cytoscape: a software environment for integrated models of biomolecular interaction networks.

  2003cited by this paper
• Diseases and Therapies

  2001cited by this paper
• The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation

  2001cited by this paper
• Mi2, an auto-antigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor.

  2001cited by this paper
• Selectivity of chromatin-remodelling cofactors for ligand-activated transcription

  2001cited by this paper
• Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.

  2001cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• RNA Interference

  2000cited by this paper
• In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment.

  1999cited by this paper
• The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

  1998cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

  1992cited by this paper
• Identification and characterization of the familial adenomatous polyposis coli gene

  1991cited by this paper
• Identification of FAP locus genes from chromosome 5q21.

  1991cited by this paper

• Advances and Challenges in Modeling Autosomal Dominant Polycystic Kidney Disease: A Focus on Kidney Organoids

  2025cites this paper
• Discovering potential therapeutic targets in glioblastoma multiforme using a multi-omics approach.

  2025cites this paper
• The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

  2025cites this paper
• Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap

  2025cites this paper
• What the fruit fly can tell us about autosomal recessive primary microcephaly

  2025cites this paper
• Wnt/β-catenin signaling pathway: an attractive potential therapeutic target in osteosarcoma

  2025cites this paper
• Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer

  2024cites this paper
• Deciphering the Role of ASPM in Breast Cancer: A Comprehensive Multicohort Study

  2024cites this paper
• Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system

  2024cites this paper
• Promotion of hepatocellular carcinoma stemness and progression by abnormal spindle-like microcephaly-associated protein via the Wnt/β-catenin pathway

  2023cites this paper
• Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in Cancers

  2023cites this paper
• Calcium signalling pathways in prostate cancer initiation and progression

  2023cites this paper
• A nomogram combining clinical factors and biomarkers for predicting the recurrence of high-risk cutaneous squamous cell carcinoma

  2022cites this paper
• Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

  2022cites this paper
• ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway

  2022cites this paper
• Identification and characterization of a special type of subnuclear structure: AGGF1‐coated paraspeckles

  2022cites this paper
• Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition

  2022cites this paper
• A CRISPR knockout screen reveals new regulators of canonical Wnt signaling

  2021influential citation
• Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling

  2021cites this paper
• Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

  2021cites this paper
• Regulation of DEAH-box RNA helicases by G-patch proteins

  2021cites this paper
• FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis

  2021influential citation
• ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

  2021cites this paper
• An Insight into GPCR and G-Proteins as Cancer Drivers

  2021cites this paper
• Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2.

  2020cites this paper
• Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen

  2020cites this paper
• Dissecting the Genetic and Etiological Causes of Primary Microcephaly

  2020cites this paper
• Cancer biology functional genomics: From small RNAs to big dreams

  2020cites this paper
• Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer

  2020cites this paper
• ASPM is a predictor of overall survival and has therapeutic potential in endometrial cancer.

  2020cites this paper
• Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1) Acts as Diagnostic Biomarker and Adverse Prognostic Factor of Hepatocellular Carcinoma (HCC): Evidence from Bioinformatic Analysis

  2020cites this paper
• ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling

  2020cites this paper
• The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.

  2020cites this paper
• Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelial–mesenchymal transition through Wnt/β-catenin pathway

  2019cites this paper
• TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells

  2019cites this paper
• APC Deficiency Leads to β-Catenin Stabilization and Signaling Independent of LRP5/6.

  2019cites this paper
• NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/ β -catenin signaling pathway and predicts good prognosis

  2019cites this paper
• IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers

  2019cites this paper
• ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling

  2018cites this paper
• High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

  2018cites this paper
• Resource High-Throughput Screening Enhances KidneyOrganoid Differentiation fromHuman Pluripotent StemCells and Enables AutomatedMultidimensional Phenotyping Graphical

  2018cites this paper
• Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective

  2018cites this paper
• Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

  2018cites this paper
• The Genetics of Primary Microcephaly.

  2018cites this paper
• C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling

  2018cites this paper
• High expression of angiogenic factor AGGF1 is an independent prognostic factor for hepatocellular carcinoma

  2017cites this paper
• Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

  2017cites this paper
• Chapter 3 – The Nucleosome Remodeling and Deacetylase Complex in Development and Disease

  2017cites this paper
• Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing

  2017cites this paper
• Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

  2017cites this paper
• High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer

  2017cites this paper
• Aggf1 attenuates hepatic inflammation and activation of hepatic stellate cells by repressing Ccl2 transcription

  2017cites this paper
• TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells

  2017cites this paper
• The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells

  2017cites this paper
• A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation

  2017cites this paper
• Snail and Axin2 expression predict the malignant transformation of oral leukoplakia.

  2017cites this paper
• The Nucleosome Remodeling and Deacetylase (NuRD) Complex in Development and Disease

  2016cites this paper
• Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling.

  2016cites this paper
• JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer

  2016cites this paper
• USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

  2016cites this paper
• Beyond canonical: The Wnt and β-catenin story

  2016cites this paper
• Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer

  2016cites this paper
• XAV939 Inhibits Intima Formation by Decreasing Vascular Smooth Muscle Cell Proliferation and Migration Through Blocking Wnt Signaling

  2016cites this paper
• Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

  2015cites this paper
• Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma

  2015cites this paper
• MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine

  2015cites this paper
• A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators

  2015influential citation
• FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma

  2015cites this paper
• Alternative Wnt Signaling Activates YAP/TAZ.

  2015cites this paper
• The nucleosome remodeling and deacetylase complex in development and disease.

  2015cites this paper
• Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth

  2015cites this paper
• β-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels

  2015influential citation
• Transcription to Trafficking: Novel Regulation of Wnt/Wingless (Wg) Pathway by Protein Phosphatases

  2015cites this paper
• Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila

  2015cites this paper
• Protein Kinase PKN 1 Represses Wnt / β-Catenin Signaling in Human Melanoma Cells

  2014cites this paper
• Sall1 balances self-renewal and differentiation of renal progenitor cells

  2014cites this paper
• Integrative ChIP-seq/Microarray Analysis Identifies a CTNNB1 Target Signature Enriched in Intestinal Stem Cells and Colon Cancer

  2014cites this paper
• Therapeutic Targetingof the Wnt Signaling Network

  2014cites this paper
• New Insights from Proteomic Analysis of Wnt Signaling

  2014cites this paper
• An Overview of Gene Regulation by Wnt/β‐Catenin Signaling

  2014cites this paper
• New Insights about Wnt/β‐Catenin Pathway Mechanisms from Global siRNA Screens

  2014cites this paper
• Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase

  2014cites this paper
• Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.

  2014cites this paper
• Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.

  2014cites this paper
• Integrated analysis of the Wnt responsive proteome in human cells reveals diverse and cell-type specific networks.

  2014cites this paper
• Pharmacologic regulation of Wnt/β-Catenin Signaling in Stem and Progenitor Cells

  2014influential citation
• The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry.

  2013cites this paper
• Analyzing the Structure, Function and Information Flow in Signaling Networks using Quantitative Cellular Signatures

  2013cites this paper
• S100A8 and S100A9 Are Associated with Colorectal Carcinoma Progression and Contribute to Colorectal Carcinoma Cell Survival and Migration via Wnt/β-Catenin Pathway

  2013cites this paper
• FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells

  2013cites this paper
• Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment

  2013cites this paper
• β‐catenin at the centrosome

  2013cites this paper
• The LNX Family of Multi-PDZ E3 Ligases: Using a Mutagenesis-based Approach to Establish the Role of PDZ Domains in LNX1 Function

  2013cites this paper
• The Wntome: A genome-wide analysis of kinases and phosphatases that regulate Wnt signaling

  2013cites this paper
• Genetic causes of microcephaly and lessons for neuronal development

  2013cites this paper
• β-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein*

  2013cites this paper
• Targeting aberrant kinase activity in myeloid leukaemias

  2013cites this paper
• FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

  2013cites this paper
• Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells*

  2013cites this paper
• Wnt/β-catenin signalling: from plasma membrane to nucleus.

  2013cites this paper