The history of sweet taste: not exactly a piece of cake

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Molecular Recognition

• Publication date

  2006-05-01

• Fields of study

  Medicine, Chemistry, History

• Identifiers
  DOI 10.1002/jmr.767PMID 16602091
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Micro and macro models of the sweet receptor.

  2005influential reference
• Structure-sweetness relationship in egg white lysozyme: role of lysine and arginine residues on the elicitation of lysozyme sweetness.

  2005cited by this paper
• Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli.

  2005cited by this paper
• Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor

  2005cited by this paper
• From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor.

  2005influential reference
• Identification of the Cyclamate Interaction Site within the Transmembrane Domain of the Human Sweet Taste Receptor Subunit T1R3*[boxs]

  2005cited by this paper
• Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.

  2005cited by this paper
• Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin.

  2004influential reference
• BMC Neuroscience BioMed Central

  2004cited by this paper
• The Cysteine-rich Region of T1R3 Determines Responses to Intensely Sweet Proteins*

  2004cited by this paper
• Taste representations in the Drosophila brain.

  2004cited by this paper
• Unraveling the biochemistry of sweet and umami tastes.

  2004cited by this paper
• Different functional roles of T1R subunits in the heteromeric taste receptors.

  2004cited by this paper
• The receptors for mammalian sweet and umami taste.

  2003cited by this paper
• The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.

  2003cited by this paper
• Critical regions for the sweetness of brazzein 1

  2003cited by this paper
• Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.

  2003influential reference
• Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+

  2002cited by this paper
• General pseudoreceptor model for sweet compounds: a semiquantitative prediction of binding affinity for sweet-tasting molecules.

  2002cited by this paper
• Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2‐T1R3 receptor

  2002influential reference
• Molecular basis of sweet taste in dipeptide taste ligands

  2002influential reference
• Human receptors for sweet and umami taste

  2002influential reference
• Homology-based model of the extracellular domain of the taste receptor T1R3

  2002cited by this paper
• Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac

  2001influential reference
• High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4

  2001cited by this paper
• Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

  2001cited by this paper
• A candidate taste receptor gene near a sweet taste locus

  2001cited by this paper
• Receptors and transduction in taste

  2001cited by this paper
• Molecular genetic identification of a candidate receptor gene for sweet taste.

  2001cited by this paper
• Positional cloning of the mouse saccharin preference (Sac) locus.

  2001cited by this paper
• Solution structure of a sweet protein: NMR study of MNEI, a single chain monellin.

  2001influential reference
• BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.

  2001cited by this paper
• Identification of a novel member of the T1R family of putative taste receptors

  2001cited by this paper
• Mammalian sweet taste receptors.

  2001cited by this paper
• Sweetness and enzymatic activity of lysozyme.

  2001cited by this paper
• A plethora of taste receptors.

  2000cited by this paper
• A family of candidate taste receptors in human and mouse

  2000cited by this paper
• Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

  2000influential reference
• Neurobiology: The good taste of genomics

  2000cited by this paper
• Human Ca2+ Receptor Cysteine-rich Domain

  2000cited by this paper
• A novel family of mammalian taste receptors.

  2000cited by this paper
• A metabotropic glutamate receptor variant functions as a taste receptor

  2000cited by this paper
• CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

  1999cited by this paper
• Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity.

  1999cited by this paper
• Signal transduction. A taste of things to come.

  1999cited by this paper
• Signal transduction: A taste of things to come

  1999cited by this paper
• Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations.

  1999cited by this paper
• Structure of an enantiomeric protein, D-monellin at 1.8 A resolution.

  1998cited by this paper
• Sweetness of lysozymes.

  1998cited by this paper
• Solution structure of the thermostable sweet-tasting protein brazzein

  1998cited by this paper
• Receptors that mediate sweetness: Inferences from biochemical, electrophysiological and psychophysical data

  1997cited by this paper
• Is chemosensory input essential for the rapid rejection of toxic foods?

  1996cited by this paper
• MOLMOL: a program for display and analysis of macromolecular structures.

  1996cited by this paper
• Taste reception.

  1996cited by this paper
• Dali: a network tool for protein structure comparison.

  1995cited by this paper
• USING MODELS TO UNDERSTAND AND DESIGN SWEETENERS

  1995cited by this paper
• The taste-active regions of monellin, a potently sweet protein.

  1995cited by this paper
• Pseudoreceptor Modeling: The Construction of Three-Dimensional Receptor Surrogates

  1995cited by this paper
• Crystallization and preliminary X-ray diffraction studies of curculin. A new type of sweet protein having taste-modifying action.

  1994cited by this paper
• Brazzein, a new high‐potency thermostable sweet protein from Pentadiplandra brazzeana B

  1994cited by this paper
• Is the bitter rejection response always adaptive?

  1994cited by this paper
• Conformational Requirements for Sweet‐Tasting Peptides and Peptidomimetics

  1994influential reference
• Purification, complete amino acid sequence and structural characterization of the heat-stable sweet protein, mabinlin II.

  1993cited by this paper
• Two crystal structures of a potently sweet protein. Natural monellin at 2.75 A resolution and single-chain monellin at 1.7 A resolution.

  1993cited by this paper
• SAR of Sweet Molecules: Conformational Analysis of Two Hypersweet and Two Conformationally Restricted Aspartame Analogues

  1992influential reference
• Crystal structure of a sweet tasting protein thaumatin I, at 1.65 A resolution.

  1992cited by this paper
• Gustducin is a taste-cell-specific G protein closely related to the transducins

  1992cited by this paper
• New aspartame-like sweeteners containing L-(αMe)Phe

  1992cited by this paper
• Sweeteners : discovery, molecular design, and chemoreception

  1991cited by this paper
• Sweet Proteins: Biochemical Studies and Genetic Engineering

  1991cited by this paper
• Structure—Activity Relationship of Sweet Molecules

  1991cited by this paper
• Model for the sweet taste of stereoisomeric retro-inverso and dipeptide amides

  1987cited by this paper
• A procedure for preparing models of receptor sites

  1986cited by this paper
• Three-dimensional structure of thaumatin I, an intensely sweet protein.

  1985cited by this paper
• CRYSTAL STRUCTURE OF ASPARTAME, A PEPTIDE SWEETENER

  1985influential reference
• Soft agonist receptor interactions: Theoretical and experimental simulation of the active site of the receptor of sweet molecules

  1984influential reference
• Structure--sweetness relationship of L-aspartyl dipeptide analogues. A receptor site topology.

  1981cited by this paper
• Three-dimensional mapping of the sweet taste receptor site.

  1978cited by this paper
• Interaction of alpha-L-aspartyl-L-phenylalanine methyl ester with the receptor site of the sweet taste bud.

  1976cited by this paper
• Sweetening agents from natural sources.

  1976cited by this paper
• Sweetening agents from natural sources.

  1976cited by this paper
• Isolation and characterization of thaumatin I and II, the sweet-tasting proteins from Thaumatococcus daniellii Benth.

  1972cited by this paper
• A molecular theory of sweet taste.

  1972cited by this paper
• Structure-taste relationships of some dipeptides.

  1969cited by this paper
• Serendipity Berries–Source of a New Intense Sweetener

  1969cited by this paper
• Taste-Modifying Protein from Miracle Fruit

  1968cited by this paper
• The chemical senses

  1967cited by this paper
• Molecular Theory of Sweet Taste

  1967cited by this paper
• A NEW THEORY RELATING CONSTITUTION TO TASTE. [PRELIMINARY PAPER.] SIMPLE RELATIONS BETWEEN THE CONSTITUTION OF ALIPHATIC COMPOUNDS AND THEIR SWEET TASTE.

  1919cited by this paper
• Die organischen Geschmacksstoffe

  year unknowncited by this paper

• Sugar‐sensing swodkoreceptors and swodkocrine signaling

  2025cites this paper
• A Review of Theoretical Approach to Sweetness in Chemical Compounds

  2024cites this paper
• Safety evaluation of oubli fruit sweet protein (brazzein) derived from Komagataella phaffii, intended for use as a sweetener in food and beverages

  2023cites this paper
• Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor

  2021cites this paper
• Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians

  2021cites this paper
• Structural and anharmonic vibrational spectroscopic analysis of artificial sweetener alitame: A DFT study for molecular basis of sweet taste

  2021cites this paper
• Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia

  2021cites this paper
• Striking Dependence of Protein Sweetness on Water Quality: The Role of the Ionic Strength

  2021cites this paper
• Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation

  2021cites this paper
• Relationship between Molecular Structure and Relative Sweetness of Various Artificial Sweeteners.

  2020cites this paper
• Structural analysis of saccharin in aqueous solution by NMR and supramolecular interactions with α-, β-, γ-cyclodextrins

  2020cites this paper
• Receptor, signal transduction and evolution of sweet, umami and bitter taste

  2019cites this paper
• Hydroxy protons as structural probes to reveal hydrogen bonding properties of polyols in aqueous solution by NMR spectroscopy

  2018cites this paper
• New Sweet-Tasting Oleanane-Type Triterpenoid Saponins from "Tugancao" (Derris eriocarpa How).

  2017cites this paper
• Stevia Glycosides: Chemical and Enzymatic Modifications of Their Carbohydrate Moieties to Improve the Sweet-Tasting Quality.

  2016cites this paper
• Gustatory Receptor-Based Taste Sensors

  2015cites this paper
• Bioinspired Smell and Taste Sensors

  2015cites this paper
• Chinchón declaration; decalogue on low- and no-calorie sweeteners (LNCS).

  2014cites this paper
• em adultos e idosos do Estado de São Paulo.

  2014cites this paper
• Contribution of oak wood ageing to the sweet perception of dry wines

  2013cites this paper
• Molecular Chirality in Chemistry and Biology: Historical Milestones

  2013cites this paper
• Silicon-Containing Dipeptidic Aspartame and Neotame Analogues

  2012cites this paper
• The discovery of stereoselectivity at biological receptors: Arnaldo Piutti and the taste of the asparagine enantiomers--history and analysis on the 125th anniversary.

  2012cites this paper
• Natural low-calorie sweeteners

  2012cites this paper
• Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners.

  2012cites this paper
• Plant derived Sweet and Ice Structuring proteins as new tools in food processing

  2012cites this paper
• Synthesis and P roduction of S weet-T asting P rotein in E . coli and P urification by A mylose R esin

  2011cites this paper
• Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin

  2011cites this paper
• Moleküle und biologische Mechanismen des Süß‐ und Umamigeschmacks

  2011cites this paper
• Validity of early indirect models of taste active sites and advances in new taste technologies enabled by improved models

  2011cites this paper
• Sweet taste receptor gene variation and aspartame taste in primates and other species.

  2011cites this paper
• Sweet and umami taste: natural products, their chemosensory targets, and beyond.

  2011cites this paper
• Sugar absorption in the intestine: the role of GLUT2.

  2008cites this paper
• Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening

  2008cites this paper
• Sweet taste in man: a review.

  2008cites this paper
• Sweetening ruthenium and osmium: organometallic arene complexes containing aspartame

  2008cites this paper
• A preliminary neutron crystallographic study of thaumatin.

  2008cites this paper
• Signal transduction and information processing in mammalian taste buds

  2007cites this paper
• Neoculin : A Sweet-Tasting , Taste-Modifying Protein and its Interaction with T 1 R 2 & T 1 R 3 of the Sweet Taste Receptor Family

  2007cites this paper
• PSYCHOPHYSICAL EVALUATION OF SWEET TASTE PERCEPTION IN MICE

  2006influential citation