(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Pharmacology, Biochemistry and Behavior

• Publication date

  1997-12-01

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1016/S0091-3057(97)00303-1PMID 9408217
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Drug discrimination is a continuous rather than a quantal process following training on a VI-TO schedule of reinforcement

  2005cited by this paper
• In a drug discrimination procedure isolation-reared rats generalize to lower doses of cocaine and amphetamine than rats reared in an enriched environment

  2005cited by this paper
• The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

  2005cited by this paper
• Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine

  2005cited by this paper
• Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effect of nicotine

  2004cited by this paper
• Role of training dose in discrimination of nicotine and related compounds by rats

  2004cited by this paper
• Nicotine and some related compounds: effects on schedule-controlled behaviour and discriminative properties in rats

  2004cited by this paper
• Brain sites mediating the discriminative stimulus effects of nicotine in rats.

  1996cited by this paper
• Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

  1996cited by this paper
• Stimulus effects of d-amphetamine II: DA, NE, and 5-HT mechanisms.

  1995cited by this paper
• Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats

  1995cited by this paper
• Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats

  1995cited by this paper
• Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.

  1995cited by this paper
• Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.

  1994cited by this paper
• Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

  1994cited by this paper
• Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus.

  1994cited by this paper
• Dopaminergic mediation of the stimulant generalization of nicotine.

  1993cited by this paper
• Preferential stimulation of locomotor activity by ventral tegmental microinjections of (-)-nicotine.

  1992cited by this paper
• Locomotor activity in rats after administration of nicotinic agonists intracerebrally

  1990cited by this paper
• Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N'-propylnornicotine.

  1990cited by this paper
• Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital.

  1989cited by this paper
• Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

  1988cited by this paper
• Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

  1988cited by this paper
• Transduction Mechanisms of Drug Stimuli

  1988cited by this paper
• Receptor mechanisms of opioid drug discrimination.

  1988cited by this paper
• Effects of the stereoisomers of nicotine and nornicotine on schedule-controlled responding and physiological parameters of dogs.

  1988cited by this paper
• Cueing effects of amphetamine and LSD: elicitation by direct microinjection of the drugs into the nucleus accumbens.

  1986cited by this paper
• Effects of nicotine, cocaine and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys.

  1985cited by this paper
• Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms.

  1983cited by this paper
• Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of nicotine in the rat.

  1982cited by this paper
• A description of the nicotine stimulus and tests of its generalization to amphetamine

  1977cited by this paper
• Role of dopamine in d-amphetamine-induced discriminative responding.

  1975cited by this paper
• Metabolism of nicotine in the human and excretion of pyridine compounds by smokers.

  1959cited by this paper

• β-Nicotyrine and e-cigarette abuse liability I: Pharmacodynamics and interaction with pharmacokinetics and discriminative stimulus effects of nicotine in rats.

  2025cites this paper
• The co-use of nicotine and prescription psychostimulants: A review of their behavioral and neuropharmacological interactions.

  2023cites this paper
• Anatabine, Nornicotine, and Anabasine Reduce Weight Gain and Body Fat through Decreases in Food Intake and Increases in Physical Activity

  2022cites this paper
• The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

  2018cites this paper
• Effects of Nicotine Metabolites on Nicotine Withdrawal Behaviors in Mice

  2017cites this paper
• The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present).

  2017cites this paper
• Nicotinic effects of tobacco smoke constituents in nonhuman primates

  2016cites this paper
• Whole tobacco smoke extracts to model tobacco dependence in animals.

  2014cites this paper
• Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.

  2013cites this paper
• Nicotine Addiction: Past and Present

  2010cites this paper
• Nicotine elicits methamphetamine-seeking in rats previously administered nicotine.

  2010cites this paper
• The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.

  2010cites this paper
• Individual vulnerability to substance abuse and affective disorders: Role of early environmental influences

  2009cites this paper
• Neuropharmacology of the interoceptive stimulus properties of nicotine.

  2009cites this paper
• Methylphenidate Enhances the Abuse-Related Behavioral Effects of Nicotine in Rats: Intravenous Self-Administration, Drug Discrimination, and Locomotor Cross-Sensitization

  2008cites this paper
• Occasion setting by drug states: Functional equivalence following similar training history.

  2008cites this paper
• Contribution of Animal Models and Preclinical Human Studies to Medication Development for Nicotine Dependence

  2008cites this paper
• Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats.

  2008cites this paper
• The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery

  2007cites this paper
• The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats

  2007cites this paper
• SYNTHESIS AND EVALUATION OF PYRIDINIUM DERIVATIVES AS CENTRAL NERVOUS SYSTEM NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

  2006cites this paper
• Stimulus Properties of Nicotine, Amphetamine, and Chlordiazepoxide as Positive Features in a Pavlovian Appetitive Discrimination Task in Rats

  2005cites this paper
• A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine

  2005cites this paper
• Effects of amphetamine-CNS depressant combinations and of other CNS stimulants in four-choice drug discriminations.

  2005cites this paper
• A (1R,2R,5R)-(+)-2α-hydroxy­pinan-3-one ketimine

  2005cites this paper
• Retention of sequential drug discriminations under fixed-interval schedules for long time periods without training.

  2003cites this paper
• Nicotine-like discriminative stimulus effects of bupropion in rats.

  2002cites this paper
• An immunotherapeutic program for the treatment of nicotine addiction: hapten design and synthesis.

  2001cites this paper
• Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.

  2001cites this paper
• Long-lasting rebound cue effects following single doses of nicotine and amphetamine: implications for understanding tolerance

  2001cites this paper
• Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress.

  2000cites this paper
• Behavioural Pharmacology and Neurobiology of Nicotine Reward and Dependence

  2000cites this paper
• Role of dopamine in the behavioural actions of nicotine related to addiction.

  2000cites this paper
• Role of dopamine in the behavioural actions of nicotine related to addiction.

  2000cites this paper
• A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template.

  1999cites this paper
• Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine

  1999cites this paper
• ASYMMETRIC GENERALIZATION BETWEENTHE DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE AND COCAINE

  1998cites this paper