Lipofuscin: mechanisms of age-related accumulation and influence on cell function.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Free Radical Biology & Medicine

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0891-5849(02)00959-0PMID 12208347
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis.

  2002cited by this paper
• Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin.

  2001cited by this paper
• Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

  2001cited by this paper
• Does A2E, a retinoid component of lipofuscin and inhibitor of lysosomal degradative functions, directly affect the activity of lysosomal hydrolases?

  2001cited by this paper
• Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells.

  2001cited by this paper
• Autophagy as a regulated pathway of cellular degradation.

  2000cited by this paper
• Increased expression of mature cathepsin B in aging rat liver

  2000cited by this paper
• Induction of cell death by the lysosomotropic detergent MSDH

  2000cited by this paper
• Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

  2000cited by this paper
• Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

  2000cited by this paper
• The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

  2000cited by this paper
• Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

  1999cited by this paper
• Centrophenoxine Slows Down, but Does Not Reverse, Lipofuscin Accumulation in Cultured Cells

  1999cited by this paper
• Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease.

  1999cited by this paper
• Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress.

  1999cited by this paper
• Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation.

  1999cited by this paper
• Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity.

  1998cited by this paper
• Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium.

  1998cited by this paper
• The free radical theory of aging matures.

  1998cited by this paper
• Ventricular myocytes are not terminally differentiated in the adult mammalian heart.

  1998cited by this paper
• Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis.

  1998cited by this paper
• On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes.

  1998cited by this paper
• Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media.

  1998cited by this paper
• Lipofuscin: Mechanisms of formation and increase with age

  1998cited by this paper
• Genetic and functional changes in mitochondria associated with aging.

  1997cited by this paper
• Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation.

  1997cited by this paper
• Formation of Lipofuscin-Like Autofluorescent Materials in NG108-15 Cells: Involvement of Lysosomal Protein Degradation

  1997cited by this paper
• Follow-up study of subunit c of mitochondrial ATP synthase (SCMAS) in Batten disease and in unrelated lysosomal disorders

  1997cited by this paper
• Mitochondria, free radicals, and neurodegeneration.

  1996cited by this paper
• Chain Migration of Neuronal Precursors

  1996cited by this paper
• Lipofuscin as a record of "rate of living" in an aquatic poikilotherm.

  1995cited by this paper
• Tissue culture loading test with storage granules from animal models of neuronal ceroid-lipofuscinosis (Batten disease): testing their lysosomal degradability by normal and Batten cells.

  1995cited by this paper
• Lectin histochemistry of lipofuscin and certain ceroid pigments

  1995cited by this paper
• Lipofuscin in bovine muscle and brain: a model for studying age pigment.

  1995cited by this paper
• Induction of age pigment accumulation in the brain cells of young male rats through iron-injection into the cerebrospinal fluid.

  1995cited by this paper
• Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron.

  1995cited by this paper
• Morphological alterations in neocortical and cerebellar GABAergic neurons in a canine model of juvenile Batten disease.

  1995cited by this paper
• Degradation of proteasomes by lysosomes in rat liver.

  1995cited by this paper
• Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans.

  1994cited by this paper
• Comparative Studies on the Free Radical Scavenger Properties of Two Nootropic Drugs, CPH and BCE‐001

  1994cited by this paper
• Accumulation of cardiac lipofuscin in crab-eating monkeys (Macaca fasicularis): the same rate of lipofuscin accumulation in several species of primates.

  1993cited by this paper
• Retinal age pigments generated by self-assembling lysosomotropic detergents

  1993cited by this paper
• Accumulation of cardiac lipofuscin depends on metabolic rate of mammals.

  1992cited by this paper
• Effect of dietary restriction on lysosomal bodies and total protein synthesis in hepatocytes of aging rats.

  1992cited by this paper
• A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis.

  1992cited by this paper
• Microfluorometric and fluorometric lipofuscin spectral discrepancies: a concentration-dependent metachromatic effect?

  1991cited by this paper
• Lysosomal storage diseases.

  1991cited by this paper
• Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition.

  1989cited by this paper
• Fluorescent and cross-linked proteins formed by free radical and aldehyde species generated during lipid oxidation.

  1989cited by this paper
• Cathepsin B activity in human skin fibroblasts from young, old and premature aging syndromes

  1985cited by this paper
• The effect of lipofuscin on cellular function.

  1983cited by this paper
• Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles.

  1981cited by this paper
• Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation

  1981cited by this paper
• Phagocytosis and degradation of rat liver mitochondria by cultivated human glial cells.

  1980cited by this paper
• [Prolongation of the mitotic life span of diploid human glia cells in a quantitative cell culture system by centrophenoxine (author's transl)].

  1979cited by this paper
• Effect of centrophenoxine on human embryonic lung cells in culture [proceedings].

  1978cited by this paper
• Effect of centrophenoxine on human embryonic lung cells in culture [proceedings].

  1978cited by this paper
• Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence.

  1973cited by this paper
• Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence.

  1973cited by this paper
• Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies.

  1972cited by this paper
• HISTOCHEMICAL INDICATIONS FOR LYSOSOMAL LOCALIZATION OF HEAVY METALS IN NORMAL RAT BRAIN AND LIVER

  1970cited by this paper
• Rate of accumulation of cardiac lipofuscin in the aging canine.

  1968cited by this paper
• Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats

  1967cited by this paper
• Effect of Centrophenoxine on the Lipofuscin Pigments in the Neurones of Senile Guinea-pigs

  1966cited by this paper
• Functions of lysosomes.

  1966cited by this paper
• Human hepatocellular pigments and lysosomes.

  1960cited by this paper
• GEE MV: Rate and magnitude of age pigment accumulation in the human myocardium.

  1959cited by this paper
• Aging: a theory based on free radical and radiation chemistry.

  1956cited by this paper
• Formation of Fluorescent Pigment in Vitamin E Deficiency

  1947cited by this paper
• Formation of flourescent pigment in vitamin E deficiency.

  1947cited by this paper

• Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy

  2026cites this paper
• Age-related lysosomal and autophagic dysfunction and intra-lysosomal ROS generation in marine mussels

  2026cites this paper
• Anti-aging potential of caffeoyl-spermidine derivatives from Lycium ruthenicum Murr.: insights from UPLC-QTOF-MS/MS, Caenorhabditis elegans, and mechanistic studies.

  2026cites this paper
• Modification of the dermal matrix by senescence associated lipids and its functional consequence.

  2026cites this paper
• Tracing refractile body biogenesis in human oocytes: the role of lysosomes and mitochondria.

  2026cites this paper
• Corylin Promotes Longevity in Caenorhabditis elegans through DAF-16 and SKN-1 Coordinated Activation of Autophagy-mitochondrial Homeostasis Axis.

  2026cites this paper
• Vitisin B rejuvenates senescence via WBP2NL regulation.

  2026cites this paper
• Dietary phenolic compounds as modulators of AGEs-induced photo-oxidation: A focus on the skin and eye lens

  2026cites this paper
• Brown bowel syndrome: a systematic review

  2025cites this paper
• The homozygous LRRK2.p.N1437D point mutation mouse is a novel model of parkinsonism

  2025cites this paper
• Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production

  2025cites this paper
• Luteolin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity through activation of Nrf2/Keap1 signaling

  2025influential citation
• Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants

  2025cites this paper
• Senolytics as Modulators of Critical Signaling Pathways: a Promising Strategy to Combat Brain Aging and Neurodegenerative Disorders

  2025cites this paper
• Diverse Perspectives Illuminate the Intestinal Toxicity of Traditional and Biodegradable Agricultural Film Microplastics to Eisenia fetida under Varying Exposure Sequences.

  2025cites this paper
• JNK signal-driven histone methylations mediate transgenerational neurotoxicity of 6-PPD Quinone at predicted environmental concentrations in Caenorhabditis elegans

  2025cites this paper
• Lipofuscin: The Missing Link in the Worsening of Obstructive Sleep Apnea.

  2025cites this paper
• In vitro and in vivo Evaluation of Modulatory Effects of Lutein and Zeaxanthin Supplementation on Retinal Antioxidant and Lipofuscin Levels

  2025cites this paper
• Red Ginseng Aqueous Extract Superior to White Ginseng Exhibited Anti‐Aging Property Through IIS Signaling Pathway in Caenorhabditis elegans

  2025cites this paper
• Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans

  2025cites this paper
• Sake lees extract obtained using a novel continuous phase-transition extraction method: evaluation of its bioactive composition, anti-aging efficacy and mechanism.

  2025cites this paper
• The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases

  2025cites this paper
• AG86 Peptide-modified Reactive Oxygen Species-responsive Polymer Nanovesicles for Transdermal Delivery of Hydrophilic Ergothioneine to Basal Keratinocytes

  2025cites this paper
• Iron metabolism in rheumatic diseases

  2025cites this paper
• SkinspanTM: A Healthy Longevity Framework for Skin Aging: Redefining Skin Aging to Hallmarks and Longevity.

  2025cites this paper
• Post-Slaughter Age Classification and Sex Determination in Deboned Beef Using Lipofuscin Autofluorescence and Amelogenin Gene Analysis

  2025cites this paper
• Maintenance and Decline of Neuronal Lysosomal Function in Aging

  2025cites this paper
• Optimized immunofluorescence for liver structure analysis: Enhancing 3D resolution and minimizing tissue autofluorescence

  2025cites this paper
• Multi-modal label-free imaging of cellular metabolism and oxidative stress in 3D brain tissue models

  2025cites this paper
• Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease

  2025cites this paper
• Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond

  2025cites this paper
• Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light.

  2025cites this paper
• The drug discovery and therapeutic nano-strategies targeting cellular senescence

  2025cites this paper
• Global Proteomic Profiling to Unravel Lipofuscin's Protein Repertoire.

  2025cites this paper
• EXPLORING GLYCOBIOMARKERS BEYOND SENESCENCE-ASSOCIATED β-GALACTOSIDASE FOR STUDYING AGING IN VITRO.

  2025cites this paper
• Dietary transition from pelleted feed to live fry of two brown trout (Salmo trutta) morphs, reared for reintroduction

  2025cites this paper
• Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

  2025cites this paper
• Expansion of lysosomal capacity in early adult neurons driven by TFEB/HLH-30 protects dendrite maintenance during aging in Caenorhabditis elegans

  2025cites this paper
• Hepatic Lipofuscin Deposition in Living Liver Donor Candidate

  2025cites this paper
• Temozolomide-induced senescent glioblastoma cells acquire sensitivity to TRAIL death receptor 5-mediated apoptosis

  2025cites this paper
• A pH-responsive anthocyanin-based hydrogel with colorimetric infection monitoring and antibacterial properties for wound healing.

  2025cites this paper
• ε-Viniferin Rejuvenates Senescence via RGS16 Regulation: In Vitro Evidence

  2025cites this paper
• PFOS-induced black liver and hepatic aging in mice: A new paradigm in environmental hepatotoxicology.

  2025cites this paper
• Polysaccharide from Ganoderma atrum delay senescence and enhance stress resistance through modulating IIS and MAPK pathway in Caenorhabditis elegans.

  2025cites this paper
• Bisretinoid Lipofuscin, Fundus Autofluorescence and Retinal Disease.

  2025cites this paper
• Studying Cellular Senescence Using the Model Organism Drosophila melanogaster.

  2025cites this paper
• Resilience to cardiac aging in Greenland shark Somniosus microcephalus

  2025cites this paper
• Proposed unified model of late-onset Alzheimer's disease: Chronic astrocytic and neuronal bioenergetic failure

  2025cites this paper
• Nesfatin-1 alleviates blue-light-emitting diodes induced retinal damage in Sprague–Dawley rats

  2025cites this paper
• Transcriptomics-Based Toxicological Study of Nickel on Caenorhabditis elegans

  2025cites this paper
• Critical factors for flow cytometry analysis of the brain

  2025cites this paper
• Low-Molecular-Weight Bovine Collagen Peptides Reduce Fat Accumulation in C. elegans and Ameliorate Obesity-Related Metabolic Dysfunction and Microbiota Diversity in C57BL/6 Male Diet-Induced Obese Mice

  2025cites this paper
• Cellular and tissue-level responses of mussels (Mytilus edulis) to aged polyethylene terephthalate (PET) micro- and nanoplastic particles.

  2025cites this paper
• An overview of contemporary theories of ageing

  2025cites this paper
• Nematicidal activity of 3-indoleacetonitrile against Bursaphelenchus xylophilus: Inhibition of development and reproduction through induction of excessive reactive oxygen species.

  2025cites this paper
• EGCG Alleviates the Aging Toxicity Induced by 3-MCPD via IIS Pathway in Caenorhabditis elegans with Abnormal Reproduction and Heat Shock Protein.

  2024cites this paper
• Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes

  2024cites this paper
• Mapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review

  2024cites this paper
• Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease

  2024cites this paper
• An optimised protocol for the detection of lipofuscin, a versatile and quantifiable marker of cellular senescence

  2024cites this paper
• Lipophilic fluorescent products as a potential biomarker of oxidative stress: A link between central (brain) and peripheral (blood)

  2024cites this paper
• Prominin-1 null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and RPE atrophy

  2024cites this paper
• Advancements in Imaging and Therapeutic Options for Dry Age-Related Macular Degeneration and Geographic Atrophy

  2024cites this paper
• Lipids and Lipid Metabolism in Cellular Senescence: Emerging Targets for Age-Related Diseases.

  2024cites this paper
• Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans.

  2024cites this paper
• Establishing chronic models of age-related macular degeneration via long-term iron ion overload.

  2024cites this paper
• Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding

  2024cites this paper
• Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice

  2024cites this paper
• Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

  2024cites this paper
• Iron imbalance in neurodegeneration

  2024cites this paper
• Chronic neurotoxicity of Tetrabromobisphenol A: Induction of oxidative stress and damage to neurons in Caenorhabditis elegans.

  2024cites this paper
• Label‐Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications

  2024cites this paper
• Supercontinuum intrinsic fluorescence imaging heralds ‘free view’ of living systems

  2024cites this paper
• Antioxidant and antiaging activities of the polysaccharide ZJP-04 M from Ziziphus jujuba in Caenorhabditis elegans.

  2024cites this paper
• Ischemic Stroke and the Biological Hallmarks of Aging

  2024cites this paper
• Neuronal Cell Rearrangement During Aging: Antioxidant Compounds as a Potential Therapeutic Approach

  2024cites this paper
• Analysis of Forsythia suspensa fruit and leaf extracts using UHPLC-Q-Exactive-Orbitrap/MS: In vivo antioxidant activity on D-galactose-induced aging mice.

  2024cites this paper
• The role of mitochondria in cytokine and chemokine signalling during ageing.

  2024cites this paper
• Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia

  2024cites this paper
• Multi-modal, Label-free, Optical Mapping of Cellular Metabolic Function and Oxidative Stress in 3D Engineered Brain Tissue Models

  2024cites this paper
• Influence of selected phenolic acids on advanced lipid oxidation end products generation in model systems

  2024cites this paper
• Dipeptidylpeptidase‐4‐targeted activatable fluorescent probes visualize senescent cells

  2024cites this paper
• Toward Systemic Lipofuscin Removal

  2024cites this paper
• prominin-1-null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy and RPE atrophy

  2024cites this paper
• Autophagy in drusen biogenesis secondary to age‐related macular degeneration

  2024cites this paper
• Histological alterations as a recommended biomarker in the mussel Mytilus platensis (Bivalvia, Mytilidae) to study anthropic impact on seaports

  2024cites this paper
• Proteostasis in T cell aging

  2023cites this paper
• Senescent Cells: Dual Implications on the Retinal Vascular System

  2023cites this paper
• Exposure to Polystyrene Nanoplastics Led to Learning and Memory Deficits in Zebrafish by Inducing Oxidative Damage and Aggravating Brain Aging

  2023cites this paper
• Endogenous Photosensitizers in Human Skin.

  2023cites this paper
• Morphological and histometric features of the caudal kidney in piranha Pygocentrus nattereri (Characiformes: Serrasalmidae)

  2023cites this paper
• Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration

  2023cites this paper
• Histomorphometric evaluation of melanomacrophage centers (MMCs) and CD3+ T cells of two morphs of brown trout (Salmo trutta) fed diets with immunostimulants.

  2023cites this paper
• Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis

  2023cites this paper
• Endogenous and Exogenous Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells: An Updated Antioxidant Perspective

  2023cites this paper
• Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?

  2023influential citation
• Retina and RPE lipid profile changes associated with ABCA4 associated Stargardt's maculopathy.

  2023cites this paper
• Endocrine and scavenging cell functions of a juvenile fish heart atrium: Fine structure aspects and translating conjectures

  2023cites this paper
• A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway.

  2023cites this paper
• Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants.

  2023cites this paper