Deletion of a conserved, central ribosomal intersubunit RNA bridge.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecules and Cells

• Publication date

  2006-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLCEL.2006.08.011PMID 16973438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conserved Loop Sequence of Helix 69 in Escherichia coli 23 S rRNA Is Involved in A-site tRNA Binding and Translational Fidelity*

  2006cited by this paper
• An Active Role for tRNA in Decoding Beyond Codon:Anticodon Pairing

  2005cited by this paper
• mRNA helicase activity of the ribosome.

  2005cited by this paper
• Effects of nucleotide substitution and modification on the stability and structure of helix 69 from 28S rRNA.

  2005cited by this paper
• Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis

  2005cited by this paper
• The conserved A-site finger of the 23S rRNA: just one of the intersubunit bridges or a part of the allosteric communication pathway?

  2005cited by this paper
• Multiple effects of S13 in modulating the strength of intersubunit interactions in the ribosome during translation.

  2005cited by this paper
• Involvement of 16S rRNA nucleotides G1338 and A1339 in discrimination of initiator tRNA.

  2005cited by this paper
• Structures of the Bacterial Ribosome at 3.5 Å Resolution

  2005cited by this paper
• Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies.

  2005cited by this paper
• The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli.

  2005cited by this paper
• Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon.

  2005cited by this paper
• The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer

  2005cited by this paper
• X‐ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit

  2005cited by this paper
• Ribosomal crystallography: initiation, peptide bond formation, and amino acid polymerization are hampered by antibiotics.

  2004cited by this paper
• Visualization of release factor 3 on the ribosome during termination of protein synthesis

  2004cited by this paper
• Definition of bases in 23S rRNA essential for ribosomal subunit association.

  2004cited by this paper
• Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

  2004cited by this paper
• Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: Functional implications

  2004cited by this paper
• The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release.

  2004cited by this paper
• Ribosomal Tolerance and Peptide Bond Formation

  2003cited by this paper
• Structure of the Escherichia coli ribosomal termination complex with release factor 2

  2003cited by this paper
• A cryo-electron microscopic study of ribosome-bound termination factor RF2

  2003cited by this paper
• Affinity Purification of Ribosomes with a Lethal G2655C Mutation in 23 S rRNA That Affects the Translocation*

  2003cited by this paper
• Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome.

  2003cited by this paper
• Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

  2003cited by this paper
• Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression.

  2003cited by this paper
• Modeling a minimal ribosome based on comparative sequence analysis.

  2002cited by this paper
• Accurate translocation of mRNA by the ribosome requires a peptidyl group or its analog on the tRNA moving into the 30S P site.

  2002cited by this paper
• Orientation of ribosome recycling factor in the ribosome from directed hydroxyl radical probing.

  2002cited by this paper
• Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

  2002cited by this paper
• Structural dynamics of ribosomal RNA during decoding on the ribosome.

  2002cited by this paper
• Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit

  2001cited by this paper
• Interaction of translation initiation factor 3 with the 30S ribosomal subunit.

  2001cited by this paper
• Crystal Structure of the Ribosome at 5.5 Å Resolution

  2001cited by this paper
• Solution structure of the E. coli 70S ribosome at 11.5 A resolution.

  2000cited by this paper
• The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.

  2000cited by this paper
• The structural basis of ribosome activity in peptide bond synthesis.

  2000cited by this paper
• Directed hydroxyl radical probing of RNA from iron(II) tethered to proteins in ribonucleoprotein complexes.

  2000cited by this paper
• Novel roles for classical factors at the interface between translation termination and initiation.

  1999cited by this paper
• X-ray crystal structures of 70S ribosome functional complexes.

  1999cited by this paper
• Nucleotides in 23S rRNA protected by the association of 30S and 50S ribosomal subunits.

  1999cited by this paper
• EF‐G‐catalyzed translocation of anticodon stem–loop analogs of transfer RNA in the ribosome

  1998cited by this paper
• Protection Patterns of tRNAs Do Not Change during Ribosomal Translocation*

  1998cited by this paper
• Ribosomes and translation.

  1997cited by this paper
• Limitations of translational accuracy

  1996cited by this paper
• Escherichia coli and Salmonella.

  1996cited by this paper
• Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA.

  1995cited by this paper
• The involvement of two distinct regions of 23 S ribosomal RNA in tRNA selection.

  1995cited by this paper
• Unusual resistance of peptidyl transferase to protein extraction procedures.

  1992cited by this paper
• Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

  1989cited by this paper
• Selection of the initiator tRNA by Escherichia coli initiation factors.

  1989cited by this paper
• Intermediate states in the movement of transfer RNA in the ribosome

  1989cited by this paper
• Defining the structural requirements for a helix in 23 S ribosomal RNA that confers erythromycin resistance.

  1989cited by this paper
• Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli.

  1988cited by this paper
• Mg2+/NH4+/polyamine system for polyuridine-dependent polyphenylalanine synthesis with near in vivo characteristics.

  1988cited by this paper
• The use of oligonucleotide-directed mutagenesis to probe molecular mechanisms of mutagenesis.

  1988cited by this paper
• Nucleoside triphosphate regeneration decreases the frequency of translation errors.

  1979cited by this paper
• [41] Reconstitution of ribosomes from subribosomal components

  1971cited by this paper
• Studies on the structure of ribosomes. IV. Participation of aminoacyl-transfer RNA and peptidyl-transfer RNA in the association of ribosomal subparticles.

  1970cited by this paper
• Catalysis of peptide bond formation by 50 S ribosomal subunits from Escherichia coli.

  1967cited by this paper
• STREPTOMYCIN, SUPPRESSION, AND THE CODE.

  1964cited by this paper
• THE FREQUENCY OF ERRORS IN PROTEIN BIOSYNTHESIS.

  1963cited by this paper
• The frequency of errors in protein biosynthesis.

  1963cited by this paper

• Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming During 50S Biogenesis

  2026cites this paper
• Essential Roles of Conserved Pseudouridines in Helix 69 for Ribosome Dynamics in Translation.

  2025cites this paper
• Mapping RNA-Binding Proteins on the Ribosome by Tethered Micrococcal Nuclease

  2025cites this paper
• Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in Translation

  2024cites this paper
• Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly

  2024cites this paper
• Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly

  2024cites this paper
• Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification

  2024cites this paper
• Cryo-EM captures a unique conformational rearrangement in 23S rRNA helices of the Mycobacterium 50S subunit.

  2023cites this paper
• Engineering orthogonal ribosomes for real-time monitoring using fluorescence

  2023cites this paper
• Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide.

  2023cites this paper
• Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

  2022cites this paper
• Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation

  2022cites this paper
• The nucleolus as a genomic safe harbor for strong gene expression in Nannochloropsis oceanica.

  2021cites this paper
• Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC.

  2020cites this paper
• Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis

  2020cites this paper
• Mutations in domain IV of elongation factor EF-G confer −1 frameshifting

  2020cites this paper
• Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

  2020cites this paper
• Disruption of evolutionarily correlated tRNA elements impairs accurate decoding

  2020cites this paper
• Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly

  2020cites this paper
• Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes

  2020cites this paper
• An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7

  2019cites this paper
• 1 As submitted to : The EMBO Journal And later published as : Initial and intermediate steps of the ribosome recycling process as revealed by cryo-EM

  2018cites this paper
• Roles of specific aminoglycoside–ribosome interactions in the inhibition of translation

  2018cites this paper
• Identification of potential allosteric communication pathways between functional sites of the bacterial ribosome by graph and elastic network models.

  2017cites this paper
• Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine

  2017cites this paper
• 1 As submitted to : The EMBO Journal And later published as : Initial and intermediate steps of the ribosome recycling process as revealed by cryo-EM

  2017cites this paper
• Analysis of ribosomal inter‐subunit sites as targets for complementary oligonucleotides

  2017cites this paper
• Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes.

  2017cites this paper
• Helix 69 of Escherichia coli 23S ribosomal RNA as a peptide nucleic acid target.

  2017cites this paper
• Disassembly of yeast 80S ribosomes into subunits is a concerted action of ribosome-assisted folding of denatured protein.

  2016cites this paper
• The development of peptide ligands that target helix 69 rRNA of bacterial ribosomes.

  2016cites this paper
• Caught on Camera: Intermediates of Ribosome Recycling.

  2016cites this paper
• Intersubunit Bridges of the Bacterial Ribosome.

  2016cites this paper
• ZMA, Taylor RW, Vila-Sanjurjo A. The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease. Mitochondrion 2015, 25, 17-27

  2015cites this paper
• The effects of disruptions in ribosomal active sites and in intersubunit contacts on ribosomal degradation in Escherichia coli

  2015cites this paper
• The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease

  2015cites this paper
• Dynamic contact network between ribosomal subunits enables rapid large-scale rotation during spontaneous translocation

  2015cites this paper
• Roles of helix H69 of 23S rRNA in translation initiation

  2015influential citation
• DNA aptamers selected against wild-type helix 69 ribosomal RNA and their implications in combating antibiotic resistance

  2015influential citation
• The role of S4-like RNA-binding and catalytic domains in the activity and specificity of bacterial pseudouridine synthases RluC and RluD in vitro

  2015cites this paper
• LOODUS- JA TEHNOLOOGIATEADUSKOND MOLEKULAAR- JA RAKUBIOLOOGIA INSTITUUT MOLEKULAARBIOLOOGIA ÕPPETOOL

  2014cites this paper
• Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

  2014cites this paper
• Interplay of the Bacterial Ribosomal A-Site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study

  2014influential citation
• In Vitro Selections for Imidazole-Modified RNA Catalysts

  2014cites this paper
• Highly conserved base A55 of 16S ribosomal RNA is important for the elongation cycle of protein synthesis.

  2013cites this paper
• Structure modulation of helix 69 from Escherichia coli 23S ribosomal RNA by pseudouridylations

  2013cites this paper
• Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit

  2013cites this paper
• Helix 69: A Multitasking RNA Motif as a Novel Drug Target

  2013cites this paper
• Structural aspects of the ribosome evolution and function

  2013cites this paper
• Different sensitivity of H69 modification enzymes RluD and RlmH to mutations in Escherichia coli 23S rRNA.

  2012cites this paper
• Structural insights into initial and intermediate steps of the ribosome‐recycling process

  2012cites this paper
• The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome.

  2012cites this paper
• Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis.

  2012cites this paper
• Modifier view of the bacterial ribosome

  2012cites this paper
• Contribution of intersubunit bridges to the energy barrier of ribosomal translocation

  2012cites this paper
• Crystal structures of 70S ribosomes bound to release factors RF1, RF2 and RF3.

  2012cites this paper
• Role of pseudouridine in structural rearrangements of helix 69 during bacterial ribosome assembly.

  2012cites this paper
• "fine-tuning" of ribosomal structure and functions by pseudouridylation and rna-protein interactions

  2012cites this paper
• Exploring conformational variability of an rna domain in the ribosome: from structure and function to potential antibiotic targeting

  2012influential citation
• Comparison of solution conformations and stabilities of modified helix 69 rRNA analogs from bacteria and human.

  2012cites this paper
• Probing conformational states of modified helix 69 in 50S ribosomes.

  2011cites this paper
• Pseudouridylation of 23S rRNA helix 69 promotes peptide release by release factor RF2 but not by release factor RF1.

  2011cites this paper
• Helix 69 Is Key for Uniformity during Substrate Selection on the Ribosome*

  2011cites this paper
• Evolution of introns in the archaeal world

  2011cites this paper
• Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis

  2011cites this paper
• Sense and nonsense recognition by the ribosome

  2011cites this paper
• Studies on the role of helix 69 of 23S rRNA in the factor-dependent stages of translation initiation, elongation, and termination

  2011influential citation
• The Role of Initiation Factor Dynamics in Translation Initiation

  2011influential citation
• Functions of elongation factor G in translocation and ribosome recycling

  2011cites this paper
• Methylated 23S rRNA nucleotide m2G1835 of Escherichia coli ribosome facilitates subunit association.

  2011cites this paper
• Mutants That Affect Recoding

  2010cites this paper
• 6.19 – Nucleoside Analogues

  2010cites this paper
• Functional interactions by transfer RNAs in the ribosome

  2010cites this paper
• Mutations in the intersubunit bridge regions of 16S rRNA affect decoding and subunit–subunit interactions on the 70S ribosome

  2010cites this paper
• Specificity and kinetics of 23S rRNA modification enzymes RlmH and RluD.

  2010cites this paper
• mRNA Translocation Occurs During the Second Step of Ribosomal Intersubunit Rotation

  2010cites this paper
• Recognition of the amber UAG stop codon by release factor RF1

  2010cites this paper
• Some reassembly required

  2010cites this paper
• Recent Progress on Understanding Ribosomal Protein Synthesis

  2010cites this paper
• The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

  2010cites this paper
• Functional elucidation of a key contact between tRNA and the large ribosomal subunit rRNA during decoding.

  2010cites this paper
• GTPase activation of elongation factor EF‐Tu by the ribosome during decoding

  2009cites this paper
• Distinct functions of elongation factor G in ribosome recycling and translocation.

  2009cites this paper
• Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity.

  2009cites this paper
• Structural Basis for the Decoding Mechanism

  2009cites this paper
• Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu

  2009cites this paper
• Helix 69 in 23S rRNA modulates decoding by wild type and suppressor tRNAs

  2009influential citation
• Suppression of ΔbipA Phenotypes in Escherichia coli by Abolishment of Pseudouridylation at Specific Sites on the 23S rRNA

  2008cites this paper
• Mutations in Conserved Helix 69 of 23S rRNA of Thermus thermophilus That Affect Capreomycin Resistance but Not Posttranscriptional Modifications

  2008cites this paper
• pH-dependent structural changes of helix 69 from Escherichia coli 23S ribosomal RNA.

  2008cites this paper
• Antibiotic Resistance Mechanisms, with an Emphasis on Those Related to the Ribosome

  2008cites this paper
• Identification of pseudouridine methyltransferase in Escherichia coli.

  2008cites this paper
• Pseudouridines in rRNA helix 69 play a role in loop stacking interactions.

  2008cites this paper
• YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA.

  2008cites this paper
• Structural Insights into ribosome recycling factor interactions with the 70S ribosome.

  2008cites this paper
• Structural dynamics of the ribosome.

  2008cites this paper
• Requirements for translation re-initiation in Escherichia coli: roles of initiator tRNA and initiation factors IF2 and IF3

  2008cites this paper
• Crystal structure of a translation termination complex formed with release factor RF2

  2008cites this paper
• Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His–Cys box homing endonucleases

  2008cites this paper
• Stephen Posttranscriptional Modifications Capreomycin Resistance but Not That Affect Thermus thermophilus rRNA of Mutations in Conserved Helix 69 of 23 S

  2008cites this paper