APOE genotype, cholesterol level, lipid-lowering treatment, and dementia

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neurology

• Publication date

  2005-05-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1212/01.WNL.0000160114.42643.31PMID 15883313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Relation of plasma lipids to Alzheimer disease and vascular dementia.

  2004cited by this paper
• Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease.

  2003cited by this paper
• Evolution of statin prescribing 1994–2001: a case of agism but not of sexism?

  2003cited by this paper
• Mild Cognitive Deterioration with Subcortical Features: Prevalence, Clinical Characteristics, and Association with Cardiovascular Risk Factors in Community‐Dwelling Older Persons (The InCHIANTI Study)

  2003cited by this paper
• Vascular Factors and Risk of Dementia: Design of the Three-City Study and Baseline Characteristics of the Study Population

  2003cited by this paper
• The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease.

  2003cited by this paper
• Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study.

  2003cited by this paper
• Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

  2003cited by this paper
• Brain cholesterol, statins and Alzheimer's Disease.

  2003cited by this paper
• Apolipoprotein E 4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

  2002cited by this paper
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.

  2002cited by this paper
• TaqMan Systems for Genotyping of Disease-Related Polymorphisms Present in the Gene Encoding Apolipoprotein E

  2002cited by this paper
• Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.

  2002cited by this paper
• Statin therapy for Alzheimer's disease: will it work?

  2002cited by this paper
• Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial.

  2002cited by this paper
• Serum lipoprotein levels, statin use, and cognitive function in older women.

  2002cited by this paper
• Statins in the Prevention and Treatment of Alzheimer Disease

  2002cited by this paper
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Commentary

  2002cited by this paper
• Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.

  2002cited by this paper
• The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.

  2002cited by this paper
• Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

  2002cited by this paper
• Use of Lipid‐Lowering Drugs in Older Adults With and Without Dementia: A Community‐Based Epidemiological Study

  2002cited by this paper
• Cholesterol metabolism in the brain

  2001cited by this paper
• Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

  2001cited by this paper
• [Statins and the risk of dementia].

  2001cited by this paper
• Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

  2001cited by this paper
• Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

  2000cited by this paper
• Statins and the risk of dementia.

  2000cited by this paper
• Cognitive Test Performance and Presence of Subclinical Cardiovascular Disease in the Cardiovascular Health Study

  2000cited by this paper
• Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: A population-based study of African Americans

  2000cited by this paper
• APOE genotype, plasma lipids, lipoproteins, and AD in community elderly

  1999cited by this paper
• The role of cholesterol in the biosynthesis of beta-amyloid.

  1999cited by this paper
• Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins

  1998cited by this paper
• Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease.

  1998cited by this paper
• The relationship between blood pressure and dementia: a review.

  1997cited by this paper
• Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.

  1997cited by this paper
• In praise of vitamin D and sleep

  1997cited by this paper
• Ultrasonographic assessment of carotid wall characteristics and cognitive functions in a community sample of 59- to 71-year-olds. The EVA Study Group.

  1996cited by this paper
• Statins do more than just lower cholesterol.

  1996cited by this paper
• Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease

  1995cited by this paper
• Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

  1993cited by this paper
• Improving screening for dementia in the elderly using, Mini-Mental State Examination subscores, Benton's Visual Retention Test, and Isaacs' Set Test.

  1992cited by this paper
• The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances.

  1991cited by this paper
• La version française de l'échelle CES-D (Center for Epidemiologic Studies-Depression Scale). Description et traduction de l'échelle d'autoévaluation.

  1989cited by this paper
• The CES-D Scale

  1977cited by this paper

• Relationships between heritable dementia risk factors, cardiovascular risk factors in young adulthood, and midlife neuropsychological outcomes

  2026cites this paper
• Rate and Predictors of White Matter Disease Volume Progression Across Different Age Groups.

  2025cites this paper
• Exploring the intersection of atherosclerosis and Alzheimer’s disease: the role of inflammation and complement activation

  2025cites this paper
• Updated LIfestyle for BRAin health (LIBRA2) Score, Genetics, and Risk of Alzheimer Disease, Vascular Dementia, and Stroke in Older Adults.

  2025cites this paper
• Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study

  2025cites this paper
• Associations of the LIBRA index with cognitive resilience to genetic susceptibility to dementia.

  2025cites this paper
• Statin therapy on dementia in elderly type 2 diabetes patients with delirium

  2025cites this paper
• Transition of mild cognitive impairment to Alzheimer’s disease: Medications as modifiable risk factors

  2024cites this paper
• Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline

  2024cites this paper
• The role of dementia in the association between APOE4 and all-cause mortality: pooled analyses of two population-based cohort studies.

  2024cites this paper
• Use of common cardiovascular disease drugs and risk of dementia: A case–control study in Swedish national register data

  2024cites this paper
• The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk

  2023cites this paper
• Is Hippocampal Volume a Relevant Early Marker of Dementia?

  2023cites this paper
• Cholesterol Levels, Hormone Replacement Therapy, and Incident Dementia among Older Adult Women

  2023cites this paper
• Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

  2023cites this paper
• Protective Effects Against Dementia Undergo Different Statin Type, Intensity, and Cumulative Dose in Older Adult Type 2 Diabetes Mellitus Patients.

  2023cites this paper
• The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

  2023cites this paper
• Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells

  2023cites this paper
• Epidemiology and Risk Factors for Dementia.

  2022cites this paper
• Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia

  2022cites this paper
• Dietary Glycemic Load and Plasma Amyloid-β Biomarkers of Alzheimer’s Disease

  2022cites this paper
• Complaints of daytime sleepiness, insomnia, hypnotic use, and risk of dementia: a prospective cohort study in the elderly

  2022cites this paper
• Genetic predisposition to increased blood cholesterol and Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: A Mendelian triglyceride lipid levels and risk of Alzheimer disease: A Mendelian randomization analysis randomization analysis

  2022cites this paper
• Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

  2022cites this paper
• Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study

  2022cites this paper
• High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E epsilon4 Allele Carriers

  2021cites this paper
• Hypertension and Hypercholesterolemia Modify Dementia Risk in Relation to APOEɛ4 Status

  2021cites this paper
• An evidence-based review of neuronal cholesterol role in dementia and statins as a pharmacotherapy in reducing risk of dementia

  2021cites this paper
• Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease

  2021cites this paper
• Basal forebrain atrophy along the Alzheimer’s disease spectrum and its relevance for subjective cognitive decline

  2020cites this paper
• High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E ε4 Allele Carriers

  2020cites this paper
• Identification of hippocampal volume as a mediator of the association between APOE4 and dementia

  2020cites this paper
• Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

  2020cites this paper
• Social Determinants of Health in Non-communicable Diseases: Case Studies from Japan

  2020cites this paper
• Association between statin use and cognitive function: A systematic review of randomized clinical trials and observational studies.

  2020cites this paper
• Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.

  2020cites this paper
• Effects of LDL Cholesterol and Statin Use on Verbal Learning and Memory in Older Adults at Genetic Risk for Alzheimer’s Disease

  2020cites this paper
• Refined carbohydrate‐rich diet is associated with long‐term risk of dementia and Alzheimer's disease in apolipoprotein E ε4 allele carriers

  2020cites this paper
• Dynamique de l'atrophie hippocampique dans le vieillissement et la maladie d'Alzheimer

  2020cites this paper
• Dementia

  2020cites this paper
• Plasma lipidome variation during the second half of the human lifespan is associated with age and sex but minimally with BMI

  2019cites this paper
• High serum high-density lipoprotein-cholesterol is associated with memory function and gyrification of insular and frontal opercular cortex in an elderly memory-clinic population

  2019cites this paper
• Medizinische Maßnahmen zur Demenzprävention

  2019cites this paper
• Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer’s Disease and Vascular Dementia

  2019cites this paper
• [Dyslipidemia management in geriatric patients: new guidelines 2017].

  2019cites this paper
• Diabetes-Associated Dementia Risk and Competing Risk of Death in the Three-City Study

  2019cites this paper
• Berberine: A plant derived alkaloid with therapeutic potential to combat Alzheimer's disease.

  2019cites this paper
• Preventing Dementia: Shifting Focus Towards Potential Modifiable Risk Factors

  2019cites this paper
• Biomarkers clinici, biologici, cognitivi e comportamentali per la malattia di Alzheimer ed il Mild Cognitive Impairment: dati di popolazione dello Zabùt Aging Project

  2019cites this paper
• Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia

  2019cites this paper
• Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

  2019cites this paper
• Gene Transfer Induced Hypercholesterolemia in Amyloid Mice

  2018cites this paper
• Statins and Brain Health: Alzheimer’s Disease and Cerebrovascular Disease Biomarkers in Older Adults

  2018cites this paper
• Leaky brain in neurological and psychiatric disorders: Drivers and consequences

  2018cites this paper
• Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach

  2018cites this paper
• Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect

  2018cites this paper
• Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet

  2018cites this paper
• Statins and Brain Health: Alzheimer’s and Cerebrovascular Disease Biomarkers in Older Adults

  2018cites this paper
• Correlation between Metabolic Syndrome and Mild Cognitive Impairment

  2018cites this paper
• Metabolomic characterization of hypertension and dyslipidemia

  2018cites this paper
• Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease

  2018cites this paper
• correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect

  2018cites this paper
• Association of Apolipoprotein E , Methylenetetrahydrofolate Genotypes , Lipids levels and Alzheimer Disease in an Algerian Population

  2017cites this paper
• Cardiometabolic and neuroimaging correlates of cognitive function in polycystic ovary syndrome

  2017cites this paper
• A Study on Clinical Determinants and one year Follow-Up of Dementia and Mild Cognitive Impairment Following Ischemic Stroke

  2017cites this paper
• Trends in dementia prevalence, incidence, and survival rate in a Japanese community

  2017cites this paper
• Statins and the Brain: More than Lipid Lowering Agents?

  2017cites this paper
• Study sponsorship The 3 C Study is conducted under a partnership agreement between Inserm , the Victor Segalen – Bordeaux II University and Sanofi-Synthélabo

  2017cites this paper
• Putative Dementia Cases Fluctuate as a Function of Mini-Mental State Examination Cut-Off Points

  2017cites this paper
• Adiponectin and sporadic Alzheimer's disease: Clinical and molecular links.

  2017cites this paper
• Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes.

  2017cites this paper
• Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study

  2017cites this paper
• Epidemiology and risk factors for dementia

  2016cites this paper
• Rolle vaskulärer Risikofaktoren für die Entstehung und Progression der Alzheimer-Demenz

  2016cites this paper
• Statins for the prevention of dementia.

  2016cites this paper
• Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial

  2016cites this paper
• Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease*

  2016cites this paper
• Statin-Associated Side Effects.

  2016cites this paper
• Apolipoprotein E ε-4 as a genetic determinant of Alzheimer’s disease heterogeneity

  2015cites this paper
• Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans.

  2015cites this paper
• VASKULARNI ČIMBENICI RIZIKA U RAZVOJU KOGNITIVNIH POREMEĆAJA

  2015cites this paper
• UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS

  2015cites this paper
• Statins, cognition, and dementia—systematic review and methodological commentary

  2015cites this paper
• Vascular risk factors and Alzheimer's disease pathogenesis: are conventional pharmacological approaches protective for cognitive decline progression?

  2015cites this paper
• Factors Related to Long-Term Post-Stroke Cognitive Impairment in Young Adult Ischemic Stroke

  2015cites this paper
• Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition.

  2014cites this paper
• Novel targets for Alzheimer's disease treatment

  2014cites this paper
• Vaszkuláris reaktivitás, érfali jellemzők és kognitív funkció vizsgálata primer hipertóniában

  2014cites this paper
• Novel targets for Alzheimer's disease treatment

  2014cites this paper
• Evidence of brain atrophy detected on magnetic resonance imaging is associated with failure of acquisition of the ability for insulin self-injection.

  2014cites this paper
• The APOE genotype: modification of therapeutic responses in Alzheimer's disease.

  2014cites this paper
• Impact of nutrition on cognition and its association with blood and brain Alzheimer disease related biomarkers

  2014cites this paper
• IMMUNOTHERAPY IN COMBINATION WITH BEHAVIORAL ENRICHMENT IN A CANINE MODEL OF AGING

  2014cites this paper
• Statins in nervous system-associated diseases: angels or devils?

  2014cites this paper
• Cardiovascular Risk Profile in Women and Dementia

  2014cites this paper
• Retinoids as potential targets for Alzheimer's disease.

  2014cites this paper
• The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation.

  2014cites this paper
• Relationship between poststroke cognition, baseline factors, and functional outcome: data from "efficacy of nitric oxide in stroke" trial.

  2014cites this paper
• Epigenomic Studies of Twins and Brain Diseases

  2014cites this paper
• Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

  2014cites this paper