The Genital Tract Virulence Factor pGP3 Is Essential for Chlamydia muridarum Colonization in the Gastrointestinal Tract

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Infection and Immunity

• Publication date

  2017-10-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00429-17PMID 29038127PMCID PMC5736818
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract

  2017influential reference
• Chlamydial Plasmid-Dependent Pathogenicity.

  2017cited by this paper
• Intravenous Inoculation with Chlamydia muridarum Leads to a Long-Lasting Infection Restricted to the Gastrointestinal Tract

  2016cited by this paper
• The Chlamydia muridarum Organisms Fail to Auto-Inoculate the Mouse Genital Tract after Colonization in the Gastrointestinal Tract for 70 days

  2016cited by this paper
• Rectal chlamydia infection in women at high risk of chlamydia attending Canberra Sexual Health Centre

  2016cited by this paper
• The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.

  2016cited by this paper
• In vitro rescue of genital strains of Chlamydia trachomatis from interferon-γ and tryptophan depletion with indole-positive, but not indole-negative Prevotella spp.

  2016cited by this paper
• Sequestration of host metabolism by an intracellular pathogen

  2016cited by this paper
• Evidence for increased Chlamydia case finding after the introduction of rectal screening among women attending 2 Canadian sexually transmitted infection clinics.

  2015cited by this paper
• The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum

  2015cited by this paper
• Escherichia coli EDL933 Requires Gluconeogenic Nutrients To Successfully Colonize the Intestines of Streptomycin-Treated Mice Precolonized with E. coli Nissle 1917

  2015cited by this paper
• Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D

  2015cited by this paper
• Chlamydial Plasmid-Encoded Virulence Factor Pgp3 Neutralizes the Antichlamydial Activity of Human Cathelicidin LL-37

  2015cited by this paper
• In Vitro Passage Selects for Chlamydia muridarum with Enhanced Infectivity in Cultured Cells but Attenuated Pathogenicity in Mouse Upper Genital Tract

  2015cited by this paper
• Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx

  2015influential reference
• Is it time to switch to doxycycline from azithromycin for treating genital chlamydial infections in women? Modelling the impact of autoinoculation from the gastrointestinal tract to the genital tract

  2015cited by this paper
• Intrauterine Infection with Plasmid-Free Chlamydia muridarum Reveals a Critical Role of the Plasmid in Chlamydial Ascension and Establishes a Model for Evaluating Plasmid-Independent Pathogenicity

  2015cited by this paper
• Mutational Analysis of the Chlamydia muridarum Plasticity Zone

  2015cited by this paper
• The Contribution of Chlamydia-Specific CD8+ T Cells to Upper Genital Tract Pathology

  2015cited by this paper
• In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract Inoculation

  2015influential reference
• Plasmid-Encoded Pgp3 Is a Major Virulence Factor for Chlamydia muridarum To Induce Hydrosalpinx in Mice

  2014influential reference
• Hidden in Plain Sight: Chlamydial Gastrointestinal Infection and Its Relevance to Persistence in Human Genital Infection

  2014cited by this paper
• Cross-Sectional Study of Genital, Rectal, and Pharyngeal Chlamydia and Gonorrhea in Women in Rural South Africa

  2014cited by this paper
• Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study

  2014cited by this paper
• Bioluminescence Imaging of Chlamydia muridarum Ascending Infection in Mice

  2014cited by this paper
• Induction of protective immunity against Chlamydia muridarum intracervical infection in DBA/1j mice.

  2014cited by this paper
• An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13

  2014cited by this paper
• Chlamydial Induction of Hydrosalpinx in 11 Strains of Mice Reveals Multiple Host Mechanisms for Preventing Upper Genital Tract Pathology

  2014cited by this paper
• Lack of Long-Lasting Hydrosalpinx in A/J Mice Correlates with Rapid but Transient Chlamydial Ascension and Neutrophil Recruitment in the Oviduct following Intravaginal Inoculation with Chlamydia muridarum

  2014cited by this paper
• Complement Factor C5 but Not C3 Contributes Significantly to Hydrosalpinx Development in Mice Infected with Chlamydia muridarum

  2014cited by this paper
• Prevalence and characteristics of rectal chlamydia and gonorrhea cases among men who have sex with men after the introduction of nucleic acid amplification test screening at 2 Canadian sexually transmitted infection clinics.

  2014cited by this paper
• OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection

  2013cited by this paper
• Transformation of Chlamydia muridarum Reveals a Role for Pgp5 in Suppression of Plasmid-Dependent Gene Expression

  2013influential reference
• Oviduct Infection and Hydrosalpinx in DBA1/j Mice Is Induced by Intracervical but Not Intravaginal Inoculation with Chlamydia muridarum

  2013cited by this paper
• B Cells Enhance Antigen-Specific CD4 T Cell Priming and Prevent Bacteria Dissemination following Chlamydia muridarum Genital Tract Infection

  2013cited by this paper
• Chlamydia trachomatis Plasmid-Encoded Pgp4 Is a Transcriptional Regulator of Virulence-Associated Genes

  2013cited by this paper
• Induction of protective immunity against Chlamydia muridarum intravaginal infection with the chlamydial immunodominant antigen macrophage infectivity potentiator.

  2013cited by this paper
• Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3*

  2013cited by this paper
• Characterization of Chlamydia trachomatis Plasmid-Encoded Open Reading Frames

  2013cited by this paper
• Reduced Live Organism Recovery and Lack of Hydrosalpinx in Mice Infected with Plasmid-Free Chlamydia muridarum

  2013influential reference
• Differential Susceptibilities to Azithromycin Treatment of Chlamydial Infection in the Gastrointestinal Tract and Cervix

  2013cited by this paper
• Guide for the Care and Use of Laboratory Animals (8th edn)

  2012cited by this paper
• Chlamydia trachomatis Antigens Recognized in Women With Tubal Factor Infertility, Normal Fertility, and Acute Infection

  2012cited by this paper
• Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility.

  2011cited by this paper
• Tumor Necrosis Factor Alpha Production from CD8+ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection

  2011cited by this paper
• Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.

  2010cited by this paper
• Characterization of Pgp3, a Chlamydia trachomatis Plasmid-Encoded Immunodominant Antigen

  2010cited by this paper
• Mice Deficient in MyD88 Develop a Th2-Dominant Response and Severe Pathology in the Upper Genital Tract following Chlamydia muridarum Infection

  2010cited by this paper
• Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.

  2010cited by this paper
• Chlamydia vaccine candidates and tools for chlamydial antigen discovery

  2009cited by this paper
• Distinct Roles of CD28- and CD40 Ligand-Mediated Costimulation in the Development of Protective Immunity and Pathology during Chlamydia muridarum Urogenital Infection in Mice

  2009cited by this paper
• The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells

  2008cited by this paper
• Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner

  2008cited by this paper
• Glycogen and Maltose Utilization by Escherichia coli O157:H7 in the Mouse Intestine

  2008cited by this paper
• Caspase-1 Contributes to Chlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection

  2007cited by this paper
• Plasmid-Deficient Chlamydia muridarum Fail to Induce Immune Pathology and Protect against Oviduct Disease1

  2007influential reference
• Histopathologic Changes Related to Fibrotic Oviduct Occlusion After Genital Tract Infection of Mice With Chlamydia muridarum

  2005cited by this paper
• Tryptophan recycling is responsible for the interferon‐γ resistance of Chlamydia psittaci GPIC in indoleamine dioxygenase‐expressing host cells

  2004cited by this paper
• Regulation of tryptophan synthase gene expression in Chlamydia trachomatis

  2003cited by this paper
• Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.

  2003cited by this paper
• Molecular Basis Defining Human Chlamydia trachomatis Tissue Tropism

  2002cited by this paper
• Immunity to Murine Chlamydial Genital Infection

  2002cited by this paper
• Vaccines for Chlamydia trachomatis infections.

  2002cited by this paper
• Identification of a Chlamydial Protease–Like Activity Factor Responsible for the Degradation of Host Transcription Factors

  2001cited by this paper
• Inflammation and Clearance of Chlamydia trachomatis in Enteric and Nonenteric Mucosae

  2001cited by this paper
• Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.

  2000cited by this paper
• Chlamydial Colonization of Multiple Mucosae following Infection by Any Mucosal Route

  1999influential reference
• Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection.

  1998cited by this paper
• Inhibition of Apoptosis in Chlamydia-infected Cells: Blockade of Mitochondrial Cytochrome c Release and Caspase Activation

  1998cited by this paper
• Plasmid diversity in Chlamydia.

  1997cited by this paper
• Characterization of a new isolate of Chlamydia trachomatis which lacks the common plasmid and has properties of biovar trachoma

  1997cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Intravaginal inoculation of mice with the Chlamydia trachomatis mouse pneumonitis biovar results in infertility

  1994cited by this paper
• The 7.5-kb plasmid present in Chlamydia trachomatis is not essential for the growth of this microorganism.

  1990cited by this paper

• Intestinal IL-22RA1 signaling regulates Chlamydia deficient in plasmid-encoded pGP3 spreading to large intestine

  2025cites this paper
• Isolation and characterization of a Chlamydia muridarum tc0237 mutant from a genetic screen that is attenuated in epithelial cells

  2025cites this paper
• Study Models for Chlamydia trachomatis Infection of the Female Reproductive Tract

  2025cites this paper
• Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique β-hairpin necessary for iteron-binding and plasmid replication

  2024cites this paper
• Plasmid-mediated virulence in Chlamydia

  2023cites this paper
• Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4+ T cells

  2023influential citation
• Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

  2023cites this paper
• Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation.

  2023cites this paper
• Chlamydia Deficient in Plasmid-Encoded Glycoprotein 3 (pGP3) as an Attenuated Live Oral Vaccine

  2022cites this paper
• Chitosan particle stabilized Pickering emulsion/interleukin-12 adjuvant system for Pgp3 subunit vaccine elicits immune protection against genital chlamydial infection in mice

  2022cites this paper
• Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

  2022influential citation
• Regulation of chlamydial colonization by IFNγ delivered via distinct cells.

  2022cites this paper
• Characterization of Chlamydia muridarum TC0668 Protein: Localization, Expression, and Inflammation-Inducing Effects on Host Cell

  2022cites this paper
• Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond

  2022cites this paper
• Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo

  2022cites this paper
• Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor

  2022cites this paper
• A Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol

  2021cites this paper
• Regulation of Chlamydia spreading from the small intestine to the large intestine via an immunological barrier

  2021cites this paper
• Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization.

  2021cites this paper
• The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.

  2021cites this paper
• Gastrointestinal Chlamydia-Induced CD8+ T Cells Promote Chlamydial Pathogenicity in the Female Upper Genital Tract

  2021cites this paper
• Characterization of Pathogenic CD8+ T cells in Chlamydia-Infected OT1 Mice

  2021cites this paper
• Completing the Genome Sequence of Chlamydia pecorum Strains MC/MarsBar and DBDeUG: New Insights into This Enigmatic Koala (Phascolarctos cinereus) Pathogen

  2021cites this paper
• Gastrointestinal Coinfection Promotes Chlamydial Pathogenicity in the Genital Tract

  2020cites this paper
• Chlamydia Deficient in Plasmid-Encoded pGP3 Is Prevented from Spreading to Large Intestine

  2020cites this paper
• The Nature and Extent of Plasmid Variation in Chlamydia trachomatis

  2020cites this paper
• A Genital Infection-Attenuated Chlamydia muridarum Mutant Infects the Gastrointestinal Tract and Protects against Genital Tract Challenge

  2020cites this paper
• Adoptive Transfer of Group 3-Like Innate Lymphoid Cells Restores Mouse Colon Resistance to Colonization of a Gamma Interferon-Susceptible Chlamydia muridarum Mutant

  2020cites this paper
• Chlamydia psittaci Plasmid-Encoded CPSIT_P7 Elicits Inflammatory Response in Human Monocytes via TLR4/Mal/MyD88/NF-κB Signaling Pathway

  2020cites this paper
• Effects of Immunomodulatory Drug Fingolimod (FTY720) on Chlamydia Dissemination and Pathogenesis

  2020cites this paper
• GlgA plays an important role in the induction of hydrosalpinx by chlamydia muridarum.

  2020cites this paper
• Evaluation of a tandem Chlamydia psittaci Pgp3 multiepitope peptide vaccine against a pulmonary chlamydial challenge in mice.

  2020cites this paper
• Distinct Roles of Chromosome- versus Plasmid-Encoded Genital Tract Virulence Factors in Promoting Chlamydia muridarum Colonization in the Gastrointestinal Tract

  2019cites this paper
• The Plasmid-Encoded pGP3 Promotes Chlamydia Evasion of Acidic Barriers in Both Stomach and Vagina

  2019influential citation
• The Cryptic Plasmid Improves Chlamydia Fitness in Different Regions of the Gastrointestinal Tract

  2019cites this paper
• Chlamydia muridarum Genital and Gastrointestinal Infection Tropism Is Mediated by Distinct Chromosomal Factors

  2018cites this paper
• Chlamydia Spreading from the Genital to Gastrointestinal Tracts —A Two-Hit Hypothesis

  2018cites this paper
• PGP3 is a Chlamydial Plasmid-Encoded Virulence Factor

  2018cites this paper
• Oral Chlamydia vaccination induces transmucosal protection in the airway.

  2018cites this paper
• The Role of Chlamydial Colonization of the Gastrointestinal Tract in the Development and Persistence of Chronic Chlamydial Infections

  2018cites this paper
• Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.

  2017cites this paper