Epigenome-based cancer risk prediction: rationale, opportunities and challenges

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Nature Reviews Clinical Oncology

• Publication date

  2018-02-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrclinonc.2018.30PMID 29485132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Health and Medicine

  2020cited by this paper
• Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations

  2018cited by this paper
• Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

  2018cited by this paper
• The microbiome and cancer

  2018cited by this paper
• DNA methylation signatures in peripheral blood strongly predict all-cause mortality

  2017cited by this paper
• DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.

  2017cited by this paper
• AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality

  2017cited by this paper
• A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

  2017cited by this paper
• The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes

  2017cited by this paper
• Erratum to: Endometrial Cancer

  2017cited by this paper
• Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

  2017cited by this paper
• CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA

  2017cited by this paper
• Contribution of epigenetic mechanisms to variation in cancer risk among tissues

  2017cited by this paper
• Anogenital Distance, a Biomarker of Prenatal Androgen Exposure Is Associated With Prostate Cancer Severity

  2017cited by this paper
• Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

  2017cited by this paper
• Global methylation of blood leukocyte DNA and risk of melanoma

  2017cited by this paper
• High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

  2017influential reference
• Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

  2017cited by this paper
• A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies

  2017cited by this paper
• Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

  2016cited by this paper
• Prediction models for cardiovascular disease risk in the general population: systematic review

  2016cited by this paper
• Smoking-associated DNA methylation markers predict lung cancer incidence

  2016cited by this paper
• Multi-organ Mapping of Cancer Risk.

  2016cited by this paper
• Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

  2016cited by this paper
• Menopause accelerates biological aging

  2016cited by this paper
• Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.

  2016cited by this paper
• Disease variants alter transcription factor levels and methylation of their binding sites

  2016cited by this paper
• Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer

  2016cited by this paper
• DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

  2016cited by this paper
• Systematic identification of genetic influences on methylation across the human life course

  2016cited by this paper
• Stochastic epigenetic outliers can define field defects in cancer

  2016cited by this paper
• Obesity-Associated Alterations in Inflammation, Epigenetics, and Mammary Tumor Growth Persist in Formerly Obese Mice

  2016cited by this paper
• Transgenerational inheritance: Models and mechanisms of non–DNA sequence–based inheritance

  2016cited by this paper
• Epigenetic field cancerization in gastrointestinal cancers.

  2016cited by this paper
• Identification of tissue-specific cell death using methylation patterns of circulating DNA

  2016cited by this paper
• Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

  2016cited by this paper
• Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity

  2016cited by this paper
• Dissecting the Biology of Menstrual Cycle-Associated Breast Cancer Risk

  2016cited by this paper
• Cost-effectiveness in health and medicine

  2016cited by this paper
• DNA methylation changes measured in pre‐diagnostic peripheral blood samples are associated with smoking and lung cancer risk

  2016cited by this paper
• Cost-Effectiveness in Health and Medicine

  2016cited by this paper
• Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

  2016cited by this paper
• Self-reported smoking, serum cotinine, and blood DNA methylation.

  2016cited by this paper
• The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

  2016cited by this paper
• Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.

  2016cited by this paper
• Blood Epigenetic Age may Predict Cancer Incidence and Mortality

  2016cited by this paper
• DNA Methylation in Cancer and Aging.

  2016cited by this paper
• Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan.

  2016cited by this paper
• Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure

  2016cited by this paper
• Comparison and combination of blood DNA methylation at smoking‐associated genes and at lung cancer‐related genes in prediction of lung cancer mortality

  2016cited by this paper
• A Simple Tool for Communicating the Benefits and Harms of Health Interventions

  2016cited by this paper
• Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges.

  2016cited by this paper
• Correlation of an epigenetic mitotic clock with cancer risk

  2016cited by this paper
• MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

  2016cited by this paper
• Predicting the impact of non-coding variants on DNA methylation

  2016cited by this paper
• The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

  2016cited by this paper
• Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

  2016cited by this paper
• Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.

  2016cited by this paper
• Epigenetic drift, epigenetic clocks and cancer risk.

  2016cited by this paper
• A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets

  2016cited by this paper
• Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

  2015cited by this paper
• F2RL3 methylation, lung cancer incidence and mortality

  2015cited by this paper
• Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk‐scoring schemes

  2015cited by this paper
• Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

  2015cited by this paper
• Integrative analysis of 111 reference human epigenomes

  2015cited by this paper
• Epigenomics and the Microbiota

  2015cited by this paper
• Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

  2015cited by this paper
• Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation.

  2015cited by this paper
• Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer.

  2015cited by this paper
• Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability.

  2015cited by this paper
• A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

  2015cited by this paper
• Substantial contribution of extrinsic risk factors to cancer development

  2015cited by this paper
• DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

  2015cited by this paper
• Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes

  2015cited by this paper
• Cancer: Risk factors and random chances

  2015cited by this paper
• Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC

  2015cited by this paper
• Aging and DNA methylation

  2015cited by this paper
• Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers

  2015cited by this paper
• What Counselors Tell Low-Risk Clients About HIV Test Performance.

  2015cited by this paper
• Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

  2015cited by this paper
• A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State

  2015cited by this paper
• Clock-like mutational processes in human somatic cells

  2015cited by this paper
• DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

  2015cited by this paper
• Variation in cancer risk among tissues can be explained by the number of stem cell divisions

  2015cited by this paper
• A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

  2014cited by this paper
• Genome‐Wide Investigation of Regional Blood‐Based DNA Methylation Adjusted for Complete Blood Counts Implicates BNC2 in Ovarian Cancer

  2014cited by this paper
• Blood DNA methylation, nevi number, and the risk of melanoma

  2014cited by this paper
• Aging and epigenetic drift: a vicious cycle.

  2014cited by this paper
• Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells

  2014cited by this paper
• Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients

  2014cited by this paper
• Myofibroblast-Derived SFRP1 as Potential Inhibitor of Colorectal Carcinoma Field Effect

  2014cited by this paper
• Chromatin repressive complexes in stem cells, development, and cancer.

  2014cited by this paper
• Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

  2014cited by this paper
• Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren

  2014cited by this paper
• Accounting for cellular heterogeneity is critical in epigenome-wide association studies

  2014cited by this paper
• Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research

  2014cited by this paper
• Most common 'sporadic' cancers have a significant germline genetic component.

  2014cited by this paper
• Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer

  2014cited by this paper
• Modulation of Age- and Cancer-Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle

  2014cited by this paper
• Reference-free cell mixture adjustments in analysis of DNA methylation data

  2014cited by this paper

• Short-term hormonal modulation with mifepristone does not induce oncogenic changes in the endometrium of BRCA1/2 pathogenic variant carriers.

  2026cites this paper
• The cervico-vaginal DNA methylation WID-qEC test: An epigenetic marker associated with ovarian cancer in the absence of endometrial and cervical cancer.

  2026cites this paper
• Non-canonically regulated heterochronic expression of Hsp70 drives clonal expansion and invasion in Drosophila epithelial tumours

  2026cites this paper
• Targeting tumor-draining lymph node to overcome resistance to cancer immunotherapy: an update

  2025cites this paper
• Mapping the state-of-the-art of the barriers for personalized preventive approaches worldwide: A scoping review of reviews

  2025cites this paper
• Integrating Nanotechnology and Artificial Intelligence for Early Detection and Prognostication of Glioblastoma: A Translational Perspective

  2025cites this paper
• Methylation Analyses in Liquid Biopsy of Lung Cancer Patients: A Novel and Intriguing Approach Against Resistance to Target Therapies and Immunotherapies

  2025cites this paper
• Multi-analyte liquid biopsy approaches for early detection of esophageal cancer: the expanding role of ctDNA

  2025cites this paper
• Is Human Chorionic Gonadotropin a Reliable Marker for Testicular Germ Cell Tumor? New Perspectives for a More Accurate Diagnosis

  2025cites this paper
• Liquid biopsy-based multi-cancer early detection: an exploration road from evidence to implementation

  2025cites this paper
• Role of multi-omics in aquaculture genetics and breeding: current status and future perspective

  2025cites this paper
• Constitutional Epimutations: From Rare Events Toward Major Cancer Risk Factors?

  2025cites this paper
• Highly Sensitive and Specific Lateral Flow Detection for DNA Methylation Based on GIaI-Mediated Specific-Terminal-Mediated Polymerase Chain Reaction

  2025cites this paper
• CPST-GAN: Conditional Probabilistic State Transition Generative Adversarial Network With the Biomedical Large Foundation Models

  2025cites this paper
• Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

  2025cites this paper
• Liquid biopsy in lung cancer screening: rationale, progress, opportunities and challenges

  2025cites this paper
• Development of a circulating tumor DNA methylation biomarker panel for hepatocellular carcinoma detection.

  2025cites this paper
• Editorial: Epigenetic biomarkers for cancer risk stratification and patient management

  2024cites this paper
• New Strategies For Detecting Early Stage Of Ovarian Cancer

  2024cites this paper
• Detection of a novel DNA methylation marker panel for esophageal cancer diagnosis using circulating tumor DNA

  2024cites this paper
• Comprehensive analysis of the relationship between RNA modification writers and immune microenvironment in head and neck squamous cell carcinoma

  2024cites this paper
• Epigenetic Ageing and Breast Cancer Risk: A Systematic Review

  2024cites this paper
• Advances and challenges in the use of liquid biopsy in gynaecological oncology

  2024cites this paper
• Upregulated DNMT3a coupling with inhibiting p62-dependent autophagy contributes to NNK tumorigenicity in human bronchial epithelial cells.

  2024cites this paper
• ASSIGN score and cancer risk in the Scottish Heart Health Extended Cohort (SHHEC) study

  2024cites this paper
• A clinically effective model based on cell-free DNA methylation and low-dose CT for risk stratification of pulmonary nodules

  2024cites this paper
• Constitutional BRCA1 Epimutations: A Key for Understanding Basal-Like Breast and High-Grade Serous Ovarian Cancer

  2024cites this paper
• Discovery and Validation of Methylation Signatures in Circulating Cell-Free DNA for the Detection of Colorectal Cancer

  2024cites this paper
• Epigenomics and the Brain-gut Axis: Impact of Adverse Childhood Experiences and Therapeutic Challenges

  2024cites this paper
• Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

  2024cites this paper
• Unraveling the Potential of Attentive Bi-LSTM for Accurate Obesity Prognosis: Advancing Public Health towards Sustainable Cities

  2024cites this paper
• Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis

  2024cites this paper
• An overview of current development and barriers on liquid biopsy in patients with early-stage non-small-cell Lung cancer

  2023cites this paper
• Editorial Comment on Epigenetic alterations in urothelial bladder cancer associated with disease outcomes

  2023cites this paper
• A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma.

  2023cites this paper
• Methylomics and cancer: the current state of methylation profiling and marker development for clinical care

  2023cites this paper
• Epigenetic field defect discriminates normal tissues from healthy and tumor-bearing kidneys

  2023cites this paper
• Peripheral surrogates of tumor burden to guide chemotherapeutic and immunotherapeutic strategies for HPV-associated malignancies

  2023cites this paper
• Epigenetic Factors and ncRNAs in Testicular Cancer

  2023cites this paper
• Should Severity Assessments in Healthcare Priority Setting be Risk- and Time-Sensitive?

  2023cites this paper
• Cancers make their own luck: theories of cancer origins

  2023cites this paper
• Potential applications of DNA methylation testing technology in female tumors and screening methods.

  2023cites this paper
• Enzymatic Cleavage-Mediated Extension Stalling Enables Accurate Recognition and Quantification of Locus-Specific Uracil Modification in DNA.

  2023cites this paper
• Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

  2023cites this paper
• Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy

  2023cites this paper
• Sequence terminus dependent PCR for site-specific mutation and modification detection

  2023cites this paper
• Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies.

  2023cites this paper
• Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and DNA methyltransferase inhibitors in non-small cell lung cancer

  2023cites this paper
• Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice.

  2023cites this paper
• Identification and Validation of a Prognostic Signature Based on Methylation Profiles and Methylation-Driven Gene DAB2 as a Prognostic Biomarker in Differentiated Thyroid Carcinoma

  2022cites this paper
• A Prognostic Model for Breast Cancer Based on Cancer Incidence-Related DNA Methylation Pattern

  2022cites this paper
• Hypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings

  2022cites this paper
• The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples

  2022cites this paper
• The DNA methylome of cervical cells can predict the presence of ovarian cancer

  2022cites this paper
• A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer

  2022cites this paper
• Ethical implications of epigenetics in the era of personalized medicine

  2022cites this paper
• Dietary Restriction and Rapamycin Affect Brain Aging in Mice by Attenuating Age-Related DNA Methylation Changes

  2022cites this paper
• Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes

  2022cites this paper
• Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development

  2022cites this paper
• Sensitive GlaI digestion and terminal transferase PCR for DNA methylation detection.

  2022cites this paper
• Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

  2022cites this paper
• Methylation related genes are associated with prognosis of patients with head and neck squamous cell carcinoma via altering tumor immune microenvironment

  2022cites this paper
• Evaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk

  2022cites this paper
• Recent Advances of Utilizing Artificial Intelligence in Lab on a Chip for Diagnosis and Treatment.

  2022cites this paper
• Prostate cancer in omics era

  2022cites this paper
• Assessing the risk of cervical neoplasia in the post‐HPV vaccination era

  2022cites this paper
• CimpleG: finding simple CpG methylation signatures

  2022cites this paper
• Non-invasive measurement of tumor immune microenvironment and prediction of survival and chemotherapeutic benefits from 18F fluorodeoxyglucose PET/CT images in gastric cancer

  2022cites this paper
• The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

  2022cites this paper
• DNA and histone modifications as potent diagnostic and therapeutic targets to advance non-small cell lung cancer management from the perspective of 3P medicine

  2022cites this paper
• Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer

  2022cites this paper
• Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis

  2022cites this paper
• Pancancer Analysis of the Prognostic and Immunotherapeutic Value of Progestin and AdipoQ Receptor 4

  2022cites this paper
• The WID‐EC test for the detection and risk prediction of endometrial cancer

  2022cites this paper
• Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer

  2021cites this paper
• Epigenome-wide scan identifies differentially methylated regions for lung cancer using pre-diagnostic peripheral blood

  2021cites this paper
• DNA methylation in lung cancer patients: Opening a "window of life" under precision medicine.

  2021cites this paper
• Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study

  2021cites this paper
• Of Screening, Stratification, and Scores

  2021cites this paper
• Inferring Functional Epigenetic Modules by Integrative Analysis of Multiple Heterogeneous Networks

  2021cites this paper
• ramr: an R/Bioconductor package for detection of rare aberrantly methylated regions

  2021cites this paper
• Epigenetic Silencing of MicroRNA-126 Promotes Cell Growth in Marek’s Disease

  2021cites this paper
• Toward a Population-Based Breast Cancer Risk Stratification Approach? The Needs and Concerns of Healthcare Providers

  2021cites this paper
• Detection and relevance of epigenetic markers on ctDNA: recent advances and future outlook

  2021cites this paper
• Exploring the Ethics of Implementation of Epigenomics Technologies in Cancer Screening: A Focus Group Study

  2021cites this paper
• Differential DNA Methylation by Hispanic Ethnicity Among Firefighters in the United States

  2021cites this paper
• OPCML Methylation and the Risk of Ovarian Cancer: A Meta and Bioinformatics Analysis

  2021cites this paper
• The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy

  2021cites this paper
• Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1

  2021cites this paper
• Integrated analysis of microRNA and mRNA expression profiling identifies BAIAP3 as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions

  2021cites this paper
• Leveraging Genetic Reports and Electronic Health Records for the Prediction of Primary Cancers: Algorithm Development and Validation Study

  2020cites this paper
• Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens

  2020cites this paper
• Value of Plasma Methylated SFRP2 in Prognosis of Gastric Cancer

  2020cites this paper
• Prevention in the age of personal responsibility: epigenetic risk-predictive screening for female cancers as a case study

  2020cites this paper
• Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer

  2020cites this paper
• Age-dependent DNA methylation Parenclitic Networks in family-based cohort patients with Down Syndrome

  2020cites this paper
• Machine learning analysis of DNA methylation in a hypoxia-immune model of oral squamous cell carcinoma.

  2020cites this paper
• Attribution Retraining Group Therapy and SSRIs Affect Differing Facets of Anxiety Among Chinese Patients with Various Diagnoses: A Single-Center, Prospective Study

  2020cites this paper
• An overview of advances in multi-omics analysis in prostate cancer.

  2020cites this paper
• Criteria for evaluating risk prediction of multiple outcomes

  2020cites this paper