The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Neurochemistry

• Publication date

  2007-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1471-4159.2006.04355.xPMID 17241116
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Volume Index

  2009cited by this paper
• Mesolimbic dopamine activation--the key to nicotine reinforcement?

  2007cited by this paper
• The scientific case that nicotine is addictive

  2005cited by this paper
• The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

  2005cited by this paper
• The Effects of Subunit Composition on the Inhibition of Nicotinic Receptors by the Amphipathic Blocker 2,2,6,6-Tetramethylpiperidin-4-yl Heptanoate

  2005cited by this paper
• Selective dopamine antagonists reduce nicotine self-administration

  2005cited by this paper
• Nicotine intake in smokers increases following a single dose of haloperidol

  2005cited by this paper
• Nicotine and some related compounds: effects on schedule-controlled behaviour and discriminative properties in rats

  2004cited by this paper
• Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

  2004cited by this paper
• The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

  2004cited by this paper
• α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors

  2003cited by this paper
• Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors.

  2003influential reference
• Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats

  2003cited by this paper
• Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics

  2003cited by this paper
• Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

  2003cited by this paper
• Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

  2002cited by this paper
• Locomotor stimulant effects of nornicotine: role of dopamine.

  2002cited by this paper
• Long‐lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys

  2002cited by this paper
• Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions.

  2002cited by this paper
• Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis

  2002cited by this paper
• Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.

  2002cited by this paper
• Overview of nicotinic receptors and their roles in the central nervous system.

  2001cited by this paper
• Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver.

  2001cited by this paper
• Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity.

  2001cited by this paper
• Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.

  2001cited by this paper
• Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.

  2001cited by this paper
• Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses

  2000cited by this paper
• Identification of a novel nicotinic binding site in mouse brain using [125I]‐epibatidine

  2000cited by this paper
• The Activation and Inhibition of Human Nicotinic Acetylcholine Receptor by RJR‐2403 Indicate a Selectivity for the α4β2 Receptor Subtype

  2000cited by this paper
• The effects of dopaminergic D2 stimulation and blockade on smoking behavior.

  1999cited by this paper
• A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template.

  1999cited by this paper
• IN VITRO METABOLISM OF (S)-(-)-[2'- 14C]NICOTINE, USING VARIOUS TISSUE PREPARATIONS OF MARMOSET

  1999cited by this paper
• Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.

  1999cited by this paper
• Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

  1998cited by this paper
• alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.

  1998cited by this paper
• Asymmetric generalization between the discriminative stimulus effects of nicotine and cocaine.

  1998cited by this paper
• Effect of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats.

  1998cited by this paper
• ASYMMETRIC GENERALIZATION BETWEENTHE DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE AND COCAINE

  1998cited by this paper
• "Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor.

  1997cited by this paper
• Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.

  1997cited by this paper
• (-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.

  1997cited by this paper
• Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking.

  1997cited by this paper
• Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits*

  1996cited by this paper
• Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.

  1995cited by this paper
• Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

  1994cited by this paper
• Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.

  1994cited by this paper
• Pharmacokinetics of (S)-nicotine and metabolites in humans

  1993influential reference
• The competition of (−)-[3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different brain regions of rat

  1993cited by this paper
• S(‐)‐Nornicotine Increases Dopamine Release in a Calcium‐Dependent Manner from Superfused Rat Striatal Slices

  1993cited by this paper
• Nicotine and metabolites: analysis and levels in body fluids

  1993influential reference
• Characterization of Nicotinic Receptor‐Mediated [3H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

  1992cited by this paper
• The Competition

  1992cited by this paper
• A comparison of the binding of nicotine and nornicotine stereoisomers to nicotinic binding sites in rat brain cortex

  1991cited by this paper
• Stable isotope studies of nicotine kinetics and bioavailability

  1991cited by this paper
• High affinity binding of [3H] (-)-nicotine to rat brain membranes and its inhibition by analogues of nicotine.

  1988cited by this paper
• Effects of the stereoisomers of nicotine and nornicotine on schedule-controlled responding and physiological parameters of dogs.

  1988cited by this paper
• Effects of nicotine, cocaine and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys.

  1985cited by this paper
• High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.

  1984cited by this paper
• Central sites and mechanisms of action of nicotine.

  1981cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper
• PHARMACOLOGICAL PROPERTIES OF SOME PYRROLIDINE N-SUBSTITUTED NORNICOTINE DERIVATIVES.

  1963cited by this paper
• Demethylation in the Metabolism of (-)-Nicotine

  1962cited by this paper
• Phytochemical studies on the tobacco alkaloids. III. Observations on the interconversion of DL-nicotine and DL-nornicotine in excised tobacco leaves.

  1961cited by this paper
• Phytochemical studies on the tobacco alkaloids. I. Optical rotatory power of nornicotine.

  1961cited by this paper
• Metabolism of nicotine in the human and excretion of pyridine compounds by smokers.

  1959cited by this paper

• β-Nicotyrine and e-cigarette abuse liability II: Behavioral economic demand and intracranial self-stimulation in rats.

  2026cites this paper
• Acetylcholine in the hippocampus: problems and achievements

  2025cites this paper
• Selective Chiral Diamine-bisoxazoline Iron(II) Catalysts for Pyrrolidine Formation via Intramolecular C(sp3)–H Amination of Aliphatic Azides

  2025cites this paper
• Dual Cholinergic Modulation in Dementia: Quinuclidine Carbamates Targeting Butyrylcholinesterase and α7 Nicotinic Receptor.

  2025cites this paper
• α6 nicotinic acetylcholine receptors: A pharmacological challenge with untapped therapeutic promise.

  2025cites this paper
• Nicotinic acetylcholine receptor signaling regulates cytokine production in Jurkat T cells

  2025cites this paper
• Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization

  2025cites this paper
• Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes

  2024cites this paper
• Switching of Protonation Sites in Hydrated Nicotine via a Grotthuss Mechanism.

  2024cites this paper
• The many enigmas of nicotine.

  2024cites this paper
• Affinity of Nicotinoids to a Model Nicotinic Acetylcholine Receptor (nAChR) Binding Pocket in the Human Brain.

  2024cites this paper
• The Gas Phase Protonation Sites of Six Naturally Occurring Nicotinoids.

  2024cites this paper
• Nicotinic acetylcholine receptors: key targets for attenuating neurodegenerative diseases.

  2023cites this paper
• Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands.

  2023cites this paper
• Loss function of NtGA3ox1 delays flowering through impairing gibberellins metabolite synthesis in Nicotiana tabacum

  2023cites this paper
• Varenicline serves as the training stimulus in the drug-discriminated goal-tracking task with rats: initial evaluation of potential neuropharmacological processes

  2022cites this paper
• Anatabine, Nornicotine, and Anabasine Reduce Weight Gain and Body Fat through Decreases in Food Intake and Increases in Physical Activity

  2022cites this paper
• Structure of Gas Phase Monohydrated Nicotine: Implications for Nicotine's Native Structure in the Acetylcholine Binding Protein.

  2022cites this paper
• Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors

  2022cites this paper
• Gas phase protonated nicotine is a mixture of pyridine- and pyrrolidine-protonated conformers: implications for its native structure in the nicotinic acetylcholine receptor.

  2021cites this paper
• Nicotine and its derivatives in healthy brain aging

  2021cites this paper
• Therapeutic Targeting of a7 Nicotinic Acetylcholine Receptors

  2021influential citation
• Antidepressant effect of methanol extract of smokeless tobacco and identification of its bioactive components

  2021cites this paper
• Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors

  2021cites this paper
• Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages

  2021cites this paper
• α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity.

  2021cites this paper
• Effects of nicotine, nornicotine and cotinine, alone or in combination, on locomotor activity and ultrasonic vocalization emission in adult rats

  2020cites this paper
• Bibliography

  2020cites this paper
• Pyridine alkaloids with activity in the central nervous system

  2020cites this paper
• Molecular Insights Into Memory-Enhancing Metabolites of Nicotine in Brain: A Systematic Review

  2019cites this paper
• Molecular mechanisms for nicotine intoxication.

  2019cites this paper
• Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds.

  2019cites this paper
• 17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-β Toxicity by Nicotinic Acetylcholine Receptors

  2018cites this paper
• HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns

  2018cites this paper
• Photoactivatable drugs for nicotinic optopharmacology

  2018cites this paper
• The effect of sazetidine‐A and other nicotinic ligands on nicotine controlled goal‐tracking in female and male rats

  2017influential citation
• The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present).

  2017cites this paper
• Effects of Nicotine Metabolites on Nicotine Withdrawal Behaviors in Mice

  2017cites this paper
• Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus.

  2017cites this paper
• The Effect of Altering Brain CYP2B Activity on Nicotine Self-administration Behaviour and Nicotine Levels in the Brain

  2016cites this paper
• Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

  2015cites this paper
• The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats

  2015cites this paper
• Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.

  2014cites this paper
• Functional Characterization of a Novel Family of Acetylcholine-Gated Chloride Channels in Schistosoma mansoni

  2014cites this paper
• Understanding the Role α7 Nicotinic Receptors Play in Dopamine Efflux in Nucleus Accumbens

  2014cites this paper
• Merging old and new perspectives on nicotinic acetylcholine receptors.

  2014cites this paper
• Isomers and conformational barriers of gas-phase nicotine, nornicotine, and their protonated forms.

  2014cites this paper
• Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153

  2013cites this paper
• Similar activity of mecamylamine stereoisomers in vitro and in vivo.

  2013cites this paper
• Novel Insights on the Effect of Nicotine in a Murine Colitis Model

  2013cites this paper
• Nicotinic receptors as therapeutic targets for drug addictive disorders.

  2013cites this paper
• Nicotinic acetylcholine receptors: from basic science to therapeutics.

  2013cites this paper
• Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma.

  2013cites this paper
• Disentangling the nature of the nicotine stimulus.

  2012cites this paper
• Impact of tobacco regulation on animal research: new perspectives and opportunities.

  2012cites this paper
• Nornicotine application on cockroach dorsal unpaired median neurons induces two distinct ionic currents: implications of different nicotinic acetylcholine receptors.

  2012cites this paper
• Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper.

  2011cites this paper
• Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors

  2011cites this paper
• The Effects of β-Amyloid on α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes

  2011cites this paper
• Brain nicotinic receptors as emerging targets for drug addiction: neurobiology to translational research.

  2011cites this paper
• The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.

  2011cites this paper
• OPIOID CODRUGS FOR PAIN MANAGEMENT

  2011cites this paper
• Alpha7 Nicotinic Acetylcholine Receptor Expression and Activity During Neuronal Differentiation of PC12 Pheochromocytoma Cells

  2010cites this paper
• Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.

  2010cites this paper
• The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.

  2010influential citation
• The frequency‐dependence of the nicotine‐induced inhibition of dopamine is controlled by the α7 nicotinic receptor

  2010cites this paper
• High throughput electrophysiology with Xenopus oocytes.

  2009cites this paper
• Efeito da nicotina na ativação do fator de transcrição NF-B no sistema nervoso central na vigência de estímulo inflamatório induzido por lipopolissacarídeo (LPS)

  2009cites this paper
• Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.

  2009cites this paper
• Nicotinic receptor-based therapeutics and candidates for smoking cessation.

  2009cites this paper
• A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.

  2009cites this paper
• Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds

  2009cites this paper
• Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology.

  2009cites this paper
• DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF A SERIES OF NOVEL, GUANIDINE AND AMIDINE-CONTAINING NEONICOTINOID-LIKE ANALOGS OF NICOTINE: SUBTYPE-SELECTIVE INTERACTIONS AT NEURONAL NICOTINIC-ACETYLCHOLINE RECEPTOR.

  2008cites this paper
• Nicotine use in patients with schizophrenia evaluated by the Fagerström Tolerance Questionnaire: a descriptive analysis from a Brazilian sample.

  2008cites this paper
• Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.

  2008influential citation
• Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats.

  2008cites this paper
• haracterization of compounds on nicotinic acetylcholine receptor alpha 7 hannels using higher throughput electrophysiology

  2008cites this paper
• Stimulation of the alpha4beta2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice.

  2008cites this paper
• Lack of beneficial galantamine effect for smoking behavior: a double-blind randomized trial in people with schizophrenia.

  2008cites this paper
• Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).

  2007cites this paper