Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biochemistry

• Publication date

  2005-05-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI0501479PMID 15909983PMCID PMC2895725
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity.

  2005cited by this paper
• Bacterial chemosensing: cooperative molecular logic.

  2004cited by this paper
• Targeting of the chemotaxis methylesterase/deamidase CheB to the polar receptor–kinase cluster in an Escherichia coli cell

  2004cited by this paper
• Diversity in Chemotaxis Mechanisms among the Bacteria and Archaea

  2004cited by this paper
• Crosslinking snapshots of bacterial chemoreceptor squads

  2004cited by this paper
• Functional interactions between receptors in bacterial chemotaxis

  2004cited by this paper
• Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor.

  2004cited by this paper
• Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model.

  2003cited by this paper
• Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation.

  2003cited by this paper
• Bacterial chemotaxis.

  2003cited by this paper
• Electron Microscopic Analysis of Membrane Assemblies Formed by the Bacterial Chemotaxis Receptor Tsr

  2003cited by this paper
• Collaborative signaling by mixed chemoreceptor teams in Escherichia coli

  2002cited by this paper
• Molecular Information Processing: Lessons from Bacterial Chemotaxis*

  2002cited by this paper
• Dynamic and clustering model of bacterial chemotaxis receptors: Structural basis for signaling and high sensitivity

  2002cited by this paper
• Cooperativity between bacterial chemotaxis receptors

  2002cited by this paper
• Polarity in Action: Asymmetric Protein Localization in Bacteria

  2001cited by this paper
• Receptor sensitivity in bacterial chemotaxis

  2001cited by this paper
• Hydrogen Exchange Reveals a Stable and Expandable Core within the Aspartate Receptor Cytoplasmic Domain*

  2001cited by this paper
• Transmembrane signaling in bacterial chemoreceptors.

  2001cited by this paper
• Two-state allosteric behavior in a single-domain signaling protein.

  2001cited by this paper
• Structure of a conserved receptor domain that regulates kinase activity: the cytoplasmic domain of bacterial taxis receptors.

  2000cited by this paper
• Covalent modification regulates ligand binding to receptor complexes in the chemosensory system of Escherichia coli.

  2000cited by this paper
• Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state.

  2000cited by this paper
• The aspartate receptor cytoplasmic domain: in situ chemical analysis of structure, mechanism and dynamics.

  1999cited by this paper
• Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies.

  1999cited by this paper
• Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor

  1999influential reference
• Bacterial tactic responses.

  1999cited by this paper
• Detection of a Conserved α-Helix in the Kinase-docking Region of the Aspartate Receptor by Cysteine and Disulfide Scanning*

  1998cited by this paper
• Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor.

  1998cited by this paper
• The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes.

  1997cited by this paper
• Cysteine and Disulfide Scanning Reveals a Regulatory α-Helix in the Cytoplasmic Domain of the Aspartate Receptor*

  1997cited by this paper
• The cytoplasmic fragment of the aspartate receptor displays globally dynamic behavior.

  1996cited by this paper
• Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand.

  1995cited by this paper
• How bacteria sense and swim.

  1995cited by this paper
• Role of glycine residues in the structure and function of lactose permease, an Escherichia coli membrane transport protein.

  1995cited by this paper
• Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface.

  1995cited by this paper
• Deducing the organization of a transmembrane domain by disulfide cross-linking. The bacterial chemoreceptor Trg.

  1994cited by this paper
• Polar location of the chemoreceptor complex in the Escherichia coli cell.

  1993cited by this paper
• Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor.

  1992cited by this paper
• Efficient site-directed mutagenesis using uracil-containing DNA.

  1991cited by this paper
• Reconstitution of the bacterial chemotaxis signal transduction system from purified components.

  1991cited by this paper
• Transmembrane signal transduction in bacterial chemotaxis involves ligand-dependent activation of phosphate group transfer.

  1989cited by this paper
• Chemotaxis in Bacteria

  1966cited by this paper

• A chemoreceptor conformational equilibrium controlled by signaling inputs

  2025cites this paper
• Bacterial chemoreceptors transmit stimulus signals through coupled entropic switches.

  2025cites this paper
• Rational engineering unlocks the therapeutic potential of WHP1: A revolutionary peptide poised to advance wound healing

  2025cites this paper
• The Structural Logic of Dynamic Signaling in the Escherichia coli Serine Chemoreceptor

  2024cites this paper
• The structural logic of dynamic signaling in the Escherichia coli serine chemoreceptor

  2024cites this paper
• Genome-wide analysis of the Cannabis sativa cytochrome P450 monooxygenase superfamily and uncovering candidate genes for improved herbicide tolerance

  2024cites this paper
• Vibrio cholerae’s mysterious Seventh Pandemic island (VSP-II) encodes novel Zur-regulated zinc starvation genes involved in chemotaxis and cell congregation

  2021influential citation
• Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts

  2020cites this paper
• Regulation of the chemotaxis histidine kinase CheA: A structural perspective.

  2020cites this paper
• Complete structure of the chemosensory array core signalling unit in an E. coli minicell strain

  2020cites this paper
• Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli

  2019cites this paper
• In Situ Conformational Changes of the Escherichia coli Serine Chemoreceptor in Different Signaling States

  2019cites this paper
• Spatial Restrictions in Chemotaxis Signaling Arrays: A Role for Chemoreceptor Flexible Hinges across Bacterial Diversity

  2019cites this paper
• Interdimer “zipping” in the chemoreceptor signaling domain revealed by molecular dynamics simulations

  2019cites this paper
• Substrate Binding and Energy Transduction in a Multidrug Resistance ABC Transporter DrrAB

  2018influential citation
• A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling

  2018cites this paper
• A Novel Link Between the Chemotaxis and Biofilm Dispersion Systems of Pseudomonas Aeruginosa

  2017cites this paper
• Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea

  2017cites this paper
• Signaling Consequences of Structural Lesions that Alter the Stability of Chemoreceptor Trimers of Dimers.

  2017cites this paper
• Mutational Replacements at the "Glycine Hinge" of the Escherichia coli Chemoreceptor Tsr Support a Signaling Role for the C-Helix Residue.

  2017cites this paper
• Flexible Hinges in Bacterial Chemoreceptors

  2017influential citation
• Origins of chemoreceptor curvature sorting in Escherichia coli

  2017cites this paper
• Mechanism of transmembrane signaling by sensor histidine kinases

  2017cites this paper
• Evolutionary Genomics Suggests That CheV Is an Additional Adaptor for Accommodating Specific Chemoreceptors within the Chemotaxis Signaling Complex

  2016cites this paper
• Bacterial Chemoreceptor Dynamics: Helical Stability in the Cytoplasmic Domain Varies with Functional Segment and Adaptational Modification.

  2016cites this paper
• Signaling and Adaptation Modulate the Dynamics of the Photosensoric Complex of Natronomonas pharaonis

  2015cites this paper
• Characterization of a novel domain 'GATE' in the ABC protein DrrA and its role in drug efflux by the DrrAB complex.

  2015cites this paper
• Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.

  2015cites this paper
• Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances

  2015cites this paper
• Both piston-like and rotational motions are present in bacterial chemoreceptor signaling

  2015cites this paper
• A Trigger Residue for Transmembrane Signaling in the Escherichia coli Serine Chemoreceptor

  2015cites this paper
• DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex’s Dynamics

  2015cites this paper
• Differential backbone dynamics of companion helices in the extended helical coiled‐coil domain of a bacterial chemoreceptor

  2015cites this paper
• Bacterial chemoreceptors and chemoeffectors

  2014cites this paper
• Bacterial chemoreceptors of different length classes signal independently

  2014cites this paper
• Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges.

  2014cites this paper
• Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor.

  2014cites this paper
• Conformational Coupling between Receptor and Kinase Binding Sites through a Conserved Salt Bridge in a Signaling Complex Scaffold Protein

  2013cites this paper
• Excitation and Adaptation in Bacteria–a Model Signal Transduction System that Controls Taxis and Spatial Pattern Formation

  2013cites this paper
• A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors

  2013cites this paper
• Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the TarEc chemoreceptor.

  2013cites this paper
• Mechanistic Studies Of Drug Resistance Conferred By An ABC Transporter DrrAB

  2013cites this paper
• Application of Computational Molecular Biophysics to Problems in Bacterial Chemotaxis

  2013influential citation
• Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36)

  2012cites this paper
• Mechanism of Bacterial Signal Transduction Revealed by Molecular Dynamics of Tsr Dimers and Trimers of Dimers in Lipid Vesicles

  2012cites this paper
• Vertebrate scavenger receptor class B member 2 (SCARB2): comparative studies of a major lysosomal membrane glycoprotein

  2012cites this paper
• Comparative studies of vertebrate scavenger receptor class B type 1: a high-density lipoprotein binding protein

  2012cites this paper
• Functional and structural effects of seven‐residue deletions on the coiled‐coil cytoplasmic domain of a chemoreceptor

  2012cites this paper
• Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins

  2012cites this paper
• Molecular architecture of chemoreceptor arrays revealed by cryoelectron tomography of Escherichia coli minicells

  2012cites this paper
• Biphasic control logic of HAMP domain signalling in the Escherichia coli serine chemoreceptor

  2011cites this paper
• A possible degree of motional freedom in bacterial chemoreceptor cytoplasmic domains and its potential role in signal transduction.

  2011cites this paper
• Functional and structural effects of seven-residue deletions on the coiled-coil cytoplasmic domain of a chemoreceptormmi

  2011cites this paper
• Signaling Mechanisms of HAMP Domains in Chemoreceptors

  2010cites this paper
• Chapter 11. Transmembrane Signaling

  2010cites this paper
• Signaling mechanisms of HAMP domains in chemoreceptors and sensor kinases.

  2010cites this paper
• Bacterial chemoreceptors: providing enhanced features to two-component signaling.

  2010cites this paper
• The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals.

  2009cites this paper
• Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor.

  2009cites this paper
• Bacterial chemoreceptors: high-performance signaling in networked arrays.

  2008influential citation
• Role of HAMP domains in chemotaxis signaling by bacterial chemoreceptors

  2008cites this paper
• Bacterial Signaling and Motility: Sure Bets

  2008cites this paper
• Different Signaling Roles of Two Conserved Residues in the Cytoplasmic Hairpin Tip of Tsr, the Escherichia coli Serine Chemoreceptor

  2008cites this paper
• Structure-Function Relationships in the HAMP and Proximal Signaling Domains of the Aerotaxis Receptor Aer

  2008cites this paper
• MEETING REVIEW Bacterial Signaling and Motility: Sure Bets

  2008cites this paper
• Aer on the inside looking out: paradigm for a PAS–HAMP role in sensing oxygen, redox and energy

  2007cites this paper
• Structural assessment of glycyl mutations in invariantly conserved motifs

  2007cites this paper
• Phenotypic suppression methods for analyzing intra- and inter-molecular signaling interactions of chemoreceptors.

  2007cites this paper
• Evolutionary genomics reveals conserved structural determinants of signaling and adaptation in microbial chemoreceptors

  2007cites this paper
• Ancient chemoreceptors retain their flexibility

  2007cites this paper
• Reconstruction of the chemotaxis receptor–kinase assembly

  2006cites this paper
• Differential Recognition of Citrate and a Metal-Citrate Complex by the Bacterial Chemoreceptor Tcp*

  2006cites this paper
• CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites.

  2006cites this paper