Elucidation of estrogen receptor function in bone with the use of mouse models.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Trends in endocrinology and metabolism

• Publication date

  2002-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1043-2760(02)00594-5PMID 12185665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males.

  2002cited by this paper
• Two Different Pathways for the Maintenance of Trabecular Bone in Adult Male Mice

  2002cited by this paper
• Gene Expression in Human Primary Osteoblasts : Evidence for the Expression of Two Receptor Proteins

  2001cited by this paper
• [Osteoporosis among the elderly is a "silent epidemics". Insufficient prophylaxis and underdiagnosing are big problems].

  2001cited by this paper
• Mechanisms of estrogen action.

  2001cited by this paper
• Female Estrogen Receptor β−/− Mice Are Partially Protected Against Age‐Related Trabecular Bone Loss

  2001cited by this paper
• Estrogen receptor specificity in the regulation of the skeleton in female mice.

  2001cited by this paper
• Increased adipose tissue in male and female estrogen receptor-α knockout mice

  2000cited by this paper
• Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.

  2000cited by this paper
• Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

  2000cited by this paper
• Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.

  2000cited by this paper
• Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.

  2000cited by this paper
• Steroid hormone receptor expression and action in bone.

  2000cited by this paper
• Bone Has a Sexually Dimorphic Response to Aromatase Deficiency

  2000cited by this paper
• Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1.

  2000cited by this paper
• Therapeutic approaches to bone diseases.

  2000cited by this paper
• Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes.

  2000cited by this paper
• Identification of a new isoform of the human estrogen receptor‐alpha (hER‐α) that is encoded by distinct transcripts and that is able to repress hER‐α activation function 1

  2000cited by this paper
• Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice.

  2000cited by this paper
• Disproportional Body Growth in Female Estrogen Receptor-α-Inactivated Mice

  1999cited by this paper
• Disproportional body growth in female estrogen receptor-alpha-inactivated mice.

  1999cited by this paper
• Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice.

  1999cited by this paper
• Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene.

  1998cited by this paper
• Generation and reproductive phenotypes of mice lacking estrogen receptor beta.

  1998cited by this paper
• Effect of testosterone and estradiol in a man with aromatase deficiency.

  1997cited by this paper
• Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.

  1995cited by this paper
• Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.

  1995cited by this paper
• Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.

  1994cited by this paper

• Calcitriol's role in fetal bone and mineral metabolism: evidence from human and animal studies.

  2025cites this paper
• Orthodontic treatment during pregnancy, lactation, and postmenopausal period: a questionnaire development

  2024cites this paper
• Follicle-stimulating hormone is associated with low bone mass in postmenopausal women

  2023cites this paper
• Bone mass and adaptation to mechanical loading are sexually dimorphic in adult osteoblast-specific ERα knockout mice.

  2022cites this paper
• Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

  2021cites this paper
• Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

  2021cites this paper
• Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

  2021cites this paper
• Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies

  2020cites this paper
• Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in mice

  2020cites this paper
• Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly

  2019cites this paper
• Ovarian Hormones and Bone

  2019cites this paper
• Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

  2019cites this paper
• Fetal Calcium Metabolism

  2018cites this paper
• A multi-factorial analysis of bone morphology and fracture strength of rat femur in response to ovariectomy

  2018cites this paper
• Fetal Control of Calcium and Phosphate Homeostasis

  2018cites this paper
• Bone and bone marrow disruption by endocrine‐active substances

  2018cites this paper
• Sex‐Dependent, Osteoblast Stage‐Specific Effects of Progesterone Receptor on Bone Acquisition

  2017cites this paper
• Estrogens in Male Physiology.

  2017cites this paper
• Transcriptomic analysis of cortical versus cancellous bone in response to mechanical loading and estrogen signaling

  2017cites this paper
• Estradiol activates chloride channels via estrogen receptor-α in the cell membranes of osteoblasts.

  2017cites this paper
• Chapter 127 – Estrogen and Progesterone Action

  2016cites this paper
• Estrogen receptors alpha and beta in bone.

  2016cites this paper
• The Role of Sex Steroids in the Effects of Immune System on Bone

  2016cites this paper
• Bone Physiology: Bone Cells, Modeling, and Remodeling

  2015cites this paper
• Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains.

  2014cites this paper
• Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.

  2014cites this paper
• Title Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains Permalink

  2014cites this paper
• Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones.

  2014cites this paper
• Endocrine Disruptors (Xenoestrogens): An Overview

  2014cites this paper
• Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model.

  2013cites this paper
• EVALUATION OF THE EFFECTS OF VITAMIN K ON GROWTH PERFORMANCE AND BONE HEALTH IN SWINE

  2013cites this paper
• The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.

  2013cites this paper
• Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling.

  2013cites this paper
• Meta‐analysis of genome‐wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

  2013cites this paper
• Fetal Control of Calcium and Phosphate Homeostasis - Lessons from Mouse Models

  2013cites this paper
• Nuclear receptors in bone physiology and diseases.

  2013cites this paper
• Animal Models of Bone Diseases-A

  2013cites this paper
• Flaxseed and Lower-dose Estrogen: Studies on Their Protective Actions and Mechanisms in Bone Using the Ovariectomized Rat Model

  2012cites this paper
• Endocrine disruptors and bone metabolism

  2012cites this paper
• Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30

  2012cites this paper
• Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts

  2012cites this paper
• Fetal Mineral Homeostasis

  2012cites this paper
• Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging

  2012cites this paper
• Genetic Polymorphisms Influence the Ovarian Response to rFSH Stimulation in Patients Undergoing In Vitro Fertilization Programs with ICSI

  2012cites this paper
• Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function

  2011cites this paper
• β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts.

  2011cites this paper
• 4-nonylphenol triggers apoptosis and affects 17-β-estradiol receptors in calvarial osteoblasts.

  2011cites this paper
• Conditional expression of constitutively active estrogen receptor α in osteoblasts increases bone mineral density in mice

  2011cites this paper
• Baicalin, a Flavone, Induces the Differentiation of Cultured Osteoblasts

  2011cites this paper
• Basic Science An injectable method for noninvasive spine fusion

  2011cites this paper
• Bone Development in the Fetus and Neonate: Role of the Calciotropic Hormones

  2011cites this paper
• Direct transcriptional targets of sex steroid hormones in bone

  2011cites this paper
• An injectable method for noninvasive spine fusion.

  2011cites this paper
• Antiestrogens and their therapeutic applications in breast cancer and other diseases.

  2011cites this paper
• The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis.

  2011cites this paper
• Impact d'une invalidation de LXRα sur la physiologie prostatique : un dialogue avec la signalisation androgénique

  2011cites this paper
• Estrogen receptor β selective nonsteroidal estrogens: seeking clinical indications

  2010cites this paper
• Role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development.

  2010cites this paper
• Minireview: osteoprotective action of estrogens is mediated by osteoclastic estrogen receptor-alpha.

  2010cites this paper
• Growth factor activation of ErbB2/ErbB3 signaling pathways regulate the activity of Estrogen Receptors (ER)

  2010cites this paper
• Regulation of bone metabolism by nuclear receptors.

  2009cites this paper
• The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.

  2009cites this paper
• Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2009cites this paper
• Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism

  2009cites this paper
• [Molecular mechanisms of postmenopausal osteoporosis].

  2009cites this paper
• Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts

  2009cites this paper
• Sex steroid hormone receptors : Inner ear & hearing

  2009cites this paper
• Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts The Osteogenic Transcription Factor Runx2 Controls Genes Involved in

  2009cites this paper
• Follicle-stimulating hormone does not directly regulate bone mass in human beings: evidence from nature.

  2008cites this paper
• Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival

  2008cites this paper
• Unraveling estrogen action in osteoporosis

  2008cites this paper
• Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome.

  2008cites this paper
• Expression of an estrogen receptor agonist in differentiating osteoblast cultures

  2008cites this paper
• Bone phenotypes in response to gonadotropin misexpression: the role for gonadotropins in postmenopausal osteoporosis

  2008cites this paper
• Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women

  2008cites this paper
• Tissue type-specific modulation of ER transcriptional activity by NFAT3.

  2007cites this paper
• The complex role of estrogens in inflammation.

  2007cites this paper
• Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

  2007cites this paper
• In Vitro Fluorescence Anisotropy Analysis of the Interaction of Full-length SRC1a with Estrogen Receptors α and β Supports an Active Displacement Model for Coregulator Utilization*

  2007cites this paper
• Estrogen Receptor-β: Recent Lessons from in Vivo Studies

  2007cites this paper
• Deoxybenzoins are novel potent selective estrogen receptor modulators.

  2007cites this paper
• Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

  2007cites this paper
• Multiple Bio-imaging Modalities in Evaluation of Epimedium-Derived Phytoestrogenic Fraction for Prevention of Postmenopausal Osteoporosis

  2007cites this paper
• Estrogen receptor-beta: recent lessons from in vivo studies.

  2007cites this paper
• Collateral resistance to oestrogen and erbB receptor activated growth in endocrine resistant breast cancer

  2007cites this paper
• Novel estrogen receptor-related Transcripts in Marisa cornuarietis; a freshwater snail with reported sensitivity to estrogenic chemicals.

  2007cites this paper
• Estrogen in men: effects on bone accrual, maintenance and prevention of bone loss

  2006cites this paper
• Contrasting effects of estradiol, testosterone and of a black cohosh extract on density, mechanical properties and expression of several genes in the metaphysis of the tibia and on fat tissue of orchidectomized rats

  2006cites this paper
• CHAPTER 27 – Transgenic Models of Bone Disease

  2006cites this paper
• Estrogen receptors and human disease.

  2006cites this paper
• Transgenic Models of Bone Disease

  2006cites this paper
• Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption.

  2006cites this paper
• FSH directly regulates bone mass.

  2006cites this paper
• Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds.

  2005cites this paper
• Is menopause getting on your nerves

  2005cites this paper
• Estrogen receptor alpha gene analysis in osteoporosis and familial osteoporosis

  2004cites this paper
• Estrogen receptor mutations in human disease.

  2004cites this paper
• Effects of Sex Steroid Receptor Specificity in the Regulation of Skeletal Metabolism

  2004cites this paper
• Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors.

  2004cites this paper
• The molecular actions of thyroid hormone in bone.

  2003cites this paper