Role of nutrients and bacterial colonization in the development of intestinal host defense.

In this introduction to the supplement on the use of pre- and probiotics in the health and disease of pediatric patients, I have summarized factors affecting the initial colonization of the neonatal intestine. The term bacterial-epithelial cross-talk was defined, and examples of the enterocyte response to both pathologic and indigenous flora stimulation illustrated. Immaturities in the human neonatal intestinal response to bacteria and their toxins were reviewed in the context of the pathogenesis of age-specific, bacterial gastrointestinal infectious diseases. Finally, the importance of pre- and probiotics as measures to strengthen the neonate's intestinal host defenses in the prevention and treatment of specific age-related disease were considered.

• Publication year

  2000

• Venue

  Journal of Pediatric Gastroenterology and Nutrition - JPGN

• Publication date

  2000-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00005176-200000002-00002PMID 10749395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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