Bioactivity and biotechnological production of punicic acid

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Applied Microbiology and Biotechnology

• Publication date

  2018-03-03

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00253-018-8883-yPMID 29502183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current status and applications of genome-scale metabolic models

  2019cited by this paper
• Insulin resistance in 3T3-L1 adipocytes by TNF-α is improved by punicic acid through upregulation of insulin signalling pathway and endocrine function, and downregulation of proinflammatory cytokines.

  2018cited by this paper
• Punicic acid: A striking health substance to combat metabolic syndromes in humans

  2017influential reference
• Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production

  2017cited by this paper
• Metabolic engineering of Schizosaccharomyces pombe to produce punicic acid, a conjugated fatty acid with nutraceutic properties

  2017influential reference
• The linin promoter is highly effective in enhancing punicic acid production in Arabidopsis

  2017influential reference
• Pomegranate as a Possible Treatment in Reducing Risk of Developing Wound Healing, Obesity, Neurodegenerative Disorders, and Diabetes Mellitus.

  2017cited by this paper
• Health Benefits of Punicic Acid: A Review.

  2016cited by this paper
• Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine

  2016cited by this paper
• Understanding the control of acyl flux through the lipid metabolic network of plant oil biosynthesis.

  2016cited by this paper
• Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 system

  2016cited by this paper
• Fatty Acid Composition

  2016cited by this paper
• Identification of multiple lipid genes with modifications in expression and sequence associated with the evolution of hydroxy fatty acid accumulation in Physaria fendleri.

  2016cited by this paper
• Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids.

  2016cited by this paper
• Heterologous expression of flax PHOSPHOLIPID:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE (PDCT) increases polyunsaturated fatty acid content in yeast and Arabidopsis seeds

  2015cited by this paper
• In Vivo and in Vitro Evidence for Biochemical Coupling of Reactions Catalyzed by Lysophosphatidylcholine Acyltransferase and Diacylglycerol Acyltransferase*

  2015cited by this paper
• Acyl-Trafficking During Plant Oil Accumulation

  2015cited by this paper
• Reducing Isozyme Competition Increases Target Fatty Acid Accumulation in Seed Triacylglycerols of Transgenic Arabidopsis1[OPEN]

  2015cited by this paper
• Microbial oils: A customizable feedstock through metabolic engineering

  2015cited by this paper
• Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease.

  2015cited by this paper
• A Small Phospholipase A2-α from Castor Catalyzes the Removal of Hydroxy Fatty Acids from Phosphatidylcholine in Transgenic Arabidopsis Seeds1[OPEN]

  2015influential reference
• Comprehensive Metabolomic, Lipidomic and Microscopic Profiling of Yarrowia lipolytica during Lipid Accumulation Identifies Targets for Increased Lipogenesis

  2015cited by this paper
• Dynamics of the Lipid Droplet Proteome of the Oleaginous Yeast Rhodosporidium toruloides

  2015cited by this paper
• A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments

  2015cited by this paper
• Insulin resistance by TNF-α is associated with mitochondrial dysfunction in 3T3-L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist.

  2015cited by this paper
• Understanding and manipulating plant lipid composition: Metabolic engineering leads the way

  2014cited by this paper
• Effects of Pomegranate Seed Oil on Insulin Release in Rats with Type 2 Diabetes

  2014cited by this paper
• An in vitro study reveals the nutraceutical potential of punicic acid relevant to diabetes via enhanced GLUT4 expression and adiponectin secretion.

  2014cited by this paper
• Physico‐chemical properties and fatty acid profile of seed oils from pomegranate (Punica granatum L.) extracted by cold pressing

  2014cited by this paper
• Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L.) Seed Oil on Breast Cancer Cell Lines

  2014cited by this paper
• Engineering production of C18 conjugated fatty acids in developing seeds of oil crops

  2014influential reference
• Open questions in lipid droplet biology.

  2014cited by this paper
• The effects of conjugated linoleic acid on growth performance, carcass traits, meat quality, antioxidant capacity, and fatty acid composition of broilers fed corn dried distillers grains with solubles.

  2014cited by this paper
• Conjugated linolenic acids and their bioactivities: a review.

  2014cited by this paper
• Combined transgenic expression of Punica granatum conjugase (FADX) and FAD2 desaturase in high linoleic acid Arabidopsis thaliana mutant leads to increased accumulation of punicic acid

  2014influential reference
• Protective effect of pomegranate seed oil against mercuric chloride-induced nephrotoxicity in rat

  2014cited by this paper
• Application of tung oil to improve adhesion strength and water resistance of cottonseed meal and protein adhesives on maple veneer

  2014cited by this paper
• Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer metastasis.

  2014cited by this paper
• Novel reactions in acyl editing of phosphatidylcholine by lysophosphatidylcholine transacylase (LPCT) and acyl-CoA:glycerophosphocholine acyltransferase (GPCAT) activities in microsomal preparations of plant tissues

  2014cited by this paper
• Genetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid

  2013cited by this paper
• Metabolic engineering of plant oils and waxes for use as industrial feedstocks.

  2013cited by this paper
• Biochemical pathways in seed oil synthesis.

  2013cited by this paper
• Plant Acyl-CoA:Lysophosphatidylcholine Acyltransferases (LPCATs) Have Different Specificities in Their Forward and Reverse Reactions

  2013cited by this paper
• Effect of Conjugated Linoleic Acid Feeding on the Growth Performance and Meat Fatty Acid Profiles in Broiler: Meta-analysis

  2013cited by this paper
• Predicting the yield of pomegranate oil from supercritical extraction using artificial neural networks and an adaptive-network-based fuzzy inference system

  2013cited by this paper
• Pomegranate and type 2 diabetes.

  2013cited by this paper
• Identification of a Pair of Phospholipid:Diacylglycerol Acyltransferases from Developing Flax (Linum usitatissimum L.) Seed Catalyzing the Selective Production of Trilinolenin*

  2013influential reference
• Toxicity of ricinoleic acid production in fission yeast Schizosaccharomyces pombe is suppressed by the overexpression of plg7, a phospholipase A2 of a platelet-activating factor (PAF) family homolog

  2013cited by this paper
• Phytochemicals in Pomegranate Seeds and Their Effect as Hypolipidemic Agent in Hypercholesterolemic Rats

  2012cited by this paper
• Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.

  2012cited by this paper
• Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets

  2012cited by this paper
• Antioxidant and anti-inflammatory effect of conjugated linolenic acid isomers against streptozotocin-induced diabetes.

  2012cited by this paper
• Extraction of pomegranate (Punica granatum L.) seed oil using superheated hexane

  2012influential reference
• CHEMICAL EVALUATION OF OILS EXTRACTED FROM FIVE DIFFERENT VARIETIES OF IRANIAN POMEGRANATE SEEDS

  2012cited by this paper
• Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice.

  2011cited by this paper
• Endoplasmic reticulum-located PDAT1-2 from castor bean enhances hydroxy fatty acid accumulation in transgenic plants.

  2011cited by this paper
• Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice.

  2011cited by this paper
• Compartmentation of Triacylglycerol Accumulation in Plants*

  2011cited by this paper
• Not just fat: the structure and function of the lipid droplet.

  2011cited by this paper
• Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation.

  2010cited by this paper
• Castor Phospholipid:Diacylglycerol Acyltransferase Facilitates Efficient Metabolism of Hydroxy Fatty Acids in Transgenic Arabidopsis1[W][OA]

  2010cited by this paper
• Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells.

  2010cited by this paper
• Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite.

  2009cited by this paper
• An enzyme regulating triacylglycerol composition is encoded by the ROD1 gene of Arabidopsis

  2009influential reference
• Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats

  2009cited by this paper
• Lipids in Health and Disease Lipoprotein-associated Phospholipase a 2 (lp-pla 2 ) Activity, Platelet-activating Factor Acetylhydrolase (paf-ah) in Leukocytes and Body Composition in Healthy Adults

  2009cited by this paper
• Acyltransferase action in the modification of seed oil biosynthesis.

  2009influential reference
• Punicic acid is an ω-5 fatty acid capable of inhibiting breast cancer proliferation

  2009cited by this paper
• Effects of conjugated linolenic acid and conjugated linoleic acid on lipid metabolism in mice.

  2009cited by this paper
• Analysis of pomegranate seed oil for the presence of jacaric acid.

  2009cited by this paper
• Supercritical CO2 extraction optimization of pomegranate (Punica granatum L.) seed oil using response surface methodology.

  2009cited by this paper
• Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice

  2008cited by this paper
• Extraction of Essential Oils From the Seeds of Pomegranate Using Organic Solvents and Supercritical CO2

  2008influential reference
• Metabolic engineering of hydroxy fatty acid production in plants: RcDGAT2 drives dramatic increases in ricinoleate levels in seed oil.

  2008influential reference
• Effects of various levels of conjugated linoleic acid supplementation on fatty acid content and carcass composition of broilers.

  2007cited by this paper
• Isomerization of conjugated linolenic acids during methylation.

  2007cited by this paper
• Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting.

  2007cited by this paper
• Re-characterization of three conjugated linolenic acid isomers by GC-MS and NMR.

  2007cited by this paper
• The production of unusual fatty acids in transgenic plants.

  2007cited by this paper
• Genetically modified rapeseed oil containing cis-9,trans-11,cis-13-octadecatrienoic acid affects body fat mass and lipid metabolism in mice.

  2007influential reference
• Conjugated fatty acids accumulate to high levels in phospholipids of metabolically engineered soybean and Arabidopsis seeds.

  2006cited by this paper
• Acetonitrile covalent adduct chemical ionization mass spectrometry for double bond localization in non-methylene-interrupted polyene fatty acid methyl esters.

  2006cited by this paper
• Identification and characterization of conjugated linolenic acid isomers by Ag+-HPLC and NMR.

  2006influential reference
• Two FAD3 Desaturase Genes Control the Level of Linolenic Acid in Flax Seed

  2005cited by this paper
• Determination of conjugated linolenic acid content of selected oil seeds grown in Turkey

  2005cited by this paper
• Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™

  2005cited by this paper
• S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes*

  2005cited by this paper
• Pomegranate Extracts Potently Suppress Proliferation, Xenograft Growth, and Invasion of Human Prostate Cancer Cells

  2004cited by this paper
• Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

  2004influential reference
• Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats

  2004cited by this paper
• Separation of conjugated trienoic fatty acid isomers by capillary electrophoresis.

  2003cited by this paper
• Delta 12-oleate desaturase-related enzymes associated with formation of conjugated trans-delta 11, cis-delta 13 double bonds.

  2003cited by this paper
• Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana

  2003cited by this paper
• Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD1 Mice

  2003cited by this paper
• Δ12-Oleate Desaturase-related Enzymes Associated with Formation of Conjugated trans-Δ11, cis-Δ13 Double Bonds*

  2003influential reference
• Identification and characterization of conjugated fatty acid methyl esters of mixed double bond geometry by acetonitrile chemical ionization tandem mass spectrometry.

  2003cited by this paper
• TLC as a tool for quantitative isolation of conjugated trienoic FA

  2003cited by this paper
• Molecular Analysis of a Bifunctional Fatty Acid Conjugase/Desaturase from Tung. Implications for the Evolution of Plant Fatty Acid Diversity1

  2002cited by this paper
• Formation of conjugated Δ11Δ13‐double bonds by Δ12‐linoleic acid (1,4)‐acyl‐lipid‐desaturase in pomegranate seeds

  2002influential reference
• Formation of conjugated Delta11Delta13-double bonds by Delta12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds.

  2002influential reference

• Comparative Expression of Diacylglycerol Acyltransferases for Enhanced Accumulation of Punicic Acid-Enriched Triacylglycerols in Yarrowia lipolytica

  2026cites this paper
• Vegetable oils as a source of Omega-3 fatty acids-An update and controversials about future applications.

  2026cites this paper
• Effect of Pomegranate Seed Oil and Punicic Acid on Alzheimer’s Disease

  2025cites this paper
• Effects of Common Fig (Ficus carica L.) and Its Extracts on Certain Cancer Types: Focusing on the Mechanism of Action

  2025cites this paper
• Advances in Producing Health-Promoting Punicic Acid: From Extraction Technologies to Cutting-Edge Biotechnology Innovations.

  2025cites this paper
• Punicic Acid: A Potential Nutraceutical Compound in Pomegranate Seed Oil and Its Cardiovascular Benefits

  2025cites this paper
• Biotechnological advances in the production of unusual fatty acids in transgenic plants and recombinant microorganisms.

  2024cites this paper
• Extraction and stabilization of pomegranate seed oil: a functional oil for the food industry

  2024cites this paper
• The Plasma Membrane H+-ATPase Promoter Driving the Expression of FADX Enables Highly Efficient Production of Punicic Acid in Rhodotorula toruloides Cultivated on Glucose and Crude Glycerol

  2024influential citation
• Phytochemical screening, antioxidant, anti-diabetic, and anti-obesity activities, formulation, and characterization of a self-nanoemulsion system loaded with pomegranate (Punica granatum) seed oil

  2024cites this paper
• Engineering Rhodosporidium toruloides for sustainable production of value-added punicic acid from glucose and wood residues

  2024cites this paper
• Engineering Saccharomyces cerevisiae for the production of punicic acid-rich yeast biomass

  2024cites this paper
• Conjugated Linolenic Acid (CLnA) vs Conjugated Linoleic Acid (CLA): A Comprehensive Review of Potential Advantages in Molecular Characteristics, Health Benefits, and Production Techniques.

  2024cites this paper
• Engineering Yarrowia lipolytica for Sustainable Production of the Pomegranate Seed Oil-Derived Punicic Acid.

  2024cites this paper
• Effect of Rhodiola rosea Rhizome and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessively Fat Diet

  2023cites this paper
• Improved Extraction of High Value-Added Polyphenols from Pomegranate Peel by Solid-State Fermentation

  2023cites this paper
• Yarrowia lipolytica as a Platform for Punicic Acid Production

  2023cites this paper
• Extraction and Composition of Lipids from Pomegranate Seed Oil from West Algeria

  2023cites this paper
• NGHIÊN CỨU QUY TRÌNH CHUẨN BỊ MẪU DẦU HẠT CHỨA ACID BÉO CÓ NỐI ĐÔI LIÊN HỢP TRONG PHƯƠNG PHÁP PHÂN TÍCH HPLC

  2023cites this paper
• Comparison of conventional and green extraction methods on oil yield, physicochemical properties, and lipid compositions of pomegranate seed oil

  2022cites this paper
• Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review

  2022cites this paper
• Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives

  2022cites this paper
• Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control.

  2022cites this paper
• Pomegranate Oil’s Potential as an Anti-Obesity Ingredient

  2022cites this paper
• Biotechnology in Future Food Lipids: Opportunities and Challenges.

  2022cites this paper
• Evaluation of green extraction processes, lipid composition and antioxidant activity of pomegranate seed oil

  2021cites this paper
• Potential Use of Plant-Based By-Products and Waste to Improve the Quality of Gluten-Free Foods.

  2021cites this paper
• Rare fatty acids and lipids in plant oilseeds: occurrence and bioactivity

  2021cites this paper
• Improving the Production of Punicic Acid in Baker's Yeast by Engineering Genes in Acyl Channeling Processes and Adjusting Precursor Supply.

  2021cites this paper
• Expanding current applications and permitting the analysis of larger intact samples by means of a 7 mm CMP-NMR probe.

  2021cites this paper
• Supercritical carbon dioxide extraction of pomegranate peel-seed mixture: Yield and modelling

  2021cites this paper
• Design of novel nutritious microcapsules comprising ω-5 fatty acids and essential amino acids by assembling pomegranate seed derived macromolecules

  2021cites this paper
• A review of the functional effects of pine nut oil, pinolenic acid and its derivative eicosatrienoic acid and their potential health benefits.

  2021cites this paper
• Punicic acid production in Brassica napus.

  2020cites this paper
• Thladiantha Seed Oils - New Source of Conjugated Fatty Acids: Characterization of Triacylglycerols and Fatty Acids.

  2020cites this paper
• Metabolism of Storage Lipids and the Role of Lipid Droplets in the Yeast Schizosaccharomyces pombe.

  2020cites this paper
• Structure determination of conjugated linoleic and linolenic acids.

  2020cites this paper
• Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders.

  2019cites this paper
• Metabolism of phospholipids in the yeast Schizosaccharomyces pombe

  2019cites this paper
• Production of conjugated fatty acids: A review of recent advances.

  2019cites this paper
• The chemical and pharmacological basis of pomegranate (Punica grantum L.) as potential therapy for type-2 diabetes and metabolic syndrome

  2019cites this paper
• Punicic acid was metabolised and incorporated in the form of conjugated linoleic acid in different rat tissues

  2018cites this paper
• Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health-Promoting Properties

  2018cites this paper
• Advances in the optimized synthesis of biotechnologically valuable products from bio-engineered microbial cell factories

  2018cites this paper