Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in Rats

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Pharmaceutical Research

• Publication date

  1991-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1023/A:1015896405389PMID 1866372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intranasal estradiol administration to oophorectomized women.

  1991cited by this paper
• Effects of Absorption Enhancers on Human Nasal Tissue Ciliary Movement in Vitro

  1990cited by this paper
• Nasal absorption of 17-beta-estradiol and progesterone from a dimethyl-cyclodextrin inclusion formulation in rats

  1990cited by this paper
• Transport of peptide and protein drugs across biological membranes

  1990cited by this paper
• The Effects of Permeation Enhancers on the Surface Morphology of the Rat Nasal Mucosa: A Scanning Electron Microscopy Study

  1990cited by this paper
• Nasal Absorption Enhancement of 17β-Estradiol by Dimethyl-β-Cyclodextrin in Rabbits and Rats

  1990cited by this paper
• Nasal administration of insulin using bioadhesive microspheres as a delivery system

  1990cited by this paper
• Nasal absorption enhancement of 17 beta-estradiol by dimethyl-beta-cyclodextrin in rabbits and rats.

  1990cited by this paper
• Differential effects of α‐, β‐ and γ‐cyclodextrins on human erythrocytes

  1989cited by this paper
• Absorption Enhancement of Intranasally Administered Insulin by Sodium Taurodihydrofusidate (STDHF) in Rabbits and Rats

  1989cited by this paper
• Enhanced nasal absorption of insulin in rats using lysophosphatidylcholine

  1989cited by this paper
• Nasal systemic drug delivery

  1989cited by this paper
• Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes.

  1989cited by this paper
• Degradable starch microspheres as a nasal delivery system for insulin

  1988cited by this paper
• Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins

  1988cited by this paper
• Cyclodextrins in drug carrier systems.

  1987cited by this paper
• The Influence of Drugs on Nasal Ciliary Movement

  1987cited by this paper
• Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats.

  1987cited by this paper
• Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep.

  1987cited by this paper
• The Oral Bioavailability of Peptides and Related Drugs

  1986cited by this paper
• Bile salts and intranasal drug absorption

  1986cited by this paper
• Nasal absorption of insulin: enhancement by hydrophobic bile salts.

  1985cited by this paper
• Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.

  1982cited by this paper
• Effect of surfactants on the nasal absorption of insulin in rats

  1981cited by this paper
• The influence of the pH and osmotic pressure upon tracheal ciliary beat frequency as determined with a new photo-electric registration device.

  1980cited by this paper

• Intranasal delivery of insulin: An update on status quo and challenges for diabetes treatment.

  2025cites this paper
• Polysaccharides: New Frontiers for Nasal Administration of Medicines

  2025cites this paper
• Recent advances in intranasal delivery of therapeutic peptides

  2024cites this paper
• Chronicle updates in cyclodextrin-based carriers for drug delivery

  2022cites this paper
• Brain targeted intranasal in-situ gelling spray of paroxetine: Formulation, characterization and in-vivo evaluation"

  2021cites this paper
• Polymers in Nasal Drug Delivery: An Overview

  2021cites this paper
• Hydrogels in Emerging Technologies for Type 1 Diabetes.

  2020cites this paper
• CYKLODEKSTRYNY — ZASTOSOWANIE W PRZEMYŚLE FARMACEUTYCZNYM

  2020cites this paper
• Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management

  2020cites this paper
• Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery

  2020cites this paper
• Improving hypoglycemic effect of insulin via the nasal administration of deep eutectic solvents.

  2019cites this paper
• Nanoparticulate drug delivery systems for the oral administration of macromolecular drugs

  2019cites this paper
• Cyclodextrin-enabled Insulin Delivery

  2018cites this paper
• Cyclodextrins: structure, physicochemical properties and pharmaceutical applications.

  2018cites this paper
• Overview of intranasally delivered peptides: key considerations for pharmaceutical development

  2018cites this paper
• Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity

  2018cites this paper
• Chemical modification of drug molecules as strategy to reduce interactions with mucus☆

  2017cites this paper
• Nasal-nanotechnology: revolution for efficient therapeutics delivery

  2016cites this paper
• Cytotoxicity of Different Excipients on RPMI 2650 Human Nasal Epithelial Cells

  2016cites this paper
• Aqueous Nasal Dosage Forms

  2016cites this paper
• Multifunctional Delivery Systems for Advanced oral Uptake of Peptide/Protein Drugs.

  2015cites this paper
• Pharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers

  2015cites this paper
• Emerging micro- and nanotechnology based synthetic approaches for insulin delivery.

  2014cites this paper
• Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines.

  2014cites this paper
• Absorption Enhancing Excipients in Systemic Nasal Drug Delivery

  2014cites this paper
• Strategie formulative per la veicolazione nasale di farmaci

  2014cites this paper
• Colloidal carriers for noninvasive delivery of insulin

  2014cites this paper
• Absorption enhancing excipients in systemic nasal drug delivery.

  2014cites this paper
• EFFECT OF ADDITIVES ON INTRANASAL PREPARATION OF CYANOCOBALAMIN

  2014cites this paper
• An updated review of cyclodextrins -an enabling technology for challenging pharmaceutical formulations

  2013cites this paper
• Nasal Drug Delivery of a Mucoadhesive Oxybutynin Chloride Gel: In Vitro Evaluation and In Vivo in Situ Study in Experimental Rats

  2013cites this paper
• CriticalSorb: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15.

  2012cites this paper
• NASAL CAVITY, A PROMISING TRANSMUCOSAL PLATFORM FOR DRUG DELIVERY AND RESEARCH APPROACHES FROM NASAL TO BRAIN TARGETTING

  2012cites this paper
• Nasal drug delivery–a review

  2012cites this paper
• MULTIFUNCTIONAL NANOCARRIERS ENCAPSULATING ANTI-ALZHEIMER DRUG FOR NASAL DELIVERY TO CENTRAL NERVOUS SYSTEM

  2012cites this paper
• Solubilizing agents in nasal formulations and their effect on ciliary beat frequency.

  2012cites this paper
• Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases

  2012cites this paper
• Solubilized nasal steroid (CDX-947) when combined in the same solution nasal spray with an antihistamine (CDX-313) provides improved, fast-acting symptom relief in patients with allergic rhinitis.

  2011cites this paper
• Cyclodextrin‐Enhanced Drug Delivery through Mucous Membranes

  2011cites this paper
• β-Cyclodextrin grafting hyperbranched polyglycerols as carriers for nasal insulin delivery

  2011cites this paper
• Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine: Current and Future Industrial Applications

  2011influential citation
• New strategies to improve the intranasal absorption of insulin.

  2010cites this paper
• Rat nasal lavage biomarkers to assess preclinical irritation potential of nasal drug formulations and excipients.

  2009cites this paper
• Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery.

  2009cites this paper
• A spectroscopic investigation into the interaction between bile salts and insulin in alkaline aqueous solution.

  2009cites this paper
• Chitosan bearing pendant cyclodextrin as a carrier for controlled protein release

  2009cites this paper
• Cyclodextrins as Drug Carrier Molecule: A Review

  2008cites this paper
• DEVELOPMENT AND EVALUATION OF LIPOSOMAL MUCOADHESIVE GEL FOR NASAL DELIVERY OF ACYCLOVIR

  2008cites this paper
• Chapter 40 – Improvement of Drug Properties by Cyclodextrins

  2008cites this paper
• Targeted drug delivery to bone: pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs.

  2008cites this paper
• Improvement of transmucosal absorption of protein and peptide drugs by cyciodextrins

  2008cites this paper
• Effect of dimethyl-beta-cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats.

  2008cites this paper
• Formulation and evaluation of ondansetron nasal delivery systems.

  2008cites this paper
• Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: single versus multiple exposure.

  2007cites this paper
• In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo.

  2007cites this paper
• Intranasal delivery: physicochemical and therapeutic aspects.

  2007cites this paper
• Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system.

  2007cites this paper
• Nanomaterials and nanosystems for biomedical applications

  2007cites this paper
• Nasal Drug Delivery System-Factors Affecting and Applications

  2007cites this paper
• Alternative Applications for Drug Delivery: Nasal and Pulmonary Routes

  2007cites this paper
• Isolation, characterization and study of enhancing effects on nasal absorption of insulin in rat of the total saponin from Acanthophyllum squarrosum.

  2006cites this paper
• Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery.

  2006cites this paper
• Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol.

  2006cites this paper
• Low molecular weight quaternised chitosan (11): in vitro assessment of absorption enhancing properties.

  2006cites this paper
• Nasal Delivery of Insulin Using Bioadhesive Chitosan Gels

  2006cites this paper
• In vitro evaluation of thiomer microparticles for nasal drug delivery

  2006cites this paper
• Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)

  2006influential citation
• 20 Nasal Delivery of Peptide Drugs

  2006cites this paper
• Cyclodextrins in drug delivery

  2005cites this paper
• Application of sterylglucoside-containing particles for drug delivery.

  2005cites this paper
• Preparation of prostaglandin E1-hydroxypropyl-beta-cyclodextrin complex and its nasal delivery in rats.

  2005cites this paper
• Optimisation and validation of an alternative mucosal irritation test

  2005cites this paper
• Advanced approaches in insulin delivery.

  2005cites this paper
• Behavior of (cid:1) -, (cid:2) -, and (cid:3) -Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier

  2004cites this paper
• Nasal route and drug delivery systems

  2004cites this paper
• Preparation and characterization of starch/cyclodextrin bioadhesive microspheres as platform for nasal administration of Gabexate Mesylate (Foy) in allergic rhinitis treatment.

  2004cites this paper
• Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier

  2004cites this paper
• Pulmonary absorption of insulin mediated by tetradecyl-beta-maltoside and dimethyl-beta-cyclodextrin.

  2003cites this paper
• Innovations in oligonucleotide drug delivery

  2003cites this paper
• A cyclosporin A/maltosyl-alpha-cyclodextrin complex for inhalation therapy of asthma.

  2003cites this paper
• Pulmonary Absorption of Insulin Mediated by Tetradecyl-β-Maltoside and Dimethyl-β-Cyclodextrin

  2003cites this paper
• Structural background of cyclodextrin-protein interactions.

  2003cites this paper
• Safety-assessment of 3-methoxyquercetin as an antirhinoviral compound for nasal application: effect on ciliary beat frequency.

  2003cites this paper
• Absorption Enhancers for Nasal Drug Delivery

  2003cites this paper
• The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres.

  2003cites this paper
• The Effect of Cyclodextrins on the In Vitro and In Vivo Properties of Insulin‐Loaded Poly (D,L‐Lactic‐Co‐Glycolic Acid) Microspheres

  2003cites this paper
• A cyclosporin A/maltosyl‐α‐cyclodextrin complex for inhalation therapy of asthma

  2003cites this paper
• THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRA-NASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS.

  2003cites this paper
• Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin.

  2003cites this paper
• Effect of excipients on the stability and transport of recombinant human epidermal growth factor (rhEGF) across CACO-2 cell monolayers

  2003cites this paper
• Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins.

  2003cites this paper
• Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation

  2002cites this paper
• The enhancing effect of nasal absorption of FITC-dextran 4,400 by β-sitosterol β-d-glucoside in rabbits

  2002cites this paper
• Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity.

  2002cites this paper
• The enhancing effect of nasal absorption of FITC-dextran 4,400 by beta-sitosterol beta-D-glucoside in rabbits.

  2002cites this paper
• The biopharmaceutical aspects of nasal mucoadhesive drug delivery

  2001cites this paper
• Cyclodextrins in oligonucleotide delivery.

  2001cites this paper
• Mutual Inhibition of the Insulin Absorption-Enhancing Properties of Dodecylmaltoside and Dimethyl-β-cyclodextrin Following Nasal Administration

  2001cites this paper
• Safety assessment of selected cyclodextrins - effect on ciliary activity using a human cell suspension culture model exhibiting in vitro ciliogenesis.

  2000cites this paper
• The enhancing effect of soybean-derived sterylglucoside and beta-sitosterol beta-D-glucoside on nasal absorption in rabbits.

  2000cites this paper