Chlamydial Plasmid-Encoded Virulence Factor Pgp3 Neutralizes the Antichlamydial Activity of Human Cathelicidin LL-37

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Infection and Immunity

• Publication date

  2015-09-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00746-15PMID 26416907PMCID PMC4645396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dendritic cell specific targeting of MyD88 signalling pathways in vivo

  2015influential reference
• β-Defensin 1 Plays a Role in Acute Mucosal Defense against Candida albicans

  2015cited by this paper
• Characterization of CPAF Critical Residues and Secretion during Chlamydia trachomatis Infection

  2015cited by this paper
• Chlamydia-secreted protease CPAF degrades host antimicrobial peptides.

  2015cited by this paper
• Plasmid-Encoded Pgp3 Is a Major Virulence Factor for Chlamydia muridarum To Induce Hydrosalpinx in Mice

  2014influential reference
• Plasmid-Free Chlamydia muridarum of Hydrosalpinx in Mice Infected with Reduced Live Organism Recovery and Lack

  2014cited by this paper
• Plasmid CDS5 Influences Infectivity and Virulence in a Mouse Model of Chlamydia trachomatis Urogenital Infection

  2014influential reference
• A path forward for the chlamydial virulence factor CPAF.

  2013cited by this paper
• Bacterial resistance to cationic antimicrobial peptides

  2013cited by this paper
• Reduced Live Organism Recovery and Lack of Hydrosalpinx in Mice Infected with Plasmid-Free Chlamydia muridarum

  2013cited by this paper
• Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3*

  2013cited by this paper
• MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

  2013cited by this paper
• Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation

  2012cited by this paper
• Epithelial antimicrobial defence of the skin and intestine

  2012cited by this paper
• Cathelicidins: family of antimicrobial peptides. A review

  2012cited by this paper
• Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

  2012cited by this paper
• Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1.

  2011cited by this paper
• Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL‐induced activation of NF‐κB and ERK

  2011influential reference
• Characterization of low molecular weight antimicrobial peptide from human female reproductive tract

  2011cited by this paper
• A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates

  2011cited by this paper
• Severity of bacterial vaginosis and the risk of sexually transmitted infection.

  2011cited by this paper
• Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections.

  2011cited by this paper
• Chlamydia-Secreted Proteins in Chlamydial Interactions with Host Cells

  2011cited by this paper
• Mice Deficient in MyD88 Develop a Th2-Dominant Response and Severe Pathology in the Upper Genital Tract following Chlamydia muridarum Infection

  2010cited by this paper
• Bacterial manipulation of innate immunity to promote infection

  2010cited by this paper
• A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans

  2010cited by this paper
• Antibacterial Activity of the Contact and Complement Systems Is Blocked by SIC, a Protein Secreted by Streptococcus pyogenes

  2010cited by this paper
• Developmental expression of non-coding RNAs in Chlamydia trachomatis during normal and persistent growth

  2010cited by this paper
• Human defensins and LL‐37 in mucosal immunity

  2009cited by this paper
• Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice

  2008cited by this paper
• Structural basis for activation and inhibition of the secreted chlamydia protease CPAF.

  2008cited by this paper
• The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells

  2008influential reference
• Corruption of Innate Immunity by Bacterial Proteases

  2008cited by this paper
• The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor

  2008cited by this paper
• Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner

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• Caspase-1 Contributes to Chlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection

  2007cited by this paper
• Plasmid-Deficient Chlamydia muridarum Fail to Induce Immune Pathology and Protect against Oviduct Disease1

  2007cited by this paper
• Intracellular Interleukin-1α Mediates Interleukin-8 Production Induced by Chlamydia trachomatis Infection via a Mechanism Independent of Type I Interleukin-1 Receptor

  2007cited by this paper
• SufA--a novel subtilisin-like serine proteinase of Finegoldia magna.

  2007cited by this paper
• Mechanisms of host cell exit by the intracellular bacterium Chlamydia

  2007cited by this paper
• Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

  2006cited by this paper
• Human α- and β-Defensins Block Multiple Steps in Herpes Simplex Virus Infection1

  2006cited by this paper
• A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin.

  2004cited by this paper
• Tarp and Arp: How Chlamydia induces its own entry.

  2004cited by this paper
• DNA immunization with pgp3 gene of Chlamydia trachomatis inhibits the spread of chlamydial infection from the lower to the upper genital tract in C3H/HeN mice.

  2003cited by this paper
• APOPTOSIS PREVENTION AS A MECHANISM OF IMMUNE EVASION

  2003cited by this paper
• Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans1

  2003cited by this paper
• The cellular paradigm of chlamydial pathogenesis.

  2003cited by this paper
• SIC, a Secreted Protein of Streptococcus pyogenesThat Inactivates Antibacterial Peptides*

  2003cited by this paper
• Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37

  2002cited by this paper
• Identification of a Chlamydial Protease–Like Activity Factor Responsible for the Degradation of Host Transcription Factors

  2001influential reference
• Inhibition of Apoptosis in Chlamydia-infected Cells: Blockade of Mitochondrial Cytochrome c Release and Caspase Activation

  1998cited by this paper
• Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

  1998cited by this paper
• Plasmid diversity in Chlamydia.

  1997cited by this paper
• Identification of CRAMP, a Cathelin-related Antimicrobial Peptide Expressed in the Embryonic and Adult Mouse*

  1997influential reference
• Expression of a plasmid gene of Chlamydia trachomatis encoding a novel 28 kDa antigen.

  1993cited by this paper

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• Pathogenic and Protective Roles of Neutrophils in Chlamydia trachomatis Infection

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• Infection of human organoids supports an intestinal niche for Chlamydia trachomatis

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• Chlamydia trachomatis plasmid-encoding Pgp3 protein induces secretion of distinct inflammatory signatures from HeLa cervical epithelial cells

  2023cites this paper
• Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4+ T cells

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• Virulence Protein Pgp3 Is Insufficient To Mediate Plasmid-Dependent Infectivity of Chlamydia trachomatis

  2023cites this paper
• The Treatment of Tubal Inflammatory Infertility using Yinjia Tablets through EGFR/MEK/ERK Signaling Pathway based on Network Pharmacology.

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• TLR2 mediates autophagy through ERK signaling pathway in Chlamydia psittaci CPSIT_p7 protein‐stimulated RAW264.7 cells

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• Plasmid-mediated virulence in Chlamydia

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• Tryptophan residue of plasmid-encoded Pgp3 is important for Chlamydia muridarum to induce hydrosalpinx in mice

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• A Machine Learning-Based Analytic Pipeline Applied to Clinical and Serum IgG Immunoproteome Data To Predict Chlamydia trachomatis Genital Tract Ascension and Incident Infection in Women

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• The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.

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• Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity

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• Reduced Endometrial Ascension and Enhanced Reinfection Associated with IgG Antibodies to Specific Chlamydia trachomatis Proteins in Women at Risk for Chlamydia.

  2021cites this paper
• Lipid droplets and the host–pathogen dynamic: FATal attraction?

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  2021cites this paper
• The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.

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• Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization.

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2019cites this paper
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  2019cites this paper
• The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice

  2018cites this paper
• Identification of proteins interacting with pORF5 in the pathogenesis of C. trachomatis.

  2018cites this paper
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  2018cites this paper
• Neutrophil extracellular traps prevent HIV infection in the female genital tract

  2018cites this paper
• PGP3 is a Chlamydial Plasmid-Encoded Virulence Factor

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• The Role of Chlamydial Colonization of the Gastrointestinal Tract in the Development and Persistence of Chronic Chlamydial Infections

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• Chlamydia muridarum plasmid induces mouse oviduct pathology by promoting chlamydial survival and ascending infection and triggering host inflammation

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• Chlamydia Spreading from the Genital to Gastrointestinal Tracts —A Two-Hit Hypothesis

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  2018cites this paper
• Development and evaluation of an enzyme-linked immunosorbent assay for the detection of antibodies to a common urogenital derivative of Chlamydia trachomatis plasmid-encoded PGP3.

  2017cites this paper
• Chlamydial Plasmid-Dependent Pathogenicity.

  2017cites this paper
• Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012). PLoS

  2017cites this paper
• Strategies Using Bio-Layer Interferometry Biosensor Technology for Vaccine Research and Development

  2017cites this paper
• Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.

  2017cites this paper
• Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012)

  2017cites this paper
• Update on Chlamydia trachomatis Vaccinology

  2017cites this paper
• The Genital Tract Virulence Factor pGP3 Is Essential for Chlamydia muridarum Colonization in the Gastrointestinal Tract

  2017cites this paper
• Natural Products as a Source for Rational Antichlamydial Lead-Discovery

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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