Macular Edema - Rationale for Therapy.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Developments in ophthalmology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000455275PMID 28351053
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diabetes and Obesity

  2020cited by this paper
• Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy

  2016cited by this paper
• Spare the rods and spoil the retina: revisited

  2016cited by this paper
• The Role of Plasma Kallikrein–Kinin Pathway in the Development of Diabetic Retinopathy: Pathophysiology and Therapeutic Approaches

  2016cited by this paper
• Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy

  2015cited by this paper
• Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in mild to moderate nonproliferative diabetic retinopathy: a randomized proof-of-concept clinical trial.

  2014cited by this paper
• Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in patients with severe nonproliferative or non-high-risk proliferative diabetic retinopathy: a randomized clinical trial.

  2014cited by this paper
• Effects of Aspirin Treatment on Diabetic Retinopathy

  2013cited by this paper
• Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications.

  2013cited by this paper
• The Role of NSAIDs in the Management of Postoperative Ophthalmic Inflammation

  2012cited by this paper
• Neurodegeneration as an early event in the pathogenesis of Diabetic Retinopathy: A multicentric, prospective, phase II‐III, randomised controlled trial to assess the efficacy of neuroprotective drugs administered topically to prevent or arrest Diabetic Retinopathy. EUROCONDOR – EU FP7 Project

  2012cited by this paper
• Alternative pathways in the development of diabetic retinopathy: the renin‐angiotensin and kallikrein‐kinin systems

  2012cited by this paper
• Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study.

  2012cited by this paper
• Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery.

  2012cited by this paper
• Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor.

  2012cited by this paper
• Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction.

  2012cited by this paper
• Calpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells.

  2011cited by this paper
• Serum inflammatory cytokines IL-1β, IL-6, TNF-α and VEGF have influence on the development of diabetic retinopathy

  2011cited by this paper
• Prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion.

  2009cited by this paper
• Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy.

  2009cited by this paper
• Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion.

  2009cited by this paper
• Physiology of vitreous surgery

  2009influential reference
• Diabetes and obesity: a challenge for every ophthalmologist.

  2009cited by this paper
• TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations

  2009cited by this paper
• Ranibizumab for diabetic retinopathy.

  2009cited by this paper
• Vitreous and Serum Levels of Platelet-Derived Growth Factor and Their Correlation in Patients with Proliferative Diabetic Retinopathy

  2009cited by this paper
• Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina.

  2009cited by this paper
• Enzyme-induced posterior vitreous detachment in the rat produces increased lens nuclear pO2 levels.

  2009cited by this paper
• Systemic management of diabetic retinopathy

  2009cited by this paper
• Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas

  2008cited by this paper
• Dexamethasone Inhibits High Glucose – , TNF-– , and IL-1 – Induced Secretion of Inflammatory and Angiogenic Mediators from Retinal Microvascular Pericytes

  2008cited by this paper
• Effect of prophylactic nonsteroidal antiinflammatory drugs on cystoid macular edema assessed using optical coherence tomography quantification of total macular volume after cataract surgery

  2008cited by this paper
• Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element.

  2008cited by this paper
• Perioperative antibiotics and anti-inflammatory agents in cataract surgery

  2008cited by this paper
• Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes.

  2008cited by this paper
• Dexamethasone inhibits leukocyte accumulation and vascular permeability in retina of streptozotocin-induced diabetic rats via reducing vascular endothelial growth factor and intercellular adhesion molecule-1 expression.

  2008cited by this paper
• Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy.

  2007cited by this paper
• Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic retina.

  2007cited by this paper
• Müller cells as players in retinal degeneration and edema

  2007influential reference
• Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats.

  2007cited by this paper
• Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

  2007cited by this paper
• Inflammatory cystoid macular edema

  2007cited by this paper
• The Use of Intravitreal Etanercept in Diabetic Macular Oedema

  2007cited by this paper
• Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy

  2007cited by this paper
• Intravitreal bevacizumab for treatment of uveitic macular edema.

  2007cited by this paper
• TUMOR NECROSIS FACTOR ANTAGONISTS: Preliminary Evidence for an Emerging Approach in the Treatment of Ocular Inflammation

  2007cited by this paper
• Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema.

  2006cited by this paper
• Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

  2006cited by this paper
• Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase.

  2006cited by this paper
• VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.

  2006cited by this paper
• Ocular oxygenation and the treatment of diabetic retinopathy.

  2006cited by this paper
• Octreotide as a Treatment for Uveitic Cystoid Macular Edema

  2006cited by this paper
• Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.

  2006cited by this paper
• INTERFERON ALFA-2A: A NEW TREATMENT OPTION FOR LONG LASTING REFRACTORY CYSTOID MACULAR EDEMA IN UVEITIS?: A Pilot Study

  2006cited by this paper
• Inflammatory mediators of uveitis: cytokines and chemokines

  2006cited by this paper
• Triamcinolone acetonide inhibits IL-6- and VEGF-induced angiogenesis downstream of the IL-6 and VEGF receptors.

  2006cited by this paper
• Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema.

  2006cited by this paper
• Interferon as a treatment for uveitis associated with multiple sclerosis

  2005cited by this paper
• Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy.

  2005cited by this paper
• Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation.

  2005cited by this paper
• The Glucocorticoid Triamcinolone Acetonide Inhibits Osmotic Swelling of Retinal Glial Cells via Stimulation of Endogenous Adenosine Signaling

  2005cited by this paper
• UvA-DARE ( Digital Academic Repository ) Spare the rod and spoil the eye

  2005cited by this paper
• Minocycline inhibits LPS-induced retinal microglia activation.

  2005cited by this paper
• Octreotide as a treatment for uveitic cystoid macular edema.

  2005cited by this paper
• VEGF increases paracellular transport without altering the solvent-drag reflection coefficient.

  2004cited by this paper
• Macular edema.

  2004cited by this paper
• Medical treatment of macular edema in patients with uveitis

  2004cited by this paper
• Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells.

  2004cited by this paper
• Inhibition of membrane-bound carbonic anhydrase decreases subretinal pH and volume

  2004cited by this paper
• Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown.

  2004cited by this paper
• Treatment of cystoid macular edema with non-steroidal anti-inflammatory drugs and corticosteroids

  2004cited by this paper
• Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin

  2002cited by this paper
• Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression

  2002cited by this paper
• The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology.

  2001cited by this paper
• Systemic considerations in the management of diabetic retinopathy.

  2001cited by this paper
• Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.

  2000cited by this paper
• Inhibition of membrane-bound carbonic anhydrase enhances subretinal fluid absorption and retinal adhesiveness

  2000cited by this paper
• Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

  1999cited by this paper
• Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

  1998cited by this paper
• Medical prophylaxis and treatment of cystoid macular edema after cataract surgery. The results of a meta-analysis.

  1998cited by this paper
• Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

  1998cited by this paper
• Effect of high glucose on permeability of retinal capillary endothelium in vitro.

  1997cited by this paper
• Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids.

  1997cited by this paper
• Nonsteroidal anti-inflammatory drugs alter chloride and fluid transport in bovine retinal pigment epithelium.

  1996cited by this paper
• Nerve Growth Factor Prevents Both Neuroretinal Programmed Cell Death and Capillary Pathology in Experimental Diabetes

  1995cited by this paper
• Membrane-bound carbonic anhydrase in human retinal pigment epithelium.

  1994cited by this paper
• Effects of intravenous acetazolamide on retinal pH in the cat.

  1992cited by this paper
• [Diclofenac-dexamethasone combination in treatment of postoperative inflammation: prospective double-blind study].

  1992cited by this paper
• Vitrectomy for diabetic macular traction and edema associated with posterior hyaloidal traction.

  1992cited by this paper
• Randomized, double-masked study of cyclosporine compared to prednisolone in the treatment of endogenous uveitis.

  1991cited by this paper
• Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine.

  1991cited by this paper
• Prophylaxis of aphakic cystoid macular edema without corticosteroids. A paired-comparison, placebo-controlled double-masked study.

  1990cited by this paper
• Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion.

  1990cited by this paper
• Surgical management of vitreomacular traction syndromes.

  1989cited by this paper
• Treatment of chronic macular edema with acetazolamide.

  1988cited by this paper
• Effectiveness of ketorolac tromethamine 0.5% ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema.

  1987cited by this paper
• Pharmacologic modification of subretinal fluid absorption in the rabbit eye.

  1986cited by this paper
• Effect of diclofenac sodium on the arachidonic acid cascade.

  1986cited by this paper
• Carbonic anhydrase isoenzymes CA I and CA II in the human eye.

  1986cited by this paper
• Vitrectomy for chronic aphakic cystoid macular edema. Results of a national, collaborative, prospective, randomized investigation.

  1985cited by this paper

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  2022cites this paper
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  2021cites this paper
• The randomized ZIPANGU trial of ranibizumab and adjunct laser for macular edema following branch retinal vein occlusion in treatment-naïve patients

  2021cites this paper
• Occurrence and Risk Factors for Macular Edema in Patients with Juvenile Idiopathic Arthritis-Associated Uveitis

  2021cites this paper
• The Carbonic Anhydrases in Health and Disease

  2021cites this paper
• Agents for the prevention and treatment of age-related macular degeneration and macular edema: a literature and patent review

  2019cites this paper
• Surgical Therapy for Macular Edema: What We Have Learned through the Decades

  2019cites this paper
• Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases

  2018cites this paper
• Beyond the Retina : Cataract Surgery Evolving Role of Steroids for RVO and DME Neovascular AMD : Pipeline Runs Full • A Long-Term Game Plan • Old Dogs and New Tricks

  year unknowncites this paper