Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Infection and Immunity

• Publication date

  1994-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/iai.62.11.5040-5047.1994PMID 7927786PMCID PMC303224
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin.

  1994cited by this paper
• Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.

  1994cited by this paper
• Structure and diversity of the murine cryptdin gene family.

  1994cited by this paper
• A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.

  1994cited by this paper
• Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium.

  1993cited by this paper
• Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins.

  1993cited by this paper
• Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated.

  1993cited by this paper
• Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages.

  1993cited by this paper
• Defensins promote fusion and lysis of negatively charged membranes

  1993cited by this paper
• Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

  1993cited by this paper
• The structure of neutrophil defensin genes

  1993cited by this paper
• The structure of neutrophil defensin genes

  1993cited by this paper
• Defensins: antimicrobial and cytotoxic peptides of mammalian cells.

  1993cited by this paper
• In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis.

  1993influential reference
• Identification of protein coding regions by database similarity search

  1993cited by this paper
• Purification and primary structure of murine cryptdin‐1, a Paneth cell defensin

  1992influential reference
• Structure of the guinea pig neutrophil cationic peptide gene

  1992cited by this paper
• Cationic defensins arise from charge‐neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

  1992cited by this paper
• Paneth cells of the human small intestine express an antimicrobial peptide gene.

  1992influential reference
• Enteric defensins: antibiotic peptide components of intestinal host defense

  1992influential reference
• Cryptdins: antimicrobial defensins of the murine small intestine

  1992cited by this paper
• The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus.

  1992cited by this paper
• NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1.

  1992cited by this paper
• Antibacterial peptides: key components needed in immunity.

  1991cited by this paper
• Defensins: endogenous antibiotic peptides of animal cells.

  1991cited by this paper
• Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.

  1991cited by this paper
• Characterization of cDNA clones encoding guinea pig neutrophil cationic peptides

  1991cited by this paper
• Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium.

  1991cited by this paper
• Defensins

  1990cited by this paper
• Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

  1990cited by this paper
• A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin.

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• Peptides from frog skin.

  1990cited by this paper
• Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium

  1989cited by this paper
• Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.

  1989cited by this paper
• The structure of the rabbit macrophage defensin genes and their organ-specific expression.

  1989cited by this paper
• Immunohistochemical observations of lysozyme in the Paneth cells of specific-pathogen-free and germ-free mice.

  1988cited by this paper
• Solution structures of the rabbit neutrophil defensin NP-5.

  1988cited by this paper
• Isolation and characterization of human defensin cDNA clones.

  1988cited by this paper
• Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine.

  1988cited by this paper
• Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin

  1987cited by this paper
• The current status and portability of our sequence handling software

  1986cited by this paper
• Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

  1985cited by this paper
• Primary structures of three human neutrophil defensins.

  1985cited by this paper
• Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes

  1984cited by this paper
• Computer methods to aid the determination and analysis of DNA sequences.

  1984influential reference
• A comprehensive set of sequence analysis programs for the VAX

  1984influential reference
• Methods for the isolation of intact epithelium from the mouse intestine

  1981cited by this paper
• The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse.

  1981cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• The Paneth cell: a source of intestinal lysozyme.

  1975cited by this paper
• Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types.

  1974cited by this paper
• Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells.

  1974cited by this paper
• Lysozyme in Paneth cell secretions.

  1973cited by this paper
• PANETH AND GOBLET CELL RENEWAL IN MOUSE DUODENAL CRYPTS

  1969cited by this paper
• Localization of lysozyme activity in a Paneth cell granule fraction.

  1967cited by this paper
• The Paneth cells: an enigma.

  1966cited by this paper
• Morphologic heterogeneity of mouse Paneth cell granules before and after secretory stimulation.

  1965cited by this paper
• Materials and Methods Brief Definitive Report Tumor Necrosis Factor Mrna Localized to Paneth Cells of Normal Murine Intestinal Epithelium by in Situ Hybridization

  year unknowncited by this paper

• NPY2R Agonist-Induced Gastric Effects Leading to Intestinal Dysbiosis and Secondary Intestinal Pathology in CD1 Mice

  2026cites this paper
• Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation

  2026cites this paper
• AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis

  2025cites this paper
• Antimicrobial peptides: evolving soldiers in the battle against drug-resistant superbugs

  2025cites this paper
• The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis

  2024cites this paper
• Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota

  2023cites this paper
• What if gastrointestinal complications in endurance athletes were gut injuries in response to a high consumption of ultra-processed foods? Please take care of your bugs if you want to improve endurance performance: a narrative review

  2023cites this paper
• Mechanisms and regulation of defensins in host defense

  2023cites this paper
• Antimicrobial Protein LECT2-b Helps Maintain Gut Microbiota Homeostasis via Selectively Targeting Certain Pathogenic Bacteria.

  2023cites this paper
• Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5

  2023cites this paper
• Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation

  2023cites this paper
• Fermented rice bran supplementation attenuates colonic injury through modulating intestinal aryl hydrocarbon receptor and innate lymphoid cells in mice with dextran sodium sulfate-induced acute colitis.

  2023cites this paper
• Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

  2022influential citation
• Traditional Patchouli Essential Oil modulates the host's immune responses and gut microbiota and exhibits potent anti-cancer effects in ApcMin/+ mice.

  2022cites this paper
• Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell-derived Wnt3.

  2022cites this paper
• Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses

  2022cites this paper
• A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

  2021cites this paper
• Differential Response of Grapevine to Infection with ‘Candidatus Phytoplasma solani’ in Early and Late Growing Season through Complex Regulation of mRNA and Small RNA Transcriptomes

  2021cites this paper
• Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides

  2021cites this paper
• Adaptogenic flower buds exert cancer preventive effects by enhancing the SCFA-producers, strengthening the epithelial tight junction complex and immune responses.

  2020cites this paper
• Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

  2020cites this paper
• Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

  2020cites this paper
• Synergism between host defence peptides and antibiotics against 3 bacterial infections.

  2020cites this paper
• Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8

  2020cites this paper
• Neonatal İshalli Buzağılarda 25 (OH) D3 Konsantrasyonlarının Araştırılması

  2019cites this paper
• Evaluation of 25 (OH) D3 Concentrations in Neonatal Calves with Diarrhea

  2019cites this paper
• ORIGINAL Cellular Plasticity of Defa4 Cre -Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury

  2019cites this paper
• Gastric Microbiota Alteration in Klebsiella pneumoniae-Caused Liver Abscesses Mice

  2019cites this paper
• An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice

  2019cites this paper
• Detection of α-defensin in eosinophils in helminth-infected mouse model

  2018cites this paper
• Studies on the overexpression of antimicrobial peptides in E. coli

  2018influential citation
• Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury

  2018cites this paper
• G.I. pros: Antimicrobial defense in the gastrointestinal tract.

  2018cites this paper
• Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

  2018cites this paper
• Cells of the Immune System

  2017cites this paper
• The gastrointestinal tract: properties and role in allogeneic hematopoietic stem cell transplantation

  2017cites this paper
• An investigation of the factors influencing Clostridium difficile germination, colonisation and persistence

  2017cites this paper
• R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

  2017influential citation
• Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes.

  2017cites this paper
• A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted α-defensin Short title: Quantification of cryptdin-4 in the bowel lumen

  2017cites this paper
• Innate and Mucosal Immunity in the Developing Gastrointestinal Tract

  2017cites this paper
• Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria.

  2017cites this paper
• Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.

  2017cites this paper
• Étude de l'implication d’une voie MyD88/IL-22 dans le contrôle de la colonisation par la bactérie segmentée filamenteuse

  2017cites this paper
• Cryptdin-2 predicts intestinal injury during heatstroke in mice

  2017cites this paper
• Association of Vitamin D status with acute respiratory infection and diarrhoea in children less than two years of age in an urban slum of Bangladesh

  2016cites this paper
• Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

  2016cites this paper
• Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

  2016cites this paper
• Organoids as a model to study the cellular microenvironment and as a potential tool for personalized cancer medicine

  2016cites this paper
• Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets.

  2016cites this paper
• Association of vitamin D status with incidence of enterotoxigenic, enteropathogenic and enteroaggregative Escherichia coli diarrhoea in children of urban Bangladesh

  2016cites this paper
• Decreased secretion of Paneth cell α‐defensins in graft‐versus‐host disease

  2015cites this paper
• Characterization of natural antimicrobial peptides adsorbed to different matrices

  2015cites this paper
• Paneth cell α-defensins and enteric microbiota in health and disease

  2015cites this paper
• On the Functional Overlap between Complement and Anti-Microbial Peptides

  2015cites this paper
• Glutamine Improves Innate Immunity and Prevents Bacterial Enteroinvasion During Parenteral Nutrition.

  2015cites this paper
• Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization.

  2015cites this paper
• Complexity of antimicrobial peptide regulation during pathogen-host interactions.

  2015cites this paper
• Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation.

  2015cites this paper
• Defensins in Enteric Mucosal Immunity

  2015cites this paper
• Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis

  2015cites this paper
• The dietary polysaccharide from Ommastrephes bartrami prevents chemotherapeutic mucositis by promoting the gene expression of antimicrobial peptides in Paneth cells

  2015cites this paper
• Role of the Intestinal Microbiota in Gut Barrier Dysfunction Following Burn Injury

  2014cites this paper
• Enhancing The Efficacy Of DNA Vaccines

  2014cites this paper
• The role of acetylation in the regulation of antimicrobial peptide gene expression in the human intestine

  2014cites this paper
• Role of antimicrobial peptides expressed by host cells upon infection by Helicobacter pylori.

  2014cites this paper
• Macaque Small Intestine -Defensins from Rhesus α

  2014cites this paper
• Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions

  2014cites this paper
• Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering.

  2013cites this paper
• Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury.

  2013cites this paper
• A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted α-defensin.

  2013cites this paper
• Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease.

  2013cites this paper
• Immunity Mediators in Intestinal Mucosa Hyperplasia and Up-Regulation of Innate IL-9 Promotes IL-13-Dependent Paneth Cell

  2013cites this paper
• Stability of antimicrobial activity of cryptdin-2 against selected pathogens under physiological conditions

  2012cites this paper
• This information is current as Dysfunction after Acute Kidney Injury Mediated Multiorgan − Paneth Cell

  2012cites this paper
• Etude des interactions du microbiote intestinal avec le récepteur de l’immunité innée NOD2 dans la maladie de Crohn et le cancer colorectal

  2012cites this paper
• Paneth Cell–Mediated Multiorgan Dysfunction after Acute Kidney Injury

  2012cites this paper
• Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease

  2012cites this paper
• Pathogenesis of Inflammatory Bowel Diseases

  2012cites this paper
• Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.

  2012cites this paper
• α‐Defensins in human innate immunity

  2012cites this paper
• CRS-peptides: unique defense peptides of mouse Paneth cells

  2012cites this paper
• Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.

  2011cites this paper
• Paneth cell α-defensins in enteric innate immunity

  2011cites this paper
• Waking the wimp: Redox-modulation activates human beta-defensin 1

  2011cites this paper
• Regulation of microbiota by antimicrobial peptides in the gut.

  2011cites this paper
• The relationship between human beta-defensins and anaerobic commensal gut microbiota

  2011cites this paper
• Paneth cell‐derived interleukin‐17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury

  2011cites this paper
• The role of human defensins in gastrointestinal diseases

  2011cites this paper
• Intestinal Immune System

  2011cites this paper
• Biosynthesis and antimicrobial evaluation of backbone-cyclized alpha-defensins #

  2011cites this paper
• Paneth Cell Hyperplasia and Metaplasia in Necrotizing Enterocolitis

  2011cites this paper
• Clinical and histological implications of genotyping in Crohn's disease

  2011cites this paper
• Antimicrobial peptides and proteins of the horse - insights into a well-armed organism

  2011cites this paper
• Cryptdin-2: a novel therapeutic agent for experimental Salmonella Typhimurium infection.

  2010cites this paper
• Chicken intestine defensins activated murine peripheral blood mononuclear cells through the TLR4-NF-kappaB pathway.

  2010cites this paper
• Lumen illuminated : Intestinal defense mechanisms in the neonate

  2010cites this paper
• The effects of genetics, age and rearing environment on AvBD gene expression and gut anti-microbial activities in three chicken lines

  2010cites this paper
• The role of defensins and C-X-C chemokines in mammalian innate immunity

  2010influential citation
• TLR9-Dependent Induction of Intestinal α-Defensins by Toxoplasma gondii

  2010cites this paper