The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans are secondary lysosomes.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Mechanisms of Ageing and Development

• Publication date

  1986-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0047-6374(86)90068-0PMID 3736133
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitative measures of aging in the nematode Caenorhabditis elegans: II. Lysosomal hydrolases as markers of senescence.

  1983cited by this paper
• A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.

  1983cited by this paper
• Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin.

  1982cited by this paper
• Total luminescence spectroscopy of fluorescence changes during aging in Caenorhabditis elegans.

  1982cited by this paper
• Genetic analysis of life-span in Caenorhabditis elegans.

  1982cited by this paper
• Rapid acidification of endocytic vesicles containing α2-macroglobulin

  1982cited by this paper
• Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters.

  1981cited by this paper
• Localization of mitochondria in living cells with rhodamine 123.

  1980cited by this paper
• The aging process of the nematode Caenorhabditis elegans in bacterial and axenic culture.

  1977cited by this paper
• Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span.

  1977cited by this paper
• The life cycle of the nematode Caenorhabditis elegans. I. Wild-type growth and reproduction.

  1976cited by this paper
• Membrane flow during pinocytosis. A stereologic analysis

  1976cited by this paper
• Lysosomes: A Survey

  1976cited by this paper
• Studies on ageing in Turbatrix aceti.

  1975cited by this paper
• CHAPTER III – LIPID PEROXIDATION AND FLUORESCENT MOLECULAR DAMAGE TO MEMBRANES

  1975cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• Studies On Aging of Turbatrix Aceti

  1974cited by this paper
• SECRETION AND ENDOCYTOSIS IN INSULIN-STIMULATED RAT ADRENAL MEDULLA CELLS

  1973cited by this paper
• Measurement of fluorescent lipid peroxidation products in biological systems and tissues.

  1973cited by this paper
• Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

  1972cited by this paper
• In vivo labeling of hepatic lysosomes by intragastric administration of acridine orange.

  1972cited by this paper
• In vivo labeling of hepatic lysosomes by intragastric administration of acridine orange.

  1972cited by this paper
• Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids.

  1969cited by this paper
• Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

  1969cited by this paper
• THE USE OF ACRIDINE ORANGE AS A LYSOSOMAL MARKER IN RAT SKELETAL MUSCLE

  1969cited by this paper
• Lysosomes in biology and pathology

  1969cited by this paper
• LOCALIZATION OF ACID PHOSPHATASE IN LIPOFUSCIN GRANULES AND POSSIBLE AUTOPHAGIC VACUOLES IN INTERSTITIAL CELLS OF THE GUINEA PIG TESTIS

  1968cited by this paper
• THE DEMONSTRATION OF ACID HYDROLASE, THERMOSTABLE REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE TETRAZOLIUM REDUCTASE AND PEROXIDASE ACTIVITIES IN HUMAN LIPOFUSCIN PIGMENT GRANULES

  1966cited by this paper
• Enzymic activities of lipofuscin age pigments: comparative histochemical and biochemical studies.

  1965cited by this paper
• ON THE HISTOCHEMISTRY AND ULTRASTRUCTURE OF AGE PIGMENT.

  1964cited by this paper
• ON THE HISTOCHEMISTRY AND ULTRASTRUCTURE OF AGE PIGMENT.

  1964cited by this paper
• Human hepatocellular pigments and lysosomes.

  1960cited by this paper

• A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode Caenorhabditis elegans

  2026cites this paper
• Machine learning-based analysis of microfluidic device immobilized C. elegans for automated developmental toxicity testing

  2025cites this paper
• Intricate interplay between ORMDL3, ER stress, and autophagy in the diabetic intestine.

  2025cites this paper
• Alkaloids extracted from Dendrobium officinale grown in diverse environments exhibited robust antioxidative and antiaging activity

  2025cites this paper
• Quantitative profiling pH heterogeneity of acidic endolysosomal compartments using fluorescence lifetime imaging microscopy

  2025cites this paper
• Where are my nematodes? labelling and visualising entomopathogenic nematodes in vivo using carbon quantum dots.

  2025cites this paper
• Structural characterization and anti-aging activity investigation of a polysaccharide from Anemarrhena asphodeloides Bge.

  2024cites this paper
• Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway

  2024cites this paper
• Mitochondrial Quality Control in Alzheimer’s Disease: Insights from Caenorhabditis elegans Models

  2024cites this paper
• vivoBodySeg: Machine learning-based analysis of C. elegans immobilized in vivoChip for automated developmental toxicity testing

  2024cites this paper
• Exploring diabesity pathophysiology through proteomic analysis using Caenorhabditis elegans

  2024cites this paper
• Toward Systemic Lipofuscin Removal

  2024cites this paper
• Biomarkers for aging in Caenorhabditis elegans high throughput screening.

  2024cites this paper
• Single-tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organelles

  2023cites this paper
• Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity

  2023cites this paper
• Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions.

  2023cites this paper
• Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes

  2023influential citation
• Spatiotemporal Tracking of Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes in C. Elegans Nematodes Confined in a Microfluidics Platform

  2023cites this paper
• Quantitative Profiling of Lysosomal pH Heterogeneity using Fluorescence Lifetime Imaging Microscopy

  2023cites this paper
• Anti-aging effects of dietary phytochemicals: From Caenorhabditis elegans, Drosophila melanogaster, rodents to clinical studies

  2023cites this paper
• Large-scale growth of C. elegans and isolation of membrane protein complexes

  2023cites this paper
• SKN‐1/NRF2 upregulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans

  2023cites this paper
• Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development

  2022cites this paper
• Immuno-electron microscopy localizes Caenorhabditis elegans vitellogenins along the classic exocytosis route

  2022cites this paper
• The endophytic fungus Penicillium oxalicum isolated from Ligusticum chuanxiong Hort possesses DNA damage-protecting potential and increases stress resistance properties in Caenorhabditis elegans

  2022cites this paper
• 3,6'‐disinapoyl sucrose attenuates Aβ1‐42‐ induced neurotoxicity in Caenorhabditis elegans by enhancing antioxidation and regulating autophagy

  2022cites this paper
• Indirect immunofluorescence assay using embryonated eggs of Toxocara in human toxocariasis diagnosis is unreliable due to autofluorescence nature.

  2022cites this paper
• The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

  2022cites this paper
• In vivo imaging of fluorescent single-walled carbon nanotubes within C. elegans nematodes in the near-infrared window

  2021cites this paper
• Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery

  2021cites this paper
• Extracts of the Tiger Milk Mushroom (Lignosus rhinocerus) Enhance Stress Resistance and Extend Lifespan in Caenorhabditis elegans via the DAF-16/FoxO Signaling Pathway

  2021cites this paper
• Feedforward regulatory logic underlies robustness of the specification-to-differentiation transition and fidelity of terminal cell fate during C. elegans endoderm development

  2021cites this paper
• Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy.

  2021cites this paper
• The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes

  2021cites this paper
• A promising strategy for investigating the anti-aging effect of natural compounds: a case study of caffeoylquinic acids.

  2021cites this paper
• Hope.

  2021cites this paper
• Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window.

  2021cites this paper
• Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans

  2021cites this paper
• Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1.

  2021cites this paper
• Evolutionary divergence of anaphase spindle mechanics in nematode embryos constrained by antagonistic pulling and viscous forces

  2021cites this paper
• Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans

  2020cites this paper
• A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans

  2020cites this paper
• A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans

  2020cites this paper
• Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

  2020cites this paper
• The role of Vitellogenin in the transfer of immune elicitors from gut to hypopharyngeal glands in honey bees (Apis mellifera).

  2019cites this paper
• In vivo measurements reveal a single 5′-intron is sufficient to increase protein expression level in Caenorhabditis elegans

  2019cites this paper
• Phagocytosis in cellular defense and nutrition: a food-centered approach to the evolution of macrophages

  2019cites this paper
• Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans

  2019cites this paper
• Extensive intraspecies cryptic variation in 1 an ancient embryonic gene regulatory 2 network 3

  2019cites this paper
• ICD-1/BTF3 antagonizes SKN-1-mediated endoderm specification in Caenorhabditis elegans

  2019cites this paper
• Leaf extract of Caesalpinia mimosoides enhances oxidative stress resistance and prolongs lifespan in Caenorhabditis elegans

  2019cites this paper
• A non-bilaterian perspective on the development and evolution of animal digestive systems

  2019cites this paper
• Mechanics of Phenotypic Aging Trajectories in C. elegans and Humans

  2019cites this paper
• Anti‐ageing and anti‐Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans

  2019cites this paper
• An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis in Caenorhabditis elegans

  2019cites this paper
• Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

  2019cites this paper
• Measurement of Lysosomal Size and Lysosomal Marker Intensities in Adult Caenorhabditis elegans.

  2018cites this paper
• Age‐induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans

  2018cites this paper
• Microfluidic cryofixation for time-correlated live-imaging cryo-fluorescence microscopy and electron microscopy of Caenorhabditis elegans

  2018cites this paper
• Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans.

  2018cites this paper
• Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis

  2018cites this paper
• In vivo measurements reveal a single 5’ intron is sufficient to increase protein expression level in C. elegans

  2018cites this paper
• Activation of the endoplasmic reticulum unfolded protein response reverses an inflammation-like response to cytoplasmic DNA

  2018cites this paper
• Model Nematodes in Obesity Research

  2017cites this paper
• Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans

  2017cites this paper
• Regulation of lysosomal function by the DAF-16 Forkhead transcription factor couples reproduction to aging in C. elegans

  2017cites this paper
• Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons.

  2017cites this paper
• Adaptive optics improves multiphoton super-resolution imaging

  2017cites this paper
• Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis elegans

  2017cites this paper
• Rapid, reversible and addressable immobilization of Caenorhabditis elegans in Pluronic F-127 using an optoelectric device

  2017cites this paper
• The C. elegans model in toxicity testing

  2016cites this paper
• Nonlinear Multimodal Optical Imaging

  2016cites this paper
• Anthelmintic effects of a cationic toxin from a South American rattlesnake venom.

  2016cites this paper
• Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7

  2016cites this paper
• Scavengers of reactive γ ‐ ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein ‐ level interactions with

  2016cites this paper
• An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans

  2016cites this paper
• Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the Caenorhabditis elegans intestine

  2016cites this paper
• Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells

  2016cites this paper
• Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health.

  2016cites this paper
• Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green

  2016cites this paper
• Ammonia excretion in Caenorhabditis elegans: Physiological and molecular characterization of the rhr-2 knock-out mutant.

  2016cites this paper
• Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

  2016cites this paper
• A Mechanism for Spatial Orientation Based on Sensory Adaptation in Caenorhabditis Elegans

  2015cites this paper
• Protection and Delivery of Anthelmintic Protein Cry5B to Nematodes Using Mesoporous Silicon Particles.

  2015cites this paper
• Simultaneous calcium imaging of multiple neurons in Caenorhabditis elegans

  2015cites this paper
• Identification of Important Cell Cycle Regulators and Novel Genes in Specific Tissues using Microarray Analysis, Bioinformatics and Molecular Tools

  2015cites this paper
• Identification of vacuoles containing extraintestinal differentiated forms of Legionella pneumophila in colonized Caenorhabditis elegans soil nematodes

  2015cites this paper
• Single Cell Quantification of Reporter Gene Expression in Live Adult Caenorhabditis elegans Reveals Reproducible Cell-Specific Expression Patterns and Underlying Biological Variation

  2015cites this paper
• A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling

  2015cites this paper
• Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes

  2015cites this paper
• Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

  2015cites this paper
• Microscopic Investigation of Protein Function in C. elegans Using Fluorescent Imaging

  2015cites this paper
• Aberrant Fat Metabolism in Caenorhabditis elegans Mutants with Defects in the Defecation Motor Program

  2015cites this paper
• Nanoparticle imaging and diagnostic of Caenorhabditis elegans intracellular pH.

  2014cites this paper
• C. elegans as a model for membrane traffic.

  2014cites this paper
• The DEAD Box RNA Helicase VBH-1 Is a New Player in the Stress Response in C. elegans

  2014cites this paper
• SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans

  2014cites this paper
• Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1

  2014cites this paper
• High-throughput imaging of neuronal activity in Caenorhabditis elegans

  2013cites this paper
• Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans.

  2013cites this paper