National Institute of Mental Health

Shouxiang Chen

Published 2020 in Definitions

ABSTRACT

a novel connection between the basolateral amygdala–a brain region critical for forming associations between experiences and outcomes–and the nucleus accumbens, which is important for processing rewarding experiences. The researchers found that selectively activating this connection caused impairments in reward behavior, mimicking the effects of early-life stress. These findings are an important step toward better understanding the biological mechanisms of stress-related mental illnesses such as post-traumatic stress disorder, potentially identifying novel targets for prevention and treatment.

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