Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular Microbiology

• Publication date

  1999-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-2958.1999.01590.xPMID 10540295
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ultrastructural localization of the secretory aspartyl proteinase in Candida albicans cell wall in vitro and in experimentally infected rat vagina

  2004cited by this paper
• Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations

  2004cited by this paper
• Effects of the Human Immunodeficiency Virus (HIV) Proteinase Inhibitors Saquinavir and Indinavir on In Vitro Activities of Secreted Aspartyl Proteinases of Candida albicans Isolates from HIV-Infected Patients

  1999cited by this paper
• In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients.

  1999cited by this paper
• In Vivo Analysis of Secreted Aspartyl Proteinase Expression in Human Oral Candidiasis

  1999cited by this paper
• Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.

  1999cited by this paper
• The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages

  1998influential reference
• Possible role of secreted proteinases in Candida albicans infections.

  1998cited by this paper
• Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

  1998cited by this paper
• Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.

  1998cited by this paper
• Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity

  1998cited by this paper
• Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes.

  1998cited by this paper
• Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice.

  1998cited by this paper
• Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats

  1997cited by this paper
• Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence

  1997cited by this paper
• Role of aspartic proteases in disseminated Candida albicans infection in mice

  1997influential reference
• A peptide antibiotic from human skin

  1997cited by this paper
• A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence

  1997cited by this paper
• The role ofCandida albicans secreted aspartic proteinase in the development of candidoses

  1996cited by this paper
• Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase

  1996cited by this paper
• Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1 beta.

  1996cited by this paper
• Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1β

  1996cited by this paper
• Candida albicans secreted aspartyl proteinases.

  1996cited by this paper
• Pseudomembranous oral candidiasis in HIV infection: ultrastructural findings.

  1995cited by this paper
• Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors

  1995cited by this paper
• Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis

  1995cited by this paper
• Antifungal drug targets: Candida secreted aspartyl protease and fungal wall beta-glucan synthesis.

  1995cited by this paper
• Multiplicity of genes encoding secreted aspartic proteinases in Candida species

  1994cited by this paper
• Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans

  1994cited by this paper
• Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes

  1993influential reference
• Isogenic strain construction and gene mapping in Candida albicans.

  1993cited by this paper
• Induction of extracellular proteinase in Candida albicans.

  1993cited by this paper
• Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans

  1992cited by this paper
• Putative virulence factors of Candida albicans.

  1991cited by this paper
• Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa

  1988cited by this paper
• Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase

  1988influential reference
• Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans.

  1986cited by this paper
• Genetic evidence for role of extracellular proteinase in virulence of Candida albicans

  1985cited by this paper
• Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck.

  1985cited by this paper
• Scanning electron microscope study of Candida albicans invasion of cultured human cervical epithelial cells.

  1983cited by this paper
• Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant.

  1983cited by this paper
• A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy

  1965influential reference

• New Curcumin Analogue (PAC) Inhibits Candida albicans Virulence, Restricts Its Adhesion Potential, and Relieves Oral Epithelial Cell Inflammation and Defense Mechanisms

  2025cites this paper
• Candida albicans Associated with Periodontal Disease Exhibits Different Clusters of Adhesion Gene and Protease Expression

  2025cites this paper
• Candida albicans Enhances Protease Activity and Activates MyD88‐Dependent IL‐1β Production in Human Keratinocytes

  2025cites this paper
• Antifungal activity of bio-active cell-free culture extracts and volatile organic compounds (VOCs) synthesised by endophytic fungal isolates of Garden Nasturtium

  2024cites this paper
• Prevalence, virulence factors and antifungal susceptibility of oral isolates of Candida albicans from patients with cystic fibrosis in Mexico.

  2024cites this paper
• Saps1–3 Antigens in Candida albicans: Differential Modulation Following Exposure to Soluble Proteins, Mammalian Cells, and Infection in Mice

  2024cites this paper
• Fungal Enzyme‐Responsive Hydrogel Drug Delivery Platform for Triggered Antifungal Release

  2024cites this paper
• Identification of effective plant extracts against candidiasis: an in silico and in vitro approach

  2023cites this paper
• The Early Endocytosis Gene PAL1 Contributes to Stress Tolerance and Hyphal Formation in Candida albicans

  2023cites this paper
• A C. albicans TRAPP Complex-Associated Gene Contributes to Cell Wall Integrity, Hyphal and Biofilm Formation, and Tissue Invasion

  2023cites this paper
• On the relationship between Pathogenic Potential and Infective Inoculum

  2022cites this paper
• Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity

  2022cites this paper
• Consecutive treatments with photodynamic therapy and nystatin altered the expression of virulence and ergosterol biosynthesis genes of a fluconazole-resistant Candida albicans in vivo.

  2021cites this paper
• Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella.

  2021cites this paper
• Evaluation of antimicrobial activity of the extract of Streptomyces euryhalinus isolated from the Indian Sundarbans

  2021cites this paper
• Expression and Purification along with Evaluation of Serological Response and Diagnostic Potential of Recombinant Sap2 Protein from C. parapsilosis for Use in Systemic Candidiasis

  2021cites this paper
• Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.

  2021cites this paper
• Pathogenesis and virulence of Candida albicans

  2021cites this paper
• Vaccination with Secreted Aspartyl Proteinase 2 Protein from Candida parapsilosis Can Enhance Survival of Mice during C. tropicalis-Mediated Systemic Candidiasis

  2020cites this paper
• New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

  2020cites this paper
• Effets de fractions d'écorce de cannelle sur Candida albicans et les cellules épithéliales buccales

  2019cites this paper
• A comparative analysis of protein virulence factors released via extracellular vesicles in two Candida albicans strains cultivated in a nutrient-limited medium.

  2019cites this paper
• The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto.

  2019cites this paper
• Biological and genomic analyses of a clinical isolate of Yarrowia galli from China

  2019cites this paper
• A comparison between DNA-DNA checkerboard hybridization and culture techniques for the detection of Candida species in denture stomatitis

  2019cites this paper
• CO2 Signaling through the Ptc2-Ssn3 Axis Governs Sustained Hyphal Development of Candida albicans by Reducing Ume6 Phosphorylation and Degradation

  2019cites this paper
• Evaluation of the Antifungal and Wound-Healing Properties of a Novel Peptide-Based Bioadhesive Hydrogel Formulation

  2019cites this paper
• Epithelial cell death induced by Candidalysin, a cytolytic peptide toxin of Candida albicans

  2018cites this paper
• Antifungal Activity of Novel C-6 Methyl Substituted Benzothiazole Derivatives against Candida albicans

  2018cites this paper
• REVIEW: Novel sources and functions of microbial lipases and their role in the infection mechanisms

  2018cites this paper
• Hyphal development in Candida albicans from different cell states

  2018cites this paper
• Characterization of a Kunitz trypsin inhibitor from Enterolobium timbouva with activity against Candida species.

  2018cites this paper
• Physiological and Molecular Plant Pathology REVIEW: Novel sources and functions of microbial lipases and their role in the infection mechanisms

  2018cites this paper
• The first isolate of Candida auris in China: clinical and biological aspects

  2018cites this paper
• Molecular analysis of candida albicans Secreted Aspartyl Proteinase 3 (SAP3) Indonesian isolate

  2018cites this paper
• Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production

  2018cites this paper
• Silver-loaded graphene as an effective SERS substrate for clotrimazole detection: DFT and spectroscopic studies.

  2018cites this paper
• Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid‐treated eosinophilic esophagitis

  2018cites this paper
• Proteases and protease inhibitors in infectious diseases

  2018cites this paper
• ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection

  2018cites this paper
• Effect of quinoline based 1,2,3-triazole and its structural analogues on growth and virulence attributes of Candida albicans

  2017cites this paper
• Pathogenic characteristics of Candida albicans isolated from oral cavities of denture wearers and cancer patients wearing oral prostheses.

  2017cites this paper
• Interaction of Candida Species with the Skin

  2017cites this paper
• Unlocking the Therapeutic Potential of the Fungal Cell Wall: Clinical Implications and Drug Resistance

  2017cites this paper
• Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison

  2016cites this paper
• Dosage and Dose Schedule Screening of Drug Combinations in Agent-Based Models Reveals Hidden Synergies

  2016cites this paper
• Zinc Cluster Transcription Factors Alter Virulence in Candida albicans

  2016cites this paper
• Discovery of the gray phenotype and white-gray-opaque tristable phenotypic transitions in Candida dubliniensis

  2016cites this paper
• The Transcriptome of Exophiala dermatitidis during Ex-vivo Skin Model Infection

  2016cites this paper
• The gray phenotype and tristable phenotypic transitions in the human fungal pathogen Candida tropicalis.

  2016cites this paper
• Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans

  2016cites this paper
• Pathogenesis of Candida albicans biofilm.

  2016cites this paper
• Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host

  2016cites this paper
• High Virulence and Antifungal Resistance in Clinical Strains of Candida albicans

  2016cites this paper
• Study the pathogenesis of Candida albicans in animal model

  2015cites this paper
• Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine

  2015cites this paper
• Inactivation of the Antifungal and Immunomodulatory Properties of Human Cathelicidin LL-37 by Aspartic Proteases Produced by the Pathogenic Yeast Candida albicans

  2015cites this paper
• Candida Virulence Factors

  2015cites this paper
• Inactivation of human kininogen-derived antimicrobial peptides by secreted aspartic proteases produced by the pathogenic yeast Candida albicans

  2015cites this paper
• Characterization and Investigation of Fungi Inhabiting the Gastrointestinal Tract of Healthy and Diseased Humans

  2015cites this paper
• Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis

  2015cites this paper
• Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity

  2015cites this paper
• Hybrid phage displaying SLAQVKYTSASSI induces protection against Candida albicans challenge in BALB/c mice

  2014cites this paper
• 9 Mucosal Immunology in Candida albicans Infection

  2014cites this paper
• Aspartic proteinases of Candida spp.: role in pathogenicity and antifungal resistance

  2014cites this paper
• Discovery of a "white-gray-opaque" tristable phenotypic switching system in candida roles of non-genetic diversity in host adaptation.

  2014cites this paper
• Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

  2014cites this paper
• Chapter 33 – Candidapepsin

  2013cites this paper
• SAP Expression in Candida albicans Strains Isolated from Mexican Patients with Vaginal Candidosis

  2013cites this paper
• Candida albicans pathogenicity mechanisms

  2013cites this paper
• Determination of the virulence and antifungal susceptibilities of oral Candiba albicans isolates from patients undergoing cancer treatment

  2013cites this paper
• Human Serum Promotes Candida albicans Biofilm Growth and Virulence Gene Expression on Silicone Biomaterial

  2013cites this paper
• Title Human Serum Promotes Candida albicans Biofilm growth andVirulence Gene Expression on Silicone Biomaterial

  2013cites this paper
• Role of secreted aspartyl proteases in Candida albicans virulence, host immune response and immunoprotection in murine disseminated candidiasis

  2012cites this paper
• ROLE OF ASPARTIC PROTEINASES IN CANDIDA ALBICANS VIRULENCE. PART I. SUBSTRATE SPECIFICITY OF ASPARTIC PROTEINASES AND CANDIDA ALBICANS PATHOGENESIS

  2012cites this paper
• Immune responses to Candida albicans in models of in vitro reconstituted human oral epithelium.

  2012cites this paper
• Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process

  2012cites this paper
• Candida albicans strain-dependent modulation of pro-inflammatory cytokine release by in vitro oral and vaginal mucosal models.

  2012cites this paper
• Encounters with Mammalian Cells: Survival Strategies of Candida Species

  2012cites this paper
• In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms.

  2012cites this paper
• Frequency and expression of ALS and HWP1 genotypes in Candida albicans strains isolated from Mexican patients suffering from vaginal candidosis

  2012cites this paper
• Role of aspartic proteinases in Candida albicans virulence. Part II. Expression of SAP1-10 aspartic proteinase during Candida albicans infections in vivo

  2012cites this paper
• CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis.

  2012cites this paper
• The effect of Dodonaea viscosa var. Angustifolia (L.F.) on the ultrastructure of Candida albicans cell wall and biofilm formation

  2012cites this paper
• In Vitro Evolutionary Dynamics of C. albicans during Adaptation to Fluocnazole

  2012cites this paper
• Fungal Aspartic Proteases as Possible Therapeutic Targets

  2011cites this paper
• In vitro models for human skin disease.

  2011cites this paper
• From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells

  2011cites this paper
• A clinico-pathological and cytological study of oral candidiasis

  2011cites this paper
• Effect of fatty acids on hyphal growth in the pathogenic yeast Candida albicans

  2011cites this paper
• Haemolytic and proteinase activities in clinical isolates of Candida parapsilosis and Candida tropicalis with reference to the isolation anatomic site

  2011cites this paper
• Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections.

  2011cites this paper
• The role of redox-sensitive antioxidants in oxidative stress signalling in Candida albicans

  2011cites this paper
• The renin prosequence enhances constitutive secretion of renin and optimizes renin activity.

  2011cites this paper
• Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis.

  2011cites this paper
• The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa.

  2011cites this paper
• Difference in virulence between fluconazole‐susceptible and fluconazole‐resistant Candida albicans in a mouse model

  2011cites this paper
• Interaction of the mucosal barrier with accessory immune cells during fungal infection.

  2011cites this paper
• The Inflammatory Response Induced by Aspartic Proteases of Candida albicans Is Independent of Proteolytic Activity

  2010cites this paper
• Differential Filamentation of Candida albicans and Candida dubliniensis Is Governed by Nutrient Regulation of UME6 Expression

  2010cites this paper