A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10779761
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice.

  1999cited by this paper
• MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti–double-stranded DNA B Cells

  1999cited by this paper
• Positive selection of natural autoreactive B cells.

  1999cited by this paper
• Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment

  1999cited by this paper
• V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

  1998cited by this paper
• A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

  1998cited by this paper
• Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase

  1998cited by this paper
• Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

  1998cited by this paper
• B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation

  1998cited by this paper
• BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro.

  1997cited by this paper
• Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

  1997cited by this paper
• In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

  1997cited by this paper
• Editing disease-associated autoantibodies.

  1997cited by this paper
• Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

  1997cited by this paper
• Distinctive developmental origins and specificities of the CD5+ B-cell subset.

  1996cited by this paper
• B-1 cells and their reactivity with the murine intestinal microflora.

  1996cited by this paper
• CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

  1996cited by this paper
• The "clonal selection hypothesis" and current concepts of B cell tolerance.

  1996cited by this paper
• Clonal selection and learning in the antibody system

  1996cited by this paper
• B-1 cells: unique origins and functions.

  1996cited by this paper
• Generation and function of natural self-reactive B lymphocytes.

  1996cited by this paper
• Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

  1996cited by this paper
• Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

  1996cited by this paper
• B cell differentiation and isotype switching is related to division cycle number

  1996cited by this paper
• B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen

  1996cited by this paper
• Transitional B cells are the target of negative selection in the B cell compartment

  1995cited by this paper
• Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

  1995cited by this paper
• Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

  1995cited by this paper
• The majority of murine VH12‐expressing B cells are excluded from the peripheral repertoire in adults

  1995cited by this paper
• B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

  1995cited by this paper
• Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

  1995cited by this paper
• Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin.

  1995cited by this paper
• Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA.

  1995cited by this paper
• Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance

  1994cited by this paper
• Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny

  1994cited by this paper
• Decreased surface IgM receptor-mediated activation of phospholipase C gamma 2 in B-1 lymphocytes.

  1994cited by this paper
• Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody.

  1994cited by this paper
• Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression

  1994cited by this paper
• Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

  1994cited by this paper
• Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes

  1993cited by this paper
• The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow

  1993cited by this paper
• Receptor editing in self-reactive bone marrow B cells

  1993cited by this paper
• Origin of murine B cell lineages.

  1993cited by this paper
• The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

  1993cited by this paper
• VH CDR3‐dependent positive selection of murine VH12‐expressing B cells in the neonate

  1993cited by this paper
• B-1 cells are made, not born.

  1993cited by this paper
• Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice.

  1993cited by this paper
• Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

  1993cited by this paper
• Generation of Ly‐1 B Cells from Developmentally Distinct Precursors

  1992cited by this paper
• Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

  1992cited by this paper
• A transgenic model of autoimmune hemolytic anemia

  1992cited by this paper
• Loss of CD23 Is a Consequence of B‐Cell Activation

  1992cited by this paper
• Differential development of progenitor activity for three B-cell lineages.

  1992cited by this paper
• Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

  1991cited by this paper
• An embryonic source of Ly1 but not conventional B cells.

  1991cited by this paper
• A developmental switch in B lymphopoiesis.

  1991cited by this paper
• Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

  1991cited by this paper
• Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways.

  1991cited by this paper
• Peripheral deletion of self-reactive B cells

  1991cited by this paper
• Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences

  1990cited by this paper
• Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B‐CLL progenitor generation.

  1990cited by this paper
• Rearrangement and selection of VH11 in the Ly-1 B cell lineage

  1990cited by this paper
• All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes.

  1990cited by this paper
• Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein

  1990cited by this paper
• Organization and expression of vh gene families preferentially expressed by ly‐1+ (cd5) b cells

  1989cited by this paper
• Biased immunoglobulin variable region gene expression by Ly‐1 B cells due to clonal selection

  1989cited by this paper
• Restricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline

  1989cited by this paper
• Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

  1989cited by this paper
• Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity.

  1989cited by this paper
• Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM.

  1988cited by this paper
• Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage?

  1988cited by this paper
• A MEMBER OF A NEW VH GENE FAMILY ENCODES ANTI‐BROMELINIZED MOUSE RED BLOOD CELL AUTOANTIBODIES

  1988cited by this paper
• Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes

  1988cited by this paper
• Rheumatoid factor secretion from human Leu-1+ B cells.

  1987cited by this paper
• Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice.

  1986cited by this paper
• Peritoneal Ly‐1 B cells: Genetic control, autoantibody production, increased lambda light chain expression

  1986cited by this paper
• The Ly-1 B cell lineage.

  1986cited by this paper
• Progenitors for Ly-1 B cells are distinct from progenitors for other B cells

  1985cited by this paper
• Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

  1984cited by this paper
• The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice

  1983cited by this paper

• Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice

  2022cites this paper
• Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire

  2022cites this paper
• Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.

  2020cites this paper
• B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.

  2019cites this paper
• Control of B-1a cell development by instructive BCR signaling.

  2018cites this paper
• Mechanisms of central tolerance for B cells

  2017cites this paper
• A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells

  2016cites this paper
• Natural IgM Is Produced by CD5− Plasma Cells That Occupy a Distinct Survival Niche in Bone Marrow

  2015cites this paper
• Dickkopf-3 Acts as a Modulator of B Cell Fate and Function

  2015cites this paper
• Fate and Function Dickkopf-3 Acts as a Modulator of B Cell

  2015cites this paper
• NF‐κB signaling in B‐1 cell development

  2015cites this paper
• High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice

  2014cites this paper
• Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia.

  2014cites this paper
• Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development.

  2013cites this paper
• Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling

  2013cites this paper
• Human B‐1 cells take the stage

  2013cites this paper
• Chronic lymphocytic leukemia: A tale of one or two signals?

  2012cites this paper
• CD22 × Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

  2010cites this paper
• A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation

  2010cites this paper
• B-1 cell-derived monoclonal antibodies and costimulatory molecules.

  2009cites this paper
• Peritoneal B-cell subsets in the genus Mus: their role in innate immunity.

  2008cites this paper
• The protean nature of cells in the B lymphocyte lineage.

  2007cites this paper
• Btk regulates multiple stages in the development and survival of B-1 cells.

  2007cites this paper
• Role of B-1a cells in autoimmunity.

  2006cites this paper
• Peritoneal B‐2 cells comprise a distinct B‐2 cell population with B‐1b‐like characteristics

  2006cites this paper
• B-1 B Cell Development1

  2006cites this paper
• Cutting Edge: Inherent and Acquired Resistance to Radiation-Induced Apoptosis in B Cells: A Pivotal Role for STAT31

  2006cites this paper
• This information is current as B Cells : A Pivotal Role for STAT 3 inResistance to Radiation-Induced Apoptosis Cutting Edge : Inherent and Acquired Rickert

  2006cites this paper
• Differential regulation of protein- and polysaccharide-specific Ig isotype production in vivo in response to intact Streptococcus pneumoniae.

  2006cites this paper
• Signals from a Self-Antigen Induce Positive Selection in Early B Cell Ontogeny but Are Tolerogenic in Adults1

  2006cites this paper
• Receptor editing in lymphocyte development and central tolerance

  2006cites this paper
• Cutting Edge: B-1 Cells Are Deficient in Lck: Defective B Cell Receptor Signal Transduction in B-1 Cells Occurs in the Absence of Elevated Lck Expression1

  2005cites this paper
• Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes

  2005cites this paper
• Pre-B cell loss in senescence coincides with preferential development of immature B cells characterized by partial activation and altered Vh repertoire.

  2005cites this paper
• The role of serum IgM in immunity and autoimmunity.

  2005cites this paper
• Selection during development of VH11+ B cells: a model for natural autoantibody‐producing CD5+ B cells

  2004cites this paper
• Peritoneal and splenic B‐1 cells are separable by phenotypic, functional, and transcriptomic characteristics

  2004cites this paper
• Latent Membrane Protein 2A, a Viral B Cell Receptor Homologue, Induces CD5+ B-1 Cell Development1

  2004cites this paper
• Transgenic Expression of a Human Polyreactive Ig Expressed in Chronic Lymphocytic Leukemia Generates Memory-Type B Cells That Respond to Nonspecific Immune Activation1

  2004cites this paper
• Development and selection of marginal zone B cells

  2004cites this paper
• Tolerance‐induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte‐positive selection

  2004cites this paper
• Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

  2004cites this paper
• Positive Selection of Anti–Thy-1 Autoreactive B-1 Cells and Natural Serum Autoantibody Production Independent from Bone Marrow B Cell Development

  2003cites this paper
• A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107

  2003cites this paper
• Régulation concertée de l'expression des chaînes d'immunoglobulines et conséquences de ses anomalies en pathologie

  2003cites this paper
• X‐chromosome‐linked immune‐deficient mice have B‐1b cells

  2003cites this paper
• Role of the Chemokine Stromal Cell-Derived Factor 1 in Autoantibody Production and Nephritis in Murine Lupus1

  2003cites this paper
• Defective CD19-dependent signaling in B-1a and B-1b B lymphocyte subpopulations.

  2002cites this paper
• Cutting Edge Commentary: Two B-1 or Not To Be One1

  2002cites this paper
• Origins and functions of B-1 cells with notes on the role of CD5.

  2002cites this paper
• Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire1

  2002cites this paper
• Age‐dependent increase of peritoneal B‐1b B cells in SCID mice

  2002cites this paper
• CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.

  2002cites this paper
• Peritoneal CD5+ B-1 Cells Have Signaling Properties Similar to Tolerant B Cells*

  2002cites this paper
• Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells.

  2001cites this paper
• B cell development pathways.

  2001cites this paper
• with Immunoglobulin (Ig) (cid:2) Immunoreceptor Tyrosine–based Activation Motif (ITAM) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig (cid:3) Cytoplasmic Tail

  2001cites this paper
• with Immunoglobulin (Ig) (cid:2) Immunoreceptor Tyrosine–based Activation Motif (ITAM) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig (cid:3) Cytoplasmic Tail

  2001cites this paper
• Cutting Edge Commentary: Origins of B-1 Cells1 2

  2001cites this paper
• Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

  2001cites this paper
• The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families

  2001cites this paper
• Relatively Normal Human Lymphopoiesis but Rapid Turnover of Newly Formed B Cells in Transplanted Nonobese Diabetic/SCID Mice1

  2001cites this paper
• Autoreactivity by design: innate B and T lymphocytes

  2001cites this paper
• B1 cells: similarities and differences with other B cell subsets.

  2001cites this paper
• The level of expression of mu heavy chain modifies the composition of peripheral B cell subpopulations.

  2000cites this paper
• CD1d-restricted mouse V alpha 14 and human V alpha 24 T cells: lymphocytes of innate immunity.

  2000cites this paper