Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Frontiers in Medicine

• Publication date

  2012-08-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11684-012-0216-4PMID 22869052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2011cited by this paper
• Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

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• Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

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• Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.

  2011influential reference
• A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

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  2009cited by this paper
• Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development.

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  2007cited by this paper
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• Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

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• Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.

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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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