Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans1

No abstract is available for this paper.

• Publication year

  2001

• Venue

  The FASEB Journal

• Publication date

  2001-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.00-0436fjePMID 11344101
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man.

  2008cited by this paper
• Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children.

  2000cited by this paper
• Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells through neuropeptide Y Y1 receptors.

  2000cited by this paper
• Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.

  2000cited by this paper
• Receptor Subtype-Induced Targeting and Subtype-Specific Internalization of Human α2-Adrenoceptors in PC12 Cells

  1999cited by this paper
• Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

  1998cited by this paper
• Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells

  1998cited by this paper
• Circulating neuropeptide Y (NPY) and catecholamines in rat under resting and stress conditions. Arguments for extra-adrenal origin of NPY, adrenal and extra-adrenal sources of catecholamines.

  1998cited by this paper
• Renal effects of neuropeptide Y

  1998cited by this paper
• Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium.

  1998cited by this paper
• Impaired cotranslational processing as a mechanism for type I antithrombin deficiency.

  1998cited by this paper
• Y-receptor subtypes--how many more?

  1997cited by this paper
• A receptor subtype involved in neuropeptide-Y-induced food intake

  1996cited by this paper
• Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses

  1996cited by this paper
• Neuropeptide Y

  1995cited by this paper
• Systematic Introduction of Proline in a Eukaryotic Signal Sequence Suggests Asymmetry within the Hydrophobic Core (*)

  1995cited by this paper
• Elevated plasma concentration of neuropeptide Y in adolescents with primary hypertension.

  1994cited by this paper
• Antilipolytic effects of alpha 2-adrenergic agonists, neuropeptide Y, adenosine, and PGE1 in mammal adipocytes.

  1994cited by this paper
• Sympatho-adrenal secretion in humans: factors governing catecholamine and storage vesicle peptide co-release.

  1994cited by this paper
• Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle.

  1994cited by this paper
• Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV.

  1993cited by this paper
• Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells.

  1993cited by this paper
• Insulin and glucagon in prevention of hypoglycemia during exercise in humans.

  1991cited by this paper
• Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers.

  1991cited by this paper
• Adrenergic regulation of lipolysis in situ at rest and during exercise.

  1990cited by this paper
• Elevated insulin, norepinephrine, and neuropeptide Y in hypertension.

  1990cited by this paper
• Radioimmunoassay for plasma neuropeptide-Y in physiological and physiopathological states and response to sympathetic activation.

  1990cited by this paper
• Hypothalamic Neuropeptide Y: a Circuit in the Regulation of Gonadotropin Secretion and Feeding Behavior a

  1990cited by this paper
• Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein.

  1990cited by this paper
• Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work.

  1989cited by this paper
• Exercise-Induced Fall in Insulin and Increase in Fat Metabolism During Prolonged Muscular Work

  1989cited by this paper
• Neuropeptide Y in the sympathetic control of blood pressure in hypertensive subjects.

  1989cited by this paper
• Elevated plasma concentration of neuropeptide Y and low level of circulating adrenaline in elderly asthmatics during rest and acute severe asthma.

  1988cited by this paper
• Cardiac vagal action and plasma levels of neuropeptide Y following intravenous injection in the dog.

  1987cited by this paper
• Presynaptic inhibition of cardiac vagal postganglionic nerves by neuropeptide Y.

  1987cited by this paper
• Co-release of neuropeptide Y (NPY)-like immunoreactivity and catecholamines in newborn infants.

  1986cited by this paper
• Studies on cardiac distribution and function of neuropeptide Y.

  1986cited by this paper
• Increases in plasma neuropeptide Y concentrations during sympathetic activation in man.

  1986cited by this paper
• Co-release of neuropeptide Y and catecholamines during physical exercise in man.

  1985cited by this paper
• Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels

  1984cited by this paper
• Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers.

  1984cited by this paper
• Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.

  1984cited by this paper
• Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat.

  1983cited by this paper
• Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

  1982cited by this paper
• Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years

  1974cited by this paper

• Correlation of Leptin in Patients With Type 2 Diabetes Mellitus

  2024cites this paper
• The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation

  2023cites this paper
• Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

  2022cites this paper
• Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice

  2021cites this paper
• Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges

  2021cites this paper
• Meta-Analysis on the Association of Neuropeptide Y rs16139 Variant With the Risk of Alcoholism

  2021cites this paper
• A novel mouse model to evaluate neuropeptide Y–mediated melanocyte pathology

  2021cites this paper
• Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study.

  2021cites this paper
• Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer

  2020cites this paper
• Relation of neuropeptide Y gene expression and genotyping with hypertension in chronic kidney disease

  2019cites this paper
• Neuropeptide Y – Its role in human performance and extreme environments

  2019cites this paper
• Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment

  2018cites this paper
• Neuropeptide Y, stressful life events and personality trait conscientiousness: Preliminary associations from a Swedish longitudinal study.

  2018cites this paper
• Peripherally Administered Y2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice

  2018cites this paper
• The Proline 7 Substitution in the Preproneuropeptide Y Is Associated with Higher Hepatic Lipase Activity In Vivo

  2017cites this paper
• Neuropeptide Y in Alcohol Addiction and Affective Disorders

  2017cites this paper
• The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons.

  2017cites this paper
• The role of brain-gut peptides in mood disorders

  2017cites this paper
• Genetic variation in glia–neuron signalling modulates ageing rate

  2017cites this paper
• Adapting to Stress: Understanding the Neurobiology of Resilience

  2017cites this paper
• Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models.

  2016influential citation
• Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure

  2016cites this paper
• Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis.

  2016cites this paper
• Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes

  2016cites this paper
• Autophagy in the hypothalamus: role of Neuropeptide Y and impact on Synaptic Plasticity

  2016cites this paper
• The Neurobiology of Executive Function Under Stress and Optimization of Performance

  2015cites this paper
• Neuropeptide Y helps us to deposit fat in adipose tissue

  2015cites this paper
• Neuropeptide Y: An Anti-Aging

  2015cites this paper
• Neuropeptide Y: An Anti-Aging Player?

  2015cites this paper
• Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice

  2015cites this paper
• The Mechanisms of Obesity in Transgenic Mice

  2015influential citation
• Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility

  2014cites this paper
• Aspects of autoantibody epitopes in type 1 diabetes

  2014cites this paper
• Scopolamine and depression: a role for muscarinic antagonism?

  2014cites this paper
• Signal peptides: new markers in cardiovascular disease?

  2014cites this paper
• Systemic treatment with neuropeptide Y receptor Y1-antagonist enhances atherosclerosis and stimulates IL-12 expression in ApoE deficient mice.

  2013cites this paper
• α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction.

  2013cites this paper
• Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy.

  2013influential citation
• Circulating signal peptides: more than just a bus ticket?

  2013cites this paper
• Coming to Our Senses : Harnessing the Mind-Body Connection to Enhance Behavioral & Pharmacologic Interventions for Depression "

  2012cites this paper
• The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)

  2012cites this paper
• Can we vaccinate against depression?

  2012cites this paper
• Diet-Induced Obesity in Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons

  2012cites this paper
• High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.

  2012cites this paper
• NPY and Stress 30 Years Later: The Peripheral View

  2012cites this paper
• Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model

  2012cites this paper
• Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study.

  2012influential citation
• GENETIC, EPIGENETIC AND DNA BIOBANK STUDIES

  2012influential citation
• EFFECTS OF SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM (5-HTTLPR) AND NEUROPEPTIDE Y GENE VARIANTS ON ALCOHOL USE IN YOUNG ADULTS

  2012cites this paper
• Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression

  2012cites this paper
• Neurobiology of PTSD

  2011cites this paper
• A Developmental Approach

  2011cites this paper
• Role of Neuropeptide Y in Depression: Current Status

  2011cites this paper
• The 1258 G>A polymorphism in the neuropeptide Y gene is associated with greater alcohol consumption in a Mediterranean population.

  2011cites this paper
• Central functions of neuropeptide Y in mood and anxiety disorders

  2011cites this paper
• The Effects of Ovariecotomy on Neuropeptide Y Neurotransmission in Skeletal Muscle Arterioles

  2011cites this paper
• The neuropeptide Y system: pathophysiological and therapeutic implications in obesity and cancer.

  2011cites this paper
• Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients

  2011cites this paper
• Can we predict top‐level sports performance in power vs endurance events? A genetic approach

  2011cites this paper
• Of Mice and Men: Neuropeptide Y and Its Receptors Are Associated with Atherosclerotic Lesion Burden and Vulnerability

  2011cites this paper
• Neuropeptide Y polymorphisms and ischemic stroke in Chinese population.

  2010cites this paper
• The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes.

  2010cites this paper
• Gene-environment factors in depressive disorders with a focus on circadian genes

  2010cites this paper
• A possible role of neuropeptide Y in depression and stress.

  2010cites this paper
• Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome

  2010cites this paper
• The effect of endogenous preproneuropeptide Y leucine 7 to proline 7 polymorphism on growth and apoptosis in primary cultured HUVECs

  2009cites this paper
• Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury.

  2009cites this paper
• The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update.

  2009cites this paper
• PreproNPY Pro7 protects against depression despite exposure to environmental risk factors.

  2009cites this paper
• The intracellular mobility of NPY and a putative mitochondrial form of NPY in neuronal cells.

  2009cites this paper
• The role of non-synonymous NPY gene polymorphism in the nitric oxide production in HUVECs.

  2009cites this paper
• Transgenic mice overexpressing neuropeptide Y: An experimental model of metabolic and cardiovascular diseases

  2009cites this paper
• Adaptation to Stress and Psychobiological Mechanisms of Resilience

  2008cites this paper
• Transgenic Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons

  2008cites this paper
• Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study.

  2008cites this paper
• NPY L7P polymorphism and metabolic diseases.

  2008cites this paper
• Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD

  2008cites this paper
• A Common Single Nucleotide Polymorphism Alters the Synthesis and Secretion of Neuropeptide Y

  2008cites this paper
• Stress, NPY and vascular remodeling: Implications for stress-related diseases.

  2007cites this paper
• NPY and cardiac diseases.

  2007cites this paper
• Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

  2007cites this paper
• NeuropeptideY: Neurogenic Mediator of Angiogenesis and Arteriogenesis

  2007cites this paper
• Genetic variations of NPY and AGRP in body fatness regulation

  2007cites this paper
• Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes.

  2007cites this paper
• Impact of the Leu7Pro Polymorphism of preproNPY on Diurnal NPY and Hormone Secretion in Type 2 Diabetes

  2007cites this paper
• Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children.

  2006cites this paper
• Human NPY gene variants in cardiovascular and metabolic diseases.

  2006cites this paper
• Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

  2006cites this paper
• Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review

  2006cites this paper
• The human gene map for performance and health-related fitness phenotypes: the 2005 update.

  2006cites this paper
• The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy.

  2006cites this paper
• Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults

  2006cites this paper
• The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.

  2005cites this paper
• Mitochondrial targeting signal in human neuropeptide Y gene.

  2005cites this paper
• Atherosclerosis and angiogenesis: what do nerves have to do with it?

  2005cites this paper
• The human gene map for performance and health-related fitness phenotypes: the 2004 update.

  2005cites this paper
• Anxiety disorders: noradrenergic neurotransmission.

  2005cites this paper
• An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk.

  2005cites this paper
• The T1128C polymorphism of neuropeptide Y gene in a chinese population.

  2005cites this paper
• A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence.

  2005cites this paper