A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Neuroimmunology

• Publication date

  2001-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0165-5728(01)00282-XPMID 11438173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain

  2004cited by this paper
• Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages

  2004cited by this paper
• Brain‐immune connection: Immuno‐regulatory properties of CNS‐resident cells

  2000cited by this paper
• Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis.

  1999cited by this paper
• Effect of macrophage depletion by liposomes containing dichloromethylene-diphosphonate on endotoxin-induced uveitis.

  1998cited by this paper
• Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine—synergistic and antagonistic effects of liposomal phospholipids and drugs

  1998cited by this paper
• ED2‐positive perivascular phagocytes produce interleukin‐1β during delayed neuronal loss in the facial nucleus of the rat

  1998cited by this paper
• Transient suppression of macrophage functions by liposome-encapsulated drugs.

  1997cited by this paper
• Elimination, blocking, and activation of macrophages: three of a kind?

  1997cited by this paper
• Intravenous lipopolysaccharide induces cyclooxygenase 2‐like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

  1997cited by this paper
• Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection

  1997cited by this paper
• ED2‐positive perivascular cells act as neuronophages during delayed neuronal loss in the facial nucleus of the rat

  1996cited by this paper
• Lymphocyte Targeting of the Central Nervous System: A Review of Afferent and Efferent CNS‐Immune Pathways

  1996cited by this paper
• In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects.

  1996cited by this paper
• Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.

  1996cited by this paper
• Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine.

  1996cited by this paper
• Kupffer cell depletion by liposome‐delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

  1996cited by this paper
• The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

  1995cited by this paper
• Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.

  1994cited by this paper
• Monoclonal antibodies against rat macrophages.

  1994cited by this paper
• Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

  1993cited by this paper
• Bone marrow derived elements and resident microglia in brain inflammation

  1993cited by this paper
• Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view.

  1992cited by this paper
• Post-formation fluorescent labelling of liposomal membranes. In vivo detection, localisation and kinetics.

  1992cited by this paper
• Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

  1992cited by this paper
• Microglial cells are a component of the perivascular glia limitans

  1991cited by this paper
• Microglia: Immune Network in the CNS

  1990cited by this paper
• Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages

  1990cited by this paper
• Identity of ED2‐positive perivascular cells in rat brain

  1989cited by this paper
• Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice

  1989cited by this paper
• Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

  1989cited by this paper
• Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.

  1988cited by this paper
• Liposome targeting to mouse brain: mannose as a recognition marker.

  1988cited by this paper
• Cellular immune reactivity within the CNS

  1986cited by this paper
• Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3.

  1986cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Histochemical comparison of naphthol AS-phosphates for the demonstration of phosphatases.

  1958cited by this paper

• Some Basics on Innate Neuroimmunology for Nonspecialists

  2025cites this paper
• Border-associated macrophages: an emerging perspective from physiological basis and multi-disease roles to the mechanism of vascular cognitive impairment and dementia

  2025cites this paper
• Macrophage Depletion by Intracerebroventricular Administration of Clodronate-Liposome Attenuates the Development of Angiotensin II-Salt-Induced Neurogenic Hypertension in Rats

  2025cites this paper
• Niche-specific therapeutic targeting of myeloid cells in the central nervous system.

  2025cites this paper
• Perivascular macrophages in the central nervous system: insights into their roles in health and disease

  2025cites this paper
• Common and distinct features of diverse macrophage populations in the central nervous system

  2025cites this paper
• All Three Supersystems—Nervous, Vascular, and Immune—Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage

  2024cites this paper
• The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders

  2024cites this paper
• CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology

  2024cites this paper
• Perivascular macrophages in cerebrovascular diseases.

  2024cites this paper
• Border‐Associated Macrophages: From Embryogenesis to Immune Regulation

  2024cites this paper
• Frontiers of neurodegeneration diseases treatment: Targeting immune cells in brain border regions.

  2024cites this paper
• Cerebral amyloid angiopathy and the immune system

  2024cites this paper
• Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

  2024cites this paper
• Peripheral and central macrophages in obesity

  2023cites this paper
• Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

  2023cites this paper
• Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice

  2023cites this paper
• Age-dependent meningeal macrophages protect against viral neuroinfection

  2023cites this paper
• Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation.

  2023cites this paper
• Brain perivascular macrophages: current understanding and future prospects

  2023cites this paper
• Macrophage and monocyte subsets in response to ischemic stroke

  2023cites this paper
• Perivascular Macrophages Mediate Microvasospasms After Experimental Subarachnoid Hemorrhage

  2023cites this paper
• Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage

  2023cites this paper
• Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

  2023cites this paper
• Immune compartments at the brain’s borders in health and neurovascular diseases

  2023cites this paper
• Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease

  2023cites this paper
• Chronic kidney disease promotes cerebral microhemorrhage formation

  2023cites this paper
• Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

  2023cites this paper
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  2023cites this paper
• A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain.

  2022cites this paper
• Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

  2022cites this paper
• Meningeal macrophages protect against viral neuroinfection.

  2022cites this paper
• Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages

  2022cites this paper
• Clodronate disodium is neither cytotoxic nor cytoprotective to normal and recombinant equine interleukin-1β-treated joint tissues in vitro.

  2022cites this paper
• Interleukin 22 and its association with neurodegenerative disease activity

  2022cites this paper
• Transcriptome analysis reveals potential marker genes for diagnosis of Alzheimer’s disease and vascular dementia

  2022cites this paper
• REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

  2022cites this paper
• CNS border-associated macrophages in the homeostatic and ischaemic brain.

  2022cites this paper
• Iron-Induced Hydrocephalus: the Role of Choroid Plexus Stromal Macrophages

  2022cites this paper
• An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway.

  2021cites this paper
• Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

  2021cites this paper
• Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair

  2021cites this paper
• Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer’s Disease

  2021cites this paper
• Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System

  2021cites this paper
• Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage

  2021cites this paper
• Control of brain tumor growth by reactivating myeloid cells with niacin

  2020cites this paper
• Depletion of brain perivascular macrophages regulates acute restraint stress-induced neuroinflammation and oxidative/nitrosative stress in rat frontal cortex.

  2020cites this paper
• Intrathecal drug delivery in the era of nanomedicine.

  2020cites this paper
• Tools and Approaches for Studying Microglia In vivo

  2020cites this paper
• Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

  2020cites this paper
• Alcohol exposure-induced neurovascular inflammatory priming impacts ischemic stroke and is linked with brain perivascular macrophages.

  2020cites this paper
• Depletion of microglia and macrophages with clodronate liposomes attenuates zymosan-induced Fos expression and hypothermia in the adult mouse.

  2020cites this paper
• Systemic and CNS inflammation crosstalk: implications for Alzheimer's Disease.

  2019cites this paper
• Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice.

  2019cites this paper
• Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity

  2019cites this paper
• Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

  2019cites this paper
• Macrophages at CNS interfaces: ontogeny and function in health and disease

  2019cites this paper
• A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa

  2019cites this paper
• Brain perivascular macrophages: Recent advances and implications in health and diseases

  2019cites this paper
• The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy

  2019cites this paper
• CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

  2018cites this paper
• Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity

  2018cites this paper
• Perivascular macrophages in health and disease

  2018cites this paper
• Pro-inflammatory immune-to-brain signaling is involved in neuroendocrine responses to acute emotional stress.

  2017cites this paper
• Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer A&bgr; Peptides

  2017cites this paper
• Nonclassical Monocytes Mediate Secondary Injury, Neurocognitive Outcome, and Neutrophil Infiltration after Traumatic Brain Injury

  2017cites this paper
• Brain perivascular macrophages: characterization and functional roles in health and disease

  2017cites this paper
• Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies

  2017cites this paper
• Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

  2017cites this paper
• Understanding the role of perivascular macrophages in Parkinson's disease pathophysiology

  2017influential citation
• This information is current as Injury Neutrophil Infiltration after Traumatic Brain Injury , Neurocognitive Outcome , and Nonclassical Monocytes Mediate Secondary

  2017cites this paper
• Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension.

  2016influential citation
• Myeloid cell involvement during the resolution of acute brain inflammation

  2016cites this paper
• Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke

  2016cites this paper
• Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation.

  2016cites this paper
• The therapeutic potential of interleukin-10 in neuroimmune diseases.

  2015cites this paper
• What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro?,

  2015cites this paper
• Efficiently stimulated adult microglia cross‐prime naive CD8+ T cells injected in the brain

  2013cites this paper
• Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells.

  2013cites this paper
• Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

  2013cites this paper
• Differential Detection and Distribution of Microglial and Hematogenous Macrophage Populations in the Injured Spinal Cord of lys-EGFP-ki Transgenic Mice

  2012cites this paper
• Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.

  2012cites this paper
• Antigen presentation in EAE: role of microglia, macrophages and dendritic cells.

  2011cites this paper
• Evaluation d'un protocole préclinique d'immunothérapie dirigé contre les tumeurs cérébrales et du potentiel de présentation antigénique croisée des cellules microgliales adultes

  2011cites this paper
• Monocyte Recruitment into the Central Nervous System Verfasserin

  2011cites this paper
• Liposomes for specific depletion of macrophages from organs and tissues.

  2010cites this paper
• Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration

  2010cites this paper
• Liposomes and Drug Delivery

  2010cites this paper
• Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats After Myocardial Infarction

  2010cites this paper
• Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

  2010cites this paper
• Dual roles for perivascular macrophages in immune-to-brain signaling.

  2010cites this paper
• Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics

  2010cites this paper
• Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage.

  2010cites this paper
• Central Neuroinvasion and Demyelination by Inflammatory Macrophages After Peripheral Virus Infection is Controlled by SHP-1

  2009cites this paper
• CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model.

  2009cites this paper
• How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B.

  2009cites this paper
• Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

  2009cites this paper
• Cerebrovascular Cyclooxygenase-1 Expression, Regulation, and Role in Hypothalamic-Pituitary-Adrenal Axis Activation by Inflammatory Stimuli

  2009cites this paper
• Microglia: gatekeepers of central nervous system immunology

  2009cites this paper
• Immune-to-brain signalling: the role of cerebral CD163-positive macrophages.

  2008cites this paper