The amino acid sensitive TOR pathway from yeast to mammals

No abstract is available for this paper.

• Publication year

  2006

• Venue

  FEBS Letters

• Publication date

  2006-05-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2006.04.068PMID 16684541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency*

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• Retrograde Response to Mitochondrial Dysfunction Is Separable from TOR1/2 Regulation of Retrograde Gene Expression*

  2005cited by this paper
• Rheb binds and regulates the mTOR kinase.

  2005cited by this paper
• Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin

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• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

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• The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses*

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• 4 EBP 1 phosphorylation is mediated by the FRAP-p 70 s 6 k pathway and is independent of mitogen-activated protein kinase ( insulin / signal transduction / translational control )

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• Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex*

  2005cited by this paper
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  2004cited by this paper
• The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver.

  2004cited by this paper
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• Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

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• Tor Signaling and Nutrient-based Signals Converge on Mks1p Phosphorylation to Regulate Expression of Rtg1p·Rtg3p-dependent Target Genes*

  2004cited by this paper
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• Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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• Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

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• The tor pathway: a target for cancer therapy

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• Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe*

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• Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

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• Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes*

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• LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

  2003cited by this paper
• Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

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• Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

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• Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.

  2003cited by this paper
• Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.

  2003cited by this paper
• Identification of a conserved motif required for mTOR signaling.

  2002cited by this paper
• Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

  2002cited by this paper
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  2002cited by this paper
• Mks1p Is Required for Negative Regulation of Retrograde Gene Expression in Saccharomyces cerevisiae but Does Not Affect Nitrogen Catabolite Repression-sensitive Gene Expression*

  2002cited by this paper
• The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

  2002cited by this paper
• Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.

  2002influential reference
• Identification of TOR signaling complexes: more TORC for the cell growth engine.

  2002cited by this paper
• mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

  2002cited by this paper
• Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

  2002cited by this paper
• Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

  2002cited by this paper
• Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.

  2002cited by this paper
• Quick guide: target of rapamycin.

  2002cited by this paper
• TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

  2002cited by this paper
• Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae.

  2002cited by this paper
• Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site*

  2002cited by this paper
• Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.

  2002cited by this paper
• RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3].

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• Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes.

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• Akt regulates growth by directly phosphorylating Tsc2

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  2000influential reference
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes.

  1998cited by this paper
• Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling.

  1998cited by this paper
• RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

  1998cited by this paper
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  1998cited by this paper
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