Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Science

• Publication date

  1999-02-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.283.5403.851PMID 9933170
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Using sea urchin gametes for the study of mitosis.

  1999cited by this paper
• Centrosome defects and genetic instability in malignant tumors.

  1998cited by this paper
• The Coordination of Centrosome Reproduction with Nuclear Events of the Cell Cycle in the Sea Urchin Zygote

  1998cited by this paper
• The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry.

  1997cited by this paper
• A role for cyclin E/Cdk2 in the timing of the midblastula transition in Xenopus embryos.

  1997cited by this paper
• Keeping the centrosome cycle on track. Genome stability.

  1996cited by this paper
• Abnormal Centrosome Amplification in the Absence of p53

  1996cited by this paper
• Cdk inhibitors in development and cancer.

  1996cited by this paper
• A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

  1996cited by this paper
• Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.

  1996cited by this paper
• Genome stability: Keeping the centrosome cycle on track

  1996cited by this paper
• Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

  1996cited by this paper
• Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.

  1995cited by this paper
• Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells

  1995cited by this paper
• Maternal Xenopus Cdk2-Cyclin E Complexes Function during Meiotic and Early Embryonic Cell Cycles That Lack a G1 Phase (*)

  1995cited by this paper
• Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes

  1994cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

  1992cited by this paper
• Centriole duplication in lysates of Spisula solidissima oocytes.

  1992cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

  1992cited by this paper
• Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome.

  1992cited by this paper
• Centrosomes competent for parthenogenesis in Xenopus eggs support procentriole budding in cell-free extracts.

  1991cited by this paper
• Cell cycle extracts.

  1991cited by this paper
• Chapter 30 Cell Cycle Extracts

  1991cited by this paper
• Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus.

  1990cited by this paper
• Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control

  1990cited by this paper
• Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin

  1988cited by this paper
• Relationship between nuclear DNA synthesis and centrosome reproduction in sea urchin eggs.

  1987cited by this paper
• Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.

  1986cited by this paper
• The reproduction of centrosomes: nuclear versus cytoplasmic controls

  1986cited by this paper
• Experimental separation of pronuclei in fertilized sea urchin eggs: chromosomes do not organize a spindle in the absence of centrosomes

  1985cited by this paper
• Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts

  1985cited by this paper
• Centriole number and the reproductive capacity of spindle poles

  1985cited by this paper
• Centrosomes and mitotic poles.

  1984cited by this paper
• Centriole cycle in Chinese hamster ovary cells as determined by whole- mount electron microscopy

  1981cited by this paper
• Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

  1978cited by this paper

• McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.

  2026cites this paper
• CEP72 Emerges as a Key Centriolar Satellite Protein in Health and Disease

  2025cites this paper
• Multimodal mechanisms of human centriole engagement and disengagement

  2025cites this paper
• Big1 is a cell cycle regulator linking cell size to basal body number

  2025cites this paper
• Balancing Plk1 activity levels: The secret of synchrony between the cell and the centrosome cycle

  2024cites this paper
• Dimethyl Sulfoxide Attenuates Ionizing Radiation-induced Centrosome Overduplication and Multipolar Cell Division in Human Induced Pluripotent Stem Cells

  2024cites this paper
• Amplified centrosomes—more than just a threat

  2024cites this paper
• Bystanders or active players: the role of extra centrosomes as signaling hubs

  2024cites this paper
• Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae

  2024cites this paper
• The Centrosomes of Haploid and Diploid Cells Have an Equal Number of Centrioles in the Parasitoid Wasp Anisopteromalus Calandrae.

  2024cites this paper
• Identification of SPRYD4 as a tumour suppressor predicts prognosis and correlates with immune infiltration in cholangiocarcinoma

  2023cites this paper
• CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells

  2023cites this paper
• Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble

  2023cites this paper
• Mitotic kinase oscillation governs the latching of cell cycle switches

  2022cites this paper
• Centriole growth is limited by the Cdk/Cyclin-dependent phosphorylation of Ana2/STIL

  2022cites this paper
• An updated view on the centrosome as a cell cycle regulator

  2022cites this paper
• McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation

  2022cites this paper
• Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells

  2022cites this paper
• DNA Replication proteins in primary microcephaly syndromes

  2022cites this paper
• Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL

  2022cites this paper
• The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number

  2021cites this paper
• Centriole is the pivot co‐ordinating dynamic signaling for cell proliferation and organization during early development in the vertebrates

  2021cites this paper
• The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis

  2021cites this paper
• The oscillation of mitotic kinase governs cell cycle latches

  2021cites this paper
• Cyclin E1 expression and malignancy in meningiomas.

  2020cites this paper
• Principal Postulates of Centrosomal Biology. Version 2020

  2020cites this paper
• The Molecular Interactome of the Centriole, Cell Cycle and Ciliary Proteins Modulates Cell Mass Growth and Structural Organization During Development in Metazoans

  2020cites this paper
• Analysis of the “centrosome-ome” identifies MCPH1 deletion as a cause of centrosome amplification in human cancer

  2020cites this paper
• Uncoupling of DNA Replication and Centrosome Duplication Cycles Is a Primary Cause of Haploid Instability in Mammalian Somatic Cells

  2020cites this paper
• Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma

  2020cites this paper
• Lawrence Berkeley National Laboratory Recent Work Title Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure Permalink

  2019cites this paper
• Mechanism and Regulation of Centriole and Cilium Biogenesis.

  2019cites this paper
• SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL

  2019cites this paper
• It Takes Two (Centrioles) to Tango.

  2019cites this paper
• Molecular crosstalk between cancer and neurodegenerative diseases

  2019cites this paper
• SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma

  2019cites this paper
• Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure.

  2019cites this paper
• 14-3-3γ prevents centrosome duplication by inhibiting NPM1 function

  2019influential citation
• On the Origin of Space

  2018cites this paper
• Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

  2018cites this paper
• Cyclin-dependent kinase control of motile ciliogenesis

  2018cites this paper
• Non‐Cell Cycle Functions of the CDK Network in Ciliogenesis: Recycling the Cell Cycle Oscillator

  2018cites this paper
• Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies.

  2018cites this paper
• The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

  2018cites this paper
• Building the right centriole for each cell type

  2018cites this paper
• Building the right centriole for each cell type

  2018cites this paper
• Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ

  2018cites this paper
• The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma

  2018cites this paper
• Building the right centriole for each cell type

  2018cites this paper
• Structural insights into the functional diversity of the CDK–cyclin family

  2018cites this paper
• Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis

  2018cites this paper
• DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

  2017cites this paper
• Cyclin E Deregulation and Genomic Instability.

  2017cites this paper
• Protéine HBx du virus de l'hépatite B : impacts sur la polyploïdisation hépatique au cours du développement et de la maladie du foie

  2017cites this paper
• Probing the biology of cell boundary conditions through confinement of Xenopus cell‐free cytoplasmic extracts

  2017cites this paper
• Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer.

  2017influential citation
• The Zebrafish curly fry Is Required for Proper Centrosome and Mitotic Spindle Assembly

  2017cites this paper
• 7 Centrosome Abnormality and Human Lung Cancer

  2017cites this paper
• Opposing Post-Translational Modifications Regulate Cep76 Function to Suppress Centriole Amplification

  2016cites this paper
• Casein Kinase II is Required for Proper Cell Division and Acts as a Negative Regulator of Centrosome Duplication in C. elegans Embryos

  2016cites this paper
• Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos

  2016cites this paper
• Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing

  2016cites this paper
• Centriole amplification in brain multiciliated cells : high resolution spatiotemporal dynamics and identification of regulatory mechanisms

  2016cites this paper
• Regulation of centriolar satellite integrity and its physiology

  2016cites this paper
• Centrosomal clustering contributes to chromosomal instability and cancer.

  2016cites this paper
• Centrosome cohesion: functions of C-NAP1

  2016cites this paper
• CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis.

  2016cites this paper
• Neue Aspekte im diffizilen Zusammenspiel der SMC-Ringkomplexe Cohesin und Condensin mit Komponenten der DNA-Replikationsmaschinerie

  2016cites this paper
• Structural investigations into functional aspects of the centriolar key proteins CEP135/Bld10p and SAS-6/Bld12p

  2016cites this paper
• The Characterization of the Novel Chloroquine Derivative VR23 for its Anticancer Properties

  2015cites this paper
• eview ripolar mitosis in human cells and embryos : Occurrence , athophysiology and medical implications

  2015cites this paper
• Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

  2015influential citation
• Causes of Chromosomal Instability.

  2015cites this paper
• Association of genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 with the risk of endometrial carcinoma and clinicopathological parameters among Chinese Han women.

  2015cites this paper
• Ubiquitin, the centrosome, and chromosome segregation

  2015cites this paper
• Virotherapy targeting cyclin E overexpression in tumors with adenovirus-enhanced cancer-selective promoter

  2015cites this paper
• Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.

  2015cites this paper
• Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B

  2015cites this paper
• Apicomplexan cell cycle flexibility: centrosome controls the clutch.

  2015cites this paper
• VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification.

  2015cites this paper
• Centrosomes and cancer: revisiting a long-standing relationship

  2015cites this paper
• Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint

  2015cites this paper
• The centrosome and its duplication cycle.

  2015cites this paper
• VR 23 : A Quinoline – Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E – Mediated Centrosome Ampli fi cation

  2015cites this paper
• The centrosome: a prospective entrant in cancer therapy

  2015cites this paper
• Tripolar mitosis in human cells and embryos: occurrence, pathophysiology and medical implications.

  2015cites this paper
• Centrobin-mediated Regulation of the Centrosomal Protein 4.1-associated Protein (CPAP) Level Limits Centriole Length during Elongation Stage*

  2015cites this paper
• Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification

  2015cites this paper
• Understanding the molecular basis of RAS-association domain family member 7 (RASSF7) function

  2015cites this paper
• Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice

  2015cites this paper
• Impact des contraintes mécaniques sur la division cellulaire : analyse dans modèle tumoral multicellulaire en 3 dimensions : le sphéroïde

  2014cites this paper
• Centrosomes and the art of mitotic spindle maintenance.

  2014cites this paper
• Centrobin-Centrosomal Protein 4.1-associated Protein (CPAP) Interaction Promotes CPAP Localization to the Centrioles during Centriole Duplication*

  2014cites this paper
• Phosphoregulation of Sfi1 is Required for Yeast Centrosome Duplication and Separation

  2014cites this paper
• The Potential Role of As-sumo-1 in the Embryonic Diapause Process and Early Embryo Development of Artemia sinica

  2014cites this paper
• The centriole duplication cycle

  2014cites this paper
• Gene delivery of cyclin-dependent kinase inhibitors p21Waf1 and p27Kip1 suppresses proliferation of MCF-7 breast cancer cells in vitro

  2014cites this paper
• Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations

  2014cites this paper
• Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model

  2013cites this paper
• RhoD participates in the regulation of cell-cycle progression and centrosome duplication

  2013cites this paper