Control of B Cell Responsiveness by Isotype and Structural Elements of the Antigen Receptor.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Trends in immunology

• Publication date

  2016-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2016.03.004PMID 27052149
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alternative adaptive immunity strategies: coelacanth, cod and shark immunity.

  2016cited by this paper
• B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation

  2015influential reference
• Responsiveness of B cells is regulated by the hinge region of IgD

  2015influential reference
• Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling

  2015cited by this paper
• The nanoscale organization of the B lymphocyte membrane☆

  2015cited by this paper
• B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk

  2014cited by this paper
• Identification of sturgeon IgD bridges the evolutionary gap between elasmobranchs and teleosts.

  2014cited by this paper
• Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region

  2014cited by this paper
• The role of BCR isotype in B-cell development and activation.

  2014cited by this paper
• CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling

  2013cited by this paper
• Pre-Clustering of the B Cell Antigen Receptor Demonstrated by Mathematically Extended Electron Microscopy

  2013cited by this paper
• The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.

  2013influential reference
• Patchwork organization of the yeast plasma membrane into numerous coexisting domains

  2012cited by this paper
• Endogenous antigen tunes the responsiveness of naive B cells but not T cells

  2012cited by this paper
• Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms.

  2012cited by this paper
• Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules.

  2012cited by this paper
• The double life of a B-1 cell: self-reactivity selects for protective effector functions

  2011cited by this paper
• Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing

  2011cited by this paper
• Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes

  2011cited by this paper
• The function and regulation of immunoglobulin D.

  2011cited by this paper
• Oligomeric organization of the B-cell antigen receptor on resting cells

  2010cited by this paper
• TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

  2010cited by this paper
• Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals

  2010cited by this paper
• A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

  2010cited by this paper
• N-linked glycosylation selectively regulates autonomous precursor BCR function

  2010cited by this paper
• CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency.

  2010cited by this paper
• The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

  2010cited by this paper
• Microscopy imaging of membrane domains.

  2010cited by this paper
• Role of PI3K in the generation and survival of B cells

  2010cited by this paper
• Tyrosine kinases and their substrates in B lymphocytes

  2009cited by this paper
• Peripheral B cell subsets.

  2008cited by this paper
• Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.

  2008cited by this paper
• Mature B cells class switched to IgD are autoreactive in healthy individuals.

  2007cited by this paper
• The impact of glycosylation on the biological function and structure of human immunoglobulins.

  2007cited by this paper
• B-cell anergy: from transgenic models to naturally occurring anergic B cells?

  2007cited by this paper
• Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster

  2007cited by this paper
• Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.

  2006cited by this paper
• The riddle of the dual expression of IgM and IgD

  2006cited by this paper
• IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates.

  2006cited by this paper
• Role of tonsillar IgD+CD27+ memory B cells in humoral immunity against pneumococcal infection.

  2006cited by this paper
• Membrane IgM influences membrane IgD mediated antigen internalization in the B cell line Bcl1.

  2006cited by this paper
• Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering.

  2005cited by this paper
• Molecular mechanisms guiding late stages of B‐cell development

  2004cited by this paper
• Phosphoinositide 3-kinase: diverse roles in immune cell activation.

  2004cited by this paper
• Differential Segmental Flexibility and Reach Dictate the Antigen Binding Mode of Chimeric IgD and IgM: Implications for the Function of the B Cell Receptor1

  2004cited by this paper
• The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin1

  2004cited by this paper
• B cell receptor signal strength determines B cell fate

  2004cited by this paper
• The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling.

  2003cited by this paper
• The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling

  2003cited by this paper
• Predominant Autoantibody Production by Early Human B Cell Precursors

  2003cited by this paper
• Deletion of immunoglobulin β in developing B cells leads to cell death

  2002cited by this paper
• Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop.

  2002cited by this paper
• Deletion of immunoglobulin beta in developing B cells leads to cell death.

  2002cited by this paper
• B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-β1

  2002cited by this paper
• Regulation of B-cell signal transduction by adaptor proteins

  2002cited by this paper
• B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.

  2002cited by this paper
• Difference in apoptosis induction between surface IgD and IgM.

  2001cited by this paper
• The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts.

  2001cited by this paper
• Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation1

  2001cited by this paper
• This information is current as Signaling into Lipid Rafts Reveals a Novel Step in Translocation of the B Cell Antigen Receptor

  2001cited by this paper
• CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

  2000cited by this paper
• Monomeric and oligomeric complexes of the B cell antigen receptor.

  2000cited by this paper
• Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter.

  1999cited by this paper
• Mutations in Igalpha (CD79a) result in a complete block in B-cell development.

  1999cited by this paper
• Mutations in Igα (CD79a) result in a complete block in B-cell development

  1999cited by this paper
• IgD can largely substitute for loss of IgM function in B cells

  1998cited by this paper
• The Normal Counterpart of IgD Myeloma Cells in Germinal Center Displays Extensively Mutated IgVH Gene, Cμ–Cδ Switch, and λ Light Chain Expression

  1998cited by this paper
• Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts.

  1996cited by this paper
• Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis.

  1995cited by this paper
• The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM

  1995cited by this paper
• Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.

  1995cited by this paper
• Antibody-antigen interactions: new structures and new conformational changes.

  1994cited by this paper
• Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.

  1993cited by this paper
• Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells

  1993cited by this paper
• Antigen receptors on B lymphocytes.

  1992cited by this paper
• Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

  1991cited by this paper
• The B-cell antigen receptor of the five immunoglobulin classes

  1991cited by this paper
• Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

  1991cited by this paper
• Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

  1991cited by this paper
• Antigen receptor tail clue

  1989cited by this paper
• CD19 is functionally and physically associated with surface immunoglobulin

  1989cited by this paper
• A novel 34‐kd protein co‐isolated with the IgM molecule in surface IgM‐expressing cells.

  1988cited by this paper
• The immunoglobulin mu chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments.

  1980cited by this paper

• Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells

  2025cites this paper
• BC-1 improves collagen-induced arthritis in mice by modulating IgD and BCR-NF-κB signalling pathway of B cells.

  2025cites this paper
• The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

  2025cites this paper
• Persistent IgG1 clones dominate and personalize the plasma antibody repertoire

  2025cites this paper
• Towards a unifying model for B-cell receptor triggering

  2024cites this paper
• Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli

  2023cites this paper
• Causal relationship between circulating immune cells and gastric cancer: a bidirectional Mendelian randomization analysis using UK Biobank and FinnGen datasets

  2023cites this paper
• IgD shapes the pre-immune naïve B cell compartment in humans

  2023influential citation
• Avidity in antibody effector functions and biotherapeutic drug design

  2022cites this paper
• Low-Level Expression of CD138 Marks Naturally Arising Anergic B Cells

  2022cites this paper
• Gingival tissue antibody gene utilization in aging and periodontitis.

  2022cites this paper
• Immunoglobulin D and its encoding genes: An updated review.

  2021cites this paper
• The therapeutic implications of activated immune responses via the enigmatic immunoglobulin D

  2021cites this paper
• Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia

  2021influential citation
• Primary Immune Responses and Affinity Maturation Are Controlled by IgD

  2021cites this paper
• The Role of B Cells in Adult and Paediatric Liver Injury

  2021cites this paper
• Defective Allelic Exclusion by IgD in the Absence of Autoantigen

  2021cites this paper
• Covalent Coupling of HIV-1 Glycoprotein Trimers to Biodegradable Calcium Phosphate Nanoparticles via Genetically Encoded Aldehyde-Tags.

  2021cites this paper
• Structure, Function, and Therapeutic Use of IgM Antibodies

  2020cites this paper
• The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)

  2019cites this paper
• Characterisation of anergic B cells in a new mouse model with altered B cell receptor signalling

  2019cites this paper
• The Immunoglobulins: New Insights, Implications, and Applications.

  2019cites this paper
• Electrostatic interactions: From immune receptor assembly to signaling

  2019cites this paper
• Ginsenoside compound-K inhibits the activity of B cells through inducing IgD-B cell receptor endocytosis in mice with collagen-induced arthritis

  2019cites this paper
• Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

  2019cites this paper
• The enigmatic function of IgD: some answers at last

  2018cites this paper
• The B-Side of the Immune Response

  2018cites this paper
• Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4

  2018cites this paper
• Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development

  2017cites this paper
• The Other Function: Class II-Restricted Antigen Presentation by B Cells

  2017cites this paper
• Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

  2017cites this paper
• Memory B Cells of Mice and Humans.

  2017cites this paper
• CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor

  2017cites this paper
• A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease

  2017cites this paper