A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction.

A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.

• Publication year

  2003

• Venue

  Journal of the American Chemical Society

• Publication date

  2003-09-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JA0373871PMID 14558801
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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